CCCn1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653842 IC50 0.0 nM
CC(C)n1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653843 IC50 0.0 nM
CC(=O)N(C)Cc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cc1 CHEMBL3653779 IC50 0.0 nM
Cc1cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)nc(-n2nccn2)n1 CHEMBL3415598 IC50 0.01 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(Cl)c(C)n4C)n2)cc1CN1CC(O)C1 CHEMBL3622956 IC50 0.03 nM
COC(=O)c1nn(C)c2c(C)cc(Nc3nccc(-c4cc(CN(C)C)n(C)n4)n3)cc12 CHEMBL4744190 IC50 0.03 nM
Cc1nn2cc1CN(C)N1CCC(O)(CCNC(=O)c3nn(C)c4ccc(cc34)Nc3nccc-2n3)CC1 CHEMBL5425739 IC50 0.046 nM
Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)c1 CHEMBL3415583 IC50 0.06 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN5CC(O)C5)c(C)n4)n3)cc12 CHEMBL4780257 IC50 0.06 nM
Cc1nn2cc1CN(C)N1CCC(CCNC(=O)c3nn(C)c4ccc(cc34)Nc3nccc-2n3)CC1 CHEMBL5435311 IC50 0.067 nM
CN(C)Cc1cnn(-c2ccnc3[nH]c(-c4cn(C)c5ccc(S(C)(=O)=O)cc45)nc23)c1 CHEMBL4776352 IC50 0.077 nM
Cc1nn2cc1CN(C)CCOCCNC(=O)c1nn(C[C@@H](C)O)c3ccc(cc13)Nc1nccc-2n1 CHEMBL5410717 IC50 0.08 nM
CNC(=O)c1ncn2ccc(Nc3nccc(-n4cc(CN(C)C)cn4)n3)cc12 CHEMBL4753469 IC50 0.09 nM
Cc1nnc(-c2ccc3c(c2)c(-c2nc4c(-n5cc(CN(C)C)c(C)n5)ccnc4[nH]2)cn3C)o1 CHEMBL4762995 IC50 0.098 nM
Cc1cc(C)nc(Nc2cc(N[C@@H]3CS(=O)(=O)CC[C@@H]3N)cnc2C(N)=O)c1 CHEMBL3415589 IC50 0.1 nM
Cc1cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)nc(C)c1-c1cnn(C)c1 CHEMBL3415594 IC50 0.1 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cccc(-n2nccn2)n1 CHEMBL3415606 IC50 0.1 nM
Cc1nn(-c2cccc(Nc3ccc4c(c3)c(C(=O)C(F)(F)F)cn4C)n2)cc1CN1CC[C@@H](O)C1 CHEMBL3657551 IC50 0.1 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C3CC3)cn4C)n2)cc1CN1CC[C@@H](O)C1 CHEMBL3657550 IC50 0.1 nM
C[C@@H](Oc1cc(-c2ccc3c(c2)COC(=O)N3)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653791 IC50 0.1 nM
C[C@@H](Oc1cc(-c2cnn(CCO)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653846 IC50 0.1 nM
CC(=O)OCCn1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653847 IC50 0.1 nM
C[C@@H](Oc1cc(-c2ccc(N3CCOCC3)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653776 IC50 0.1 nM
C[C@@H](Oc1nc(-c2ccc(N3CCOCC3)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3695989 IC50 0.1 nM
CC[C@@H](Oc1nc(-c2ccc(OC3CCOCC3)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696007 IC50 0.1 nM
COc1ccc(-c2cc3ncccc3c(OC([C@H]3CNC(=O)C3)C(F)(F)F)n2)cc1OC CHEMBL3696011 IC50 0.1 nM
COc1ccc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc1OC CHEMBL3696026 IC50 0.1 nM
CC[C@@H](Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696035 IC50 0.1 nM
COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(C)c1OC CHEMBL3696044 IC50 0.1 nM
COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)ccc1OC(C)C CHEMBL3696046 IC50 0.1 nM
CC[C@@H](Oc1nc(-c2ccc(OC(C)C)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696047 IC50 0.1 nM
Cc1cc(Nc2cc(C)c(F)cn2)nc(-c2cnc(C(C)(O)[C@H]3CC[C@H](C(=O)O)CC3)s2)c1 CHEMBL3898524 IC50 0.1 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN(C)C)c(OC)n4)n3)cc12 CHEMBL4753141 IC50 0.11 nM
Cc1nnc(-c2nn(C)c3ccc(Nc4nccc(-c5cc(CN(C)C)n(C)n5)n4)cc23)o1 CHEMBL4784088 IC50 0.13 nM
Cc1nn2cc1CN(C)CCOCCNC(=O)c1nn(C)c3ccc(cc13)Nc1nccc-2n1 CHEMBL5434339 IC50 0.13 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.133 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN(C)C)c(F)n4)n3)cc12 CHEMBL4752008 IC50 0.14 nM
CNC(=O)c1ccc2c(c1)c(-c1nc3c(-n4cc(CN(C)C)cn4)ccnc3[nH]1)cn2C CHEMBL4754597 IC50 0.15 nM
CC(=O)Nc1ccc2c(c1)c(-c1nc3c(-n4cc(CN(C)C)c(C)n4)ccnc3[nH]1)cn2C CHEMBL4776842 IC50 0.17 nM
CNC(=O)c1cc2c(-c3nc4c(-n5cc(CN(C)C)cn5)ccnc4[nH]3)cn(C)c2cn1 CHEMBL4752127 IC50 0.18 nM
Cc1nn2cc1CN(C)CCOCCNC(=O)c1nn(C[C@H](C)O)c3ccc(cc13)Nc1nccc-2n1 CHEMBL5423731 IC50 0.18 nM
Cc1nnc(-c2nc(C)n3ccc(Nc4nccc(-c5cc(CN(C)C)n(C)n5)n4)cc23)o1 CHEMBL4753164 IC50 0.19 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(O[C@@H]5CCCNC5)c(C)n4)n3)cc12 CHEMBL4758052 IC50 0.19 nM
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)cc(OCC(C)(C)O)n1 CHEMBL3415597 IC50 0.2 nM
CCn1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653806 IC50 0.2 nM
Cc1nc2ccc(-c3cc(O[C@H](C)[C@H]4CNC(=O)C4)c4cccnc4c3)cc2s1 CHEMBL3653813 IC50 0.2 nM
C[C@@H](Oc1cc(-c2ccc(C3(N)CC3)c(Cl)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653814 IC50 0.2 nM
Cc1nc2cc(-c3cc(O[C@H](C)[C@H]4CNC(=O)C4)c4cccnc4c3)ccc2n1C CHEMBL3653833 IC50 0.2 nM
C[C@@H](Oc1cc(-c2cnn(C)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653775 IC50 0.2 nM
CCN(Cc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cc1)C(C)=O CHEMBL3653796 IC50 0.2 nM
COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(OC)c1OC CHEMBL3695979 IC50 0.2 nM
COc1ccc(-c2cc3ncccc3c(O[C@@H]([C@H]3CNC(=O)C3)C(F)(F)F)n2)cc1OC CHEMBL3696013 IC50 0.2 nM
COCC[C@@H](Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696023 IC50 0.2 nM
C[C@@H](Oc1nc(-c2ccccc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696058 IC50 0.2 nM
CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc([C@@H]5C[C@@H](F)CN5C)cn4)n3)cc12 CHEMBL4792651 IC50 0.2 nM
Cc1nnc(-c2nn(C)c3ccc(Nc4nccc(-n5cc(N[C@@H]6CCOC[C@@H]6N)c(C)n5)n4)cc23)o1 CHEMBL4740533 IC50 0.2 nM
Cc1nn2cc1CN(C)CCOCCNC(=O)c1nn(C3COC3)c3ccc(cc13)Nc1nccc-2n1 CHEMBL5416490 IC50 0.2 nM
CCn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc21 CHEMBL3929860 IC50 0.21 nM
Cn1ccc2c(-c3nc4c(-n5cc(N[C@@H]6CCOC[C@@H]6N)cn5)ccnc4[nH]3)cccc21 CHEMBL4740065 IC50 0.21 nM
Cc1nnc(-c2ncn3ccc(Nc4nccc(-c5cc(CN(C)C)n(C)n5)n4)cc23)o1 CHEMBL4759636 IC50 0.21 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN(C)C)cn4)n3)cc12 CHEMBL4786316 IC50 0.21 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2c1ccn2C(F)F CHEMBL3942835 IC50 0.22 nM
CNC(=O)c1nn(C)c2c(C)cc(Nc3nccc(-n4cc(CN(C)C)cn4)n3)cc12 CHEMBL4762290 IC50 0.22 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C(F)(F)F)cn4C)n2)cc1N[C@@H]1CCOC[C@@H]1N CHEMBL4797815 IC50 0.22 nM
Cn1cc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc(-c3ccccc3)c2n1 CHEMBL3951701 IC50 0.23 nM
CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc(NCCN)cn4)n3)cc12 CHEMBL4785413 IC50 0.23 nM
CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc([C@@H]5C[C@H](O)CN5C)cn4)n3)cc12 CHEMBL4784783 IC50 0.24 nM
CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc(CN(C)C)cn4)n3)cc12 CHEMBL4800498 IC50 0.24 nM
Cn1cc(-n2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)nnc4C(N)=O)cccc32)cn1 CHEMBL3966264 IC50 0.26 nM
Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2nn(C)cc12 CHEMBL3985707 IC50 0.26 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2sccc2c1 CHEMBL3925148 IC50 0.26 nM
CNC(=O)c1nn(C)c2c(C)cc(Nc3nccc(-c4cc(CN(C)C)n(C)n4)n3)cc12 CHEMBL4790107 IC50 0.26 nM
COc1ccc2sc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)c(C)c2c1 CHEMBL3928419 IC50 0.27 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cc2ccccc2s1 CHEMBL3903852 IC50 0.28 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cc(-c2ccccc2)cs1 CHEMBL3927595 IC50 0.29 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1csc2ccccc12 CHEMBL3942131 IC50 0.29 nM
COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(-c3ccccc3)c3nn(C)cc3c2)n1 CHEMBL4109655 IC50 0.29 nM
CCOc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653797 IC50 0.3 nM
COc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)nc1 CHEMBL3653816 IC50 0.3 nM
C[C@@H](Oc1cc(-c2ccc3c(c2)ncn3C)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653822 IC50 0.3 nM
C[C@@H](Oc1cc(-c2ccc3ncccc3c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653758 IC50 0.3 nM
C[C@@H](Oc1cc(-c2ccc3[nH]cnc3c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653769 IC50 0.3 nM
C[C@@H](Oc1cc(-c2ccc(CN3CCOCC3)cc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653771 IC50 0.3 nM
C[C@@H](Oc1cc(-c2ccc(CN3CCCCC3=O)cc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653783 IC50 0.3 nM
CC[C@@H](Oc1nc(-c2cc(OC)c(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3695985 IC50 0.3 nM
COc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)O3)n2)cc1OC CHEMBL3696014 IC50 0.3 nM
COc1ccc(-c2cc3ncccc3c(O[C@@H](C)C3CNC(=O)C3)n2)cc1OC CHEMBL3696024 IC50 0.3 nM
CCC(Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696033 IC50 0.3 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@H]5CNC[C@@H]5F)c(C)n4)n3)cc12 CHEMBL4776734 IC50 0.3 nM
CCn1cc2ccc(Nc3nc(N[C@@H]4CCCCC[C@@H]4N)nnc3C(N)=O)cc2n1 CHEMBL3977902 IC50 0.31 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN(C)C)c(C)n4)n3)cc12 CHEMBL4751083 IC50 0.31 nM
Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)c2ccn(C)c2c1 CHEMBL3935081 IC50 0.33 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2nn(C(F)F)cc12 CHEMBL3937625 IC50 0.33 nM
Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2cccnc12 CHEMBL3954832 IC50 0.33 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@@H]5CCOC[C@@H]5N)cn4)n3)cc12 CHEMBL4786007 IC50 0.33 nM
COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)c3c(cnn3C(C)C)c2)n1 CHEMBL4106524 IC50 0.34 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@@H]5CCOC[C@@H]5N)c(C)n4)n3)cc12 CHEMBL4742918 IC50 0.34 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(NCC5(N)CC5)c(C)n4)n3)cc12 CHEMBL4748041 IC50 0.34 nM
CC[C@H](N)CNc1nnc(C(N)=O)c(Nc2cccc3sccc23)n1 CHEMBL3964579 IC50 0.35 nM
COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)cc3c2ccn3C)n1 CHEMBL4106498 IC50 0.35 nM
Cn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc21 CHEMBL3915461 IC50 0.36 nM
Cn1ccc(-n2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)nnc4C(N)=O)cccc32)n1 CHEMBL3956355 IC50 0.36 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2cnn(C(F)F)c2c1 CHEMBL3916136 IC50 0.36 nM
CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc(N[C@@H]5CCOC[C@@H]5N)cn4)n3)cc12 CHEMBL4763433 IC50 0.36 nM
Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2cn(C(C)(C)C)nc12 CHEMBL3962569 IC50 0.37 nM
Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2cn(C(F)F)nc12 CHEMBL3980587 IC50 0.37 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2c1ccn2C1CCC(O)CC1 CHEMBL3937428 IC50 0.37 nM
CCn1cc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc(-n3cccn3)c2n1 CHEMBL3915963 IC50 0.37 nM
Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2ccsc12 CHEMBL3891798 IC50 0.37 nM
Cc1nn2cc1CN(C)CCOCCNC(=O)c1nn(CCO)c3ccc(cc13)Nc1nccc-2n1 CHEMBL5427639 IC50 0.37 nM
NC(=O)c1nnc(N[C@@H]2CCOC[C@@H]2N)nc1Nc1cccc2c1ccn2C1CC1 CHEMBL3940859 IC50 0.38 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1nc(-c2ccccc2)cs1 CHEMBL3910738 IC50 0.38 nM
Cn1cc2cc(Nc3nc(N[C@@H]4CCOC[C@@H]4N)nnc3C(N)=O)cc(-c3ccccc3)c2n1 CHEMBL3955036 IC50 0.38 nM
CCn1ncc2c(C)cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc21 CHEMBL3894832 IC50 0.39 nM
Cc1cc(CCC(C)(C)O)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)n1 CHEMBL3415604 IC50 0.4 nM
NC(=O)c1cccnc1COc1cc(-c2ccc(C3(N)CC3)c(Cl)c2)cc2ncccc12 CHEMBL3653790 IC50 0.4 nM
C[C@@H](Oc1cc(-c2ccc3[nH]c(C(F)(F)F)nc3c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653821 IC50 0.4 nM
C[C@@H](Oc1cc(-c2ccc3c(c2)CNCC3)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653829 IC50 0.4 nM
Cc1nc2cc(-c3cc(O[C@H](C)[C@H]4CNC(=O)C4)c4cccnc4c3)ccc2[nH]1 CHEMBL3653837 IC50 0.4 nM
C[C@@H](Oc1cc(-c2ccccc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3650441 IC50 0.4 nM
COc1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cc(OC)c1OC CHEMBL3650442 IC50 0.4 nM
COc1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)ccc1OC(C)C CHEMBL3650449 IC50 0.4 nM
C[C@@H](Oc1cc(-c2ccc3ccccc3n2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653763 IC50 0.4 nM
COc1ccc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cn1 CHEMBL3695990 IC50 0.4 nM
COc1ccc(-c2cc3ncccc3c(NCc3n[nH]c(=O)o3)n2)cc1OC CHEMBL3696009 IC50 0.4 nM
C[C@@H](Oc1nc(-c2ccc(C#N)cc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696053 IC50 0.4 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2ncccc2c1 CHEMBL3920952 IC50 0.4 nM
N#Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)c2ccsc2c1 CHEMBL3938678 IC50 0.4 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(O[C@H]5CNC[C@H]5F)c(C)n4)n3)cc12 CHEMBL4795975 IC50 0.4 nM
CC(C)(C)n1cc2cc(Nc3nc(N[C@@H]4CCOC[C@@H]4N)nnc3C(N)=O)cc(Cl)c2n1 CHEMBL3983643 IC50 0.41 nM
Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)c2ccn(C)c2c1 CHEMBL3960134 IC50 0.41 nM
NC(=O)c1nnc(N[C@@H]2CCOC[C@@H]2N)nc1Nc1cccc2c1ccn2C1CCC1 CHEMBL3971204 IC50 0.41 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2c1ccn2C1COC1 CHEMBL3954998 IC50 0.42 nM
CCn1nc(C)c2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc21 CHEMBL3956032 IC50 0.42 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cc(-c2ccccn2)cs1 CHEMBL3975728 IC50 0.42 nM
Cc1nn2cc1CN(C)CCOCCNC(=O)c1nn(CC(C)(C)O)c3ccc(cc13)Nc1nccc-2n1 CHEMBL5411721 IC50 0.42 nM
CCn1ncc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc21 CHEMBL3912860 IC50 0.43 nM
COc1cc(Nc2nc(-c3ccc4cn[nH]c4c3)cn3ccnc23)ccc1N1CCOCC1 CHEMBL3265037 IC50 0.44 nM
CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4c(c3)NC(=O)C(F)(F)O4)n2)=C1 CHEMBL3893049 IC50 0.45 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2sccc12 CHEMBL3943426 IC50 0.46 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2nn(C3CCC3)cc2c1 CHEMBL3968416 IC50 0.47 nM
CCOC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)c3ncccc3c2)n1 CHEMBL4107501 IC50 0.48 nM
Cn1ccc2c(-c3nc4c(-n5cc(CN6CC[C@@H](O)C6)cn5)ccnc4[nH]3)cccc21 CHEMBL4779316 IC50 0.48 nM
Cn1cc(-c2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)c3cnn(C)c3c2)cn1 CHEMBL3942355 IC50 0.49 nM
Cc1cc(C)nc(Nc2cc(NCC3(N)CC3)cnc2C(N)=O)c1 CHEMBL3415587 IC50 0.5 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cccc(C(F)(F)F)n1 CHEMBL3415592 IC50 0.5 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)nc1-c1cc2ccccc2[nH]1 CHEMBL3414584 IC50 0.5 nM
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C#N)c3c2C(=O)NC3)c1 CHEMBL3953104 IC50 0.5 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@]3(O)CCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698418 IC50 0.5 nM
CC(C)n1cc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)cn1 CHEMBL3653841 IC50 0.5 nM
C[C@@H](Oc1cc(-c2ccc(C(F)(F)F)cn2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653777 IC50 0.5 nM
COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(Cl)c1OC CHEMBL3695952 IC50 0.5 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)ccc1OC1CCOCC1 CHEMBL3696002 IC50 0.5 nM
COc1cc(OC)cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)c1 CHEMBL3696028 IC50 0.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(N)=O)[nH]c12 CHEMBL3664145 IC50 0.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3ccccn3)[nH]c12 CHEMBL3668864 IC50 0.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(-c3nnco3)[nH]c12 CHEMBL3668883 IC50 0.5 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C(C)(O)[C@H]3CC[C@H](C(=O)O)CC3)s2)c1 CHEMBL3889567 IC50 0.5 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2cnc(C(C)(O)C3CCC(C(=O)O)CC3)s2)c1 CHEMBL3982109 IC50 0.5 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C(C)(O)C3CCC(C(=O)O)C3)s2)c1 CHEMBL3943235 IC50 0.5 nM
CCC(O)(c1ncc(-c2cc(C)cc(Nc3cc(C(F)(F)F)ccn3)n2)s1)C1CCC(C(=O)O)CC1 CHEMBL3969168 IC50 0.5 nM
CCn1nc(C)c2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)ccc21 CHEMBL3933863 IC50 0.5 nM
Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2nn(C(F)F)cc12 CHEMBL3894619 IC50 0.5 nM
Cn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cnc3C(=O)O)cccc21 CHEMBL3895637 IC50 0.5 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2c1ccn2CCF CHEMBL3980489 IC50 0.51 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(O[C@@H]5CCNC5)c(C)n4)n3)cc12 CHEMBL4782062 IC50 0.51 nM
CCn1ncc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)ccc21 CHEMBL3926200 IC50 0.52 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2nn(C(F)F)cc2c1 CHEMBL3967134 IC50 0.52 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2cn(C(F)F)nc2c1 CHEMBL3959686 IC50 0.53 nM
Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)c2ccn([C@H]3CC[C@H](O)CC3)c2c1 CHEMBL3965597 IC50 0.53 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(N)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698439 IC50 0.55 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cc(-c2ncccn2)cs1 CHEMBL3909488 IC50 0.55 nM
CCn1ncc2cc(Nc3nc(N[C@H](C)[C@@H](N)COC)nnc3C(N)=O)cc(C)c21 CHEMBL4112113 IC50 0.55 nM
Cc1cc(Nc2cc(C(C)(C)C)ccn2)nc(-c2cnc(C3(O)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698455 IC50 0.56 nM
NC(=O)c1nnc(N[C@@H]2CCOC[C@@H]2N)nc1Nc1ccc2cnn(C(F)F)c2c1 CHEMBL3947485 IC50 0.58 nM
CCn1ncc2c(C)cc(Nc3nc(N[C@@H]4CCOC[C@@H]4N)nnc3C(N)=O)cc21 CHEMBL3921557 IC50 0.59 nM
COc1cc(C)nc(Nc2cc(N[C@@H]3CS(=O)(=O)CC[C@@H]3N)cnc2C(N)=O)c1 CHEMBL3415599 IC50 0.6 nM
CO[C@@H]1CN(Cc2cn(-c3ccnc(Nc4ccc5c(c4)c(Cl)c(C)n5C)n3)nc2C)C[C@@H]1O CHEMBL3657556 IC50 0.6 nM
COc1ccnc(Nc2cc(C)cc(-c3cnc([C@]4(O)CCCc5cc(C(=O)O)ccc54)s3)n2)c1 CHEMBL3698444 IC50 0.6 nM
C[C@@H](Oc1cc(-c2ccc(OC3CCC3)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653818 IC50 0.6 nM
C[C@@H](Oc1cc(-c2ccc(C(F)F)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653848 IC50 0.6 nM
COc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cc1OC CHEMBL3650447 IC50 0.6 nM
COc1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)ccc1O CHEMBL3650450 IC50 0.6 nM
COc1ccc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)cc1OC CHEMBL3653754 IC50 0.6 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N3CCC4(CC3)COCC(=O)N4C)[nH]c12 CHEMBL3664174 IC50 0.6 nM
CCN(CC)C1CN(C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)C1 CHEMBL3664181 IC50 0.6 nM
CCn1ccc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)n1 CHEMBL3668818 IC50 0.6 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3nc4ccncc4[nH]3)[nH]c12 CHEMBL3668831 IC50 0.6 nM
Cn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4cn[nH]c(=O)c34)cccc21 CHEMBL3949807 IC50 0.6 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@@H]5CCNC5)c(C)n4)n3)cc12 CHEMBL4753097 IC50 0.6 nM
CC(C)(C)n1cc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc(-n3cccn3)c2n1 CHEMBL3891358 IC50 0.61 nM
CCn1ncc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc21 CHEMBL3978816 IC50 0.61 nM
Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2cn(C(C)(C)CO)nc12 CHEMBL3955020 IC50 0.63 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2cc[nH]c12 CHEMBL3416026 Kd 0.64 nM
Cc1cc(Nc2cc(OC3CCCC3)ccn2)nc(-c2cnc(C3(O)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698387 IC50 0.67 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2c1ccn2CCO CHEMBL3969465 IC50 0.67 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(O)CCCc4cc(-c5nnn[nH]5)ccc43)s2)c1 CHEMBL3698426 IC50 0.68 nM
COc1cccc2[nH]c(-c3nc(N[C@@H]4CCOC[C@@H]4N)cnc3C(N)=O)cc12 CHEMBL3415610 IC50 0.7 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(Cl)cn4C)n2)cc1CN1CC(O)C1 CHEMBL3622955 IC50 0.7 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(Cl)nn4C)n2)cc1CN1CC(O)C1 CHEMBL3622961 IC50 0.7 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(S(C)(=O)=O)nn4C)n2)cc1CN1C[C@@H](O)[C@@H](O)C1 CHEMBL3657558 IC50 0.7 nM
Cc1ccc2cc(-c3cc(O[C@H](C)[C@H]4CNC(=O)C4)c4cccnc4c3)ccc2n1 CHEMBL3653762 IC50 0.7 nM
COc1c(F)cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc1F CHEMBL3695959 IC50 0.7 nM
CC[C@@H](Oc1nc(-c2cc(OC)c(OCCN3CCOCC3)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3695965 IC50 0.7 nM
COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc2c1OCO2 CHEMBL3695966 IC50 0.7 nM
CCOc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(OCC)c1OCC CHEMBL3695998 IC50 0.7 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)ccc1O[C@@H]1CCCOC1 CHEMBL3696003 IC50 0.7 nM
COc1ccc(-c2cc3ncccc3c(NCc3n[nH]c(=O)[nH]3)n2)cc1OC CHEMBL3696010 IC50 0.7 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)ccc1OC(C)C CHEMBL3696045 IC50 0.7 nM
CN1C(=O)COCC12CCN(C(=O)c1cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]1)CC2 CHEMBL3664189 IC50 0.7 nM
Cc1cc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc2n1C1CC1 CHEMBL3972448 IC50 0.71 nM
Cc1cc(Nc2cc(-c3ccsc3)ccn2)nc(-c2cnc(C3(O)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698383 IC50 0.73 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@@H]5CCCNC5)c(C)n4)n3)cc12 CHEMBL4760325 IC50 0.73 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCc4cc(C(=O)NC#N)ccc43)s2)c1 CHEMBL3698430 IC50 0.74 nM
CONC(=O)c1ccc2c(c1)CCC[C@]2(O)c1ncc(-c2cc(C)cc(Nc3cc(C(F)(F)F)ccn3)n2)s1 CHEMBL3698433 IC50 0.74 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(F)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698438 IC50 0.78 nM
COC[C@H](N)CNc1cnc(C(N)=O)c(Nc2cc(C)cc(C)n2)c1 CHEMBL3415588 IC50 0.8 nM
COc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)c1 CHEMBL3415593 IC50 0.8 nM
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(Cl)c3c2C(=O)NC3)c1 CHEMBL3941633 IC50 0.8 nM
COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(OC)c1OCCN1CCOCC1 CHEMBL3695964 IC50 0.8 nM
CN1CCN(C2CCN(C(=O)c3cc4cc(Nc5nccc(-c6cn(C)cn6)n5)cc(Cl)c4[nH]3)CC2)C1=O CHEMBL3664185 IC50 0.8 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3ccccc3F)[nH]c12 CHEMBL3668829 IC50 0.8 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc(F)cc12 CHEMBL3965225 IC50 0.8 nM
CCN1CCN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)CC1 CHEMBL4649800 IC50 0.8 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc12 CHEMBL3932871 IC50 0.8 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2[nH]ccc12 CHEMBL3416027 IC50 0.8 nM
Cn1ncc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc21 CHEMBL3962214 IC50 0.8 nM
Cn1cc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc2n1 CHEMBL3967315 IC50 0.8 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2c(Cl)c[nH]c12 CHEMBL3893313 IC50 0.8 nM
N#Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc12 CHEMBL3930413 IC50 0.8 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2[nH]ncc12 CHEMBL3962915 IC50 0.8 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cc(F)cc2cc[nH]c12 CHEMBL3899231 IC50 0.8 nM
CC(=O)Nc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698405 IC50 0.83 nM
Cc1nn(-c2ccnc3[nH]c(-c4cccc5c4ccn5C)nc23)cc1CN(C)C CHEMBL4796370 IC50 0.83 nM
COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4ccc(C(=O)O)cc4)c3)cn3ccnc23)cc1OC CHEMBL3264995 IC50 0.84 nM
Cn1ccc(-n2ccc3c(Nc4nc(NCC5(N)CCC5)nnc4C(N)=O)cccc32)n1 CHEMBL3918296 IC50 0.85 nM
CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc(OCCN)cn4)n3)cc12 CHEMBL4741509 IC50 0.88 nM
NC(=O)c1nnc(N[C@@H]2CCOC[C@@H]2N)nc1Nc1csc2ccccc12 CHEMBL3907341 IC50 0.89 nM
Cc1cc(CC(C)(C)O)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)n1 CHEMBL3415595 IC50 0.9 nM
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(-c3cn[nH]c3)c3c2C(=O)NC3)c1 CHEMBL3916444 IC50 0.9 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OCC(C)(C)CO)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3641570 IC50 0.9 nM
C[C@@H](Oc1cc(-c2cnc3c(c2)CCCO3)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653828 IC50 0.9 nM
COc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653750 IC50 0.9 nM
C[C@@H](Oc1cc(-c2ccc3cnn(C)c3c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653770 IC50 0.9 nM
C[C@@H](Oc1cc(-c2ccc3c(c2)CCNC3=O)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653781 IC50 0.9 nM
COc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc1OC CHEMBL3695991 IC50 0.9 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)ccc1OCC1CCOCC1 CHEMBL3696042 IC50 0.9 nM
CNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(C)c2[nH]1 CHEMBL3664149 IC50 0.9 nM
CC(C)n1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N(C)C)cc4c3)n2)c1 CHEMBL3664158 IC50 0.9 nM
CC(C)n1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3664169 IC50 0.9 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cnn(C)c3C)[nH]c12 CHEMBL3668820 IC50 0.9 nM
CN(C)C[C@@H]1CN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)CCO1 CHEMBL4637943 IC50 0.9 nM
COCCN1CCN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)CC1 CHEMBL4638089 IC50 0.9 nM
Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 CHEMBL3685796 IC50 0.9 nM
Cc1nn(-c2ccnc3[nH]c(-c4cccc5c4ccn5C)nc23)cc1CN1CC[C@@H](O)C1 CHEMBL4791746 IC50 0.91 nM
CCn1ncc2cc(Nc3nc(N[C@H]4CCCNC4)nnc3C(N)=O)ccc21 CHEMBL3907311 IC50 0.92 nM
Cc1cc(Nc2cc(C(F)(F)F)c(Cl)cn2)nc(-c2cnc(C3(O)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698448 IC50 0.94 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cncc(C2CC2)c1 CHEMBL3957413 IC50 0.94 nM
CN(C)Cc1cnn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)N(C)C)nn4C)n2)c1 CHEMBL4793844 IC50 0.94 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCCc4ccc(C(=O)O)cc43)s2)c1 CHEMBL3698413 IC50 0.95 nM
COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)c3nn(C(C)(C)C)cc3c2)n1 CHEMBL4108411 IC50 0.95 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-c4cc(CN(C)C)n(C)n4)n3)cc12 CHEMBL4757235 IC50 0.95 nM
C[C@@H]1C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4cn[nH]c4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4106610 IC50 0.9588 nM
COc1cc(Nc2nc(NC3CCCC[C@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1 CHEMBL471948 IC50 1.0 nM
COc1ccc(Nc2cc(-c3cccc(C(=O)Nc4ccc(C(=O)O)cc4)c3)nn3ccnc23)nc1OC CHEMBL2177726 IC50 1.0 nM
NC(=O)c1cnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc(-n2nccn2)c1 CHEMBL2177736 IC50 1.0 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2cc(OC(F)F)ccc21 CHEMBL2346686 IC50 1.0 nM
N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3[nH]ccc23)n1 CHEMBL3262616 IC50 1.0 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCOC[C@@H]4N)cc4nc[nH]c(=O)c34)cccc12 CHEMBL3262620 IC50 1.0 nM
Cn1cc2c(Nc3nc(N[C@@H]4CCOC[C@@H]4N)cc4cc[nH]c(=O)c34)cccc2n1 CHEMBL3262622 IC50 1.0 nM
Cc1cc(Nc2cc(N[C@@H]3CS(=O)(=O)CC[C@@H]3N)cnc2C(N)=O)nc(C)c1-c1cnn(C)c1 CHEMBL3415605 IC50 1.0 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc(-n2nccn2)c1 CHEMBL3416023 IC50 1.0 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(Cl)c(C)n4C)n2)cc1CN1CC[C@@H](O)C1 CHEMBL3622957 IC50 1.0 nM
Cc1nn(-c2nc(Nc3ccc4c(c3)c(Cl)c(C)n4C)ncc2F)cc1CN1CC(O)C1 CHEMBL3657547 IC50 1.0 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(C4CC4)c3)s2)CC[C@@H]1C(=O)O CHEMBL3685786 IC50 1.0 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Cl)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC[C@@H]1C(=O)O CHEMBL3685804 IC50 1.0 nM
Cc1cc(Nc2nccc(-c3cccs3)n2)cc(-c2cnc(C3(O)CCC(C(=O)O)CC3)s2)c1 CHEMBL3685806 IC50 1.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)NCCCN4CCCC4=O)C(C)(C)C3)s2)c1 CHEMBL3685820 IC50 1.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)[C@H](C)C3)s2)c1 CHEMBL3685821 IC50 1.0 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4ccccn4)n3)cc(Cl)c2[nH]1 CHEMBL3643782 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)[C@H]3CC[C@H](CO)CC3)nc2)c1 CHEMBL3933885 IC50 1.0 nM
CC(C)Oc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653794 IC50 1.0 nM
CCn1cc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)cn1 CHEMBL3653805 IC50 1.0 nM
COc1cc(-c2cc(OC[C@H]3CNC(=O)O3)c3cccnc3c2)ccc1O CHEMBL3653742 IC50 1.0 nM
Cn1ncc2ccc(-c3cc(OCc4ncccc4C(N)=O)c4cccnc4c3)cc21 CHEMBL3653772 IC50 1.0 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)ccc1OC1CCS(=O)(=O)CC1 CHEMBL3695955 IC50 1.0 nM
C[C@@H](Oc1nc(-c2ccc(=O)[nH]c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3695967 IC50 1.0 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)ccc1O[C@@H]1CCOC1 CHEMBL3695997 IC50 1.0 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCC(N6CCCC6=O)CC5)cc4c3)n2)c1 CHEMBL3664193 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C3(O)CCC(C(=O)O)CC3)nc2)c1 CHEMBL3905224 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C3(O)CCCc4cc(C(=O)O)ccc43)nc2)c1 CHEMBL3889646 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C3(O)CCC(C(=O)O)C(C)(C)C3)nc2)c1 CHEMBL3953374 IC50 1.0 nM
Cc1cc(Nc2cc(C(C)(C)C)c(F)cn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3913050 IC50 1.0 nM
Cc1cc(Nc2cc(C(C)(C)C)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3910052 IC50 1.0 nM
Cc1cc(Nc2cc(OC(C)(C)C)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3937990 IC50 1.0 nM
Cc1cc(Nc2cc(C3CC3)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3924403 IC50 1.0 nM
CC(C)(O)c1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3936887 IC50 1.0 nM
CC(=O)C(C)(c1ccc(-c2cc(C)cc(Nc3cc(C(F)F)ccn3)n2)cn1)C1CCC(C(=O)O)CC1 CHEMBL3902229 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC(C)(C)C(=O)O)nc2)c1 CHEMBL3891097 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3896611 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CC(C(=O)O)CC3=O)nc2)c1 CHEMBL3942837 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCC(C(=O)O)C(C)C3)nc2)c1 CHEMBL3922195 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccc5ccn(C)c5c4)CC3)nc2)c1 CHEMBL3939117 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5c(c4)C(=O)NC5)CC3)nc2)c1 CHEMBL3954389 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cnn5cccnc45)CC3)nc2)c1 CHEMBL3942919 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4cccnc4)CC3)nc2)c1 CHEMBL3909126 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)CCCN4CCCC4=O)CC3)nc2)c1 CHEMBL3915368 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CC[C@H](N)C3)nc2)c1 CHEMBL3949746 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C[C@H]3CC[C@H](C(=O)O)CC3)nc2)c1 CHEMBL3906189 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C[C@@H](O)[C@H]3CC[C@H](C(=O)O)CC3)nc2)c1 CHEMBL3909914 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C[C@@H](O)C3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3903211 IC50 1.0 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)[C@H]3CC[C@H](C(=O)O)CC3)nc2)c1Br CHEMBL3955380 IC50 1.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(cnn5CCN5CCOCC5)c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3936603 IC50 1.0 nM
Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(OCCN5CCOCC5)nc4)c4ccccc34)n2)cc2cn[nH]c12 CHEMBL3972709 IC50 1.0 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cnc3C(N)=O)cccc12 CHEMBL3986813 IC50 1.0 nM
CC(C)(C(=O)O)C1C[C@@H]1[C@](C)(O)c1ncc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)s1 CHEMBL3905969 IC50 1.0 nM
Cc1cc(Nc2nccc(C)n2)cc(-c2cnc(C(C)(O)C3CCC(C(=O)O)CC3)s2)c1 CHEMBL3928792 IC50 1.0 nM
COC(C)(c1ncc(-c2cc(C)cc(Nc3nccc(C(F)(F)F)n3)c2)s1)[C@H]1CC[C@H](C(=O)O)CC1 CHEMBL3966249 IC50 1.0 nM
CC(=O)C1CCC(C(C)(O)c2ncc(-c3cccc(Nc4nccc(CF)n4)c3)s2)CC1 CHEMBL3955089 IC50 1.0 nM
CC(O)(c1ncc(-c2cc(Nc3nccc(C(F)(F)F)n3)cc(C3CC3)c2)s1)[C@H]1CC[C@H](C(=O)O)CC1 CHEMBL3974088 IC50 1.0 nM
C[C@@](O)(c1ncc(-c2cc(F)cc(Nc3nccc(C(F)(F)F)n3)c2)s1)[C@H]1CC[C@H](C(=O)O)CC1 CHEMBL3897995 IC50 1.0 nM
Cn1ccc2c(-c3nc4c(-n5cc(CN6CC[C@H](O)C6)cn5)ccnc4[nH]3)cccc21 CHEMBL4748597 IC50 1.0 nM
CC(=O)NC1(c2ncc(-c3cc(C)cc(Nc4cc(C(F)(F)F)ccn4)n3)s2)CCCc2cc(C(=O)O)ccc21 CHEMBL3698442 IC50 1.01 nM
Cc1cc(Nc2cc(OC3CCCCC3)ccn2)nc(-c2cnc(C3(O)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698384 IC50 1.02 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(O)CCCc4cc(C(N)=O)ccc43)s2)c1 CHEMBL3698399 IC50 1.08 nM
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)c1 CHEMBL3983415 IC50 1.1 nM
C[C@@H](Oc1cc(-c2ccc(CS(C)(=O)=O)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653823 IC50 1.1 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Br)c2[nH]1 CHEMBL3664156 IC50 1.1 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C(C)(O)C3CCC(C(=O)O)CC3)s2)c1 CHEMBL3973662 IC50 1.1 nM
Cn1cc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4cn[nH]c(=O)c34)cccc2n1 CHEMBL3910748 IC50 1.1 nM
OC[C@H]1CN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)CCO1 CHEMBL4643354 IC50 1.1 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4ccn[nH]4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4112040 IC50 1.112 nM
Cc1ccc(S(=O)(=O)NC(=O)c2ccc3c(c2)CCC[C@]3(O)c2ncc(-c3cc(C)cc(Nc4cc(C(F)(F)F)ccn4)n3)s2)cc1 CHEMBL3698429 IC50 1.18 nM
CCCn1c(C)c(Cl)c2cc(Nc3nccc(-n4cc(CN5CC(O)C5)c(C)n4)n3)ccc21 CHEMBL3657559 IC50 1.2 nM
COc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCC6(CC5)COCC(=O)N6C)cc4c3)n2)c1 CHEMBL3641518 IC50 1.2 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cc(OC5CCC(O)C5)ccn4)n3)ccc2[nH]1 CHEMBL3641529 IC50 1.2 nM
Clc1cc(Nc2nccc(-c3ccccn3)n2)cc2nc[nH]c12 CHEMBL3643819 IC50 1.2 nM
NC(=O)c1cccnc1COc1cc(-c2ccc(CN3CCOCC3)cc2)cc2ncccc12 CHEMBL3653768 IC50 1.2 nM
Cc1c(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cnn1C CHEMBL3653840 IC50 1.2 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)O3)n2)cc(OC)c1OC CHEMBL3695972 IC50 1.2 nM
Cc1cc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)n(C)n1 CHEMBL3668812 IC50 1.2 nM
Cc1nn(C)cc1CNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(C)c2[nH]1 CHEMBL3668853 IC50 1.2 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)OCC(=O)N(C)C)CC3)nc2)c1 CHEMBL3942532 IC50 1.2 nM
OC1CCN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)CC1 CHEMBL4647927 IC50 1.2 nM
CN(C)Cc1cnn(-c2ccnc3[nH]c(-c4cn(C)c5ccc(C(=O)N(C)C)cc45)nc23)c1 CHEMBL4745530 IC50 1.2 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCc4ccc(C(=O)O)cc43)s2)c1 CHEMBL3698411 IC50 1.26 nM
COc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@]3(O)CC[C@@H](C(=O)O)CC3)s2)c1 CHEMBL3966354 IC50 1.286 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4ccc(N)nc4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4109279 IC50 1.289 nM
CC(=O)c1cn(C)c2ccc(Nc3nccc(-n4cc(CN5CC(O)C5)c(C)n4)n3)cc12 CHEMBL3657544 IC50 1.3 nM
CC(=O)c1c[nH]c2ccc(Nc3nccc(-n4cc(CN5CC(O)C5)c(C)n4)n3)cc12 CHEMBL3657552 IC50 1.3 nM
C[C@@H](Oc1cc(-c2ccc(OC3CCOCC3)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653800 IC50 1.3 nM
Cc1nc2cc(-c3cc(OCc4ncccc4C(N)=O)c4cccnc4c3)ccc2n1C CHEMBL3653834 IC50 1.3 nM
CN1CCC2(CCN(C(=O)c3cc4cc(Nc5nccc(-c6cn(C)cn6)n5)cc(Cl)c4[nH]3)C2)C1 CHEMBL3664194 IC50 1.3 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3nc4ccccc4n3C)[nH]c12 CHEMBL3668828 IC50 1.3 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4cn[nH]c(=O)c34)cc(F)cc12 CHEMBL3926611 IC50 1.3 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(C(C)(O)[C@H]3CC[C@H](C(=O)O)CC3)cc2)c1 CHEMBL3956908 IC50 1.3 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(OC5CNC5)c(C)n4)n3)cc12 CHEMBL4758301 IC50 1.3 nM
Cc1nn2cc1CN(C)CCCCCNC(=O)c1nn(C)c3ccc(cc13)Nc1nccc-2n1 CHEMBL5416190 IC50 1.3 nM
CC1(O)CCN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)CC1 CHEMBL3265031 IC50 1.4 nM
O=C(c1cc2cc(Nc3nccc(-c4ccccn4)n3)cc(Cl)c2[nH]1)N1CCC(N2CCCC2=O)CC1 CHEMBL3643795 IC50 1.4 nM
C[C@@H](Oc1cc(-c2cnn(C(F)(F)F)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653815 IC50 1.4 nM
CNC(=O)c1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653784 IC50 1.4 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)ccc1O[C@H]1CCOC1 CHEMBL3695996 IC50 1.4 nM
CNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3664148 IC50 1.4 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NCC5CCOCC5)cc4c3)n2)c1 CHEMBL3664182 IC50 1.4 nM
CN(CC1CCOCC1)C(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3664195 IC50 1.4 nM
COC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(C)c2[nH]1 CHEMBL3668804 IC50 1.4 nM
Cc1cnc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)s1 CHEMBL3639676 IC50 1.4 nM
Cc1noc(-c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)n1 CHEMBL3668879 IC50 1.4 nM
Cc1nnc(-c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)o1 CHEMBL3668881 IC50 1.4 nM
COc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 CHEMBL4106740 IC50 1.4 nM
COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4ccc(-c5nn[nH]n5)cc4)c3)cn3ccnc23)cc1OC CHEMBL3265001 IC50 1.5 nM
Cc1cn(-c2nc(Nc3ccc4c(c3)c(Cl)nn4C)ncc2F)cc1CN1CC(O)C1 CHEMBL3657549 IC50 1.5 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OCC6CC6(F)F)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3643745 IC50 1.5 nM
C[C@@H](Oc1cc(-c2ccc(C(=O)N3CCN(C)CC3)cc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653804 IC50 1.5 nM
CCCn1cc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)cn1 CHEMBL3653845 IC50 1.5 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3664147 IC50 1.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cccnc3)[nH]c12 CHEMBL3668873 IC50 1.5 nM
CC(=O)OC(C)OC(=O)C1CCC(C(C)(O)c2ccc(-c3cc(C)cc(Nc4cc(C(F)F)ccn4)n3)cn2)CC1 CHEMBL3906145 IC50 1.5 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(NC5CNC5)c(C)n4)n3)cc12 CHEMBL4743842 IC50 1.5 nM
COc1cc(NC(=O)c2cccc(-c3cc(Nc4ccc(OC)c(OC)n4)c4nccn4n3)c2)ccc1C(=O)O CHEMBL3984163 IC50 1.55 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4ccncc4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4108628 IC50 1.558 nM
COc1cc(Nc2nc(NC3CCCCC[C@H]3N)n3ccnc3c2C(N)=O)cc(OC)c1 CHEMBL515910 IC50 1.6 nM
CC[C@H](C)Oc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3641535 IC50 1.6 nM
C[C@@H](Oc1cc(-c2ccc3ncn(C)c3c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653809 IC50 1.6 nM
NC(=O)c1cccnc1COc1cc(-c2ccc(N3CCOCC3)nc2)cc2ncccc12 CHEMBL3653773 IC50 1.6 nM
CCN(Cc1ccc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)cc1)C(C)=O CHEMBL3653778 IC50 1.6 nM
CC(=O)N(C)Cc1ccc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)cc1 CHEMBL3653786 IC50 1.6 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCC(N6CC[S+]([O-])CC6)CC5)cc4c3)n2)c1 CHEMBL3664187 IC50 1.6 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NCc5nccn5C)cc4c3)n2)c1 CHEMBL3664206 IC50 1.6 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cn(C6CC6)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3664170 IC50 1.6 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3664144 IC50 1.6 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4cn[nH]c(=O)c34)cccc12 CHEMBL3913045 IC50 1.6 nM
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2ccc3ncccc3c2)n1 CHEMBL3898569 IC50 1.6 nM
COC(=O)c1ccc2c(c1)CCC[C@]2(O)c1ncc(-c2cc(C)cc(Nc3cc(-c4c[nH]nn4)ccn3)n2)s1 CHEMBL3698400 IC50 1.62 nM
CC1CCCN1c1cccc(Nc2cc(-c3cccc(C(=O)Nc4ccc(C(=O)O)cc4)c3)nn3ccnc23)n1 CHEMBL3911581 IC50 1.65 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C)c(C)n4C)n2)cc1CN1CC(O)C1 CHEMBL3622958 IC50 1.7 nM
C[C@@H](Oc1cc(-c2ccccn2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3650445 IC50 1.7 nM
Cc1cc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)ccc1S(C)(=O)=O CHEMBL3653764 IC50 1.7 nM
CCCC(Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696039 IC50 1.7 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NCc5ccn(C)n5)cc4c3)n2)c1 CHEMBL3664153 IC50 1.7 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3ccnn3C)[nH]c12 CHEMBL3668826 IC50 1.7 nM
c1cn2cc(-c3cnc4cc[nH]c4n3)nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c2n1 CHEMBL4643695 IC50 1.7 nM
Cc1cc(Nc2cc(C3CCCCC3)ccn2)nc(-c2cnc(C3(O)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698388 IC50 1.75 nM
CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4c(c3)NC(=O)C(F)(F)O4)n2)c1 CHEMBL2170582 Ki 1.8 nM
CNC(=O)c1cc2cc(Nc3nccc(-c4ccccn4)n3)cc(Cl)c2[nH]1 CHEMBL3643814 IC50 1.8 nM
CC(=O)Nc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 CHEMBL3653759 IC50 1.8 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)ccc1O[C@H]1CCCOC1 CHEMBL3696004 IC50 1.8 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3ccn(C)n3)[nH]c12 CHEMBL3664154 IC50 1.8 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(C3CC3)c2[nH]1 CHEMBL3664151 IC50 1.8 nM
COc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N(C)C)[nH]c12 CHEMBL3668810 IC50 1.8 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cc(C)n(C)n3)[nH]c12 CHEMBL3668835 IC50 1.8 nM
N[C@H]1COCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cccc3sccc23)n1 CHEMBL3909966 IC50 1.8 nM
Cc1cc(C)cc(Nc2nccc(-n3cc(CN4CC(O)C4)c(C4CC4)c3)n2)c1 CHEMBL3622935 IC50 1.9 nM
Cc1cn2cc(-c3cc(O[C@H](C)[C@H]4CNC(=O)C4)c4cccnc4c3)ccc2n1 CHEMBL3653789 IC50 1.9 nM
COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)ccc1OC(F)(F)F CHEMBL3695949 IC50 1.9 nM
CC(C)N1CCCN(C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3664190 IC50 1.9 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cccc(C(=O)O)c2)c1 CHEMBL3906224 IC50 1.9 nM
Cc1nn2cc1CN(C)N1CC(CNC(=O)c3nn(C)c4ccc(cc34)Nc3nccc-2n3)C1 CHEMBL5407502 IC50 1.9 nM
Cc1cc(-c2cnc([C@@]3(O)CCCc4cc(C(=O)O)ccc43)s2)nc(Nc2cc(C(F)(F)F)ccn2)c1Br CHEMBL3698403 IC50 1.99 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCC(O)CO)c4ccc(OC(F)F)cc34)nc12 CHEMBL2347988 IC50 2.0 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3n[nH]c4ccc(OC(F)F)cc34)nc12 CHEMBL2347405 IC50 2.0 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4nc[nH]c(=O)c34)cccc12 CHEMBL3262357 IC50 2.0 nM
CC(C)c1cccc(Nc2cc(N[C@@H]3CS(=O)(=O)CC[C@@H]3N)cnc2C(N)=O)n1 CHEMBL3415607 IC50 2.0 nM
Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1 CHEMBL3979920 IC50 2.0 nM
Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)NCC#N)C(C)(C)C3)s2)c1 CHEMBL3685799 IC50 2.0 nM
CC1(C(=O)O)CCC(O)(c2ncc(-c3cccc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC1 CHEMBL3685815 IC50 2.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(C(N)=O)CCC(NC(=O)CO)CC3)s2)c1 CHEMBL3685819 IC50 2.0 nM
CO[C@]1(c2ncc(-c3cc(C)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC[C@H](C(=O)O)C(C)(C)C1 CHEMBL3685822 IC50 2.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@]3(O)CC[C@@H](C(=O)O)C(C)(C)C3)s2)c1 CHEMBL3685823 IC50 2.0 nM
COc1ccc(-c2cc(OC[C@H]3CNC(=O)O3)c3cccnc3c2)cc1OC CHEMBL3650451 IC50 2.0 nM
Cn1cc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)cn1 CHEMBL3653774 IC50 2.0 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(C(=O)C6CCCO6)CC5)cc4c3)n2)c1 CHEMBL3664188 IC50 2.0 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3c[nH]cn3)[nH]c12 CHEMBL3668878 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCN(C(=O)N4CCCC(C(=O)O)C4)CC3)nc2)c1 CHEMBL3974105 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CC(C4CCCC(C(=O)O)C4)C3)nc2)c1 CHEMBL3907627 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCCC(C(=O)N4CCCC(C(=O)O)C4)C3)nc2)c1 CHEMBL3915270 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCC(C(=O)O)C(C)(C)C3)nc2)c1 CHEMBL3978264 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5c(c4)CNC5=O)CC3)nc2)c1 CHEMBL3985239 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)CCN4CCCC4=O)CC3)nc2)c1 CHEMBL3961953 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccccn4)CC3)nc2)c1 CHEMBL3897644 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccnc4)CC3)nc2)c1 CHEMBL3931209 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5nc(C)c(C)nc5c4)CC3)nc2)c1 CHEMBL3946316 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccccn4)CC3)nc2)c1 CHEMBL3900257 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCCC(N)C3)nc2)c1 CHEMBL3981578 IC50 2.0 nM
Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(CN5CCCC5=O)c4)c4ccccc34)n2)cc2cn[nH]c12 CHEMBL3915981 IC50 2.0 nM
COc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(OCCN6CCOCC6)c5c4)n3)c3ccccc23)cc1 CHEMBL3927937 IC50 2.0 nM
COc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(C(=O)N(C)C)c5c4)n3)c3ccccc23)cc1 CHEMBL3922538 IC50 2.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)NC(=O)C5)n3)c3ccccc23)n(-c2cccc(OCCN3CCOCC3)c2)n1 CHEMBL3936935 IC50 2.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@](C)(O)[C@H]3CC[C@H](C(=O)O)CC3)s2)c1 CHEMBL3933876 IC50 2.0 nM
Cc1cc(Nc2nccc(C(C)C)n2)cc(-c2cnc(C(C)(O)C3CCC(C(=O)O)CC3)s2)c1 CHEMBL3915472 IC50 2.0 nM
Cc1cc(Nc2nccc(C)n2)cc(-c2cnc(C(O)(C3CCC(C(=O)O)CC3)C(F)(F)F)s2)c1 CHEMBL3949823 IC50 2.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C(C)(O)C3CCC(C(=O)O)C3)s2)c1 CHEMBL3894917 IC50 2.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C(F)C3CCC(C(=O)O)CC3)s2)c1 CHEMBL3977942 IC50 2.0 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)c(F)c4cn[nH]c(=O)c34)cc(F)cc12 CHEMBL3908848 IC50 2.0 nM
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cccc3occc23)n1 CHEMBL3984568 IC50 2.0 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCOC[C@@H]4N)cc4cn[nH]c(=O)c34)cc(F)cc12 CHEMBL3980107 IC50 2.0 nM
Cc1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)sn1 CHEMBL3969758 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O CHEMBL4065618 IC50 2.0 nM
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CCOCC4)cc3)c2n1 CHEMBL3265032 EC50 2.0 nM
COc1cc(F)c(-c2nc3c(NCC4CCNCC4)c(Cl)cnc3[nH]2)cc1OC CHEMBL3746463 IC50 2.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@]3(O)CCCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698416 IC50 2.07 nM
O=S1(=O)CCN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)CC1 CHEMBL3265033 IC50 2.1 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(-c3nccs3)cn4C)n2)cc1CN1CC(O)C1 CHEMBL3657548 IC50 2.1 nM
CN(C)C(=O)c1cc2ccc(Nc3nccc(-c4cc(O[C@H]5CCC(=O)NC5)ccn4)n3)cc2n1C CHEMBL3643800 IC50 2.1 nM
Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 CHEMBL3695999 IC50 2.1 nM
COc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc1 CHEMBL3696050 IC50 2.1 nM
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cccc3sccc23)n1 CHEMBL3964499 IC50 2.1 nM
COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4ccc(C(=O)NS(C)(=O)=O)cc4)c3)cn3ccnc23)cc1OC CHEMBL3265000 IC50 2.2 nM
COCc1ccnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3643783 IC50 2.2 nM
NC(=O)c1cccnc1COc1cc(-c2ccc(CN3CCCCC3=O)cc2)cc2ncccc12 CHEMBL3653782 IC50 2.2 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCC(N6CCCC6)C5)cc4c3)n2)c1 CHEMBL3664186 IC50 2.2 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NCCCCN5CCCC5=O)cc4c3)n2)c1 CHEMBL3668793 IC50 2.2 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NNC=O)[nH]c12 CHEMBL3668882 IC50 2.2 nM
Cc1cc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)[nH]n1 CHEMBL3668845 IC50 2.2 nM
COc1ccc(Nc2cc(N3CCCC(NC(=O)c4ccc(C(=O)O)cc4)C3)nn3ccnc23)nc1OC CHEMBL3981189 IC50 2.2 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cccc(S(=O)(=O)Nc3ccc(C(=O)O)cc3)c2)c1 CHEMBL3927555 IC50 2.2 nM
COc1ccc(Nc2nc(-c3ccc4c(c3)NC(=O)CO4)cn3ccnc23)cc1OC CHEMBL3265024 IC50 2.3 nM
Cc1cc(C)cc(Nc2nccc(-n3cc(C)c(CN4CC[C@@H](O)C4)c3)n2)c1 CHEMBL3622924 IC50 2.3 nM
N#Cc1c(N[C@@H]2CCCC[C@@H]2N)nc(-c2cnn3ccccc23)c2c1CNC2=O CHEMBL3944381 IC50 2.3 nM
COC[C@@H](C)Oc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc1OC CHEMBL3695995 IC50 2.3 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(C6CCOCC6)CC5)cc4c3)n2)c1 CHEMBL3664202 IC50 2.3 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)OCCN(C)C)CC3)nc2)c1 CHEMBL3963876 IC50 2.3 nM
Cc1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4cn[nH]c(=O)c34)cccc2n1 CHEMBL3952471 IC50 2.3 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@]3(O)CCCc4cc(C(=O)O)c(F)cc43)s2)c1 CHEMBL3698394 IC50 2.36 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4cn[nH]c4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4109397 IC50 2.378 nM
CCCOc1ccnc(Nc2cc(C)cc(-c3cnc([C@]4(O)CCCc5cc(C(=O)O)ccc54)s3)n2)c1 CHEMBL3698446 IC50 2.39 nM
CC[C@@H](C)Oc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3641532 IC50 2.4 nM
CC(C)c1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3641552 IC50 2.4 nM
Cc1nc2c(C(F)(F)F)cc(Nc3nccc(-c4ccccn4)n3)cc2[nH]1 CHEMBL3643820 IC50 2.4 nM
NC(=O)c1cccnc1COc1cc(-c2ccc3c(c2)COC(=O)N3)cc2ncccc12 CHEMBL3653792 IC50 2.4 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NCCN5CCOCC5)cc4c3)n2)c1 CHEMBL3668787 IC50 2.4 nM
COCCN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3668792 IC50 2.4 nM
CC(C)Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3664171 IC50 2.4 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@]3(N)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698441 IC50 2.44 nM
Cn1cc(C(=O)C2CC2)c2cc(Nc3nccc(-n4cc(CN5C[C@H](O)CO5)cn4)n3)ccc21 CHEMBL3897322 IC50 2.46 nM
Cc1cc(C)cc(Nc2nc(CC3CCCC[C@H]3N)n3ccnc3c2C(N)=O)c1 CHEMBL504558 IC50 2.5 nM
NC(=O)c1ncc(N[C@@H]2CS(=O)(=O)CC[C@@H]2N)nc1-c1cc2ccccc2[nH]1 CHEMBL3415609 IC50 2.5 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cc(OCC(F)F)ccn4)n3)ccc2[nH]1 CHEMBL3641525 IC50 2.5 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(C(C)(C)C#N)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3641543 IC50 2.5 nM
Cc1nc2cc(-c3cc(OCc4ncccc4C(N)=O)c4cccnc4c3)ccc2[nH]1 CHEMBL3653836 IC50 2.5 nM
COc1c(F)cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cc1F CHEMBL3653743 IC50 2.5 nM
COc1cc(-c2cc(OC[C@H]3CNC(=O)O3)c3cccnc3c2)ccc1OC(C)C CHEMBL3653745 IC50 2.5 nM
C[C@@H](Oc1cc(-c2ccc(C(F)(F)F)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653760 IC50 2.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)O)[nH]c12 CHEMBL3668806 IC50 2.5 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4nccs4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4107512 IC50 2.5 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cccc(C2CC2)n1 CHEMBL3237558 pIC50 2.512 nM
CN(C)c1ccc(-c2cc3nccnc3c(NC[C@@H]3CNCCC3(F)F)n2)cn1 CHEMBL4460676 pIC50 2.512 nM
COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4ccc(CC(=O)O)cc4)c3)cn3ccnc23)cc1OC CHEMBL3264998 IC50 2.6 nM
C[C@@H](Oc1cc(-c2ccc(OC(C)(C)C)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653817 IC50 2.6 nM
CC/C=C\c1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 CHEMBL4112132 IC50 2.684 nM
COc1ccc(Nc2nc(-c3ccc4cc[nH]c4c3)cn3ccnc23)cc1OC CHEMBL3265016 IC50 2.7 nM
CNC(=O)c1cc2cc(Nc3nccc(-c4ccccn4)n3)cc(C)c2[nH]1 CHEMBL3643817 IC50 2.7 nM
CS(=O)(=O)c1ccc(-c2cc(OCc3ncccc3C(N)=O)c3cccnc3c2)cc1 CHEMBL3653753 IC50 2.7 nM
COC[C@H](C)Oc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc1OC CHEMBL3695994 IC50 2.7 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1=O CHEMBL3668791 IC50 2.7 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2cc[nH]c12 CHEMBL3416024 IC50 2.7 nM
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cccc3[nH]ccc23)n1 CHEMBL3920811 IC50 2.7 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cc(C#N)cc(C(=O)O)c2)c1 CHEMBL3890601 IC50 2.7 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCc4cc(C(=O)O)ccc43)s2)c1 CHEMBL3698392 IC50 2.75 nM
C/C=C(\C)c1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 CHEMBL4110824 IC50 2.75 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4cccc(C(=O)NC5CC5)c4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4107922 IC50 2.78 nM
Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)ccc2C(N)=O)c1 CHEMBL3260318 IC50 2.8 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)O)cc4c3)n2)c1 CHEMBL3668807 IC50 2.8 nM
CC(=O)NNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(C)c2[nH]1 CHEMBL3668880 IC50 2.8 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cc(F)cc(C(=O)O)c2)c1 CHEMBL3977646 IC50 2.8 nM
c1cn2cc(-c3cnc4cn[nH]c4c3)nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c2n1 CHEMBL4634466 IC50 2.8 nM
CN(C)Cc1cc(-c2ccnc3[nH]c(-c4cccc5c4ccn5C)nc23)nn1C CHEMBL4750942 IC50 2.8 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C(F)(F)F)cn4C)n2)cc1CN1C[C@H](O)CO1 CHEMBL3969502 IC50 2.82 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCC(N6CCOCC6)CC5)cc4c3)n2)c1 CHEMBL3668789 IC50 2.9 nM
CCC(O)(c1ncc(-c2cc(C)cc(Nc3cc(C4CC4)ccn3)n2)s1)[C@H]1CC[C@H](C(=O)O)CC1 CHEMBL3935495 IC50 2.9 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(O[C@H]5CCNC5)c(C)n4)n3)cc12 CHEMBL4760470 IC50 2.9 nM
C[C@@H]1C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4cn[nH]c4)c3)s2)CC[C@@H]1C(N)=O CHEMBL4110907 IC50 2.946 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C3CC3)cn4CC(F)(F)F)n2)cc1CN1C[C@H](O)CO1 CHEMBL3891184 IC50 2.98 nM
COc1ccc(Nc2cc(-c3cccc(C(=O)Nc4ccc(C(=O)O)cc4)c3)cn3ncnc23)nc1OC CHEMBL2177725 IC50 3.0 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCCS(C)(=O)=O)c4ccc(OC(F)F)cc34)nc12 CHEMBL2347420 IC50 3.0 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCCN4CCOCC4)c4ccc(OC(F)F)cc34)nc12 CHEMBL2347418 IC50 3.0 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3n[nH]c4c(CO)cccc34)nc12 CHEMBL2347406 IC50 3.0 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4cc[nH]c(=O)c34)cccc12 CHEMBL3262625 IC50 3.0 nM
Cc1cc(Nc2nccc(OCCO)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(N)=O)C(C)(C)C3)s2)c1 CHEMBL3685800 IC50 3.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(CCC(=O)O)s2)c1 CHEMBL3685807 IC50 3.0 nM
Cc1cc(Nc2nccc(C3CC3)n2)cc(-c2cnc(C3(N)CCC3)s2)c1 CHEMBL3685824 IC50 3.0 nM
COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(OC)c1Cl CHEMBL3695953 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCCC3C(=O)O)nc2)c1 CHEMBL3956639 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCC3C(=O)O)nc2)c1 CHEMBL3932634 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CC(C4CCC(C(=O)O)CC4)C3)nc2)c1 CHEMBL3935578 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NCC3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3962140 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCC(C(=O)N4CCC(C(=O)O)CC4)CC3)nc2)c1 CHEMBL3900470 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(OCC3CCC(C(=O)O)CC3)nc2)c1 CHEMBL3914842 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCC(C4CCCCC4C(=O)O)CC3)nc2)c1 CHEMBL3955117 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc(Cn5ccnc5)c4)CC3)nc2)c1 CHEMBL3974724 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc(C(N)=O)cc4)CC3)nc2)c1 CHEMBL3912840 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc(C(N)=O)c4)CC3)nc2)c1 CHEMBL3950971 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5c(c4)C=CC5C)CC3)nc2)c1 CHEMBL3903265 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4nccc5ncccc45)CC3)nc2)c1 CHEMBL3915318 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4cccc(C#N)c4)CC3)nc2)c1 CHEMBL3898957 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4cccc(O)c4)CC3)nc2)c1 CHEMBL3914470 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccc(O)cc4)CC3)nc2)c1 CHEMBL3963342 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5ncccc5c4)CC3)nc2)c1 CHEMBL3964386 IC50 3.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc(-c5ccccc5)c4)CC3)nc2)c1 CHEMBL3958406 IC50 3.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(OCCN6CCOCC6)c5c4)n3)c3ccccc23)cc1 CHEMBL3950258 IC50 3.0 nM
CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(-c2cccc(OCCN3CCOCC3)c2)n1 CHEMBL3893816 IC50 3.0 nM
Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(OCCN5CCOCC5)c4)c4ccccc34)n2)cc2cn[nH]c12 CHEMBL3898242 IC50 3.0 nM
Cc1n[nH]c2ccc(Nc3nccc(Oc4ccc(NC(=O)Nc5cc(C(C)(C)C)nn5-c5ccc(OCCN6CCOCC6)cc5)c5ccccc45)n3)cc12 CHEMBL3896872 IC50 3.0 nM
Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(=O)n(CCN5CCOCC5)c4)c4ccccc34)n2)cc2cn[nH]c12 CHEMBL3961674 IC50 3.0 nM
CC(O)(c1ncc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)s1)C1CC2C(C1)C2C(=O)O CHEMBL3958345 IC50 3.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C(N)[C@H]3CC[C@H](C(=O)O)CC3)s2)c1 CHEMBL3957912 IC50 3.0 nM
CC1=NN2CC1CN(C)CCCCNC(=O)c1nn(C)c3ccc(cc13)Nc1nccc2n1 CHEMBL5394096 IC50 3.0 nM
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C)c3c2C(=O)NC3)c1 CHEMBL3925430 IC50 3.1 nM
CCC1(COc2ccnc(-c3ccnc(Nc4ccc5[nH]c(C(=O)N6CCN(C)CC6)cc5c4)n3)c2)COC1 CHEMBL3641607 IC50 3.1 nM
COc1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)ccn1 CHEMBL3653801 IC50 3.1 nM
CCC(O)(c1ncc(-c2cc(C)cc(Nc3cc(C4CC4)ccn3)n2)s1)[C@H]1CC[C@H](C(N)=O)CC1 CHEMBL3911099 IC50 3.1 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C3CC3)cn4CCF)n2)cc1CN1C[C@H](O)CO1 CHEMBL3899766 IC50 3.1 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 3.162 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 3.162 nM
CCc1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)n1 CHEMBL3237556 pIC50 3.162 nM
Cc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)nc1C(C)C CHEMBL3237573 pIC50 3.162 nM
CC(C)c1nc(Nc2cc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)ccc1F CHEMBL3237580 pIC50 3.162 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(C(C)(C)C#N)ccn5)n4)ccc3n2C)CC1 CHEMBL3641547 IC50 3.2 nM
CN(C)CCCCNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3668802 IC50 3.2 nM
Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cc1 CHEMBL3981827 IC50 3.2 nM
COc1ccc(-c2cc(C)cc(Nc3nccc(C(F)(F)F)n3)c2)cc1C(=O)O CHEMBL3981402 IC50 3.2 nM
c1cn2cc(-c3cnc4cn[nH]c4n3)nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c2n1 CHEMBL4637326 IC50 3.2 nM
CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc(N[C@@H]5CCOC[C@@H]5N)c(C)n4)n3)cc12 CHEMBL4741959 IC50 3.2 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(-c4cncc(F)c4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4115640 IC50 3.224 nM
CC(Oc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1)C(F)(F)F CHEMBL3643737 IC50 3.3 nM
Cc1nc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)cs1 CHEMBL3668837 IC50 3.3 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3nccs3)[nH]c12 CHEMBL3668838 IC50 3.3 nM
c1ccc(-c2cc(Nc3nccc(OC4CCNCC4)n3)cc(N3CCOCC3)c2)cc1 CHEMBL3975451 IC50 3.3 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(O)CCCc4cc(CO)c(F)cc43)s2)c1 CHEMBL3698396 IC50 3.33 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(O)CCCc4cc(C#N)ccc43)s2)c1 CHEMBL3698425 IC50 3.37 nM
C[C@@H](Oc1cc(-c2ccc(OCC(F)(F)F)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653839 IC50 3.4 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N(C)Cc3ccnn3C)[nH]c12 CHEMBL3668846 IC50 3.4 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)[C@H]3CC[C@H](C(=O)OCCO)CC3)nc2)c1 CHEMBL3940496 IC50 3.4 nM
Cc1cc(C)cc(Nc2nccc(-n3cc(CN4CC[C@@H](O)C4)c(C)n3)n2)c1 CHEMBL3622928 IC50 3.5 nM
CCn1cc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)c(C)n1 CHEMBL3668825 IC50 3.5 nM
Cc1nc2c(s1)CN(C(=O)c1cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]1)C2 CHEMBL3668851 IC50 3.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3nccn3C)[nH]c12 CHEMBL3668870 IC50 3.5 nM
Cn1ccc2c(-c3nc4c(OCC5CCNCC5)c(Cl)cnc4[nH]3)cccc21 CHEMBL4783471 IC50 3.51 nM
O=C(c1cn(CCF)c2ccc(Nc3nccc(-n4cc(CN5C[C@H](O)CO5)cn4)n3)cc12)C1CC1 CHEMBL3950127 IC50 3.52 nM
COC(=O)c1cccc2c1CCC[C@@]2(O)c1ncc(-c2cc(C)cc(Nc3cc(C(F)(F)F)ccn3)n2)s1 CHEMBL3698408 IC50 3.54 nM
C[C@@H](Oc1cc(-c2ccc3c(=O)n(C)cnc3c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653819 IC50 3.6 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(CC(=O)N6CCCC6)CC5)cc4c3)n2)c1 CHEMBL3664191 IC50 3.6 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN6CCCC6C5)cc4c3)n2)c1 CHEMBL3668794 IC50 3.6 nM
COc1ccc(-c2cc(Nc3nccc(C(F)(F)F)n3)cc(-c3cnc([C@@]4(O)CC[C@H](C(=O)O)C(C)(C)C4)s3)c2)cn1 CHEMBL4106484 IC50 3.678 nM
COc1cc(Nc2nc(NC3CCCC[C@H]3N)n3cnnc3c2C(N)=O)cc(OC)c1 CHEMBL516061 IC50 3.7 nM
Cc1cc(C)cc(Nc2nccc(-n3cc(CN4CC[C@@H](O)C4)c(C4CC4)c3)n2)c1 CHEMBL3622934 IC50 3.7 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cc(O[C@H]5CCC(=O)NC5)ccn4)n3)ccc2[nH]1 CHEMBL3643759 IC50 3.7 nM
C[C@@H](Oc1nc(-c2ccc(C(F)(F)F)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3695948 IC50 3.7 nM
CC(C)Oc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc1 CHEMBL3696051 IC50 3.7 nM
CN(C)CCCN(C)C(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3664204 IC50 3.7 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NC[C@H]3CCCO3)[nH]c12 CHEMBL3668849 IC50 3.7 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCS(=O)(=O)CC5)cc4c3)n2)c1 CHEMBL3668856 IC50 3.7 nM
COc1ccc(Nc2nc(-c3ccc4cn[nH]c4c3)cn3ccnc23)cc1OC CHEMBL3265017 IC50 3.8 nM
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(C4CCOCC4)cc3)c2n1 CHEMBL3265034 IC50 3.8 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OCC(F)F)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3639404 IC50 3.8 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OCC(C)(F)F)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3643744 IC50 3.8 nM
CCCCC(Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696041 IC50 3.8 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(CCO)CC5)cc4c3)n2)c1 CHEMBL3664192 IC50 3.8 nM
CN(C)CCCNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3668799 IC50 3.8 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cccnn3)[nH]c12 CHEMBL3668871 IC50 3.8 nM
Cn1cnc2cc(-c3ccc(N4CCOCC4)cc3)nc(N[C@H]3CC[C@@H](N)CC3)c2c1=O CHEMBL3643503 IC50 3.89 nM
CC1(O)CN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)C1 CHEMBL3265030 IC50 3.9 nM
CCn1nccc1CNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(C)c2[nH]1 CHEMBL3668836 IC50 3.9 nM
C=C(C)c1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 CHEMBL4108438 IC50 3.938 nM
Cc1cccc(Nc2nc(N[C@@H]3CC(F)(F)CC[C@@H]3N)ncc2C(N)=O)c1 CHEMBL1835069 pIC50 3.981 nM
CC(C)c1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)n1 CHEMBL3237559 pIC50 3.981 nM
COc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)nc1OC CHEMBL3237565 pIC50 3.981 nM
CN(C)c1ccc(-c2cc3nccnc3c(OC[C@H]3CCCNC3)n2)cn1 CHEMBL3546703 pIC50 3.981 nM
Cn1cc(-c2cc3nccnc3c(NC[C@@H]3CNCCC3(F)F)n2)cn1 CHEMBL4439328 pIC50 3.981 nM
Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1 CHEMBL249317 IC50 4.0 nM
Cc1cc(C)cc(Nc2nccc(-c3ncc(CO)s3)n2)c1 CHEMBL511670 Ki 4.0 nM
COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1 CHEMBL475575 IC50 4.0 nM
COc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1 CHEMBL474654 IC50 4.0 nM
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1 CHEMBL1235110 IC50 4.0 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(C4CCNCC4)c4cc(F)ccc34)nc12 CHEMBL2347994 IC50 4.0 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCCN4CC(C#N)C4)c4ccc(OC(F)F)cc34)nc12 CHEMBL2347417 IC50 4.0 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@]4(C)C[C@H](N)C4)c3n2)c2ccc(F)cc21 CHEMBL2347413 IC50 4.0 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2ccc(F)cc21 CHEMBL2348854 IC50 4.0 nM
N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 CHEMBL3262356 IC50 4.0 nM
N[C@H]1CCCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3c(Cl)c[nH]c23)n1 CHEMBL3262623 IC50 4.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(O)CCC(N4CCCC4=O)CC3)s2)c1 CHEMBL3685825 IC50 4.0 nM
NC(=O)c1cccnc1COc1cc(-c2ccc3[nH]cnc3c2)cc2ncccc12 CHEMBL3639526 IC50 4.0 nM
CN1CCC(N(C)C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3664211 IC50 4.0 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(CCN6CCOCC6)CC5)cc4c3)n2)c1 CHEMBL3668795 IC50 4.0 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cc[nH]n3)[nH]c12 CHEMBL3668865 IC50 4.0 nM
Nc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCNC3=O)nc2)c1 CHEMBL3930197 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCNC3=O)nc2)c1 CHEMBL3941611 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4cccc5ncccc45)CC3)nc2)c1 CHEMBL3892940 IC50 4.0 nM
CC(=O)N1CCC(Nc2ccc(-c3cc(C)cc(Nc4cc(C(F)(F)F)ccn4)n3)cn2)CC1 CHEMBL3970601 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccccc4N4CCN(C)CC4)CC3)nc2)c1 CHEMBL3936268 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc(N(C)C)c4)CC3)nc2)c1 CHEMBL3897017 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)nc2)c1 CHEMBL3980747 IC50 4.0 nM
CC(=O)Nc1cccc(C(=O)N2CCC(Nc3ccc(-c4cc(C)cc(Nc5cc(C(F)(F)F)ccn5)n4)cn3)CC2)c1 CHEMBL3972974 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cc5ccccc5cn4)CC3)nc2)c1 CHEMBL3985225 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5nc(C)sc5c4)CC3)nc2)c1 CHEMBL3976242 IC50 4.0 nM
CC(=O)Nc1ccc(C(=O)N2CCC(Nc3ccc(-c4cc(C)cc(Nc5cc(C(F)(F)F)ccn5)n4)cn3)CC2)cc1 CHEMBL3900073 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccncc4)CC3)nc2)c1 CHEMBL3984297 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc(C#N)cc4)CC3)nc2)c1 CHEMBL3907634 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccc(C#N)cc4)CC3)nc2)c1 CHEMBL3894265 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cnc5ccccc5c4)CC3)nc2)c1 CHEMBL3922293 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc(F)c(O)c4)CC3)nc2)c1 CHEMBL3931055 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccc(O)c(F)c4)CC3)nc2)c1 CHEMBL3906587 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(N)=O)CC3)nc2)c1 CHEMBL3952074 IC50 4.0 nM
Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(OCCN5CCOCC5)cc4)c4ccccc34)n2)cc2cn[nH]c12 CHEMBL3960541 IC50 4.0 nM
Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(=O)n(CCO)c4)c4ccccc34)n2)cc2cn[nH]c12 CHEMBL3921640 IC50 4.0 nM
CC(C)(O)c1ccc2cc(-c3n[nH]c4ccsc34)[nH]c2c1 CHEMBL2017552 IC50 4.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCc4cc(B(O)O)ccc43)s2)c1 CHEMBL3698436 IC50 4.04 nM
CC1(C)C[C@@](O)(c2ncc(-c3cc(/C=C\C4CC4)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC[C@@H]1C(=O)O CHEMBL4114181 IC50 4.058 nM
CNC(=O)c1cc2cc(Nc3nccc(-c4ccccn4)n3)cc(OC)c2[nH]1 CHEMBL3641642 IC50 4.1 nM
COc1cc(-c2cc3ncccc3c(OC([C@H]3CNC(=O)C3)C(F)(F)F)n2)cc(OC)c1OC CHEMBL3695971 IC50 4.1 nM
COc1ccc(-c2cc3ncccc3c(OCc3n[nH]c(=O)o3)n2)cc1OC CHEMBL3696008 IC50 4.1 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCCOCC5)cc4c3)n2)c1 CHEMBL3664184 IC50 4.1 nM
Cc1cc(Nc2nccc(C3CC3)n2)cc(-c2ccc(CCC(=O)O)cc2)c1 CHEMBL3961699 IC50 4.2 nM
COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4ccc(C(N)=O)cc4)c3)cn3ccnc23)cc1OC CHEMBL3264999 IC50 4.3 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OCC6(C)CC6)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3643740 IC50 4.3 nM
COc1cc(-c2cc3c(ccc[n+]3[O-])c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(OC)c1OC CHEMBL3695981 IC50 4.3 nM
C=CC(Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696038 IC50 4.3 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCC3CCOCC3)[nH]c12 CHEMBL3668862 IC50 4.3 nM
COC(=O)COC(=O)C1CCC(C(C)(O)c2ccc(-c3cc(C)cc(Nc4cc(C(F)F)ccn4)n3)cn2)CC1 CHEMBL3940964 IC50 4.3 nM
CS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3645121 Kd 4.5 nM
CC(C)(C#N)c1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCOCC5)cc4c3)n2)c1 CHEMBL3643807 IC50 4.5 nM
COCc1ccnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCC(N6CCCC6=O)CC5)cc4c3)n2)c1 CHEMBL3643821 IC50 4.5 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCc4cc(C(=O)NS(=O)(=O)C(F)(F)F)ccc43)s2)c1 CHEMBL3698431 IC50 4.5 nM
COc1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)ccc1C(F)(F)F CHEMBL3653830 IC50 4.5 nM
COc1cc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc(C)c1OC CHEMBL3696043 IC50 4.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cn(C)cn3)[nH]c12 CHEMBL3668832 IC50 4.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3nc4ccccc4[nH]3)[nH]c12 CHEMBL3668839 IC50 4.5 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cccc(C(=O)NCC(=O)O)c2)c1 CHEMBL3930263 IC50 4.6 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cccc(S(=O)(=O)NCCC(=O)O)c2)c1 CHEMBL3946554 IC50 4.6 nM
Cc1nn(-c2ccnc3[nH]c(-c4cccc5c4ccn5C)nc23)cc1CN1CC[C@H](O)C1 CHEMBL4760511 IC50 4.6 nM
CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(-n4cc(CN5C[C@H](O)CO5)c(C)n4)n3)ccc21 CHEMBL3912713 IC50 4.69 nM
COc1ccc(Nc2nc(-c3ccc4c(c3)NCCO4)cn3ccnc23)cc1OC CHEMBL3265026 IC50 4.7 nM
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)cc3c2C(=O)NC3)c1 CHEMBL3892927 IC50 4.7 nM
COc1cc(Nc2nccc(-c3ccccn3)n2)cc2cc(C(=O)N3CCN(C)CC3)[nH]c12 CHEMBL3641620 IC50 4.7 nM
O=C(c1cc2cc(Nc3nccc(-c4ccccn4)n3)ccc2[nH]1)N1CCC(N2CCCC2)C1 CHEMBL3641656 IC50 4.7 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5ccccn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3643781 IC50 4.7 nM
COc1ccc(-c2cc3ncccc3c(OC(C(C)C)[C@H]3CNC(=O)C3)n2)cc1OC CHEMBL3696040 IC50 4.7 nM
COC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3668808 IC50 4.7 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCC(F)F)[nH]c12 CHEMBL3668809 IC50 4.7 nM
COc1ccnc(Nc2cc(C)cc(-c3cnc([C@@]4(O)CCCc5cc(C(=O)O)ccc54)s3)n2)c1 CHEMBL3698443 IC50 4.75 nM
COc1ccc(-c2cc3ncccc3c(O[C@H]([C@H]3CNC(=O)C3)C(F)(F)F)n2)cc1OC CHEMBL3696012 IC50 4.8 nM
Cc1csc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)n1 CHEMBL3668833 IC50 4.8 nM
Cc1nc2[nH]cc(C(=O)NC(C)(C)C)c2nc1Nc1ccccc1 CHEMBL3902041 IC50 4.8 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(Cl)c(C(=O)O)c2)c1 CHEMBL3946704 IC50 4.8 nM
Cc1nc(C)c2cc(-c3cc(O[C@H](C)[C@H]4CNC(=O)C4)c4cccnc4c3)ccc2n1 CHEMBL3653835 IC50 4.9 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NC5CCNCC5)cc4c3)n2)c1 CHEMBL3664208 IC50 4.9 nM
C[C@@H]1CN(c2ccc(Nc3nc(-c4ccc5cn[nH]c5c4)cn4ccnc34)cc2)C[C@H](C)O1 CHEMBL4642016 IC50 4.9 nM
COc1ccc2c(c1)c(/C=C1\C(=O)Nc3ccc(S(N)(=O)=O)cc31)cn2C CHEMBL104333 IC50 5.0 nM
COc1ccc2c(c1)C(/C=C1\C(=O)Nc3ccc(S(N)(=O)=O)cc31)CN2C CHEMBL471424 IC50 5.0 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCC(O)CO)c4cc(F)ccc34)nc12 CHEMBL2347991 IC50 5.0 nM
CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCCS(C)(=O)=O)c4cc(F)ccc34)nc12 CHEMBL2347989 IC50 5.0 nM
CN(C)CCCn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2cc(OC(F)F)ccc21 CHEMBL2347415 IC50 5.0 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2cc(CO)ccc21 CHEMBL2348858 IC50 5.0 nM
N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc(-n3nccn3)c2)n1 CHEMBL3262355 IC50 5.0 nM
Cc1cc(C)nc(Nc2cc(NC[C@@H](N)CCS(C)(=O)=O)cnc2C(N)=O)c1 CHEMBL3415591 IC50 5.0 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc(-n2nccn2)c1 CHEMBL3416025 IC50 5.0 nM
COc1ccc(-c2cc3ncsc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc1OC CHEMBL3622208 IC50 5.0 nM
Cc1cn(-c2ccnc(Nc3cc(C)c(OCCO)c(C)c3)n2)cc1CN1CC(O)C1 CHEMBL3622938 IC50 5.0 nM
C[C@H](N)CNc1cnc(C(N)=O)c(-c2cc3ccccc3[nH]2)n1 CHEMBL3951922 IC50 5.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(CNCCS(N)(=O)=O)s2)c1 CHEMBL3685813 IC50 5.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C3(O)CCN(C(=O)c4ccc5nc(C)c(C)nc5c4)CC3)nc2)c1 CHEMBL3956289 IC50 5.0 nM
COc1cc(-c2cc3c(ccc[n+]3[O-])c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(Cl)c1OC CHEMBL3695954 IC50 5.0 nM
COc1cc(-c2cc3ncccc3c(NCc3n[nH]c(=O)o3)n2)cc(OC)c1OC CHEMBL3695969 IC50 5.0 nM
CN(C)CCNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3664214 IC50 5.0 nM
Cc1nn(C)cc1CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(C)c2[nH]1 CHEMBL3668847 IC50 5.0 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C3(O)CCC3)nc2)c1 CHEMBL3956296 IC50 5.0 nM
COc1ccc(C(=O)N2CCC(Nc3ccc(-c4cc(C)cc(Nc5cc(C(F)(F)F)ccn5)n4)cn3)CC2)cc1 CHEMBL3899691 IC50 5.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5[nH]ncc5c4)CC3)nc2)c1 CHEMBL3965398 IC50 5.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)CCc4nc5ccccc5s4)CC3)nc2)c1 CHEMBL3927389 IC50 5.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCCC(NC(N)=O)C3)nc2)c1 CHEMBL3953258 IC50 5.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)cc1 CHEMBL3967247 IC50 5.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(C(=O)N(C)C)c5c4)n3)c3ccccc23)cc1 CHEMBL3975188 IC50 5.0 nM
CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3891402 IC50 5.0 nM
Cc1cc(Nc2ncc(Cl)c(C)n2)cc(-c2cnc(C(C)(O)C3CCC(C(=O)O)CC3)s2)c1 CHEMBL3946533 IC50 5.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@](C)(O)[C@]3(O)CC[C@@H](c4nn[nH]n4)CC3)s2)c1 CHEMBL4109519 IC50 5.0 nM
COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)ccn2)ccc1C(=O)O CHEMBL3915286 IC50 5.0 nM
CC1(C)OCC(=O)Nc2cc(Nc3nc(NC4CC4)c4occc4n3)ccc21 CHEMBL4090753 IC50 5.0 nM
CC1(C)CCC(=O)Nc2cc(Nc3nc(NC4CC4)c4occc4n3)ccc21 CHEMBL4098474 IC50 5.0 nM
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4C[C@@H]5C[C@H]4CO5)cc3)c2n1 CHEMBL4634723 IC50 5.0 nM
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CC5(COC5)C4)cc3)c2n1 CHEMBL4633338 IC50 5.0 nM
COc1ccc(-c2nc3c(NCC4CCNCC4)c(Cl)cnc3[nH]2)cc1 CHEMBL3746067 IC50 5.0 nM
CC(C)(C)Nc1nc(Nc2ccc(CC(=O)O)cc2)nc2[nH]cnc12 CHEMBL5283028 IC50 5.0 nM
CC(C)Nc1nc(Nc2ccc(S(=O)(=O)N(C)C)cc2)nc2[nH]cnc12 CHEMBL5273296 IC50 5.0 nM
CN1CCN(c2ccc(Nc3nc(NC4CC4)c4nc[nH]c4n3)cc2)CC1 CHEMBL5285207 IC50 5.0 nM
C/C=N/Nc1ccc(Nc2nc(NCC)c3nc[nH]c3n2)cc1 CHEMBL5270442 IC50 5.0 nM
CC(C)(C)OC(=O)Nc1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL5268541 IC50 5.0 nM
N#CCC1CCN(c2nc(Nc3ccc(N4CCC(O)CC4)cc3)c3c(=O)[nH]ncc3n2)CC1 CHEMBL4594275 IC50 5.0 nM
CCCc1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)n1 CHEMBL3237557 pIC50 5.012 nM
Cc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)nc1C CHEMBL3237561 pIC50 5.012 nM
Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)c1 CHEMBL3237563 pIC50 5.012 nM
CCCc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)ccc1OC CHEMBL3237574 pIC50 5.012 nM
Cn1cc(-c2cc3nccnc3c(OCC3CNCCC3(F)F)n2)cn1 CHEMBL4561098 pIC50 5.012 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cc(OCC(C)(C)CO)ccn4)n3)ccc2[nH]1 CHEMBL3641530 IC50 5.1 nM
CN(CCCN1CCOCC1)C(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3664183 IC50 5.1 nM
COCCn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N(C)C)cc4c3)n2)c1 CHEMBL3668811 IC50 5.1 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N(C)Cc3cnn(C)c3)[nH]c12 CHEMBL3668877 IC50 5.1 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCC(C#N)CC5)cc4c3)n2)c1 CHEMBL3668860 IC50 5.1 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(N4Cc5cccc(N(C)S(C)(=O)=O)c5C4)n3)cc2)CC1 CHEMBL4476226 IC50 5.1 nM
CC1(C)C[C@](O)(c2ncc(-c3cc(Nc4nccc(C(F)(F)F)n4)cc(S(C)(=O)=O)c3)s2)CC[C@H]1C(=O)O CHEMBL3903017 IC50 5.103 nM
CC(C)C(C)Oc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3641533 IC50 5.2 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)OCc4oc(=O)oc4C)CC3)nc2)c1 CHEMBL3901446 IC50 5.2 nM
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cccc3[nH]ncc23)n1 CHEMBL3909360 IC50 5.2 nM
C[C@@H](Oc1cc(-c2ccc3nc(C(F)(F)F)cn3c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653811 IC50 5.3 nM
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4C[C@H]5CC[C@@H](C4)O5)cc3)c2n1 CHEMBL4640287 IC50 5.3 nM
Cn1cnc2cc(-c3ccc(N4CCOCC4)cc3)nc(O[C@H]3CC[C@@H](N)CC3)c2c1=O CHEMBL3643529 IC50 5.31 nM
O=C(c1cn(CC(F)F)c2ccc(Nc3nccc(-n4cc(CN5C[C@H](O)CO5)cn4)n3)cc12)C1CC1 CHEMBL3897559 IC50 5.34 nM
Cc1cc(C)cc(Nc2nccc(-n3cc(C)c(CN4CC(O)C4)c3)n2)c1 CHEMBL3622926 IC50 5.4 nM
C[C@@H](Oc1cc(-c2ccc(OC(F)F)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3653832 IC50 5.4 nM
CCn1cc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)cn1 CHEMBL3668823 IC50 5.4 nM
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cnc3ccccc3c2)n1 CHEMBL3937287 IC50 5.4 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 IC50 5.5 nM
COCCC(Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696022 IC50 5.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N3CCC3)[nH]c12 CHEMBL3664172 IC50 5.5 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NC5CCCNC5)cc4c3)n2)c1 CHEMBL3664200 IC50 5.5 nM
CN(c1cnn(-c2ccnc3[nH]c(-c4cccc5c4ccn5C)nc23)c1)[C@@H]1CCOC[C@@H]1N CHEMBL4781060 IC50 5.5 nM
CC(C)(CO)NC(=O)c1c[nH]c2ncc(Nc3cccnc3)nc12 CHEMBL3913537 IC50 5.6 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(N)c(C(=O)O)c2)c1 CHEMBL3904334 IC50 5.6 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(OCc3cn(C)cn3)c(C(=O)O)c2)c1 CHEMBL3919226 IC50 5.6 nM
Cn1cnc2cc(-c3ccc(N4CCC(C)(O)CC4)cc3)nc(N[C@H]3CC[C@@H](N)CC3)c2c1=O CHEMBL3641466 IC50 5.61 nM
Cc1c(Br)c(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc([C@@]3(O)CCCc4cc(C(=O)O)ccc43)s2)c1Br CHEMBL3698404 IC50 5.69 nM
COc1c(C)cc(Nc2nccc(-n3cc(C)c(CN4CC(O)C4)c3)n2)cc1C CHEMBL3622944 IC50 5.7 nM
CN(C(=O)c1cc2cc(Nc3nccc(-c4cc(C(C)(C)C#N)ccn4)n3)ccc2[nH]1)C1CCOCC1 CHEMBL3643808 IC50 5.7 nM
COc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3(C)C)n2)cc1OC CHEMBL3696036 IC50 5.7 nM
CN1CCC(NC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3664207 IC50 5.7 nM
CC1(C)C[C@](O)(c2ncc(-c3cc(C#N)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC[C@H]1C(=O)O CHEMBL3947575 IC50 5.769 nM
COC(=O)c1cccc2c1CCC[C@]2(O)c1ncc(-c2cc(C)cc(Nc3cc(C(F)(F)F)ccn3)n2)s1 CHEMBL3698407 IC50 5.78 nM
COc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C(=O)[C@@H]6CCCO6)CC5)cc4c3)n2)c1 CHEMBL3641521 IC50 5.8 nM
CN(C)C(=O)c1cc2ccc(Nc3nccc(-c4ccccn4)n3)cc2n1C CHEMBL3641565 IC50 5.8 nM
CCN(CC)C1CN(C(=O)c2cc3cc(Nc4nccc(-c5ccccn5)n4)ccc3[nH]2)C1 CHEMBL3641623 IC50 5.8 nM
O=C(c1cn(CC(F)(F)F)c2ccc(Nc3nccc(-n4cc(CN5C[C@H](O)CO5)cn4)n3)cc12)C1CC1 CHEMBL3978254 IC50 5.8 nM
CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(-n4cc(CN5C[C@H](O)CO5)c(C5CC5)n4)n3)ccc21 CHEMBL3890784 IC50 5.85 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C3CC3)cn4S(C)(=O)=O)n2)cc1CN1C[C@H](O)CO1 CHEMBL3893140 IC50 5.89 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cc(C(C)(C)C#N)ccn4)n3)ccc2[nH]1 CHEMBL3643809 IC50 5.9 nM
CC(O)c1cccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c1 CHEMBL3922528 IC50 5.9 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(-c3ccccc3)c(C(=O)O)c2)c1 CHEMBL3935919 IC50 5.9 nM
Cc1cc(C)cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ccnc3c2C(N)=O)c1 CHEMBL459146 IC50 6.0 nM
COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ccnc3c2C(N)=O)cc(OC)c1 CHEMBL485204 IC50 6.0 nM
Cc1cc(C)cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)n3ccnc3c2C(N)=O)c1 CHEMBL474655 IC50 6.0 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)c2ccc(Cl)cc21 CHEMBL2348856 IC50 6.0 nM
CC(=O)NCc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(N)=O)C(C)(C)C3)s2)c1 CHEMBL3685801 IC50 6.0 nM
Cc1cc(Nc2nccc(-c3ccccn3)n2)cc2cc(C(=O)N(C)C)[nH]c12 CHEMBL3643775 IC50 6.0 nM
COc1cc(-c2cc(OC[C@H]3CNC(=O)O3)c3cccnc3c2)cc(OC)c1OC CHEMBL3653747 IC50 6.0 nM
COc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)[C@@H]3C)n2)cc1OC CHEMBL3696027 IC50 6.0 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2cnc(C(C)(O)C3CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 CHEMBL4115523 IC50 6.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(N3CCC4CCC(C(=O)O)CC4C3)nc2)c1 CHEMBL3937432 IC50 6.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5sc(C)nc5c4)CC3)nc2)c1 CHEMBL3929998 IC50 6.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc5c4NC(=O)C5)CC3)nc2)c1 CHEMBL3894214 IC50 6.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccccc4C#N)CC3)nc2)c1 CHEMBL3916862 IC50 6.0 nM
COc1ccccc1C(=O)N1CCC(Nc2ccc(-c3cc(C)cc(Nc4cc(C(F)(F)F)ccn4)n3)cn2)CC1 CHEMBL3908736 IC50 6.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc(O)cc4)CC3)nc2)c1 CHEMBL3968208 IC50 6.0 nM
COc1cccc(C(=O)N2CCC(Nc3ccc(-c4cc(C)cc(Nc5cc(C(F)(F)F)ccn5)n4)cn3)CC2)c1 CHEMBL3957515 IC50 6.0 nM
COc1cccc(CC(=O)N2CCC(Nc3ccc(-c4cc(C)cc(Nc5cc(C(F)(F)F)ccn5)n4)cn3)CC2)c1 CHEMBL3937539 IC50 6.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccccc4C#N)CC3)nc2)c1 CHEMBL3921052 IC50 6.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCNCC3)nc2)c1 CHEMBL3898421 IC50 6.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)CC(=O)N5C)n3)c3ccccc23)cc1 CHEMBL3975927 IC50 6.0 nM
CCNc1nc(Nc2ccc3c(c2)NC(=O)COC3(C)C)nc2ccoc12 CHEMBL4093260 IC50 6.0 nM
Cc1cc(C)cc(Nc2nccc(-c3nc(C)c(C(=O)N[C@@H](C)CO)s3)n2)c1 CHEMBL512172 IC50 6.0 nM
CCOc1ccnc(-c2ccnc(Nc3cc(C)c4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3643779 IC50 6.1 nM
CN(C)C(=O)c1cc2ccc(Nc3nccc(-c4cc(C(C)(C)C#N)ccn4)n3)cc2[nH]1 CHEMBL3643803 IC50 6.1 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3nc4ccccc4o3)[nH]c12 CHEMBL3668830 IC50 6.1 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C3CC3)cn4C)n2)cc1CN1C[C@H](O)CO1 CHEMBL3921923 IC50 6.15 nM
Cc1cc(C)cc(Nc2nccc(-n3cc(C)c(CN(C)C)c3)n2)c1 CHEMBL3622930 IC50 6.2 nM
COC1CN(C2CCN(C(=O)c3cc4cc(Nc5nccc(-c6cn(C)cn6)n5)cc(Cl)c4[nH]3)CC2)C1 CHEMBL3664210 IC50 6.2 nM
Cc1ncc(-c2cn3ccnc3c(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)nc1N CHEMBL3917084 IC50 6.2 nM
COc1ccnc(Nc2cc(C)cc(-c3cccc(C(=O)O)c3)c2)n1 CHEMBL3933644 IC50 6.2 nM
Nc1cncc(-c2cn3ccnc3c(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)n1 CHEMBL3986824 IC50 6.2 nM
CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(-n4cc(CN5C[C@@H](O)CO5)c(C)n4)n3)ccc21 CHEMBL4115366 IC50 6.28 nM
COc1ccc(Nc2nc(-c3ccc4nc[nH]c4c3)cn3ccnc23)cc1OC CHEMBL3265018 IC50 6.3 nM
Cc1cn(-c2ccnc(Nc3cc(C)c(OS(C)(=O)=O)c(C)c3)n2)cc1CN1CC(O)C1 CHEMBL3622945 IC50 6.3 nM
COc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc1F CHEMBL3695992 IC50 6.3 nM
COc1cc(-c2cc3ncccc3c(NCc3ccc(=O)[nH]c3)n2)ccc1OC1CCOCC1 CHEMBL3696006 IC50 6.3 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N3CCc4oncc4C3)[nH]c12 CHEMBL3668872 IC50 6.3 nM
CC(=O)Nc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc([C@@H](O)C(F)F)cc2)c1 CHEMBL3980704 IC50 6.3 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 6.31 nM
CC(C)C[C@H](CN)Nc1cc(Nc2cccc(C(C)(C)C)n2)c(C(N)=O)nn1 CHEMBL3237572 pIC50 6.31 nM
CN(C)c1ccc(-c2cc(NC[C@H]3CCCNC3)c3cccnc3c2)cn1 CHEMBL4472827 pIC50 6.31 nM
CC(C)N1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3668797 IC50 6.4 nM
COCCOC(=O)C1CCC(C(C)(O)c2ccc(-c3cc(C)cc(Nc4cc(C(F)F)ccn4)n3)cn2)CC1 CHEMBL3924655 IC50 6.4 nM
Cc1cc(Nc2nccc(C3CC3)n2)cc(-c2cccc(CCC(=O)O)c2)c1 CHEMBL3966921 IC50 6.4 nM
CN1CCCC(NC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)C1 CHEMBL3664197 IC50 6.5 nM
Cc1cc(Nc2nccc(C)n2)cc(-c2ccc(C(C)(O)[C@H]3CC[C@H](C(=O)O)CC3)cc2)c1 CHEMBL3979177 IC50 6.5 nM
COC[C@@H]1C[C@@H](O)CN1Cc1cn(-c2ccnc(Nc3ccc4c(c3)c(Cl)c(C)n4C)n2)nc1C CHEMBL3657554 IC50 6.6 nM
COCc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3641507 IC50 6.6 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NCCCN5CC[C@@H](F)C5)cc4c3)n2)c1 CHEMBL3668798 IC50 6.6 nM
N#Cc1cc(C(=O)O)cc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)c1 CHEMBL3977593 IC50 6.6 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OCC6(CO)CC6)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3641602 IC50 6.7 nM
c1cn2cc(-c3ccc4cn[nH]c4n3)nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c2n1 CHEMBL4644977 IC50 6.7 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(O)CCCc4cc(Br)ccc43)s2)c1 CHEMBL3698424 IC50 6.8 nM
NC(=O)c1ccc(NC2CCCCC2N)cc1Nc1cccc2c1OCO2 CHEMBL3944358 IC50 6.8 nM
CN1CCC(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3668803 IC50 6.9 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N(C)Cc3nccs3)[nH]c12 CHEMBL3668866 IC50 6.9 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(OCCF)c(C(=O)O)c2)c1 CHEMBL3890644 IC50 6.9 nM
c1cn2cc(-c3cnc4cc[nH]c4c3)nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c2n1 CHEMBL4640138 IC50 6.9 nM
COc1cc(Nc2nc(NC3CCCC[C@H]3N)n3nc(-c4cccc(O)c4)nc3c2C(N)=O)cc(OC)c1 CHEMBL474832 IC50 7.0 nM
COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4ccc(C(=O)O)cc4)c3)nc3scnc23)cc1OC CHEMBL2177737 IC50 7.0 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2ccc(Cl)cc21 CHEMBL2348853 IC50 7.0 nM
COc1ccc(Nc2nc(-c3ccc4cn[nH]c4c3)cn3ccnc23)cc1 CHEMBL3265029 IC50 7.0 nM
Cc1cc(C)nc(Nc2cc(NC[C@@H](N)CC(F)F)cnc2C(N)=O)c1 CHEMBL3415585 IC50 7.0 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)cc1-c1nc2ccccc2[nH]1 CHEMBL3415608 IC50 7.0 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)nc1-c1nc2ccccc2[nH]1 CHEMBL3943181 IC50 7.0 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(CC(C)(C)c3nnco3)s2)c1 CHEMBL3685808 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)nc2)c1 CHEMBL3935467 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)nc2)c1 CHEMBL3941046 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccc5ccccc5n4)CC3)nc2)c1 CHEMBL3986097 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4ccccc4Cn4cncn4)CC3)nc2)c1 CHEMBL3894982 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc(Cn5cccn5)c4)CC3)nc2)c1 CHEMBL3934611 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc5[nH]ccc45)CC3)nc2)c1 CHEMBL3890738 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc5cc(O)ccc45)CC3)nc2)c1 CHEMBL3933964 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc5cccnc45)CC3)nc2)c1 CHEMBL3897614 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cnc5ccccn45)CC3)nc2)c1 CHEMBL3931330 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc(C#N)c4)CC3)nc2)c1 CHEMBL3942558 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4n[nH]c5ccccc45)CC3)nc2)c1 CHEMBL3911140 IC50 7.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4cn(C)c5ccccc45)CC3)nc2)c1 CHEMBL3891236 IC50 7.0 nM
CCC(C)OC(=O)C1CCC(C(C)(O)c2ccc(-c3cc(C)cc(Nc4cc(C(F)F)ccn4)n3)cn2)CC1 CHEMBL3913909 IC50 7.0 nM
COc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)cc1 CHEMBL3943934 IC50 7.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3cc(Nc4ccc5[nH]ncc5c4)ncn3)c3ccccc23)n(-c2ccc(=O)n(CCO)c2)n1 CHEMBL3899497 IC50 7.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)nc2)n1 CHEMBL3933021 IC50 7.0 nM
CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)NC(=O)C5)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3898648 IC50 7.0 nM
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 CHEMBL3921823 IC50 7.0 nM
Cc1ccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)cc3cn[nH]c(=O)c23)c2cccnc12 CHEMBL3937623 IC50 7.0 nM
CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc21 CHEMBL4069365 IC50 7.0 nM
NCCNc1ncc(C(N)=O)c(Nc2cccc(C(F)(F)F)c2)n1 CHEMBL471901 IC50 7.0 nM
COc1cc(-c2cc3ncccc3c(OCC3CNC(=O)C3)n2)cc(OC)c1OC CHEMBL3695977 IC50 7.1 nM
CNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(OC)c2[nH]1 CHEMBL3664150 IC50 7.1 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(CCC(=O)O)cc2)c1 CHEMBL3921552 IC50 7.1 nM
CNC(=O)c1cc2cc(Nc3nccc(-c4cc(COC)ccn4)n3)cc(C)c2[nH]1 CHEMBL3643824 IC50 7.2 nM
COc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)cc1Cl CHEMBL3695961 IC50 7.2 nM
C[C@@H](Oc1nc(-c2ccccn2)cc2ncccc12)[C@H]1CNC(=O)C1 CHEMBL3696049 IC50 7.2 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NCCCCCN5CCOCC5)cc4c3)n2)c1 CHEMBL3668785 IC50 7.2 nM
Cc1cc(C)cc(Nc2nccc(-n3cc(CN4CC(O)C4)c(C)n3)n2)c1 CHEMBL3622929 IC50 7.3 nM
Cc1cn(-c2ccnc(Nc3cc(C)c(OCC(=O)N4CCCC4)c(C)c3)n2)cc1CN1CC(O)C1 CHEMBL3622940 IC50 7.3 nM
COc1ccc(-c2cc3ncccc3c(OC(CC(C)C)[C@H]3CNC(=O)C3)n2)cc1OC CHEMBL3639949 IC50 7.3 nM
CN(C)CC#CCNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(Cl)c2[nH]1 CHEMBL3664209 IC50 7.3 nM
COc1ccc(Nc2cc(-c3cccc(C(=O)Nc4ccc5[nH]ncc5c4)c3)nn3ccnc23)nc1OC CHEMBL3913308 IC50 7.33 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C3CC3)cn4C(C)C)n2)cc1CN1C[C@H](O)CO1 CHEMBL3918484 IC50 7.37 nM
Cc1cc(Nc2nccc(-c3ncn(C)c3C)n2)cc2cc(C(=O)N(C)C)[nH]c12 CHEMBL3664142 IC50 7.4 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cccc(S(=O)(=O)NCCCC(=O)O)c2)c1 CHEMBL3915124 IC50 7.4 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1242100 Ki 7.5 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 Ki 7.5 nM
O=C1C[C@@H](COc2nc(-c3ccccc3)cc3ncccc23)CN1 CHEMBL3696056 IC50 7.5 nM
CN1CCN(CCN(C)C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3664205 IC50 7.5 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N3CCc4nocc4C3)[nH]c12 CHEMBL3668876 IC50 7.5 nM
CN(CCO)c1ccc(Nc2nc(-c3ccc4cn[nH]c4c3)cn3ccnc23)cc1 CHEMBL3265035 IC50 7.6 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCn6cnnc6C5)cc4c3)n2)c1 CHEMBL3664152 IC50 7.6 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N3CCc4c(cnn4C(C)C)C3)[nH]c12 CHEMBL3668821 IC50 7.6 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cccc(CCC(=O)O)c2)c1 CHEMBL3893534 IC50 7.6 nM
CC(O)C(C)Oc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3641582 IC50 7.7 nM
NC(=O)c1cccnc1COc1cc(-c2ccc3c(c2)CCNC3=O)cc2ncccc12 CHEMBL3653780 IC50 7.7 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NC(C)(C)CN5CCCC5)cc4c3)n2)c1 CHEMBL3664196 IC50 7.8 nM
c1cn2cc(-c3cnc4c(n3)NCCO4)nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c2n1 CHEMBL4633180 IC50 7.8 nM
Cc1cn(-c2ccnc(Nc3cc(C)c(OS(C)(=O)=O)c(C)c3)n2)cc1CN1CC[C@@H](O)C1 CHEMBL3622946 IC50 7.9 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OC6CCCC6)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3641534 IC50 7.9 nM
CC(CO)COc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3641587 IC50 7.9 nM
COc1ncc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cc1F CHEMBL3653795 IC50 7.9 nM
CN1CCCN(C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(Cl)c3[nH]2)CC1 CHEMBL3668788 IC50 7.9 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cncn3C)[nH]c12 CHEMBL3668824 IC50 7.9 nM
CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@@H]5CCN(C)C5)c(C)n4)n3)cc12 CHEMBL4787606 IC50 7.9 nM
CN(C)c1ccc(-c2cc3ncccc3c(NC[C@H]3CCCNC3)n2)cn1 CHEMBL4468047 pIC50 7.943 nM
NCCCNc1nc(-c2ccc(N3CCOCC3)cc2)cc2ncccc12 CHEMBL287478 IC50 8.0 nM
Cc1cc(C)cc(Nc2nccc(-c3nccs3)n2)c1 CHEMBL509161 Ki 8.0 nM
NCCCNc1nc(-c2ccc(N3CCOCC3)cc2)cc2ccccc12 CHEMBL512345 IC50 8.0 nM
CCOc1cc2[nH]c(-c3n[nH]cc3NC(=O)N(CC)CC)nc2cc1F CHEMBL2017551 IC50 8.0 nM
Cc1nn(-c2ccnc(Nc3ccc4c(cnn4C4CC4)c3)n2)cc1CN1CC(O)C1 CHEMBL3622960 IC50 8.0 nM
COc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(C)(C)C)cc4c3)n2)c1 CHEMBL3641526 IC50 8.0 nM
COC(=O)[C@H]1CC[C@H](C(C)(O)c2ccc(-c3cc(C)cc(Nc4cc(C(F)F)ccn4)n3)cn2)CC1 CHEMBL3910149 IC50 8.0 nM
Cc1cc(CN(C)C(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)n(C)n1 CHEMBL3668816 IC50 8.0 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(C)O)nc2)c1 CHEMBL3960670 IC50 8.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cnc5ccc(F)cc5c4)CC3)nc2)c1 CHEMBL3969915 IC50 8.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccc5cn[nH]c5c4)CC3)nc2)c1 CHEMBL3983041 IC50 8.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccc5[nH]c(C)c(C)c5c4)CC3)nc2)c1 CHEMBL3925040 IC50 8.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc(O)c4)CC3)nc2)c1 CHEMBL3960299 IC50 8.0 nM
COc1ccc(-n2nc(C3CCOC3)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)cc1 CHEMBL3921479 IC50 8.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)cn1 CHEMBL3971588 IC50 8.0 nM
N#Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4cn[nH]c(=O)c34)cccc12 CHEMBL3894892 IC50 8.0 nM
O=C(O)c1cc(F)cc(-c2cccc(Nc3nccc(C(F)(F)F)n3)c2)c1 CHEMBL3908451 IC50 8.0 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 IC50 8.0 nM
Cn1cnc2ccc(-c3cc(OCc4ncccc4C(N)=O)c4cccnc4c3)cc21 CHEMBL3653810 IC50 8.1 nM
COc1ccc(-c2cc3ncccc3c(OCCC3CNC(=O)C3)n2)cc1OC CHEMBL3696029 IC50 8.1 nM
CN(C)C(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(-c3cnn(C)c3)c2[nH]1 CHEMBL3664160 IC50 8.1 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N[C@H]5[C@@H]6CNC[C@@H]65)cc4c3)n2)c1 CHEMBL3664201 IC50 8.2 nM
Cc1nn(-c2ccnc(Nc3ccc4[nH]cc(C(=O)C(F)(F)F)c4c3)n2)cc1CN1C[C@H](O)CO1 CHEMBL3938691 IC50 8.28 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OC6CCOCC6)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3641589 IC50 8.3 nM
Cc1n[nH]cc1CNC(=O)c1cc2cc(Nc3nccc(-c4cn(C)cn4)n3)cc(C)c2[nH]1 CHEMBL3668843 IC50 8.3 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CC[S+]([O-])CC5)cc4c3)n2)c1 CHEMBL3668855 IC50 8.3 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OCCCO)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3641584 IC50 8.4 nM
COc1ccc(-c2cc(OC[C@H]3CNC(=O)C3)c3cccnc3c2)cc1OC CHEMBL3650446 IC50 8.4 nM
c1cn2cc(-c3cnc4c(c3)NCCO4)nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c2n1 CHEMBL4636843 IC50 8.4 nM
N#Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(O)CCC(C(=O)O)CC3)s2)c1 CHEMBL3970114 IC50 8.476 nM
COc1cccc(Nc2nc(-c3ccc4cn[nH]c4c3)cn3ccnc23)c1 CHEMBL3265028 IC50 8.5 nM
CN1CCc2ccc(NC(=O)c3cc4cc(Nc5nccc(-c6cn(C)cn6)n5)cc(Cl)c4[nH]3)cc2CC1 CHEMBL3664198 IC50 8.5 nM
Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)nc1 CHEMBL3914695 IC50 8.5 nM
COc1ccnc(Nc2cc(C)cc(-c3cccc(CCC(=O)O)c3)c2)n1 CHEMBL3984214 IC50 8.5 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cccc(S(=O)(=O)O)c2)c1 CHEMBL3924134 IC50 8.5 nM
COc1ccc(Nc2nc(-c3ccc4[nH]ccc4c3)cn3ccnc23)cc1OC CHEMBL3265020 IC50 8.6 nM
COc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)NCCCN(C)C)cc4c3)n2)c1 CHEMBL3641515 IC50 8.6 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCCNCC5)cc4c3)n2)c1 CHEMBL3664155 IC50 8.6 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C(C)C)cn4C)n2)cc1CN1C[C@H](O)CO1 CHEMBL3897383 IC50 8.63 nM
Cc1cc(Nc2nccc(-c3ccccn3)n2)cc2cc(C(=O)N3CCN(C)CC3)[nH]c12 CHEMBL3643777 IC50 8.7 nM
COC(=O)c1ccc2c(c1)CCCC2(O)c1ncc(-c2cc(C)cc(Nc3cc(C(F)(F)F)ccn3)n2)s1 CHEMBL3698397 IC50 8.7 nM
CCN1CC2(CCN(C(=O)c3cc4cc(Nc5nccc(-c6cn(C)cn6)n5)cc(Cl)c4[nH]3)C2)C1 CHEMBL3668800 IC50 8.7 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)OC4CCOCC4)CC3)nc2)c1 CHEMBL3949872 IC50 8.7 nM
Cc1cc(Nc2cc(C(F)F)ccn2)nc(-c2ccc(C(C)(O)C3CCC(C(=O)OCCN4CCOCC4)CC3)nc2)c1 CHEMBL3894330 IC50 8.7 nM
Cc1ncc(-c2cn3ccnc3c(Nc3ccc(N4CCN(C5COC5)CC4)c(OCCO)c3)n2)nc1N CHEMBL3911668 IC50 8.7 nM
Cc1cc(C)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)c1 CHEMBL3415584 IC50 8.8 nM
COc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C(=O)N5CCN(C)CC5)cc4c3)n2)c1 CHEMBL3641545 IC50 8.8 nM
COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4cccc(C(=O)O)c4)c3)cn3ccnc23)cc1OC CHEMBL3264997 IC50 8.9 nM
Cc1cc(Nc2nccc(-n3cc(CN4CC(O)C4)c(C)n3)n2)cc(C)c1OCCN1CCCC1 CHEMBL3622943 IC50 8.9 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N3CCCOCC3)[nH]c12 CHEMBL3664173 IC50 8.9 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N3Cc4cnn(C)c4C3)[nH]c12 CHEMBL3668817 IC50 8.9 nM
COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3cnnc3c2C(N)=O)cc(OC)c1 CHEMBL475609 IC50 9.0 nM
Cc1cc(C)cc(Nc2nccc(-c3nc(C)c(C(=O)N[C@H](C)CO)s3)n2)c1 CHEMBL473229 IC50 9.0 nM
COc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)n3cnnc3c2C(N)=O)cc(OC)c1 CHEMBL514012 IC50 9.0 nM
COc1cc(Nc2nc(NCCN)n3cnnc3c2C(N)=O)cc(OC)c1 CHEMBL474582 IC50 9.0 nM
Cc1cc(C(C)(C)O)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)n1 CHEMBL3415596 IC50 9.0 nM
C[C@@H](Oc1cc(-c2cnn(C(F)F)c2)cc2ncsc12)[C@H]1CNC(=O)O1 CHEMBL3622698 IC50 9.0 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)cc1COc1ccccc1 CHEMBL3961713 IC50 9.0 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)N(C)Cc3ccn(C)n3)[nH]c12 CHEMBL3668842 IC50 9.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccc(-c5cn[nH]c5)cc4)CC3)nc2)c1 CHEMBL3962992 IC50 9.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc5ncccc45)CC3)nc2)c1 CHEMBL3969554 IC50 9.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)Cc4ccc(O)c(Cl)c4)CC3)nc2)c1 CHEMBL3966898 IC50 9.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cccc5[nH]ncc45)CC3)nc2)c1 CHEMBL3966160 IC50 9.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C3(O)CCNCC3)nc2)c1 CHEMBL3969611 IC50 9.0 nM
Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(C3(O)CCN(C(=O)c4ccc5cc[nH]c5n4)CC3)nc2)c1 CHEMBL3958527 IC50 9.0 nM
COC(=O)[C@H]1CC[C@H](C(C)(O)c2ccc(-c3cc(C)cc(Nc4cc(C(F)F)ccn4)n3)cn2)CC1 CHEMBL3976879 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(-c2cccc(OCCN3CCOCC3)c2)n1 CHEMBL3920935 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)NC(=O)C5(C)C)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3969828 IC50 9.0 nM
Cc1n[nH]c2cc(Nc3nccc(Oc4ccc(NC(=O)Nc5cc(C(C)(C)C)nn5-c5ccc(OCCN6CCOCC6)cc5)c5ccccc45)n3)ccc12 CHEMBL3980630 IC50 9.0 nM
Cc1ccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)cc3cn[nH]c(=O)c23)c2cc[nH]c12 CHEMBL3894773 IC50 9.0 nM
N[C@H]1CCCC[C@H]1Nc1cc2cn[nH]c(=O)c2c(Nc2cccc3ncccc23)n1 CHEMBL3900350 IC50 9.0 nM
Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCOC[C@@H]4N)cc4cn[nH]c(=O)c34)cccc12 CHEMBL3985104 IC50 9.0 nM
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CC5(CCOCC5)C4)cc3)c2n1 CHEMBL4643774 IC50 9.0 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(c6ccccn6)CC5)cc4c3)n2)c1 CHEMBL3664212 IC50 9.1 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(OCc3cccnc3)c(C(=O)O)c2)c1 CHEMBL3902379 IC50 9.1 nM
CCn1ccc2cc(Nc3nccc(-n4cc(CN5CC(O)C5)c(C5CC5)n4)n3)ccc21 CHEMBL3622953 IC50 9.2 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cscn3)[nH]c12 CHEMBL3668827 IC50 9.2 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCC3CNC(=O)C3)[nH]c12 CHEMBL3668844 IC50 9.2 nM
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c2n1 CHEMBL4634721 IC50 9.2 nM
NC(=O)c1cnc(Nc2ccc(N3CCC[C@@H](C(N)=O)C3)cc2)nc1NC1CC1 CHEMBL3645122 Kd 9.4 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(C(C)(C)C)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3641548 IC50 9.4 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C(F)F)cn4C)n2)cc1CN1C[C@H](O)CO1 CHEMBL3928167 IC50 9.42 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 9.5 nM
Cc1nnc(CNC(=O)c2cc3cc(Nc4nccc(-c5cn(C)cn5)n4)cc(C)c3[nH]2)o1 CHEMBL3668869 IC50 9.6 nM
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CC5COCC5C4)cc3)c2n1 CHEMBL4637020 IC50 9.6 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)NCCCN5CCOCC5)cc4c3)n2)c1 CHEMBL3668790 IC50 9.7 nM
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(OCc3cncn3C)c(C(=O)O)c2)c1 CHEMBL3939657 IC50 9.7 nM
CN1CCN(C(=O)c2cc3cc(Nc4nccc(-c5cc(OCC(F)(F)F)ccn5)n4)ccc3[nH]2)CC1 CHEMBL3643747 IC50 9.8 nM
Cc1cc(Nc2nccc(-c3cn(C)cn3)n2)cc2cc(C(=O)NCc3cccc(F)c3)[nH]c12 CHEMBL3668841 IC50 9.8 nM
COc1ccnc(-c2ccnc(Nc3ccc4[nH]c(C)cc4c3)n2)c1 CHEMBL3641528 IC50 9.9 nM
Cn1cnc(-c2ccnc(Nc3cc(Cl)c4[nH]c(C(=O)N5CCN(c6nccn6C)CC5)cc4c3)n2)c1 CHEMBL3664203 IC50 9.9 nM
CCNC(=O)Nc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc([C@@H](O)C(F)F)cc2)c1 CHEMBL3977895 IC50 9.9 nM