COC(=O)[C@@]12O[C@]34[C@H]([C@@H](O)[C@@H]1O)[C@@]1(C)CC(=O)C(O)=C(C)[C@@H]1C[C@H]3OC(=O)[C@H](OC(=O)/C=C(\C)C(C)(C)OC(C)=O)[C@@H]24 CHEMBL5270588 IC50 0.0024 nM
COc1cc(NC(=O)c2cc(C(C)C)on2)c(OC)cc1Cl CHEMBL1389016 EC50 1.04 nM
COc1cc(NC(=O)c2cc(C3CC3)on2)c(OC)cc1Cl CHEMBL1449962 EC50 2.19 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(-c3cccnc3C(F)(F)F)cn2)c1OC CHEMBL5437070 IC50 2.4 nM
COc1ccc(Cl)cc1NC(=O)c1cc(C2CC2)on1 CHEMBL1703740 EC50 4.55 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3c(O)ccc4ccccc34)c(O)c3ccccc23)cc1 CHEMBL3392776 Kd 4.7 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(=O)P(=O)(O)O)ccc4[nH]3)C(=O)N21)C(=O)NC(c1ccccc1)c1ccccc1 CHEMBL4776801 Ki 5.1 nM
COc1ccc(-c2noc(-c3cnc(Oc4ccc5cc(C(=O)N6CCN(Cc7ccc(OCC(F)(F)F)cc7)CC6)n(C)c5c4)cn3)n2)cc1 CHEMBL5177956 IC50 5.3 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(F)cc5)no4)cn3)cc21 CHEMBL5209107 IC50 5.9 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(N3CC(O)C3)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL5439447 IC50 5.9 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCCC[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N21)C(=O)NCc1ccccc1 CHEMBL4560429 Ki 7.0 nM
CNc1cc(Nc2cccc3c2OCCC3)nc2c(C(=O)N[C@@H]3CCN(C)C3=O)cnn12 CHEMBL5405538 IC50 7.0 nM
CCCc1cc(C(=O)Nc2cc(OC)c(Cl)cc2OC)no1 CHEMBL1430610 EC50 8.15 nM
CNc1cc(Nc2ccccc2OC)nc2c(C(=O)N[C@@H]3CCN(C)C3=O)cnn12 CHEMBL5433451 IC50 9.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 IC50 10.0 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N21)C(=O)NC(c1ccccc1)c1ccccc1 CHEMBL4452527 Ki 11.7 nM
CN1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1 CHEMBL4471887 Ki 12.0 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCCC(C3)N4CCC#N)n2)sn1 CHEMBL5404765 IC50 13.0 nM
CNC(=O)c1cnc(Nc2ccc(C#N)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL4469750 IC50 13.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccccc5F)no4)cn3)cc21 CHEMBL5201151 IC50 13.1 nM
CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1 CHEMBL4575382 Ki 14.0 nM
CN1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCc3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1 CHEMBL4443339 Ki 14.0 nM
CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCc3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1 CHEMBL4515406 Ki 14.0 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4444178 IC50 15.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn([C@H](CC#N)C2CCCC2)c1 CHEMBL5395308 IC50 17.0 nM
C[C@H]1CN(C(=O)CC#N)[C@]12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL4297507 IC50 18.0 nM
COc1cccc(-c2noc(-c3cnc(Oc4ccc5cc(C(=O)N6CCN(Cc7ccc(OCC(F)(F)F)cc7)CC6)n(C)c5c4)cn3)n2)c1 CHEMBL5171007 IC50 19.8 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 IC50 20.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5178622 IC50 22.3 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 CHEMBL1231124 IC50 23.0 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCCC[C@H](NC(=O)c3cc4cc(OP(=O)(O)O)ccc4[nH]3)C(=O)N21)C(=O)NCc1ccccc1 CHEMBL4571181 Ki 25.0 nM
O=C(c1ccc(-c2noc(-c3ccc(C(F)(F)F)cc3)n2)cc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5176684 IC50 27.8 nM
CNC(=O)c1nnc(NC(=O)N2CCC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL5419627 IC50 28.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(Br)cc5)no4)cn3)cc21 CHEMBL5189135 IC50 28.1 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)CNC(=O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL4868479 Kd 28.81 nM
CCOc1cccc(Nc2cc(NC)n3ncc(C(=O)N[C@@H]4CCN(C)C4=O)c3n2)n1 CHEMBL5428659 IC50 29.0 nM
O=C(c1cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc2[nH]1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5184385 IC50 30.5 nM
O=C(c1cc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)ccn1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5176948 IC50 32.3 nM
CCCC[C@H](NC(=O)/C=C(\C)c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 CHEMBL1774957 Ki 33.0 nM
CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(OP(=O)(O)O)ccc3[nH]2)C1 CHEMBL4443240 Ki 33.0 nM
COc1cc(/C=C/c2ccc(OCCCCCCC(=O)NO)cc2)cc(OC)c1 CHEMBL5175648 Kd 33.61 nM
CCCC[C@H](NC(=O)COCCOCCOCCNC(=O)c1cccc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCCC)c2)n(C)c(=O)n3C)c1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1 CHEMBL5279856 IC50 35.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(Cl)cc5)no4)cn3)cc21 CHEMBL5201419 IC50 35.7 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5182844 IC50 37.4 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCC(C3)N4CCC#N)n2)sn1 CHEMBL5405344 IC50 38.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5cccc(F)c5)no4)cn3)cc21 CHEMBL5209399 IC50 38.3 nM
C/C(=C\C(=O)N[C@@H](CC(C)C)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)NCCNC(N)=O)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774964 Ki 39.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(OC(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5205645 IC50 39.2 nM
COCCn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5175035 IC50 39.9 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(Br)cc2)CC1 CHEMBL5185530 IC50 40.2 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)c(F)c3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5199234 IC50 40.2 nM
C/C(=C\C(=O)N[C@@H](CC(C)C)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774955 Ki 43.0 nM
COc1ccccc1-c1noc(-c2cnc(Oc3ccc4cc(C(=O)N5CCN(Cc6ccc(OCC(F)(F)F)cc6)CC5)n(C)c4c3)cn2)n1 CHEMBL5200170 IC50 45.5 nM
CCCC[C@H](NC(=O)/C=C(\C)c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)NCCNC(N)=O CHEMBL1774967 Ki 46.0 nM
CCCC[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 CHEMBL1774956 Ki 48.0 nM
O=C(c1cccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)c1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5196490 IC50 52.1 nM
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccc(OC)cc4)sc3c2)c(OC)c1C CHEMBL4846365 Kd 53.04 nM
C/C(=C\C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1)C3)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774958 Ki 57.0 nM
O=C(c1cnc(-c2noc(-c3ccc(C(F)(F)F)cc3)n2)cn1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5189947 IC50 58.0 nM
O=C(c1ccc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5170615 IC50 60.2 nM
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccccc4)sc3c2)c(OC)c1C CHEMBL4864495 Kd 62.61 nM
COc1ccc(CN2CCN(C(=O)c3cc4ccc(Oc5cnc(-c6nc(-c7ccc(C(F)(F)F)cc7)no6)cn5)cc4n3C)CC2)cc1 CHEMBL5206754 IC50 63.6 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5182625 IC50 63.6 nM
Cc1cc(Nc2ncc(C)c(N3CCC(CC#N)CC3)n2)sn1 CHEMBL5434965 IC50 65.0 nM
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(C(=O)N[C@@H]3CCN(C)C3=O)cnn12 CHEMBL5424441 IC50 65.0 nM
C/C(=C\C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774954 Ki 66.0 nM
CCCC[C@H](NC(=O)/C=C(\C)c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@H](C)CCC(N)=O CHEMBL1774965 Ki 66.0 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1-c1cnn(CCC#N)c1 CHEMBL5435482 IC50 66.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 CHEMBL575497 IC50 68.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)[C@@H](C)OCc1ccccc1 CHEMBL573443 IC50 69.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)NCCOCc1ccccc1 CHEMBL583728 IC50 69.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1N1CC2CCCC(C1)N2CCC#N CHEMBL5412619 IC50 69.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(C(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5193538 IC50 72.4 nM
Cc1cc(Nc2ncc(C)c(N3CCN(CC#N)[C@@H](C)C3)n2)sn1 CHEMBL5415481 IC50 73.0 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)cn1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5171708 IC50 75.9 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5201590 IC50 76.1 nM
C/C(=C\C(=O)N[C@@H](CC(C)C)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@H](C)CCC(N)=O)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774962 Ki 83.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(O)(C4CC4)C3)n2)sn1 CHEMBL5434489 IC50 83.0 nM
CC(C)(C)c1ccc(CN2CCN(C(=O)c3ccc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)nc3)CC2)cc1 CHEMBL5177332 IC50 88.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL4435170 IC50 89.0 nM
NC(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O CHEMBL4561663 IC50 89.0 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(C(F)(F)F)cc2)[C@@H](C)C1 CHEMBL5397297 EC50 89.0 nM
O=C(c1ccc(-c2nc(-c3ccc(Br)cc3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5189774 IC50 93.2 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)COCc1ccccc1 CHEMBL583727 IC50 94.0 nM
C/C(=C\C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCCNC(N)=O)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774961 Ki 94.0 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)co2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5183263 IC50 94.1 nM
NS(=O)(=O)c1cccc2c1C(=O)c1cccc(O)c1C2=O CHEMBL2380760 IC50 98.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)c(F)c3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5201252 IC50 101.3 nM
Cc1cc(Nc2ncc(C)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423027 IC50 103.0 nM
C/C(=C\C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)N[C@H](C)CCC(N)=O)C3)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774968 Ki 105.0 nM
CC(=O)N[C@@H](Cc1ccc(OC(C(=O)O)C(=O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O CHEMBL231705 IC50 108.0 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(Cl)cc2)CC1 CHEMBL5199713 IC50 108.5 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)CCC(N)=O CHEMBL578635 IC50 110.0 nM
O=C(NCCN1CCCCC1)c1cc2c(o1)C(=O)c1ccccc1C2=O CHEMBL4474417 Kd 110.2 nM
O=C(c1ccc(-c2cn(-c3ccc(C(F)(F)F)cc3)nn2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5200334 IC50 112.7 nM
COc1ccc(-c2noc(-c3ccc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)cn3)n2)cc1 CHEMBL5189465 IC50 113.3 nM
CCCC[C@H](NC(=O)/C=C(\C)c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)NCCOC(N)=O CHEMBL1774966 Ki 114.0 nM
Cc1cc(Nc2ncc(C)c(N3CCN(CC#N)CC3)n2)sn1 CHEMBL5402554 IC50 115.0 nM
COc1ccc([C@H](C)NC(=O)CSc2nc3ccc(NC(=O)c4ccc(OC)c(C)c4OC)cc3s2)cc1 CHEMBL4846651 IC50 120.0 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCC(C3)N4CC#N)n2)sn1 CHEMBL5402797 IC50 121.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCCCC4)C3)n2)sn1 CHEMBL5432029 IC50 123.0 nM
O=C(c1ccc(-c2nc(-c3ccc(F)cc3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5189640 IC50 123.3 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)CCc1ccccc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 CHEMBL370763 IC50 125.0 nM
O=C(c1ccc(-c2nc(-c3cccc(C(F)(F)F)c3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5204997 IC50 129.7 nM
N#Cc1c(F)c(F)c(-n2cc(C(=O)OCc3ccccc3)c(=O)c3cc(F)c(F)c(F)c32)c(F)c1F CHEMBL493450 EC50 130.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)NCCNC(N)=O CHEMBL574636 IC50 131.0 nM
COc1ccc(CN2CCN(C(=O)c3cc4ccc(Oc5cnc(-c6nc(-c7ccc(C(F)(F)F)cc7)no6)cn5)cc4n3C)CC2)cc1F CHEMBL5176872 IC50 133.7 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 CHEMBL267246 IC50 135.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL470227 IC50 136.0 nM
COC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)CC3 CHEMBL503365 IC50 141.0 nM
C/C(=C\C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)CCC(N)=O)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774959 Ki 144.0 nM
COc1ccc(CN2CCN(C(=O)c3ccc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)nc3)CC2)cc1 CHEMBL5175537 IC50 147.5 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)C(C)C)[C@H](C)O CHEMBL502473 IC50 150.0 nM
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4cccc(O)c4)sc3c2)c(OC)c1C CHEMBL4850444 IC50 150.0 nM
Cc1cc(Nc2ncc(C)c(N3CCN(CC#N)C(C)C3)n2)sn1 CHEMBL5429675 IC50 152.0 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)CC3)C(=O)NCc1ccccc1 CHEMBL449547 IC50 162.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCN(C)CC4)C3)n2)sn1 CHEMBL5396135 IC50 162.0 nM
CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)/C=C(\C)c2ccc(C(F)(F)P(=O)(O)O)cc2)C1 CHEMBL4538737 Ki 164.0 nM
CCn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5170042 IC50 167.3 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)s1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5182268 IC50 167.3 nM
CCOC(=O)c1cn(-c2c(F)c(F)c(C#N)c(F)c2F)c2c(F)c(F)c(F)cc2c1=O CHEMBL524195 EC50 170.0 nM
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccccc4O)sc3c2)c(OC)c1C CHEMBL4870012 IC50 170.0 nM
O=C(/C=C/c1ccc(OC(F)(F)F)cc1)N1CCN(C(=O)c2ccc(-c3nc(-c4ccc(C(F)(F)F)cc4)no3)nc2)CC1 CHEMBL5196843 IC50 172.7 nM
CCCN(CCC)C(=O)Cn1c2ccccc2c2nc(=O)cc(C)n21 CHEMBL1430550 IC50 174.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@H](C)CCC(N)=O CHEMBL576784 IC50 175.0 nM
O=C(c1ccc(-c2nc(-c3cccc(F)c3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5199802 IC50 177.4 nM
Cc1ccc(CN2CCN(C(=O)c3ccc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)nc3)CC2)cc1 CHEMBL5191059 IC50 181.9 nM
CC(C)C[C@H](NC(=O)c1cc2cc(OP(=O)(O)O)ccc2[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL485921 IC50 186.0 nM
C/C(=C\C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)NCCOC(N)=O)C3)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774969 Ki 188.0 nM
NC(=O)CC[C@H](NC(=O)CN1CCCC[C@H](NC(=O)[C@H](Cc2ccc(OP(=O)(O)O)cc2)NC(=O)OCc2ccccc2)C1=O)C(=O)NCc1ccccc1 CHEMBL502848 Ki 190.0 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)c1cc2cc(OP(=O)(O)O)ccc2[nH]1)CC3)C(=O)NCc1ccccc1 CHEMBL452194 IC50 190.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCCC4)C3)n2)sn1 CHEMBL5430060 IC50 192.0 nM
C/C(=C\C(=O)N[C@@H](CC(C)C)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)NCCOC(N)=O)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774963 Ki 193.0 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C=C3)C(=O)NCc1ccccc1 CHEMBL508912 IC50 195.0 nM
N#Cc1c(F)c(F)c(-n2cc(C(=O)NCc3ccc(F)cc3)c(=O)c3cc(F)c(F)c(F)c32)c(F)c1F CHEMBL493451 EC50 200.0 nM
COc1ccc(S(=O)(=O)Nc2ccccc2-c2ccc(C#N)c(F)c2)cc1 CHEMBL3600757 IC50 200.0 nM
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccc(O)cc4)sc3c2)c(OC)c1C CHEMBL4864939 IC50 200.0 nM
COc1ccc([C@H](C)NC(=O)CSc2nc3ccc(NC(=O)c4ccc(OCC(C)C)c(C)c4OC)cc3s2)cc1 CHEMBL4845781 IC50 200.0 nM
CC(CO)C1OC(=O)C=C2C13OC3CC13COC(=O)C1(C)CC(O)CC23C CHEMBL5271752 IC50 200.0 nM
C/C(=C\C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCCOC(N)=O)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774960 Ki 203.0 nM
O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O CHEMBL1448 IC50 210.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccccc5)no4)cn3)cc21 CHEMBL5169762 IC50 216.5 nM
COc1ccc([C@H](C)NC(=O)CSc2nc3ccc(NC(=O)c4ccc(OC(C)C)c(C)c4OC)cc3s2)cc1 CHEMBL4853904 IC50 220.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn(CCC#N)c1 CHEMBL5438892 IC50 228.0 nM
CC(C)(C)OC(=O)c1ccc(NC(=O)c2ccc(Cl)c(S(N)(=O)=O)c2)cc1 CHEMBL4860361 IC50 230.0 nM
CNC(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4526283 IC50 230.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O)C3 CHEMBL503765 IC50 231.0 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)CC3)C(N)=O CHEMBL449511 IC50 233.0 nM
COc1ccc([C@H](C)NC(=O)CSc2nc3ccc(NC(=O)c4ccc(OCCN5CCOCC5)c(C)c4OC)cc3s2)cc1 CHEMBL4878402 IC50 240.0 nM
C=CCn1c(SCC(=O)Nc2ccc(/C(C)=N\O)cc2)nnc1-c1cc(-c2ccc(Cl)cc2)nc2ccccc12 CHEMBL4740393 IC50 250.0 nM
C[C@@H]1C=C2C(=O)O[C@@H]3CC[C@H](C1)[C@]23O CHEMBL3823609 IC50 250.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(C4CC4)C3)n2)sn1 CHEMBL5403288 IC50 251.0 nM
Cc1cc(Nc2ncc(Cl)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423566 IC50 257.0 nM
Cc1ccc(-c2noc(-c3ccc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)cn3)n2)cc1 CHEMBL5204672 IC50 257.5 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)C3)n2)sn1 CHEMBL5417435 IC50 259.0 nM
COCCOc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccc(OC)cc4)sc3c2)c(OC)c1C CHEMBL4860381 IC50 260.0 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cnn(CCC#N)c1 CHEMBL5402073 IC50 260.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL436319 IC50 265.0 nM
CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)CC3 CHEMBL454365 IC50 269.0 nM
C=C(C)C(=O)CC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]3CC[C@]12C CHEMBL3581710 IC50 270.0 nM
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4cccc(OC)c4)sc3c2)c(OC)c1C CHEMBL4876597 IC50 270.0 nM
O=C(c1ccc(-c2nc(-c3ccc(Cl)cc3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5190384 IC50 270.5 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)[C@@H](C)OCc1ccccc1 CHEMBL583758 IC50 272.0 nM
CS(=O)(=O)c1ccc(CN2CCN(C(=O)c3ccc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)nc3)CC2)cc1 CHEMBL5189435 IC50 272.9 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL197844 IC50 276.0 nM
C1=Cc2nc1cc1ccc([nH]1)c(-c1ccccc1)c1nc(cc3ccc([nH]3)c2-c2ccccc2)C=C1 CHEMBL207155 IC50 280.0 nM
CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(C(=O)O)c(O)c2)cc(C(C)(C)C)c1 CHEMBL3358611 Kd 287.0 nM
CC(=O)OC[C@H](CCC(N)=O)NC(=O)[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)[C@H](CC(C)C)NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1 CHEMBL583726 IC50 290.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)COCc1ccccc1 CHEMBL573904 IC50 294.0 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(Br)c(F)c2)CC1 CHEMBL5208052 IC50 295.7 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)C(C)C)[C@H](C)O CHEMBL2367507 IC50 300.0 nM
CN(CC(=O)N(Cc1ccc(C2CCCCC2)cc1)c1ccc(C(=O)O)cc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F CHEMBL3108909 Kd 300.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)NCCCC(N)=O CHEMBL577143 IC50 303.0 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(F)cc2)CC1 CHEMBL5199392 IC50 304.0 nM
CC(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)CC3 CHEMBL447460 IC50 305.0 nM
CC(=O)Oc1ccc(CN2CCN(C(=O)c3ccc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)nc3)CC2)cc1 CHEMBL5191928 IC50 305.6 nM
Cc1ccc(C(=O)N2CCc3c(sc(NC(=O)c4cnn(C)c4)c3C#N)C2)o1 CHEMBL5174100 Kd 310.0 nM
COc1ccc(S(=O)(=O)N(C(C)=O)c2ccccc2-c2ccc(C#N)cc2)cc1 CHEMBL3600853 IC50 320.0 nM
C=CCn1c(SCC(=O)Nc2ccc(/C(C)=N\O)cc2)nnc1-c1cc(-c2ccccc2)nc2ccccc12 CHEMBL4747318 IC50 320.0 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2cccc(OC(F)(F)F)c2)CC1 CHEMBL5205208 IC50 325.4 nM
CC(C)C(=O)n1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5205634 IC50 337.2 nM
O=C(NO)c1ccc(N(Cc2ccc(C3CCCCC3)cn2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)cc1O CHEMBL4789779 IC50 340.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(OC4CC5(CC5)C4)C3)n2)sn1 CHEMBL5436997 IC50 341.0 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 CHEMBL502403 Ki 350.0 nM
O=C(Cc1ccc(OC(F)(F)F)cc1)N1CCN(C(=O)c2ccc(-c3nc(-c4ccc(C(F)(F)F)cc4)no3)nc2)CC1 CHEMBL5208462 IC50 358.9 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)CC3)C(=O)O CHEMBL510008 IC50 359.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)NCCOC(N)=O CHEMBL576590 IC50 360.0 nM
Cn1cc(C(=O)Nc2sc3c(c2C#N)CCN(C(=O)c2ccc(Br)s2)C3)cn1 CHEMBL5178793 Kd 360.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](COC(N)=O)C(=O)NCc1ccccc1 CHEMBL414034 IC50 379.0 nM
C/C(=C\C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)NCCNC(N)=O)C3)c1ccc(OP(=O)(O)O)cc1 CHEMBL1774970 Ki 386.0 nM
CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O CHEMBL160733 IC50 400.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](C)C(=O)O)[C@@H](C)O CHEMBL157727 IC50 400.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 CHEMBL194855 IC50 409.0 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)CNC(=O)CCNC(=O)CCNC(=O)CC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O CHEMBL4757551 IC50 410.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5182559 IC50 426.6 nM
O=C(Cc1c(-c2ccccc2)nc2ccccn12)Nc1ccc2c(c1)S(=O)(=O)C=C2 CHEMBL4861762 Kd 432.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)[C@@H](C)O CHEMBL583725 IC50 437.0 nM
COc1ccc(S(=O)(=O)Nc2ccccc2-c2ccc(C#N)cc2)cc1 CHEMBL3600746 IC50 440.0 nM
NS(=O)(=O)c1cccc2c1C(=O)C=C(Nc1ccccc1N1CCNCC1)C2=O CHEMBL4096680 Ki 440.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](COCc1ccccc1)COC(N)=O CHEMBL573902 IC50 454.0 nM
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccccc4)sc3c2)c(C)c1C CHEMBL4873424 IC50 460.0 nM
COc1ccc(NC(=O)N2CCc3c(sc(NC(=O)c4cnn(C)c4)c3C#N)C2)cc1 CHEMBL5182175 Kd 460.0 nM
CC(C)CC(=O)NC(=S)Nc1nc(-c2ccccc2)cs1 CHEMBL1328233 IC50 468.0 nM
N#Cc1ccc(CN2CCN(C(=O)c3ccc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)nc3)CC2)cc1 CHEMBL5189395 IC50 476.9 nM
Cc1cc(Nc2ncc(C)c(N3CC(CCC#N)C3)n2)sn1 CHEMBL5432284 IC50 481.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL372429 IC50 484.0 nM
Cc1ccc(CN2CCN(C(=O)c3cc4ccc(Oc5cnc(-c6nc(-c7ccc(C(F)(F)F)cc7)no6)cn5)cc4n3C)CC2)cc1 CHEMBL5199129 IC50 491.7 nM
CCC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL197580 IC50 497.0 nM
CCCC[C@H](CCC(N)=O)NC(=O)[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)[C@H](CC(C)C)NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1 CHEMBL583116 IC50 499.0 nM
CC(C)/C=C/C[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]3CC[C@]12C CHEMBL3581714 IC50 500.0 nM
CC(C)=CCC/C(C)=C/C(=O)OCC1=C2/C(=C\[C@@]3(C)CC[C@](O)(O3)[C@H](C)C[C@@H]2O)OC1=O CHEMBL3628036 IC50 500.0 nM
CC(C)=CCCC(C)CC(=O)OCC1=C2/C(=C\[C@@]3(C)CC[C@](O)(O3)[C@H](C)C[C@@H]2O)OC1=O CHEMBL3628038 IC50 500.0 nM
C[C@@H]1C[C@H](O)C2=C(COC(=O)CCc3ccccc3)C(=O)O/C2=C/[C@@]2(C)CC[C@]1(O)O2 CHEMBL3628241 IC50 500.0 nM
C/C=C(\C)C(=O)OCC1=C2/C(=C\[C@@]3(C)CC[C@](O)(O3)[C@H](C)C[C@@H]2OC(=O)/C(C)=C/C)OC1=O CHEMBL3628243 IC50 500.0 nM
C/C=C(\C)C(=O)OCC1=C2/C(=C\[C@@]3(C)CC[C@](OC)(O3)[C@H](C)C[C@@H]2OC(=O)/C(C)=C/C)OC1=O CHEMBL3628244 IC50 500.0 nM
CN(CC(=O)N(Cc1ccc(C2CCCCC2)cc1)c1ccc(C(=O)O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F CHEMBL1829876 Kd 500.0 nM
CONC(=O)c1ccc(N(Cc2ccc(C3CCCCC3)cn2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)cc1O CHEMBL4751709 IC50 510.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(C)C CHEMBL573930 IC50 511.0 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5175861 IC50 515.7 nM
COc1ccc([C@H](C)NC(=O)CSc2nc3ccc(NC(=O)c4ccc(OCCN(C)C)c(C)c4OC)cc3s2)cc1 CHEMBL4862807 IC50 520.0 nM
CCOc1ccccc1-c1nnc(S)o1 CHEMBL1605444 IC50 521.0 nM
COc1cc(NC(=O)[C@@H](Cc2ccccc2)NC2=C/C(=N/O)c3ccccc3C2=O)cc(OC)c1 CHEMBL4568628 Kd 530.0 nM
O=C(NO)c1ccc(N(Cc2cnc(C3CCCCC3)cn2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)cc1O CHEMBL4741716 IC50 530.0 nM
CCCN1CCN(C(=O)c2ccc(-c3nc(-c4ccc(C(F)(F)F)cc4)no3)nc2)CC1 CHEMBL5191288 IC50 533.2 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(Br)cc2F)CC1 CHEMBL5186501 IC50 564.0 nM
O=C(COc1ccccc1Cl)Nc1cc(Cl)ccc1O CHEMBL1490917 IC50 571.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)NCCCC(N)=O CHEMBL573048 IC50 574.0 nM
CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(CP(=O)(O)O)ccc3[nH]2)C1 CHEMBL4567312 Ki 584.0 nM
CC(=O)NC[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1 CHEMBL573442 IC50 589.0 nM
C=C(C)C(=O)CC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]3CC[C@]12C CHEMBL3581712 IC50 590.0 nM
COc1ncccc1NC(=O)N1CCc2c(sc(NC(=O)c3cnn(C)c3)c2C#N)C1 CHEMBL5175326 Kd 590.0 nM
NC(=O)C1CCN(C(=O)[C@@H]2Cc3cccc4c3N2C(=O)[C@@H](NC(=O)/C=C/c2ccc(OP(=O)(O)O)cc2)CC4)C1 CHEMBL515762 IC50 595.0 nM
Cn1c(C(=O)N2CCN(CCc3ccccc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5179803 IC50 595.1 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)c1ccccc1 CHEMBL370208 IC50 596.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(N)=O)[C@H](C)O CHEMBL160353 IC50 600.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL382978 IC50 600.0 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CC[C@H](NC(=O)/C=C/c3ccc(OP(=O)(O)O)cc3)C(=O)N21)C(=O)NCc1ccccc1 CHEMBL445970 IC50 604.0 nM
O=C([C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)N(Cc1ccc(C2CCCCC2)cn1)c1ccc2nn[nH]c2c1 CHEMBL4782959 IC50 610.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)O CHEMBL4748862 IC50 610.0 nM
CCCn1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5179525 IC50 613.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)COC(N)=O CHEMBL573643 IC50 615.0 nM
Cc1cnc(Nc2ccccc2)nc1-c1cnn(CCC#N)c1 CHEMBL5440510 IC50 620.0 nM
O=C([C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)N(Cc1cnc(C2CCCCC2)cn1)c1ccc2nn[nH]c2c1 CHEMBL4782417 IC50 630.0 nM
CN1C(=O)/C(=C\c2cc(Br)cs2)c2ccccc21 CHEMBL1548996 IC50 635.0 nM
O=C1C(N[C@H](Cc2ccccc2)C(=O)Nc2ccc(C(F)(F)F)cc2)=C/C(=N/O)c2ccccc21 CHEMBL4445234 IC50 640.0 nM
O=C1NCc2cc(N(Cc3ccc(C4CCCCC4)cn3)C(=O)[C@H]3CCN3S(=O)(=O)c3c(F)c(F)c(F)c(F)c3F)ccc21 CHEMBL4749034 IC50 640.0 nM
Cn1cc(C(=O)Nc2sc3c(c2C#N)CCN(C(=O)Nc2ccccn2)C3)cn1 CHEMBL5204232 Kd 640.0 nM
CCOc1ccc(CN2CCN(Cc3cc4ccccc4[nH]3)CC2CCO)cc1 CHEMBL1410722 IC50 644.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5199213 IC50 649.2 nM
NC(=O)c1ccc(N(Cc2ccc(C3CCCCC3)cn2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)cc1O CHEMBL4756412 IC50 660.0 nM
O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)C=C2 CHEMBL1337170 IC50 670.0 nM
O=C(c1ccccc1)C1CCN(c2ncnc3sccc23)CC1 CHEMBL1720343 IC50 687.51 nM
C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5CC[C@]5(C)[C@@H](C7=CC(=O)OC7)CC[C@]65O)C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O CHEMBL254219 IC50 700.0 nM
O=C(Nc1ncc([N+](=O)[O-])s1)c1ccc(C(F)(F)F)cc1 CHEMBL4746255 IC50 700.0 nM
O=S(=O)(Nc1cc(Sc2ccccc2)c(O)c2ccccc12)c1c(F)c(F)c(F)c(F)c1F CHEMBL5280147 IC50 700.0 nM
CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL197513 IC50 717.0 nM
COc1cc(NC(=O)c2ccc(Cl)c(S(N)(=O)=O)c2)cc(OC)c1OC CHEMBL4850967 IC50 720.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@H](C)O CHEMBL505076 IC50 739.0 nM
CNc1ccc(Br)cc(C(=O)/C=C/c2c(Cl)cccc2Cl)c1=O CHEMBL4294523 Ki 740.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)O CHEMBL382544 IC50 748.0 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL435121 IC50 750.0 nM
NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCCC[C@H](NC(=O)c3cc4cc(CP(=O)(O)O)ccc4[nH]3)C(=O)N21)C(=O)NCc1ccccc1 CHEMBL4461538 Ki 761.0 nM
CNC(=O)c1ccc(N(Cc2ccc(C3CCCCC3)cn2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)cc1O CHEMBL4753131 IC50 770.0 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCCC(C3)N4CC#N)n2)sn1 CHEMBL5410239 IC50 771.0 nM
O=C([C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)N(Cc1ccc(C2CCCCC2)cn1)c1ccc2c(=O)[nH]ccc2c1 CHEMBL4754768 IC50 790.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)COC(N)=O CHEMBL584376 IC50 797.0 nM
CC(=O)N[C@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(N)=O)C(C)C CHEMBL156407 IC50 800.0 nM
CC1=CC(C)(C)N=C(Nc2nc(C)c3cc(C)cc(C)c3n2)N1 CHEMBL522887 IC50 800.0 nM
CC(=O)c1cc2c(o1)-c1ccccc1C(=O)C2=O CHEMBL4171066 EC50 800.0 nM
O=C(Nc1ncc([N+](=O)[O-])s1)c1ccc(Cl)c(Cl)c1 CHEMBL4752864 IC50 800.0 nM
CCCN1CCN(C(=O)c2cc3ccc(Oc4cnc(-c5nc(-c6ccc(C(F)(F)F)cc6)no5)cn4)cc3n2C)CC1 CHEMBL5198840 IC50 800.5 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL193433 IC50 801.0 nM
O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2cccc(OCC(F)(F)F)c2)CC1 CHEMBL5207761 IC50 802.5 nM
CCN(CC)c1ccc2cc(C(=O)Nc3ccccn3)c(=O)oc2c1 CHEMBL1497574 EC50 803.53 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL425571 IC50 814.0 nM
O=C(O)CCCNC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)CC3 CHEMBL475488 IC50 815.0 nM
COCc1cc(O)n2c(-c3ccccc3OC)nnc2n1 CHEMBL1299373 IC50 821.0 nM
Cn1c(C(=O)N2CCN(Cc3ccc(Br)cc3)CC2)cc2ccc(Oc3cnc(-c4nc(-c5ccc(C(F)(F)F)cc5)no4)cn3)cc21 CHEMBL5181349 IC50 835.5 nM
O=C(c1ccc(Cl)cc1)C1CCN(c2ncnc3sccc23)CC1 CHEMBL1700610 IC50 837.0 nM
CC(=O)C1=CC2C(=O)c3ccccc3C(=O)C2O1 CHEMBL4846078 IC50 840.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)Cc1ccc(O)cc1 CHEMBL573903 IC50 848.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCc1ccccc1)[C@@H](C)OC(N)=O CHEMBL376795 IC50 850.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O CHEMBL194516 IC50 856.0 nM
Cn1ccc2cc(N(Cc3ccc(C4CCCCC4)cn3)C(=O)[C@H]3CCN3S(=O)(=O)c3c(F)c(F)c(F)c(F)c3F)ccc2c1=O CHEMBL4753190 IC50 870.0 nM
CC(C)C[C@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCc1ccccc1 CHEMBL573901 IC50 874.0 nM
O=C1OCc2cc(N(Cc3ccc(C4CCCCC4)cn3)C(=O)[C@H]3CCN3S(=O)(=O)c3c(F)c(F)c(F)c(F)c3F)ccc21 CHEMBL4777016 Kd 880.0 nM
CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(C)=O CHEMBL370095 IC50 882.0 nM
O=C(NO)c1ccc(N(Cc2ccc(C3CCCCC3)cn2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c(F)c1 CHEMBL4776532 IC50 890.0 nM
O=C1CCC(N2C(=O)c3cccc(NCCCCCC4CCN(CCNC(=O)c5cc6c(o5)C(=O)c5ccccc5C6=O)CC4)c3C2=O)C(=O)N1 CHEMBL4750508 IC50 900.0 nM
CCC[C@@H](C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccccc4)sc3c2)cc1C CHEMBL4869871 IC50 900.0 nM
CC(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O CHEMBL371871 IC50 910.0 nM
CC(C)(C)OC(=O)c1ccc(NC(=O)c2cccc(S(N)(=O)=O)c2)cc1 CHEMBL4875020 IC50 920.0 nM
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccccc4)sc3c2)cc1C CHEMBL4879356 IC50 950.0 nM
O=C1NC(=O)c2cc(N(Cc3ccc(C4CCCCC4)cn3)C(=O)[C@H]3CCN3S(=O)(=O)c3c(F)c(F)c(F)c(F)c3F)ccc21 CHEMBL4787896 Kd 960.0 nM
O=C([C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)N(Cc1ccc(C2CCCCC2)cn1)c1ccc2c(=O)[nH]cnc2c1 CHEMBL4764925 IC50 980.0 nM
C=C1CC[C@H]2[C@@](C)(CCC(=O)[C@@]2(C)CO[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C1/C(=O)OC[C@H]1OC(C)=O CHEMBL4168778 EC50 990.0 nM
O=C1C(N[C@H](Cc2ccccc2)C(=O)Nc2cccc(C(F)(F)F)c2)=C/C(=N/O)c2ccccc21 CHEMBL4462450 IC50 990.0 nM