Cc1cc2c(C3=CCOCC3)cnc(NC3CCN(C(=O)C(F)CN)CC3)c2[nH]c1=O CHEMBL4868363 pKi 0.1995 nM
Cc1cc2c(C3=CCOCC3)cnc(NC3CCN(CCCN)CC3)c2[nH]c1=O CHEMBL4850335 pKi 0.3981 nM
Cc1cc2c(C3=CCOCC3)cnc(NC3CCN(C(=O)C(F)(F)CN)CC3)c2[nH]c1=O CHEMBL4864027 pKi 0.7943 nM
Cc1cc2c(C3=CCOCC3)cnc(NC3CCN(CC(F)CN)CC3)c2[nH]c1=O CHEMBL4873236 pKi 1.0 nM
Cc1cc2c(C3=CCOCC3)cnc(NC3CCN(C(=O)CCN)CC3)c2[nH]c1=O CHEMBL4854161 pKi 1.259 nM
CCCNc1ccc2c3c(cccc13)C(=O)N(c1cc3c(cc1C)n(C)c(=O)n3C)C2=O CHEMBL4062266 IC50 3.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(Br)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4086958 IC50 4.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(N5CCN(C)CC5)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4072812 IC50 4.0 nM
C=CCCn1cc(-c2cnc(OCC)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4440829 IC50 4.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(N(C)CCN5CCCC5)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4091912 IC50 6.0 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3ncn(CC)c3c2)c2cc[nH]c2c1=O CHEMBL4453202 IC50 6.0 nM
C=CCCn1cc(-c2ccc(Cl)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4441257 IC50 6.0 nM
C=CCCn1cc(-c2cc(OC(F)F)cc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4586175 IC50 6.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(N5CCCCC5)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4092917 IC50 7.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(CCCCO)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4059651 IC50 7.0 nM
C=CCCn1cc(-c2cnc(OC)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4566599 IC50 7.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(Cl)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4075478 IC50 8.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(CCCO)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4086276 IC50 8.0 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1 CHEMBL4648912 Kd 9.1 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)cc3c2ncn3C)c2cc[nH]c2c1=O CHEMBL4463538 IC50 10.0 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3c(c2)ncn3C)c2cc[nH]c2c1=O CHEMBL4455513 IC50 10.0 nM
C=CCCn1cc(-c2ccc(F)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4520419 IC50 10.0 nM
C=CCCn1cc(-c2cc(F)c(F)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4437997 IC50 11.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4cc(O)cc(c34)C1=O)n(C)c(=O)n2C CHEMBL4077317 IC50 13.0 nM
C=CCCn1cc(-c2cnc(C)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4459660 IC50 13.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(N5CCN(CC6CC6)CC5)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4076067 IC50 14.0 nM
COC1CCN(c2ccc3c4c(cccc24)C(=O)N(c2cc4c(cc2C)n(C)c(=O)n4C)C3=O)CC1 CHEMBL4104538 IC50 15.0 nM
C=CCCn1cc(-c2cc(C#N)cc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4448723 IC50 15.0 nM
C[C@H]1CCN(S(=O)(=O)c2cc(NC(=O)CN3C(=O)N[C@@](C)(C4CC4)C3=O)ccc2Br)C1 CHEMBL4449894 pKd 15.85 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ccc2c(n1)N(C1CCCC1)[C@H](C)C(=O)N2C CHEMBL4589721 IC50 16.0 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3c(c2)ncn3CC)c2cc[nH]c2c1=O CHEMBL4445482 IC50 16.0 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3ncn(C)c3c2)c2cc[nH]c2c1=O CHEMBL4513694 IC50 16.0 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3nc[nH]c3c2)c2cc[nH]c2c1=O CHEMBL4468549 IC50 16.0 nM
C=CCCn1cc(-c2cncc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4459431 IC50 16.0 nM
CCOC(=O)Nc1cc(-c2ccc(C)c(NS(C)(=O)=O)c2)nn2c(C)nnc12 CHEMBL3133807 Kd 16.6 nM
Cc1cc2c(cc1N1C(=O)c3cccc4cc(Br)cc(c34)C1=O)n(C)c(=O)n2C CHEMBL4081145 IC50 17.0 nM
C=CCCn1cc(-c2cc(F)cc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4483679 IC50 17.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(N5CCC(O)CC5)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4065133 IC50 19.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4cc(C#N)cc(c34)C1=O)n(C)c(=O)n2C CHEMBL4099171 IC50 22.0 nM
C=CCCn1cc(-c2cccc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4463398 IC50 23.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(N5CCN(CCN(C)C)CC5)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4064164 IC50 25.0 nM
C=CCCn1cc(-c2cc(N)cc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4448345 IC50 26.0 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)cc3[nH]cnc23)c2cc[nH]c2c1=O CHEMBL4534244 IC50 28.0 nM
C[C@@H]1C(=O)N(C)c2ccc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC3CCCC3)nc2N1C1CCCC1 CHEMBL4534000 IC50 31.0 nM
Cc1cc2c(-c3cncc(CO)c3)cnc(NC3CCN(CCCN)CC3)c2[nH]c1=O CHEMBL4860188 pIC50 31.62 nM
Cc1cc2c(cc1N1C(=O)c3cccc4cc(N)cc(c34)C1=O)n(C)c(=O)n2C CHEMBL4076603 IC50 33.0 nM
C=CCCn1cc(-c2ccc(C)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4465624 IC50 35.0 nM
C=CCCn1cc(-c2cccc(C(=O)N3CCCC3)c2)c2cc[nH]c2c1=O CHEMBL4483624 IC50 35.0 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(n1)N(C1CCOCC1)[C@H](C)C(=O)N2C CHEMBL4542872 IC50 38.0 nM
C=CCCn1cc(-c2cccc(C(=O)N(CC)CC)c2)c2cc[nH]c2c1=O CHEMBL4466746 IC50 46.0 nM
C=CCCn1cc(-c2cccc(C(=O)N(C)C)c2)c2cc[nH]c2c1=O CHEMBL4436158 IC50 46.0 nM
Cc1cncc(-c2cnc(N[C@@H]3CCN(C)C[C@H]3OCC3CCS(=O)(=O)CC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL3590408 pKi 50.12 nM
Cc1cc2c(-c3ccco3)cnc(N[C@@H]3CCN(C)C[C@H]3C(=O)NC3CCCCC3)c2[nH]c1=O CHEMBL4648362 pKd 50.12 nM
Cc1cncc(-c2cnc(NC3CCN(CCCN)CC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL4878541 pIC50 50.12 nM
Cc1cc2c(C3=CCOCC3)cnc(NC3CCN(CC(F)(F)CN)CC3)c2[nH]c1=O CHEMBL4874167 pKi 50.12 nM
CN(C)c1cc2c(cc1N1C(=O)c3cccc4cccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4064292 IC50 55.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4cc([N+](=O)[O-])cc(c34)C1=O)n(C)c(=O)n2C CHEMBL4068180 IC50 58.0 nM
CN(C)C(=O)c1cccc(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL4436408 IC50 59.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4cccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4098824 IC50 60.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ccc2c(n1)N1CCCC[C@@H]1C(=O)N2C CHEMBL4573352 IC50 63.0 nM
CN1CCc2c(nnn2CC(=O)Nc2ccc(Br)c(S(=O)(=O)N3CC[C@H](C4CC4)C3)c2)C1 CHEMBL4465880 pKd 63.1 nM
C=CCCn1cc(-c2cccc(C(=O)N(C)C3CCCCC3)c2)c2cc[nH]c2c1=O CHEMBL4518929 IC50 67.0 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(n1)N(C1CCCCC1)[C@H](C)C(=O)N2C CHEMBL4556917 IC50 72.0 nM
Cc1cncc(-c2cnc(NC3CCN(CCN)CC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL4865495 pIC50 79.43 nM
Cc1ccc(-c2cc(NC(=O)CCNC(=O)[C@H](CN)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)N[C@@H](CN)C(=O)NCCC(=O)Nc3cc(-c4ccc(C)c(NS(C)(=O)=O)c4)nn4c(C)nnc34)c3nnc(C)n3n2)cc1NS(C)(=O)=O CHEMBL4868318 pKd 79.43 nM
C=CCCN1C(=O)[C@@H](C)N(C2CCOCC2)c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ccc21 CHEMBL4474288 IC50 82.0 nM
C=CCCn1cc(-c2cccc(C(=O)N3CCN(CCO)CC3)c2)c2cc[nH]c2c1=O CHEMBL4470836 IC50 83.0 nM
Cn1c(=O)n(C)c2cc(N3C(=O)c4cccc5cccc(c45)C3=O)c(Br)cc21 CHEMBL4075962 IC50 87.0 nM
C[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3)nc2N1C1CCCC1 CHEMBL4440443 IC50 87.0 nM
CC(C)Oc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ccc2c(n1)N(C1CCCC1)[C@H](C)C(=O)N2C CHEMBL4539891 IC50 89.0 nM
C=CCCn1cc(-c2cccc(C(=O)N3CCN(C)CC3)c2)c2cc[nH]c2c1=O CHEMBL4572531 IC50 89.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(N5CCOCC5)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4067968 IC50 90.0 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(n1)N(C1CCCC1)[C@H](C)C(=O)N2C CHEMBL4466613 IC50 93.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC3CCCC3)nc2N1C1CCCC1 CHEMBL3609314 IC50 100.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC3CCC3)nc2N1C1CCCC1 CHEMBL4437749 IC50 110.0 nM
CN1CCC(NC(=O)c2cn(C)c(=O)c3[nH]ccc23)CC1 CHEMBL4102588 IC50 130.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3)nc2N1C1CCCC1 CHEMBL3609309 IC50 150.0 nM
Cc1cc2c(-c3cncc(COC(N)=O)c3)cnc(NC3CCNCC3)c2[nH]c1=O CHEMBL3585461 pIC50 158.49 nM
Cc1nnc2c(NC3CCN(CC(C)(C)F)CC3)cc(C(=O)N3[C@@H]4c5ccccc5C[C@H]3C(=O)N[C@@H]4C(C)C)nn12 CHEMBL5079885 pKd 158.49 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 IC50 160.0 nM
CN(C)C(=O)/C(C#N)=C/c1ccc(-c2nc3cnc4c(ccn4C)c3n2C2CCCCC2)o1 CHEMBL4798701 IC50 170.0 nM
C[C@@H]1COCCN1c1cc(C2([S@](C)(=N)=O)CC2)nc(-c2cc[nH]c3nccc2-3)n1 CHEMBL4285417 Kd 175.0 nM
CN1CCc2c(nnn2CC(=O)Nc2ccc(Cl)c(S(=O)(=O)N3CC[C@H](C4CC4)C3)c2)C1 CHEMBL4577486 pKd 199.53 nM
Cc1cncc(-c2cnc(NC3CCNCC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL3585452 pIC50 199.53 nM
C=CCCc1cc2c(C3=CCOCC3)cnc(NC3CCN(C(=O)C(F)(F)CN)CC3)c2[nH]c1=O CHEMBL4871251 pKi 199.53 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(n1)N1CCCC[C@@H]1C(=O)N2C CHEMBL4475297 IC50 210.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC(C)C)nc2N1C1CCCC1 CHEMBL4468126 IC50 210.0 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(n1)N(C1CCCCCC1)[C@H](C)C(=O)N2C CHEMBL4572284 IC50 240.0 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(n1)N(C1CCC(C)(C)C1)[C@H](C)C(=O)N2C CHEMBL4447984 IC50 300.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)cc2)c2cc[nH]c2c1=O CHEMBL5270178 Kd 310.0 nM
Cc1cncc(-c2cnc(NC3CCN(C)CC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL4855456 pIC50 316.23 nM
CC(C)Oc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)[C@H](C)C(=O)N2C CHEMBL4552957 IC50 320.0 nM
C[C@@H]1C(=O)N(C)c2ccc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3)nc2N1C1CCCC1 CHEMBL4590890 IC50 340.0 nM
Cc1cc2c(C3CCOCC3)cnc(NC3CCN(CCCN)CC3)c2[nH]c1=O CHEMBL4856376 pIC50 398.11 nM
CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3COC[C@@H]32)cc2c1O[C@H](CF)[C@H]2c1ccccc1 CHEMBL4637208 pKd 398.11 nM
CC[C@@H]1C(=O)N(CC)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL3609300 IC50 410.0 nM
C/C=C/Cn1cc(-c2cccc(C(=O)N(C)C)c2)c2cc[nH]c2c1=O CHEMBL4519632 IC50 410.0 nM
C[C@@H]1COCCN1c1cc(C2(S(C)(=N)=O)CC2)nc(-c2ccnc3[nH]ccc23)n1 CHEMBL5184230 IC50 427.0 nM
CC[C@@H]1C(=O)N(C)c2ccc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL4524310 IC50 450.0 nM
Cc1cncc(-c2cnc(NC3CCN(CCO)CC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL4868866 pIC50 501.19 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(C#N)c2)c2cc(C)[nH]c2c1=O CHEMBL5268936 IC50 520.0 nM
Cc1noc(C)c1-c1ccc(-c2nc3cnccn3c2NC(C)(C)C)cc1 CHEMBL3356559 Kd 560.0 nM
C=CCCN1C(=O)[C@@H](C)N(C2CCCC2)c2nc(Nc3ccc(C(=O)N4CCC(O)CC4)cc3OC)ccc21 CHEMBL4514849 IC50 570.0 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(c1)N(C1CCCC1)[C@H](C)C(=O)N2C CHEMBL4476205 IC50 580.0 nM
C=CCn1cc(C(=O)N(C)C2CCN(c3cc(-c4cccc(OC)c4)ncn3)CC2)c2cc[nH]c2c1=O CHEMBL4073178 Kd 620.0 nM
Cc1cc2c(C3CCCCC3)cnc(NC3CCN(CCCN)CC3)c2[nH]c1=O CHEMBL4872504 pIC50 630.96 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(n1)N(Cc1ccccc1)[C@H](C)C(=O)N2C CHEMBL4470053 IC50 720.0 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1cc2c(cc1OC)N(C)C(=O)[C@@H](C)N2C1CCCC1 CHEMBL4521536 IC50 750.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)cc2)c2cc(C)[nH]c2c1=O CHEMBL5284261 IC50 750.0 nM
C=CCn1cc(-c2cccc(C(=O)N(C)C)c2)c2cc[nH]c2c1=O CHEMBL4460783 IC50 770.0 nM
COc1cc(C(=O)N2CCC(O)CC2)ccc1Nc1ccc2c(c1C)N(C)[C@H](C)C(=O)N2C CHEMBL4546931 IC50 980.0 nM
Cc1cccc(-c2cnc(NC3CCN(CCCN)CC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL4857270 pIC50 1000.0 nM