CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 0.03 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 0.53 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 0.92 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 3.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 5.7 nM
Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(C#N)cc(S(F)(F)(F)(F)F)c1 CHEMBL3907057 Kd 5.9 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 7.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 7.1 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 9.5 nM
CC(C)c1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4168305 Kd 10.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(F)c1)c(C)n2C CHEMBL4571241 Kd 10.0 nM
COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O CHEMBL156277 IC50 12.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 13.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 13.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 14.0 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 Kd 19.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 19.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 22.0 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 23.0 nM
COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4875188 IC50 23.0 nM
COc1cc(Br)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4878325 Ki 35.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 44.0 nM
COc1ccccc1C1=C(Nc2cccc3ccccc23)C(=O)NC1=O CHEMBL4877889 Ki 47.0 nM
COc1cnccc1Nc1nc(-c2nn(Cc3c(F)cc(OCCO)cc3F)c3ccccc23)ncc1OC CHEMBL5084426 Kd 57.0 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 Kd 60.0 nM
COc1ccc(Br)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4856751 Ki 61.0 nM
C[C@@H](Oc1cc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F CHEMBL1908394 Kd 69.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 70.0 nM
CC[C@@](C)(Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(=O)NCC(F)(F)F CHEMBL3039513 Kd apparent 71.0 nM
COc1ccccc1C1=C(Nc2ccc(O)c(Cl)c2)C(=O)NC1=O CHEMBL157089 Ki 73.0 nM
COc1ccccc1C1=C(Nc2cccc(F)c2)C(=O)NC1=O CHEMBL4855513 Ki 76.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 77.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 81.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 82.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 82.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 84.0 nM
COc1ccccc1C1=C(Nc2ccc3c(c2)OCO3)C(=O)NC1=O CHEMBL4869745 Ki 84.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 87.0 nM
COc1cc(NC(=O)C(C)C)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4867952 Ki 88.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 Kd apparent 96.0 nM
Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL6291 IC50 99.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 110.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 110.0 nM
COc1ccccc1C1=C(Nc2cccc(SC)c2)C(=O)NC1=O CHEMBL4857159 Ki 110.0 nM
N#Cc1cccc(NC2=C(c3cccc4ccccc34)C(=O)NC2=O)c1 CHEMBL4877101 Ki 110.0 nM
COc1ccccc1C1=C(Nc2ccc3ncccc3c2)C(=O)NC1=O CHEMBL4868821 Ki 110.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 120.0 nM
COc1ccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc1 CHEMBL4852101 Ki 120.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 136.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 Kd 140.0 nM
COc1ccccc1C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O CHEMBL349540 Ki 140.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 149.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)c(Cl)c1 CHEMBL157141 Ki 150.0 nM
COc1cccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)c1 CHEMBL4847820 Ki 180.0 nM
COc1ccccc1C1=C(Nc2ccc(O)cc2)C(=O)NC1=O CHEMBL160338 Ki 200.0 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1 CHEMBL377300 Kd 220.0 nM
C#Cc1cccc(Nc2ncnc3cc4c(cc23)OCCOCCOCCO4)c1 CHEMBL2087361 Kd apparent 227.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 230.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 Kd 280.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 290.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)cc1 CHEMBL347702 Ki 300.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 Kd apparent 309.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(Cl)c1 CHEMBL156506 Ki 310.0 nM
O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1 CHEMBL3544966 Kd apparent 317.0 nM
COc1ccccc1C1=C(Nc2ccc(-c3ccccc3)cc2)C(=O)NC1=O CHEMBL4851482 Ki 320.0 nM
COc1ccc(-c2ccccc2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4869281 Ki 320.0 nM
COc1cc(-c2ccc(Cl)nc2Cl)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4845800 Ki 320.0 nM
CSc1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 CHEMBL4858023 Ki 340.0 nM
COc1ccccc1C1=C(Nc2cccc(C(F)(F)F)c2)C(=O)NC1=O CHEMBL4847807 Ki 340.0 nM
N#Cc1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 CHEMBL4848202 Ki 350.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 360.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 379.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 Kd 380.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(F)c1 CHEMBL4878748 Ki 380.0 nM
COc1ccccc1C1=C(Nc2ccc(-c3ccsc3)cc2)C(=O)NC1=O CHEMBL4863077 Ki 400.0 nM
C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 CHEMBL31965 Kd 430.0 nM
COc1cc(-c2cccnc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4852451 Ki 440.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 460.0 nM
COc1ccccc1C1=C(Nc2ccc(N3CCOCC3)cc2)C(=O)NC1=O CHEMBL4854271 Ki 460.0 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 Kd 470.0 nM
COc1ccccc1C1=C(Nc2cccc(O)c2)C(=O)NC1=O CHEMBL160231 Ki 480.0 nM
COc1cc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc(OC)c1 CHEMBL4848740 Ki 480.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 481.0 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 Kd apparent 515.0 nM
COc1cc(-c2ccsc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4875006 Ki 540.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 550.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccccc1 CHEMBL347647 Ki 560.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(O)c1 CHEMBL160937 Ki 560.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 590.0 nM
COc1ccccc1C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O CHEMBL345800 Ki 590.0 nM
COc1ccccc1C1=C(Nc2ccc(C(=O)c3ccccc3)cc2)C(=O)NC1=O CHEMBL4876254 Ki 600.0 nM
O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1ccc(O)c(Cl)c1 CHEMBL4851803 Ki 610.0 nM
COc1ccccc1C1=C(Nc2cccc(S(C)(=O)=O)c2)C(=O)NC1=O CHEMBL4877795 Ki 630.0 nM
COc1ccccc1C1=C(Nc2cccc(-c3ccsc3)c2)C(=O)NC1=O CHEMBL4855633 Ki 640.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 680.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 CHEMBL1231124 Kd apparent 728.0 nM
CSc1cccc(NC2=C(c3ccccc3C(F)(F)F)C(=O)NC2=O)c1 CHEMBL4860051 Ki 730.0 nM
CSc1ccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)cc1 CHEMBL156563 Ki 760.0 nM
COc1ccccc1C1=C(Nc2ccc(OCc3ccccc3)c(Cl)c2)C(=O)NC1=O CHEMBL4859423 Ki 790.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 Kd apparent 793.0 nM
COc1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL5197792 Kd 880.0 nM
CCS(=O)(=O)c1cccc(-c2cc(C(=O)NC3CCN(C)CC3)c(C)c3[nH]c4ncc(C)cc4c23)c1 CHEMBL3544932 Kd apparent 949.0 nM
COc1cccc(C2=C(Nc3cccc(Cl)c3)C(=O)NC2=O)c1 CHEMBL346829 Ki 950.0 nM
O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1cccc(Cl)c1 CHEMBL4848852 Ki 960.0 nM