Cc1c([C@@H](C)Nc2nnc(C)c3ccc(N4CCNCC4)cc23)cccc1C(F)(F)F CHEMBL5208088 Ki 0.33 nM
Cc1c([C@@H](C)Nc2nnc(C)c3cnc(N4CCNCC4)cc23)cccc1C(F)(F)F CHEMBL5202472 Ki 0.36 nM
Cc1c([C@@H](C)Nc2nnc(C)c3ccc(N4CCN(C)C(=O)C4)cc23)cccc1C(F)(F)F CHEMBL5191446 Ki 0.43 nM
CNCc1ccccc1-c1csc([C@@H](C)Nc2nnc(C)c3cc(OC)c(OC)cc23)c1 CHEMBL5206295 Ki 0.5 nM
Cc1c([C@@H](C)Nc2nnc(C)c3cnc(N4CCOCC4)cc23)cccc1C(F)(F)F CHEMBL5209371 Ki 0.91 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(-c4ccn(CC(=O)N(C)C)c(=O)c4)cc23)c1 CHEMBL4442809 IC50 1.0 nM
Cc1c([C@@H](C)Nc2nnc(N(C)C)c3ccc(N4CCNCC4)cc23)cccc1C(F)(F)F CHEMBL5176365 Ki 1.1 nM
Cc1c(Br)cccc1[C@@H](C)Nc1nnc(C)c2cnc(N3CCOCC3)cc12 CHEMBL5193021 Ki 1.6 nM
Cc1c(C#N)cccc1[C@@H](C)Nc1nnc(C)c2cnc(N3CCOCC3)cc12 CHEMBL5192659 Ki 1.9 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@H](C(=O)N2CCOCC2)CC1 CHEMBL4465802 IC50 2.0 nM
COCC(=O)N1CCC(c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4469357 IC50 2.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C)CC3)c(C)cc2n1 CHEMBL4554249 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@H](C(=O)N2CCN(C)CC2)CC1 CHEMBL4557641 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 CHEMBL4515975 IC50 2.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C[C@H](C)O)CC3)ccc2n1 CHEMBL4593376 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)CCO)CC1 CHEMBL4588008 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@@H](C(=O)N(C)CCO)CC1 CHEMBL4586874 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)C[C@@H](C)O)CC1 CHEMBL4519925 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(C)=O)CC1 CHEMBL4532163 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1C1CCN(C(C)=O)CC1 CHEMBL4475551 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1C1=CCC(C(=O)N(C)C)CC1 CHEMBL4529467 IC50 2.0 nM
COCC(=O)N1CC=C(c2cc3c(N[C@H](C)c4cccc(C(F)(F)CO)c4)nc(C)nc3cc2OC)CC1 CHEMBL4449786 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1C1=CCN(C(C)=O)CC1 CHEMBL4476562 IC50 2.0 nM
COCCN1CCN(C(=O)[C@H]2CC[C@H](c3ccc4nc(C)nc(N[C@H](C)c5cc(N)cc(C(F)(F)F)c5)c4c3)CC2)CC1 CHEMBL4550769 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 CHEMBL4449981 IC50 2.0 nM
COCCN1CCN(C(=O)[C@H]2CC[C@H](c3cc4c(N[C@H](C)c5cc(N)cc(C(F)(F)F)c5F)nc(C)nc4cc3OC)CC2)CC1 CHEMBL4584280 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 CHEMBL4436505 IC50 2.0 nM
COCCN(C)C(=O)[C@H]1CC[C@H](c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4474160 IC50 2.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N4CCOCC4)CC3)ccc2n1 CHEMBL4540213 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3F)c2cc1C1(O)CCN(C(C)=O)CC1 CHEMBL4555192 IC50 2.0 nM
COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C(F)(F)CO)c4)nc(C)nc3cc2OC)CC1 CHEMBL4456066 IC50 2.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1C1CCN(C(C)=O)CC1 CHEMBL4471555 IC50 2.0 nM
Cc1c([C@@H](C)Nc2nnc(C)c3ccc(N(C)C)cc23)cccc1C(F)(F)F CHEMBL5179610 Ki 2.2 nM
Cc1c([C@@H](C)Nc2nnc(C)c3cnc(N4CCOCC4)cc23)cccc1S(C)(=O)=O CHEMBL5198950 Ki 2.3 nM
COc1cc2c(C)nnc(N[C@H](C)c3cccc(C(F)(F)F)c3C)c2cc1OC CHEMBL5171096 Ki 2.6 nM
COCCN(C)C(=O)[C@H]1CC[C@H](c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2OC)CC1 CHEMBL4513254 IC50 3.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCN(C(=O)CN(C)C)CC3)ccc2n1 CHEMBL4539190 IC50 3.0 nM
COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)CC1 CHEMBL4474479 IC50 3.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCS(=O)(=O)CC3)c(C)cc2n1 CHEMBL4449118 IC50 3.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCS(=O)(=O)CC3)ccc2n1 CHEMBL4476263 IC50 3.0 nM
COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4F)nc(C)nc3cc2OC)CC1 CHEMBL4585988 IC50 3.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)CCO)CC3)ccc2n1 CHEMBL4552956 IC50 3.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C[C@@H](C)O)CC3)ccc2n1 CHEMBL4545778 IC50 3.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)CC(C)(C)O)CC3)ccc2n1 CHEMBL4456153 IC50 3.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)CC(C)(C)O)CC1 CHEMBL4460195 IC50 3.0 nM
COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2OC)CC1 CHEMBL4582516 IC50 3.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C)CC3)ccc2n1 CHEMBL4441565 IC50 3.0 nM
CCN(C)C(=O)[C@H]1CC[C@H](c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4462383 IC50 3.0 nM
COCC(=O)N1CC=C(c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4534957 IC50 3.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1O[C@H]1CCN(C(C)=O)C1 CHEMBL4435672 IC50 3.0 nM
CC(=O)N1CC[C@H](Oc2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)C1 CHEMBL4441648 IC50 3.0 nM
CCC(=O)N1CC[C@H](Oc2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)C1 CHEMBL4442848 IC50 3.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1O[C@H]1CCOC1 CHEMBL4551407 IC50 3.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1O[C@@H]1CCOC1 CHEMBL4540709 IC50 3.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1C1CCOCC1 CHEMBL4571098 IC50 3.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1O[C@H]1CCOC1 CHEMBL4519023 Kd 3.0 nM
Cc1nnc(N[C@H](C)c2cccc(C(F)(F)F)c2F)c2cc(N3CCOCC3)ncc12 CHEMBL5176509 Ki 3.0 nM
Cc1c([C@@H](C)Nc2nnc(C)c3ccc(C4CCNCC4)cc23)cccc1C(F)(F)F CHEMBL5176696 Ki 3.1 nM
CNCc1ccccc1-c1csc([C@@H](C)Nc2nncc3cc(OC)c(OC)cc23)c1 CHEMBL5174300 Ki 3.9 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)C)CC3)cc(C)c2n1 CHEMBL4462950 IC50 4.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2C)c2cc(C3CCS(=O)(=O)CC3)ccc2n1 CHEMBL4441820 IC50 4.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCS(=O)(=O)CC3)c(F)cc2n1 CHEMBL4449483 IC50 4.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)[C@H]4CCOC4)CC3)ccc2n1 CHEMBL4461311 IC50 4.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1-c1ccc(C(=O)N(C)CCO)nc1 CHEMBL4541237 IC50 4.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1O[C@H]1CCOC1 CHEMBL4448891 IC50 4.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1C1(O)CCN(C(C)=O)CC1 CHEMBL4545944 IC50 4.0 nM
COCC(=O)N1CCC(O)(c2cc3c(N[C@H](C)c4cccc(C(F)(F)F)c4F)nc(C)nc3cc2OC)CC1 CHEMBL4541922 IC50 4.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(O[C@H]3CCN(C(=O)C4CC4)C3)c(C)cc2n1 CHEMBL4445163 IC50 4.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(C)c3)c(C)cc2n1 CHEMBL4546191 IC50 4.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N4CCN(C)CC4)CC3)cc(C)c2n1 CHEMBL4572414 IC50 5.0 nM
CCn1ccc(-c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)cc1=O CHEMBL4551748 IC50 5.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)CCO)CC1 CHEMBL4565777 IC50 5.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)[C@@H]4CCOC4)CC3)ccc2n1 CHEMBL4545115 IC50 5.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1O[C@H]1CCOC1 CHEMBL4572076 IC50 5.0 nM
COCC(=O)N1CCC(O)(c2cc3c(N[C@H](C)c4cccc(C(F)(F)F)c4)nc(C)nc3cc2OC)CC1 CHEMBL4579770 IC50 5.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3F)c2cc1C1(O)CCC(C(=O)N(C)C)CC1 CHEMBL4459389 IC50 5.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCS(=O)(=O)CC3)cc(C)c2n1 CHEMBL4572664 IC50 6.0 nM
CCn1cc(-c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)ccc1=O CHEMBL4449876 IC50 6.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1C1CCS(=O)(=O)CC1 CHEMBL4436318 IC50 6.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1O[C@@H]1CCOC1 CHEMBL4572787 IC50 6.0 nM
CC(=O)N1CC[C@H](Oc2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2F)C1 CHEMBL4463205 IC50 6.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3F)c2cc1[C@]1(O)CC[C@@H](O)CC1 CHEMBL4517886 IC50 6.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(C)c3)ccc2n1 CHEMBL4533406 IC50 6.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1-c1cnn(CC(=O)N(C)C)c1 CHEMBL4536359 IC50 6.0 nM
CNCc1ccccc1-c1csc([C@@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 CHEMBL4535474 IC50 6.6 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccn(C)c(=O)c3)c(C)cc2n1 CHEMBL4445184 IC50 7.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2F)c2cc(C3CCS(=O)(=O)CC3)ccc2n1 CHEMBL4584919 IC50 7.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)CCO)CC3)ccc2n1 CHEMBL4466752 IC50 7.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)C[C@@H](C)O)CC3)ccc2n1 CHEMBL4471328 IC50 7.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 CHEMBL4546881 IC50 7.0 nM
COCCN1CCN(C(=O)[C@H]2CC[C@@H](c3ccc4nc(C)nc(N[C@H](C)c5cc(N)cc(C(F)(F)F)c5)c4c3)CC2)CC1 CHEMBL4571606 IC50 7.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C)CC3)ccc2n1 CHEMBL4555880 IC50 7.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(O[C@H]3CCOC3)c(C)cc2n1 CHEMBL4447334 IC50 7.0 nM
COc1c(C2(O)CCN(C(C)=O)CC2)cc2c(N[C@H](C)c3cccc(C(F)(F)F)c3F)nc(C)nc2c1C CHEMBL4467456 IC50 7.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3cc4n(n3)CCC(=O)N4)ccc2n1 CHEMBL4469774 IC50 7.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1[C@]1(O)CC[C@@H](C(=O)N(C)CCO)CC1 CHEMBL4464802 IC50 7.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N4CCN(C)CC4)CC3)cc(C)c2n1 CHEMBL4467079 IC50 8.0 nM
CONC(=O)CC(C)c1cc2c(N[C@H](C)c3cccc(C(F)(F)F)c3)nc(C)nc2cc1C CHEMBL4464090 IC50 8.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(C)(C)O)c3)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 CHEMBL4435342 IC50 8.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)C[C@H](C)O)CC3)ccc2n1 CHEMBL4541022 IC50 8.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N4CCOCC4)CC3)ccc2n1 CHEMBL4582622 IC50 8.0 nM
CC(=O)N1CCC(O)(c2cc(C)c3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4517853 IC50 8.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1-c1ccc(=O)n(C)c1 CHEMBL4575386 IC50 8.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1-c1ccc(=O)n(C)c1 CHEMBL4473906 IC50 8.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3cnn(CC(=O)N(C)C)c3)ccc2n1 CHEMBL4546387 IC50 8.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](O)CC3)ccc2n1 CHEMBL4563461 IC50 8.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2F)c2cc([C@]3(O)CC[C@@H](O)CC3)ccc2n1 CHEMBL4554806 IC50 8.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL5287923 Kd 8.13 nM
COc1cc2ncnc(NC(C)c3ccc(-c4ccccc4CNCCO)s3)c2cc1OC CHEMBL5290935 IC50 8.5 nM
Cc1cc(Cn2c(N3CC4(CNC4)C3)nc3c(-c4c(C)n[nH]c4C)cc(Cl)cc32)cc(C)c1F CHEMBL4214703 Kd 9.0 nM
CCn1cc(-c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2OC)ccc1=O CHEMBL4544247 IC50 9.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1C1CCN(C(C)=O)CC1 CHEMBL4518543 IC50 9.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 CHEMBL4456108 IC50 9.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)[C@@H]4CCOC4)CC3)ccc2n1 CHEMBL4557066 IC50 9.0 nM
COCCN(C)C(=O)[C@H]1CC[C@@H](c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4585263 IC50 9.0 nM
COCC(=O)N1CCC(O)(c2ccc3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4455004 IC50 9.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccc(=O)[nH]c3)ccc2n1 CHEMBL4557299 IC50 9.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2C)c2cc([C@]3(O)CC[C@@H](O)CC3)ccc2n1 CHEMBL4460510 IC50 9.0 nM
CNC(=O)CC(C)c1cc2c(N[C@H](C)c3cccc(C(F)(F)F)c3)nc(C)nc2cc1C CHEMBL4528666 IC50 10.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)[C@H]4CCOC4)CC3)ccc2n1 CHEMBL4534547 IC50 10.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)CC(C)(C)O)CC3)ccc2n1 CHEMBL4590891 IC50 10.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3cc(C)c(C4CCN(CC(=O)O)CC4)cc23)c1 CHEMBL4552865 IC50 10.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)C)CC3)ccc2n1 CHEMBL4583324 IC50 10.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1[C@]1(O)CC[C@@H](O)CC1 CHEMBL4483763 IC50 10.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@]3(O)CC[C@@H](O)CC3)ccc2n1 CHEMBL4436392 IC50 10.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(=O)[C@@H]2CCOC2)CCN31 CHEMBL5171547 IC50 10.0 nM
Cc1nnc(N[C@H](C)c2cccc(C#N)c2)c2cc(N3CCOCC3)ncc12 CHEMBL5186883 Ki 10.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3=CCS(=O)(=O)CC3)cc(C)c2n1 CHEMBL4472469 IC50 11.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3CCN(CC(=O)N(C)C)CC3)ccc2n1 CHEMBL4462643 IC50 11.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3CCN(CC(=O)O)CC3)ccc2n1 CHEMBL4519580 IC50 11.0 nM
CC(=O)N1CC=C(c2ccc3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4514294 IC50 11.0 nM
COCCN1CCN2c3cc4c(N[C@H](C)c5cccc(C(F)F)c5F)nc(C)nc4cc3OCC[C@H]2C1 CHEMBL5184087 IC50 11.0 nM
Cc1c([C@@H](C)Nc2n[nH]c(=O)c3ccc(N4CCNCC4)cc23)cccc1C(F)(F)F CHEMBL5193110 Ki 11.0 nM
Cc1cc(Cn2c(N3CC4(CNC4)C3)nc3c(-c4ccccc4Cl)cc(Cl)cc32)cc(C)c1F CHEMBL4203017 Kd 12.0 nM
Cc1cc(Cn2c(N3CC4(CNC4)C3)nc3c(-c4cnc(N)nc4C)cc(Cl)cc32)cc(C)c1F CHEMBL4208983 Kd 12.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C(C)CC(=O)NC3CC3)c(C)cc2n1 CHEMBL4563866 IC50 12.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1C1CCN(C(C)=O)CC1 CHEMBL4465268 IC50 12.0 nM
Cc1c(C#N)cccc1[C@@H](C)Nc1nnc(C)c2cc(C#N)c(N3CCOCC3)cc12 CHEMBL5198132 Ki 12.5 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(C)O)c3)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 CHEMBL4587128 IC50 13.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1-c1ccc(=O)n(C(C)C)c1 CHEMBL4470667 IC50 13.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc([C@H]4CC[C@H](C(=O)N(C)C)CC4)cc23)c1 CHEMBL4436461 IC50 13.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1O[C@H]1CCN(C(C)=O)C1 CHEMBL4462016 IC50 13.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OC[C@H]1CN(C(=O)C2(C#N)CC2)CCN31 CHEMBL5184590 IC50 13.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(=O)C2COC2)CCN31 CHEMBL5201901 IC50 13.0 nM
COc1cc2cnnc(N[C@H](C)c3cccc(C(F)(F)F)c3C)c2cc1OC CHEMBL5202863 Ki 13.0 nM
Cc1nnc(N[C@H](C)c2cc(N)cc(C(F)(F)F)n2)c2cc(N3CCOCC3)ncc12 CHEMBL5191745 Ki 13.0 nM
CC(=O)N1CCC(O)(c2ccc3nc(C)nc(N[C@H](C)c4cccc(C)c4)c3c2)CC1 CHEMBL4524954 IC50 14.0 nM
CCN(C)C(=O)[C@H]1CC[C@@H](c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4575645 IC50 15.0 nM
CC(=O)N1CCC(O)(c2ccc3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4438031 IC50 15.0 nM
Cc1c(C#N)cccc1[C@@H](C)Nc1nnc(C)c2cc(F)c(N3CCOCC3)cc12 CHEMBL5187475 Ki 15.0 nM
Cc1c(C#N)cccc1[C@@H](C)Nc1nnc(C)c2cc(Cl)c(N3CCOCC3)cc12 CHEMBL5182064 Ki 15.0 nM
Cc1cc(Cn2c(N3CC4(CNC4)C3)nc3c(-c4cncnc4C)cc(Cl)cc32)cc(C)c1F CHEMBL4215883 Kd 16.0 nM
CONC(=O)CC(C)c1cc2c(N[C@H](C)c3cccc(C(F)(F)F)c3)nc(C)nc2cc1OC CHEMBL4561153 IC50 16.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(S(N)(=O)=O)c3)c2cc1OC CHEMBL5085531 Kd 16.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1OC CHEMBL5088924 Kd 16.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(CC(F)(F)F)CCN31 CHEMBL5196432 IC50 16.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(CCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL5266447 Kd 16.3 nM
CNC(=O)CC(C)c1cc2c(N[C@H](C)c3cccc(C(F)(F)F)c3)nc(C)nc2cc1OC CHEMBL4436478 IC50 17.0 nM
CC(=O)N1CCC(c2ccc3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4552980 IC50 17.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(=O)COCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL5284648 Kd 17.4 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1C1CCS(=O)(=O)CC1 CHEMBL4470459 IC50 18.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc([C@H]4CC[S@](=N)(=O)CC4)cc23)c1 CHEMBL4471945 IC50 18.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3c(C)cc(C4CCN(C(C)C)CC4)cc23)c1 CHEMBL4450467 IC50 18.0 nM
COCCN1CCN(C(=O)[C@H]2CC[C@@H](c3cc4c(N[C@H](C)c5cc(N)cc(C(F)(F)F)c5F)nc(C)nc4cc3OC)CC2)CC1 CHEMBL4564552 IC50 18.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(C)c3)c(F)cc2n1 CHEMBL4453641 IC50 18.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C4(O)COC4)c3)c2cc1C1CCN(C(C)=O)CC1 CHEMBL4467720 IC50 18.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3=CCNCC3)ccc2n1 CHEMBL4439562 IC50 18.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(-c4cc5n(n4)CCC(=O)N5)cc23)c1 CHEMBL4539333 IC50 18.0 nM
COc1cc2ncnc(NC(C)c3cc(-c4ccccc4CNCCO)cs3)c2cc1OC CHEMBL5280958 IC50 18.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3=CCC(C(=O)N(C)C)CC3)ccc2n1 CHEMBL4444961 IC50 19.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N4CC(F)C4)CC3)ccc2n1 CHEMBL4468458 IC50 19.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(=O)C2(C#N)CC2)CCN31 CHEMBL5209105 IC50 19.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(C4CCS(=N)(=O)CC4)cc23)c1 CHEMBL4550237 IC50 20.0 nM
COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C)c4)nc(C)nc3cc2OC)CC1 CHEMBL4564282 IC50 20.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3(O)CCS(=O)(=O)CC3)ccc2n1 CHEMBL4517368 IC50 20.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@]3(O)CC[C@H](O)CC3)cc(C)c2n1 CHEMBL4443330 IC50 20.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@]3(O)CC[C@H](O)CC3)ccc2n1 CHEMBL4439042 IC50 20.0 nM
CNCc1ccccc1-c1csc(C(C)Nc2ncnc3cc(OC)c(OC)cc23)c1 CHEMBL5286756 IC50 20.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1C(C)CC(=O)NC1CC1 CHEMBL4474106 IC50 21.0 nM
COCC(=O)N1CCC(c2cc(C)c3nc(C)nc(N[C@H](C)c4cccc(C)c4)c3c2)CC1 CHEMBL4524148 IC50 21.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@@H](C(=O)N2CCN(C)CC2)CC1 CHEMBL4445186 IC50 22.0 nM
COCC(=O)N1CCC(c2ccc3nc(C)nc(N[C@H](C)c4cccc(C)c4)c3c2)CC1 CHEMBL4455700 IC50 22.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3cc(C)c(C4CCN(C(C)C)CC4)cc23)c1 CHEMBL4558099 IC50 22.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(C4CC[S+]([O-])CC4)cc23)c1 CHEMBL4561965 IC50 22.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3CCNCC3)ccc2n1 CHEMBL4524303 IC50 22.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3(O)CCN(C(=O)N(C)C)CC3)ccc2n1 CHEMBL4528578 IC50 23.0 nM
CC(=O)N1CCC2(CC1)CC(O)(c1ccc3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c1)C2 CHEMBL4562224 IC50 23.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1-c1ccc(C(=O)N(C)C)nc1 CHEMBL4446624 IC50 23.0 nM
CC(=O)N1CCC(c2cc(C)c3nc(C)nc(N[C@H](C)c4cccc(C)c4)c3c2)CC1 CHEMBL4460443 IC50 24.0 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C)c4)nc(C)nc3cc2C)CC1 CHEMBL4533661 IC50 24.0 nM
Cc1nc(N[C@H](C)c2cccc(Cl)c2F)c2cc(C3=CCNCC3)ccc2n1 CHEMBL4467754 IC50 24.0 nM
COc1ccc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2c1 CHEMBL5087825 Kd 24.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@@H](C(=O)N2CCOCC2)CC1 CHEMBL4451252 IC50 25.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc([C@H]4CC[S@@](=N)(=O)CC4)cc23)c1 CHEMBL4440619 IC50 25.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc([C@H]4CC[C@H](C(=O)N5CCC(O)C5)CC4)cc23)c1 CHEMBL4516767 IC50 25.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(C)c3)c(C)cc2n1 CHEMBL4571785 IC50 25.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(CC(=O)N(C)C)c3)ccc2n1 CHEMBL4586636 IC50 26.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(-c4ccc(=O)n(CC(=O)N(C)C)c4)cc23)c1 CHEMBL4476673 IC50 26.0 nM
CC(=O)N1CC2(C1)CC(O)(c1cc(C)c3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c1)C2 CHEMBL4445660 IC50 26.0 nM
CC(=O)O[C@H]1CC[C@](O)(c2ccc3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)CC1 CHEMBL4540165 IC50 26.0 nM
COc1cc2nc(C)nc(NC(C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(C)=O)CC1 CHEMBL5274108 Kd 26.5 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL5279126 Kd 26.7 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1-c1ccc(=O)n(CC(=O)N(C)C)c1 CHEMBL4456180 IC50 27.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3=CCC(C(=O)N4CCN(C)CC4)CC3)ccc2n1 CHEMBL4449723 IC50 27.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1C1CCC(C(=O)N(C)CC(O)CO)CC1 CHEMBL4456784 IC50 27.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@]3(O)CC[C@H](C(=O)N(C)C)CC3)ccc2n1 CHEMBL4533487 IC50 27.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2F)c2cc([C@]3(O)CC[C@H](O)CC3)ccc2n1 CHEMBL4513298 IC50 27.0 nM
CNCc1ccccc1-c1csc(C(C)Nc2nc(C)nc3cc4c(cc23)OCCO4)c1 CHEMBL5278156 IC50 27.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL5289218 Kd 27.1 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(=O)CCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL5273007 Kd 27.8 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3c(C)cc(C4CCN(C5CCOC5)CC4)cc23)c1 CHEMBL4452078 IC50 28.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3c(C)cc(C4CCN(CC(=O)O)CC4)cc23)c1 CHEMBL4439239 IC50 28.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1-c1ccc(=O)[nH]c1 CHEMBL4455684 IC50 28.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(-c4ccc(=O)[nH]c4)cc23)c1 CHEMBL4474187 IC50 29.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(C4CCS(=O)(=O)CC4)cc23)c1 CHEMBL4443395 IC50 29.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(CC2COC2)CCN31 CHEMBL5195849 IC50 29.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1O[C@H]1CCN(C(C)=O)C1 CHEMBL4475185 IC50 30.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3cc4n(n3)CCC(=O)N4)ccc2n1 CHEMBL4570224 IC50 30.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C)CCN31 CHEMBL5201816 IC50 30.0 nM
COC1CN(C(=O)[C@H]2CC[C@H](c3ccc4nc(C)nc(N[C@H](C)c5cccc(C(F)(F)F)c5)c4c3)CC2)C1 CHEMBL4517475 IC50 32.0 nM
Cc1c([C@@H](C)Nc2nn(C)c(=O)c3ccc(N4CCNCC4)cc23)cccc1C(F)(F)F CHEMBL5198767 Ki 32.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C3CCOCC3)ccc2n1 CHEMBL4452192 IC50 33.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(=O)CCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL5288734 Kd 33.6 nM
CONC(=O)CC(C)c1ccc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2c1 CHEMBL4441162 IC50 34.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@@H](C(=O)N(C)C)CC1 CHEMBL4467575 IC50 34.0 nM
COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C)c4)nc(C)nc3cc2C)CC1 CHEMBL4448274 IC50 34.0 nM
COCC(=O)N1CCC(n2cc(-c3ccc4nc(C)nc(N[C@H](C)c5cccc(C)c5)c4c3)cn2)CC1 CHEMBL4471363 IC50 34.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C4(O)COC4)c3)c2cc1C1=CCN(C(C)=O)CC1 CHEMBL4467937 IC50 34.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3cc4n(n3)CCC(=O)N4)c(C)cc2n1 CHEMBL4445555 IC50 34.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1-c1ccc(C(=O)N(C)C)nc1 CHEMBL4438125 IC50 34.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc([C@H]4CC[C@H](O)CC4)cc23)c1 CHEMBL4446100 IC50 34.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(O[C@H]3CCOC3)c(O)cc2n1 CHEMBL5203150 IC50 34.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(c2ccnn2C)CCN31 CHEMBL5185398 IC50 34.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(CC(=O)O)c3)ccc2n1 CHEMBL4583121 IC50 35.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1[C@H]1CC[C@@H](C(=O)N(C)C)CC1 CHEMBL4572922 IC50 35.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1-c1ccc(C(=O)N(C)C)cn1 CHEMBL4515122 IC50 35.0 nM
Cc1nnc(N[C@H](C)c2cccc(C(F)(F)F)n2)c2cc(N3CCOCC3)ncc12 CHEMBL5203468 Ki 35.0 nM
Cc1nc(N)ncc1-c1cc(Cl)cc2c1nc(N1CC3(CNC3)C1)n2Cc1ccc(F)cc1 CHEMBL4210312 Kd 36.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc([C@H]4CC[C@H](C(=O)N5CC(C#N)C5)CC4)cc23)c1 CHEMBL4463184 IC50 36.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3cc(C)c(-c4ccc(=O)n(C)c4)cc23)c1 CHEMBL4473214 IC50 36.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3ccn(CC(=O)N(C)C)c(=O)c3)ccc2n1 CHEMBL4579517 IC50 37.0 nM
CNC(=O)Cn1cc(-c2ccc3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)ccc1=O CHEMBL4449932 IC50 37.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1-c1ccc(C(=O)N2CCOCC2)cc1 CHEMBL4588358 IC50 37.0 nM
CNC(=O)CC(C)c1ccc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2c1 CHEMBL4548261 IC50 38.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@@H](C(=O)N(C)C)CC1 CHEMBL4547816 IC50 38.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C4COC4)CC3)ccc2n1 CHEMBL4582002 IC50 38.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C4(O)COC4)c3)c2cc1O[C@H]1CCOC1 CHEMBL4460996 IC50 38.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(C4CCNCC4)cc23)c1 CHEMBL4550683 IC50 38.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1-c1ccn(CC(=O)N(C)C)c(=O)c1 CHEMBL4457382 IC50 39.0 nM
Cc1nc(N[C@H](C)c2cccc(Cl)c2)c2cc(C3=CCNCC3)ccc2n1 CHEMBL4567663 IC50 39.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(CC(N)=O)c3)ccc2n1 CHEMBL4564198 IC50 40.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1-c1ccc(C(=O)N(C)CCO)cc1 CHEMBL4453639 IC50 40.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(=O)c2ccnn2C)CCN31 CHEMBL5183723 IC50 40.0 nM
Cc1ncccc1[C@@H](C)Nc1nnc(C)c2cnc(N3CCOCC3)cc12 CHEMBL5207802 Ki 40.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3cnn(CC(=O)N(C)C)c3)ccc2n1 CHEMBL4459409 IC50 41.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1[C@]1(O)CC[C@H](C(=O)N(C)C[C@H](C)O)CC1 CHEMBL4521039 IC50 41.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(C(C)CC(=O)NCC(F)(F)F)c(C)cc2n1 CHEMBL4565839 IC50 42.0 nM
COc1cc(-c2cc3c(N[C@H](C)c4cccc(C(F)(F)F)c4)nc(C)nc3cc2OC)ccc1C(=O)N(C)C CHEMBL4515045 IC50 43.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(C4CCOCC4)cc23)c1 CHEMBL4583745 IC50 43.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](O)CC3)ccc2n1 CHEMBL4466264 IC50 43.0 nM
Cc1cc(Cn2c(N3CC4(CNC4)C3)nc3c(N4CCN(C)CC4)cc(Cl)cc32)cc(C)c1F CHEMBL4213025 Kd 44.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3cc(C)c(-c4ccc(C(=O)N5CCOCC5)cc4)cc23)c1 CHEMBL4436096 IC50 44.0 nM
Cc1nc(NC(C)c2cc(-c3ccccc3CNCCO)cs2)c2cc3c(cc2n1)OCCO3 CHEMBL5284477 IC50 45.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(-c4ccc(=O)n(C)c4)cc23)c1 CHEMBL4435778 IC50 46.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3cc(C)c(C4CCNCC4)cc23)c1 CHEMBL4466637 IC50 46.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(S(C)(=O)=O)c3)c2cc1O[C@H]1CCOC1 CHEMBL4541856 IC50 47.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(-c4ccn(CC(=O)O)c(=O)c4)cc23)c1 CHEMBL4470485 IC50 48.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1-c1ccc(C(=O)N(C)C)c(C)c1 CHEMBL4451132 IC50 48.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3ccc(=O)[nH]c3)ccc2n1 CHEMBL4445088 IC50 48.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc(-c3cnn(C4CCNCC4)c3)ccc2n1 CHEMBL4476563 IC50 48.0 nM
COCCN(C)C(=O)[C@H]1CC[C@@H](c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2OC)CC1 CHEMBL4557571 IC50 49.0 nM
Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(-c4cnn(CC(=O)N(C)C)c4)cc23)c1 CHEMBL4444096 IC50 49.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(=O)C(C)(C)C)CCN31 CHEMBL5170314 IC50 49.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(=O)c2cccnc2)CCN31 CHEMBL5185573 IC50 51.0 nM
COc1cc2cnnc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1OC CHEMBL5169564 Ki 52.0 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN([C@H]2CCOC2)CCN31 CHEMBL5193498 IC50 53.0 nM
Cc1nnc(N[C@H](C)c2cn(C)nc2C(F)(F)F)c2cc(N3CCOCC3)ncc12 CHEMBL5190699 Ki 53.0 nM
Cc1c([C@@H](C)Nc2nnc(C(F)(F)F)c3ccc(N4CCNCC4)cc23)cccc1C(F)(F)F CHEMBL5183207 Ki 59.0 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)ncnc3[nH]c2=O)CC1 CHEMBL5275216 IC50 67.4 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(CC#N)CCN31 CHEMBL5208418 IC50 70.0 nM
C[C@@H](Nc1ncnc2c1cc(-c1ccncc1)c(=O)n2C)c1cc(N)cc(C(F)(F)F)c1 CHEMBL5280533 IC50 70.5 nM
CC(=O)N1CCN(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)ncnc3n(C)c2=O)CC1 CHEMBL5290547 IC50 72.1 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C(F)(F)CO)c4)ncnc3n(C)c2=O)CC1 CHEMBL5286601 IC50 73.4 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(C)C)CCN31 CHEMBL5183879 IC50 75.0 nM
COc1cc2cnnc(N[C@H](C)c3cccc4ccccc34)c2cc1OC CHEMBL5200949 Ki 76.0 nM
CCCn1c(=O)c(C2CCN(C(C)=O)CC2)cc2c(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)ncnc21 CHEMBL5269963 IC50 77.5 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(=O)OC2COC2)CCN31 CHEMBL5191638 IC50 78.0 nM
C[C@@H](Nc1ncnc2c1cc(-c1ccccc1)c(=O)n2C)c1cc(N)cc(C(F)(F)F)c1 CHEMBL5284292 IC50 85.6 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)ncnc3n(C)c2=O)CC1 CHEMBL5266985 IC50 87.8 nM
Cc1nc(N[C@H](C)c2cccc(C(F)F)c2F)c2cc3c(cc2n1)OCC[C@H]1CN(C(N)=O)CCN31 CHEMBL5181797 IC50 88.0 nM
CCn1c(=O)c(C2CCN(C(C)=O)CC2)cc2c(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)ncnc21 CHEMBL5267612 IC50 90.8 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C(F)(F)CO)c4F)ncnc3n(C)c2=O)CC1 CHEMBL5275839 IC50 92.8 nM
C[C@@H](Nc1ncnc2c1cc(C1CCNCC1)c(=O)n2C)c1cc(N)cc(C(F)(F)F)c1 CHEMBL5280431 IC50 94.0 nM
Cc1c(C#N)cccc1[C@@H](C)Nc1nnc(C)c2cc(C(F)(F)F)c(N3CCOCC3)cc12 CHEMBL5185048 Ki 95.0 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3n(C)c2=O)CC1 CHEMBL5274267 IC50 95.4 nM
CNCc1ccccc1-c1csc(C(C)Nc2ncnc3cc4c(cc23)OCCO4)c1 CHEMBL5287441 IC50 97.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4cncnc4C(C)C)cc(Cl)cc32)cc(C)c1F CHEMBL4212206 Kd 100.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1OC CHEMBL5084571 Kd 104.0 nM
COc1nnc(N[C@H](C)c2cccc(C(F)(F)F)c2C)c2cc(N3CCNCC3)ccc12 CHEMBL5199603 Ki 109.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4cncnc4C)cc(Cl)cc32)cc(C)c1F CHEMBL4217185 Kd 110.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4ccccc4Cl)cc(Cl)cc32)cc(C)c1F CHEMBL4214176 Kd 120.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(N)c3)c2cc1OC CHEMBL5087341 Kd 123.0 nM
Cc1cc(Cn2c(N3CC4(CNC4)C3)nc3c(N4CCN(CCCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)c5ccc(-c6scnc6C)cc5)C(C)(C)C)CC4)cc(Cl)cc32)cc(C)c1F CHEMBL5205396 DC50 126.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(N4CCOCC4)cc(Cl)cc32)cc(C)c1F CHEMBL4209907 Kd 130.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc4ccccc34)c2cc1OC CHEMBL5413061 IC50 130.0 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C(F)(F)F)c4)ncnc3n(C)c2=O)CC1 CHEMBL5279147 IC50 134.0 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C(F)(F)F)c4C)ncnc3n(C)c2=O)CC1 CHEMBL5266146 IC50 138.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(N4CCN(C)CC4)cc(Cl)cc32)cc(C)c1F CHEMBL4214821 Kd 140.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(N4CCC[C@H]4CN)cc(Cl)cc32)cc(C)c1F CHEMBL4215257 Kd 140.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4ccccc4CO)cc(Cl)cc32)cc(C)c1F CHEMBL4204971 Kd 140.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3cccc(-c4cn[nH]c4)c3)c2cc1OC CHEMBL5428389 IC50 140.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4ccccc4C(F)(F)F)cc(Cl)cc32)cc(C)c1F CHEMBL4205351 Kd 150.0 nM
C[C@@H](Nc1ncnc2c1cc(C1CCN(C(=O)C3CCN(C)CC3)CC1)c(=O)n2C)c1cc(N)cc(C(F)(F)F)c1 CHEMBL5282775 IC50 171.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4cn[nH]c4)cc(Cl)cc32)cc(C)c1F CHEMBL4205896 Kd 180.0 nM
Cc1ncncc1-c1cc(Cl)cc2c1nc(N1CC3(CNC3)C1)n2Cc1ccc(F)cc1 CHEMBL4212702 Kd 180.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(N4CCCCC4)cc(Cl)cc32)cc(C)c1F CHEMBL4202637 Kd 200.0 nM
CCc1ccccc1-c1cc(Cl)cc2c1nc(N1CCNCC1)n2Cc1cc(C)c(F)c(C)c1 CHEMBL4210108 Kd 210.0 nM
Cc1ccccc1-c1cc(Cl)cc2c1nc(N1CCNCC1)n2Cc1cc(C)c(F)c(C)c1 CHEMBL4206374 Kd 210.0 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C#N)c4C)ncnc3n(C)c2=O)CC1 CHEMBL5279160 IC50 226.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(N4CCC(N)CC4)cc(Cl)cc32)cc(C)c1F CHEMBL4210420 Kd 240.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(N4CCC[C@@H]4CN)cc(Cl)cc32)cc(C)c1F CHEMBL4203578 Kd 240.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4ccncc4)cc(Cl)cc32)cc(C)c1F CHEMBL4216651 Kd 240.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(C4=CCNCC4)cc(Cl)cc32)cc(C)c1F CHEMBL4205543 Kd 250.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4ccccc4)cc(Cl)cc32)cc(C)c1F CHEMBL4213612 Kd 270.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4c(C)cccc4C)cc(Cl)cc32)cc(C)c1F CHEMBL4214306 Kd 300.0 nM
COc1cc2ncnc(N[C@H](C)c3ccccc3)c2cc1OC CHEMBL1714813 Kd 301.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(N4CCC[C@H]4CO)cc(Cl)cc32)cc(C)c1F CHEMBL4217774 Kd 310.0 nM
COc1cc2ncnc(N[C@H](C)c3cccc4ccccc34)c2cc1OC CHEMBL5412768 IC50 320.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4cccnc4)cc(Cl)cc32)cc(C)c1F CHEMBL4209338 Kd 330.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4cncnc4)cc(Cl)cc32)cc(C)c1F CHEMBL4207854 Kd 350.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2ccccc2n1 CHEMBL5084055 Kd 350.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(N4CCC[C@@H]4CO)cc(Cl)cc32)cc(C)c1F CHEMBL4206057 Kd 380.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4ccccc4C(C)C)cc(Cl)cc32)cc(C)c1F CHEMBL4209734 Kd 390.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4cnccn4)cc(Cl)cc32)cc(C)c1F CHEMBL4212756 Kd 390.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4ccccc4C4CCC4)cc(Cl)cc32)cc(C)c1F CHEMBL4204856 Kd 440.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4cccnn4)cc(Cl)cc32)cc(C)c1F CHEMBL4204468 Kd 450.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3ccc(Cl)cc32)cc(C)c1F CHEMBL4218552 Kd 460.0 nM
C[C@@H](Nc1ncnc2c1cc(NC1CCCC1)c(=O)n2C)c1cc(N)cc(C(F)(F)F)c1 CHEMBL5287813 IC50 463.0 nM
COc1cc2nc(C)nc(N[C@H](C)c3ccccc3)c2cc1OC CHEMBL5087955 Kd 469.0 nM
COc1cc2cnnc(N[C@H](C)c3ccccc3)c2cc1OC CHEMBL5200875 Ki 637.0 nM
Cc1cc(Cn2c(N3CCNCC3)nc3c(-c4cccc(C(F)(F)F)c4)cc(Cl)cc32)cc(C)c1F CHEMBL4217068 Kd 670.0 nM
CC(=O)N1CCC(c2cc3c(NCc4cc(N)cc(C(F)(F)F)c4)ncnc3n(C)c2=O)CC1 CHEMBL5281607 IC50 690.0 nM
Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(F)ccc2n1 CHEMBL5092944 Kd 751.0 nM
N[C@@H](Cc1c[nH]c2cc(Cl)ccc12)C(=O)N1CCC2(CC1)CCN2Cc1c[nH]c2ccc(Cl)cc12 CHEMBL4168133 EC50 800.0 nM
Cc1ccc2c(C[C@H](N)C(=O)N3CCC4(CC3)CCN4Cc3c[nH]c4ccc(Cl)cc34)c[nH]c2c1 CHEMBL4172582 EC50 800.0 nM
N[C@@H](Cc1c[nH]c2cc(Cl)ccc12)C(=O)N1CC2CN(Cc3c[nH]c4ccc(Cl)cc34)CC2C1 CHEMBL4164690 EC50 800.0 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(N)c4)ncnc3n(C)c2=O)CC1 CHEMBL5271901 IC50 801.0 nM
CC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(OC(F)(F)F)c4)ncnc3n(C)c2=O)CC1 CHEMBL5275170 IC50 869.0 nM
CC(C)c1noc2ncc(C(=O)NC(C)c3cccc(S(N)(=O)=O)c3)cc12 CHEMBL5084899 Kd 937.0 nM
Fc1ccc(Cn2c(N3CCNCC3)nc3ccc(Cl)cc32)cc1Cl CHEMBL4217465 EC50 1000.0 nM