Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Oc3ccc([N+](=O)[O-])cc3)n2)n[nH]1 CHEMBL3604928 IC50 0.06 nM
COCc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4566796 IC50 0.7 nM
Cc1nc2c(F)cc(-c3n[nH]c4ncc(-c5cccc(S(C)(=O)=O)c5)cc34)cc2n1C(C)C CHEMBL5413962 IC50 0.8 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 0.89 nM
N#Cc1cc(-c2ccnc(Nc3ccc4c(c3)CC(=O)N4)n2)ccc1N1CCCC1 CHEMBL3650697 IC50 1.0 nM
C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL4435393 IC50 1.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 1.259 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1 CHEMBL4227907 IC50 1.3 nM
CCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1 CHEMBL4224757 Kd 1.3 nM
O=C(NCCCNc1nc(Nc2cnn(C3CCOCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL2207214 IC50 2.0 nM
O=C(NCCCNc1nc(Nc2cnn(C3CCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL2207212 IC50 2.0 nM
CN1CCN(C(=O)c2ccc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)cc2)CC1 CHEMBL2207195 IC50 2.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1Br)C1CCC1 CHEMBL2207181 IC50 2.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCC4CCNCC4)c3)n2)ccc1OC1CCOCC1 CHEMBL3687186 IC50 2.0 nM
N#Cc1cc(-c2ccnc(Nc3cc(C4CCNCC4)ccn3)c2)ccc1OC1CCOCC1 CHEMBL3682430 IC50 2.0 nM
CC(C)Oc1cncnc1-c1ccc2nc(Nc3cc([C@@H](C)N4CCN(C(=O)CC(F)(F)F)CC4)ccn3)[nH]c2c1 CHEMBL4543618 IC50 2.0 nM
C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(N(C)C)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL4537673 IC50 2.0 nM
C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(OCC5CC5)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL4454902 IC50 2.0 nM
Cc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4538751 IC50 2.0 nM
C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CCC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL4436188 IC50 2.0 nM
Nc1cccc(-c2nc3c(NCCCNC(=O)C4CCC4)c(Br)cnc3[nH]2)c1 CHEMBL2011940 IC50 3.0 nM
O=C(NCCCNc1nc(Nc2ccc(-n3cncn3)cc2)ncc1C1CC1)C1CCC1 CHEMBL2207199 IC50 3.0 nM
O=C(NCCCNc1nc(Nc2cccc(Cn3cncn3)c2)ncc1C1CC1)C1CCC1 CHEMBL2207194 IC50 3.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCO)c3)n2)ccc1OC1CCOCC1 CHEMBL3682431 IC50 3.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn([C@H]4CC[C@H](O)CC4)c3)n2)ccc1OC1CCOCC1 CHEMBL3639859 IC50 3.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4(CN)CC4)c(Br)cnc3[nH]2)cc1 CHEMBL2011932 IC50 4.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CCC4)c(Br)cnc3[nH]2)cc1 CHEMBL2011933 IC50 4.0 nM
O=C(NCCCNc1c(Br)cnc2[nH]c(-c3ccc(OCCN4CCCCC4)cc3)nc12)C1CCC1 CHEMBL2011941 IC50 4.0 nM
NC(=O)c1cnc2[nH]c(-c3ccc(OCCN4CCCCC4)cc3)nc2c1NCCCNC(=O)C1CCC1 CHEMBL2011942 IC50 4.0 nM
O=C(NCCCNc1nc(Nc2cnn(C3CCCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL2207213 IC50 4.0 nM
CC(C)n1cc(Nc2ncc(C3CC3)c(NCCCNC(=O)C3CCC3)n2)cn1 CHEMBL2207209 IC50 4.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(I)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1 CHEMBL4225766 Kd 4.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 4.0 nM
COc1ccc(-c2nc3c(NCCCN(C)C(=O)C4CCC4)c(Br)cnc3[nH]2)cc1 CHEMBL2011934 IC50 5.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CC(F)F)c3)n2)ccc1OC1CCOCC1 CHEMBL3687185 IC50 5.0 nM
CN1CCC(c2ccnc(Nc3cc(-c4ccc(OC5CCOCC5)c(C#N)c4)ccn3)c2)CC1 CHEMBL3682434 IC50 5.0 nM
N#Cc1cc(-c2ccnc(Nc3cnc(C4CCOCC4)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687128 IC50 5.0 nM
COc1ccc(-c2ccc(-c3nc4c(NNCCCNC(=O)C5CCCCC5)c(C(N)=O)cnc4[nH]3)cc2)cc1 CHEMBL4532014 IC50 5.0 nM
O=C(CC(F)(F)F)N1CCN(Cc2ccnc(Nc3nc4ccc(-c5cnn(CC6CC6)c5)cc4[nH]3)c2)CC1 CHEMBL4468020 IC50 5.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1 CHEMBL4226693 Kd 5.9 nM
O=C(NCCCNc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1C1CC1)C1CCC1 CHEMBL2207198 IC50 6.0 nM
CN(C)Cc1ccc(Nc2ncc(C3CC3)c(NCCCNC(=O)C3CCC3)n2)cc1 CHEMBL2207196 IC50 6.0 nM
O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br)c1cccs1 CHEMBL2207217 IC50 6.0 nM
N#Cc1cc(-c2ccnc(Nc3cn[nH]c3)n2)ccc1OC1CCOCC1 CHEMBL3687175 IC50 6.0 nM
COCCn1cc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)cn1 CHEMBL3687176 IC50 6.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(C4CCNCC4)c3)n2)ccc1OC1CCOCC1 CHEMBL3682420 IC50 6.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(C[C@H]4C[C@@H]4CO)c3)n2)ccc1OC1CCOCC1 CHEMBL3682423 IC50 6.0 nM
N#Cc1cc(-c2ccnc(Nc3cnc(CO)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687129 IC50 6.0 nM
O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)c1cccs1 CHEMBL577784 IC50 6.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 IC50 6.22 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C(C)(C)C)c(Br)cnc3[nH]2)cc1 CHEMBL2011930 IC50 7.0 nM
CC(C)N1CCC(n2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)cn2)CC1 CHEMBL2207216 IC50 7.0 nM
CCn1cc(Nc2ncc(C3CC3)c(NCCCNC(=O)C3CCC3)n2)cn1 CHEMBL2207210 IC50 7.0 nM
Cc1nn(C)c2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc12 CHEMBL2207206 IC50 7.0 nM
O=C(NCCCNc1nc(Nc2ccc3c(c2)CN(C2CC2)CC3)ncc1C1CC1)C1CCC1 CHEMBL2207204 IC50 7.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CCCC4)c(-c4nc(C(N)=O)cs4)cnc3[nH]2)cc1 CHEMBL3125721 IC50 7.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(C4CCNC4)c3)n2)ccc1OC1CCOCC1 CHEMBL3687181 IC50 7.0 nM
COCCn1cc(Nc2nccc(-c3ccc(OCC4CCC4)c(C#N)c3)n2)cn1 CHEMBL3687132 IC50 7.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 7.943 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CC(O)C4)c(Br)cnc3[nH]2)cc1 CHEMBL2011935 IC50 8.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CCCC4)c(Br)cnc3[nH]2)cc1 CHEMBL2011936 EC50 8.0 nM
Cn1cc(Nc2ncc(C3CC3)c(NCCCNC(=O)C3CCC3)n2)cn1 CHEMBL2207208 IC50 8.0 nM
CN1CCC(c2ccc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)cc2)CC1 CHEMBL2207197 IC50 8.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1C1CC1)C1CCC1 CHEMBL2207187 IC50 8.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1Br)C1CCCC1 CHEMBL2207180 IC50 8.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(N4CCOCC4)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687151 IC50 8.0 nM
N#Cc1cc(-c2ccnc(Nc3cc(CO)ccn3)c2)ccc1OC1CCOCC1 CHEMBL3687160 IC50 8.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn([C@H]4CC[C@@H](O)CC4)c3)n2)ccc1OC1CCOCC1 CHEMBL3682429 IC50 8.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CCCC4)c(C(N)=O)cnc3[nH]2)cc1 CHEMBL2011943 IC50 9.0 nM
O=C(NCCCNc1nc(Nc2cnn(CCN3CCOCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL2207215 IC50 9.0 nM
O=C(NCCCNc1nc(Nc2ccc(CN3CCCCC3)nc2)ncc1C1CC1)C1CCC1 CHEMBL2207202 IC50 9.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1Br)c1cccs1 CHEMBL2207218 IC50 9.0 nM
CCN1CCN(Cc2ccc(Nc3nccc(-c4cnc(N5CC[C@H](F)C5)c(C#N)c4)n3)cn2)CC1 CHEMBL4295211 INH 9.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 9.0 nM
CN(C)c1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4453292 IC50 9.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 9.3 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C(C)C)c(Br)cnc3[nH]2)cc1 CHEMBL2011929 IC50 10.0 nM
O=C(NCCCNc1nc(Nc2cnn(C3CC3)c2)ncc1C1CC1)C1CCC1 CHEMBL2207211 IC50 10.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc4oc(C(N)=O)cc4c3)n2)ccc1OC1CCOCC1 CHEMBL3687183 IC50 10.0 nM
N#Cc1cc(-c2ccnc(Nc3cnc(C4CCNCC4)cn3)c2)ccc1OC1CCOCC1 CHEMBL3682428 IC50 10.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(C[C@H]4C[C@@H]4CO)c3)n2)ccc1OCC1CCC1 CHEMBL3687125 IC50 10.0 nM
Cc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCc2ccc(S(N)(=O)=O)cc2)n1 CHEMBL4446892 pKd 10.0 nM
CNc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4594167 IC50 10.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Cl)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1 CHEMBL4226319 Kd 10.4 nM
O=C(NCCCNc1nc(Nc2cccc(-c3cnco3)c2)ncc1C1CC1)C1CCC1 CHEMBL2207192 IC50 11.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn([C@H]4CC[C@@H](O)CC4)c3)n2)ccc1OCC1CCC1 CHEMBL3687127 IC50 11.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CC4CCOC4)c3)n2)ccc1OC1CCOCC1 CHEMBL3687182 IC50 12.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 12.59 nM
O=C(NCCCNc1nc(Nc2cccnc2)ncc1C1CC1)C1CCC1 CHEMBL2207200 IC50 13.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1 CHEMBL4226591 Kd 13.0 nM
COc1ccc(-n2ncc3cnc(Nc4cc(OC)c(OC)c(OCCCN5CCN(C)CC5)c4)nc32)cc1 CHEMBL4582703 IC50 13.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(CO)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687158 IC50 14.0 nM
CN(C)Cc1ccnc(Nc2cc(-c3ccc(OC4CCOCC4)c(C#N)c3)ccn2)c1 CHEMBL3687111 IC50 14.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCO)c3)n2)ccc1OCC1CCC1 CHEMBL3687124 IC50 14.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(C4CCOCC4)nn3)c2)ccc1OC1CCOCC1 CHEMBL3687130 IC50 14.0 nM
O=C(NCCCNc1nc(Nc2ccc(N3CCOCC3)nc2)ncc1C1CC1)C1CCC1 CHEMBL2207201 IC50 15.0 nM
Cc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4552254 IC50 15.0 nM
Cn1ncc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc21 CHEMBL2207205 IC50 16.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCN4CCOCC4)c3)n2)ccc1OC1CCOCC1 CHEMBL3687180 IC50 16.0 nM
COc1ccc(F)cc1-c1nc2c(NCCCNC(=O)C3CCC3)c(Br)cnc2[nH]1 CHEMBL2011945 EC50 17.0 nM
CN1CCN(Cc2ccc(Nc3nccc(-c4cnc(N5CC[C@H](F)C5)c(C#N)c4)n3)cn2)CC1 CHEMBL4280039 INH 17.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 17.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 18.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CC4)c(Br)cnc3[nH]2)cc1 CHEMBL2011931 IC50 18.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(C[C@H]4C[C@@H]4CO)c3)c2)ccc1OC1CCOCC1 CHEMBL3687168 IC50 18.0 nM
O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL3605057 IC50 19.0 nM
Cc1noc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)n1 CHEMBL4553949 IC50 19.0 nM
CCN1CCN(Cc2ccc(Nc3nccc(-c4cnc(N5CC[C@@H](F)C5)c(C#N)c4)n3)cn2)CC1 CHEMBL4287265 INH 20.0 nM
CC(C)(C)c1cc(Nc2cc(-c3ccc(OC4CCOCC4)c(C#N)c3)ccn2)n[nH]1 CHEMBL3687153 IC50 21.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(C4CCNCC4)nn3)c2)ccc1OC1CCOCC1 CHEMBL3682427 IC50 21.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1Br)c1cnccn1 CHEMBL2207178 IC50 22.0 nM
CC(=O)N1CCN(Cc2cccc(Nc3ncc4ccn(CCCNC(=O)C5CCC5)c4n3)c2)CC1 CHEMBL5412271 IC50 22.4 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 23.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(N4CCOCC4)cn3)c2)ccc1OCC1CC1 CHEMBL3687138 IC50 23.0 nM
CN(C)c1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ccn1 CHEMBL4451595 IC50 23.0 nM
N#Cc1cc(-c2ccnc(Nc3cncc(C4CCNCC4)n3)c2)ccc1OC1CCOCC1 CHEMBL3687126 IC50 24.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(CN4CCOCC4)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687133 IC50 24.0 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 25.12 nM
COc1ccc(-c2nc3c(NCCCNC(=O)c4cccs4)c(Br)cnc3[nH]2)cc1 CHEMBL2011939 EC50 26.0 nM
COc1nc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)ccc1C1=CCNCC1 CHEMBL3682432 IC50 27.0 nM
O=C(NCCCNc1nc(Nc2cccc(N3CCOCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL2207193 IC50 28.0 nM
N#Cc1ccc2nc(Nc3cc(CN4CCN(C(=O)CC(F)(F)F)CC4)ccn3)[nH]c2c1 CHEMBL4459120 IC50 29.0 nM
COc1ccc(-c2nc3cc(-c4csc(C(=O)NCC(C)(C)C)c4)cnc3[nH]2)cc1 CHEMBL3125726 IC50 30.0 nM
COc1ccc(-c2nc3cc(-c4csc(C(N)=O)c4)cnc3[nH]2)cc1 CHEMBL3125732 IC50 30.0 nM
N#Cc1cc(-c2ccnc(Nc3cc(C4CC4)n[nH]3)c2)ccc1OC1CCOCC1 CHEMBL3687155 IC50 30.0 nM
N#Cc1cc(-c2ccnc(Nc3cc(CN)ccn3)c2)ccc1OC1CCOCC1 CHEMBL3682433 IC50 30.0 nM
COc1ccccc1-c1nc2c(NCC(O)CNC(=O)C3CCC3)c(Br)cnc2[nH]1 CHEMBL2011944 IC50 32.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(C(N)=O)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687178 IC50 32.0 nM
N#Cc1cc(-c2ccnc(Nc3cccc(C4CCNCC4)n3)c2)ccc1OC1CCOCC1 CHEMBL3687121 IC50 32.0 nM
COc1cc(F)ccc1-c1nc2c(NCCCNC(=O)C3CCC3)c(Br)cnc2[nH]1 CHEMBL2010815 EC50 34.0 nM
Cc1cc(Nc2cc(-c3ccc(OC4CCOCC4)c(C#N)c3)ccn2)no1 CHEMBL3687149 IC50 34.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(C(C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)n1 CHEMBL4455930 IC50 34.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 IC50 35.0 nM
COCCN(C)Cc1cccc(Nc2ncc3ccn(CCCNC(=O)C4CCC4)c3n2)c1 CHEMBL5438323 IC50 35.7 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CCCC4)c(-c4nc(C(=O)O)cs4)cnc3[nH]2)cc1 CHEMBL3125722 IC50 36.0 nM
COc1ccc(-c2nc3cc(-c4csc(C(=O)NCC(C)C)c4)cnc3[nH]2)cc1 CHEMBL3125727 IC50 37.0 nM
COc1ccc(-c2nc3c(OCC4CCNCC4)c(Br)cnc3[nH]2)cc1 CHEMBL2011927 IC50 39.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 39.81 nM
N#Cc1cc(-c2ccnc(Nc3ccc(CN4CC5(COC5)C4)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687118 IC50 41.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(CO)cn3)c2)ccc1OCC1CC1 CHEMBL3687136 IC50 41.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCC4CCN(C(=O)CN)CC4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687172 IC50 42.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CCCC4)c(C(N)=S)cnc3[nH]2)cc1 CHEMBL3125723 IC50 46.0 nM
COc1cnccc1-c1nc(C(N)=O)c(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)s1 CHEMBL3950168 IC50 46.0 nM
COc1ccc(-c2nc3cc(-c4csc(C(=O)O)c4)cnc3[nH]2)cc1 CHEMBL3125741 IC50 49.0 nM
[C-]#[N+]c1cc(-c2ccnc(Nc3ccn(C4CCNCC4)n3)c2)ccc1OCC1CC1 CHEMBL3687137 IC50 50.0 nM
CCn1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)cn1 CHEMBL4453481 IC50 50.0 nM
O=C(NCCCn1ccc2cnc(Nc3cccc(CN4CCN(C5COC5)CC4)c3)nc21)C1CCC1 CHEMBL5412535 IC50 50.0 nM
CN1CCN(Cc2cccc(Nc3ncc4ccn(CCCNC(=O)C5CCC5)c4n3)c2)CC1 CHEMBL5394835 IC50 53.6 nM
N#Cc1cc(-c2ccnc(Nc3ccc(N4CCOCC4)cn3)c2)ccc1CCC1CCC1 CHEMBL3687143 IC50 54.0 nM
Cc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ccn1 CHEMBL4515413 IC50 54.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CC(F)F)c3)c2)ccc1OC1CCOCC1 CHEMBL3687162 IC50 55.0 nM
Cn1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)cn1 CHEMBL4436416 IC50 55.0 nM
CC(C)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5407680 IC50 56.0 nM
COc1ccc(-c2nc3c(NCC4CCNCC4)c(Br)cnc3[nH]2)cc1 CHEMBL2011926 IC50 57.0 nM
O=C(CC(F)(F)F)N1CCN(Cc2ccnc(Nc3nc4ccc(-c5nc(C6CC6)no5)cc4[nH]3)c2)CC1 CHEMBL4466150 IC50 58.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)c4cccnc4)c(Br)cnc3[nH]2)cc1 CHEMBL2011938 IC50 59.0 nM
COCCC(=O)NCCCNc1nc(Nc2cccc(F)c2)ncc1Br CHEMBL2207219 IC50 60.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCN4CCCC4)c3)n2)ccc1OC1CCOCC1 CHEMBL3687113 IC50 60.0 nM
CCc1cnc(Nc2cccc(F)c2)nc1NCCCNC(=O)C1CCC1 CHEMBL2207184 IC50 63.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 63.1 nM
CNc1c(Br)cnc2[nH]c(-c3cccc(N)c3)nc12 CHEMBL2011910 IC50 65.0 nM
[C-]#[N+]c1cc(-c2ccnc(Nc3ccn(C4CCNCC4)n3)c2)ccc1OCC1CCC1 CHEMBL3687142 IC50 65.0 nM
NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2Br)cc1 CHEMBL5083125 IC50 66.0 nM
O=C(NCCCn1ccc2cnc(Nc3cccc(CN4CCOCC4)c3)nc21)C1CCC1 CHEMBL5401353 IC50 66.7 nM
COCCn1cc(-c2cnc(N)c(C(=O)Nc3ccncc3)c2)cn1 CHEMBL3937942 IC50 67.0 nM
CCc1nnc(-c2c(OC)cc(-c3cnc4cc(-c5cnn(C)c5)ccn34)cc2OC)o1 CHEMBL5407103 IC50 67.0 nM
COc1ccc(-c2nc3c(NCCCNC(C)=O)c(Br)cnc3[nH]2)cc1 CHEMBL2011928 IC50 70.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCC4CCNCC4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687163 IC50 70.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCn4cccn4)c3)n2)ccc1OC1CCOCC1 CHEMBL3687184 IC50 70.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(C4CCNCC4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687159 IC50 71.0 nM
COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(C#N)s3)c2cc1OC CHEMBL373751 IC50 72.0 nM
CC(C)Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)n1 CHEMBL4547610 IC50 72.0 nM
CC(=O)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5427137 IC50 73.0 nM
COc1ccc(-c2nc3cc(-c4csc(C(=O)NCCC(C)C)c4)cnc3[nH]2)cc1 CHEMBL3125728 IC50 78.0 nM
Cc1cc(NC(=O)c2cc(-c3ccc(CN4CCOCC4)s3)cnc2N)ccn1 CHEMBL3943325 IC50 78.0 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 79.43 nM
CN(C)CC(=O)NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1991725 pKi 79.43 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 79.43 nM
CN1CCC(n2cc(Nc3cc(-c4ccc(OC5CCOCC5)c(C#N)c4)ccn3)cn2)CC1 CHEMBL3687148 IC50 83.0 nM
COc1ccc(-c2nc3c(NCCCNC(=O)c4ccccc4)c(Br)cnc3[nH]2)cc1 CHEMBL2011937 EC50 84.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CC4CCOC4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687169 IC50 85.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(N4CCOCC4)nn3)c2)ccc1OC1CCOCC1 CHEMBL3687120 IC50 88.0 nM
Nc1ncc(-c2ccc(CN3CCOCC3)s2)cc1C(=O)Nc1ccncc1 CHEMBL3982817 IC50 88.0 nM
CCC(C)CNC(=O)c1cc(-c2cnc3[nH]c(-c4ccc(OC)cc4)nc3c2)cs1 CHEMBL3125729 IC50 89.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(CO)cn3)c2)ccc1OCC1CCC1 CHEMBL3687141 IC50 89.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 92.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccnc(N)c3)nc12 CHEMBL2011912 IC50 93.0 nM
O=C(NCC1CC1)c1ccc2nc(Nc3cc(CN4CCN(C(=O)CC(F)(F)F)CC4)ccn3)[nH]c2c1 CHEMBL4456062 IC50 93.0 nM
NC(=O)c1nc(-c2ccncc2)sc1NC(=O)c1ccc(CC2CCN(C(N)=O)CC2)cc1 CHEMBL3958876 IC50 94.0 nM
NC(=O)c1nc(-c2ccncc2)sc1NC(=O)c1ccc(CN2CCNCC2)cc1 CHEMBL3923270 IC50 95.0 nM
Cn1ccc(Nc2cc(-c3ccc(OC4CCOCC4)c(C#N)c3)ccn2)n1 CHEMBL3687150 IC50 97.0 nM
COCCNC(=O)c1cc(-c2cnc3[nH]c(-c4ccc(OC)cc4)nc3c2)cs1 CHEMBL3125731 IC50 98.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(CC(F)F)CC5)ccn4)[nH]c3c2)n1 CHEMBL4587843 IC50 98.0 nM
CN(C)C(=O)CCCCc1ccc(C(=O)Nc2sc(-c3ccncc3)nc2C(N)=O)cc1 CHEMBL3896126 IC50 99.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 100.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 100.0 nM
COc1ccc(-c2nc3cc(-c4csc(C(=O)NCC(C)(C)CO)c4)cnc3[nH]2)cc1 CHEMBL3125730 IC50 100.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCN4CCOCC4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687164 IC50 100.0 nM
N#Cc1cc(-c2ccnc(Nc3ncc(C4CCNCC4)cn3)c2)ccc1OC1CCOCC1 CHEMBL3682422 IC50 100.0 nM
CN1CCC(Cc2ccc(C(=O)Nc3sc(-c4ccncc4)nc3C(N)=O)cc2)CC1 CHEMBL3943590 IC50 100.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 102.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(F)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1 CHEMBL4228790 Kd 103.5 nM
Brc1cnc2[nH]c(-c3ccc(OCCN4CCCCC4)cc3)nc2c1NCC1CCNCC1 CHEMBL2011899 IC50 105.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(OCCN4CCN(C)CC4)cc3)nc12 CHEMBL2011918 IC50 106.0 nM
Cc1noc(-c2ccc3nc(Nc4cc([C@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)n1 CHEMBL4577511 IC50 106.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1C1CC1)c1cccs1 CHEMBL2207188 IC50 110.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CC4CC4C#N)c3)c2)ccc1OC1CCOCC1 CHEMBL3687166 IC50 110.0 nM
NC(=O)c1nc(-c2ccncc2)sc1NC(=O)c1ccc(N)cc1 CHEMBL3956252 IC50 110.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(N)cc3)nc12 CHEMBL2011911 IC50 111.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC6CC6)CC5)ccn4)[nH]c3c2)n1 CHEMBL4483062 IC50 115.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 120.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(-c4cn[nH]c4)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687152 IC50 120.0 nM
COCCCn1cc(Nc2cc(-c3ccc(OC4CCOCC4)c(C#N)c3)ccn2)cn1 CHEMBL3687165 IC50 120.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCC4CCN(C(=O)CO)CC4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687171 IC50 120.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCO)c3)c2)ccc1OC1CCOCC1 CHEMBL3682435 IC50 120.0 nM
NC(=O)c1nc(-c2ccncc2)sc1NC(=O)c1ccc[nH]1 CHEMBL3934112 IC50 120.0 nM
Cc1ccc(-c2cnc(N)c(C(=O)Nc3ccncc3)c2)s1 CHEMBL3900950 IC50 120.0 nM
Nc1ncc(-c2ccc(-n3cccn3)cc2)cc1C(=O)Nc1ccncc1 CHEMBL3906387 IC50 120.0 nM
Nc1ncc(-c2cnn(Cc3ccccc3)c2)cc1C(=O)Nc1ccncc1 CHEMBL3975183 IC50 120.0 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 125.89 nM
COc1ccc(-c2nc3c(NCCCNC(=O)C4CCCC4)c(-c4nc(C(=O)NCC(C)C)cs4)cnc3[nH]2)cc1 CHEMBL3125720 IC50 128.0 nM
NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2C2CC2)cc1 CHEMBL5088682 IC50 128.0 nM
COc1ccc(-c2nc3cc(-c4cc(C(=O)O)cs4)cnc3[nH]2)cc1 CHEMBL3125739 IC50 129.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)n1 CHEMBL4549459 IC50 129.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 130.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 130.0 nM
Cn1ccc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)n1 CHEMBL3687174 IC50 130.0 nM
Nc1ncc(-c2ccc(CN3CCCC3)s2)cc1C(=O)Nc1ccncc1 CHEMBL3924260 IC50 130.0 nM
C=Cc1cnc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)nc1NCCCN(C)C(=O)C1CCC1 CHEMBL4227097 Kd 130.0 nM
N#Cc1cc(-c2ccnc(Nc3nccc(C4CCNCC4)n3)c2)ccc1OC1CCOCC1 CHEMBL3687119 IC50 140.0 nM
CC(=O)N1CCN(Cc2ccc(C(=O)Nc3sc(-c4ccncc4)nc3C(N)=O)cc2)CC1 CHEMBL3973084 IC50 140.0 nM
Nc1ncc(-c2csc(CN3CCOCC3)c2)cc1C(=O)Nc1ccncc1 CHEMBL3922312 IC50 140.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)C6CCC6)CC5)ccn4)[nH]c3c2)n1 CHEMBL4573638 IC50 146.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)C6CC6)CC5)ccn4)[nH]c3c2)n1 CHEMBL4450510 IC50 148.0 nM
Cc1nn(CC(F)(F)F)cc1Nc1ncc(C2CC2)c(NCc2ccc(S(N)(=O)=O)cc2)n1 CHEMBL5084750 IC50 149.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 150.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 150.0 nM
Nc1ncc(-c2ccc(S(N)(=O)=O)cc2)cc1C(=O)Nc1ccncc1 CHEMBL3915353 IC50 150.0 nM
Nc1ncc(-c2cc[nH]c2)cc1C(=O)Nc1ccncc1 CHEMBL3899325 IC50 150.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(OCCN4CCCCC4)cc3)nc12 CHEMBL2011895 IC50 151.0 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 158.49 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 158.49 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 158.49 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 160.0 nM
Cn1nc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)ccc1=O CHEMBL3682424 IC50 160.0 nM
NC(=O)c1nc(-c2ccncc2)sc1NC(=O)c1ccc(CCCCCC(=O)O)cc1 CHEMBL3955705 IC50 160.0 nM
CC(=O)c1ccc(-c2cnc(N)c(C(=O)Nc3ccncc3)c2)s1 CHEMBL3943921 IC50 160.0 nM
Cn1cc(-c2cnc(N)c(C(=O)Nc3ccncc3)c2)cn1 CHEMBL3925601 IC50 160.0 nM
CNc1c(C(N)=O)cnc2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc12 CHEMBL2011923 IC50 162.0 nM
C=CC(=O)N(C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(C#N)cc3)n2)ccc1F CHEMBL5178711 IC50 162.0 nM
N#Cc1cc(-c2ccnc(Nc3cc(C(=O)O)ccn3)c2)ccc1OC1CCOCC1 CHEMBL3682421 IC50 170.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc12 CHEMBL2011917 IC50 178.0 nM
N#Cc1cc(-c2ccnc(Nc3cc(CO)ccn3)n2)ccc1OC1CCOCC1 CHEMBL3682426 IC50 180.0 nM
NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2C2CC2)cc1 CHEMBL5093111 IC50 187.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(CC(F)(F)F)CC5)ccn4)[nH]c3c2)n1 CHEMBL4438389 IC50 188.0 nM
NC(=O)c1nc(-c2ccncc2)sc1NC(=O)c1ccc(CC2CCNCC2)cc1 CHEMBL3981105 IC50 190.0 nM
CC(=O)Nc1cc(NC(=O)c2cc(-c3ccc(CN4CCOCC4)s3)cnc2N)ccn1 CHEMBL3959788 IC50 190.0 nM
CNc1c(Br)cnc2[nH]c(-c3cnn(C4CCN(C)CC4)c3)nc12 CHEMBL2011920 IC50 192.0 nM
Cc1nn(CC(F)(F)F)cc1Nc1ncc(C2CC2)c(NCCCNC(=O)C2CCC2)n1 CHEMBL5079601 IC50 192.0 nM
NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2Br)cc1 CHEMBL5079149 IC50 192.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(C(=O)NCCN4CCN(C)CC4)cc3)nc12 CHEMBL2011919 IC50 196.0 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 pKi 199.53 nM
O=C(Cc1ccc(-c2cccnc2)cc1)Nc1ccc(SC(F)F)cc1 CHEMBL1992581 pKi 199.53 nM
CC(=O)N1CCC(Cc2ccc(C(=O)Nc3sc(-c4ccncc4)nc3C(N)=O)cc2)CC1 CHEMBL3929152 IC50 200.0 nM
NC(=O)c1nc(-c2ccncc2)sc1NC(=O)c1ccsc1 CHEMBL3955236 IC50 200.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(O)cc3)nc12 CHEMBL2011906 IC50 201.0 nM
CNC(=O)c1cc(-c2cnc3[nH]c(-c4ccc(OC)cc4)nc3c2)cs1 CHEMBL3125733 IC50 203.0 nM
CN(C)CCNCc1ccc(C(=O)Nc2sc(-c3ccncc3)nc2C(N)=O)cc1 CHEMBL3956700 IC50 210.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(N4CCOCC4)cc3)nc12 CHEMBL2011915 IC50 213.0 nM
COCCn1cc(Nc2cc(-c3ccc(OCC4CC4)c(C#N)c3)ccn2)cn1 CHEMBL3687135 IC50 220.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(S(C)(=O)=O)cc3)nc12 CHEMBL2011908 IC50 229.0 nM
Cc1cc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)no1 CHEMBL3687110 IC50 230.0 nM
N#Cc1cc(-c2ccnc(Nc3cc(N4CCOCC4)ccn3)c2)ccc1OC1CCOCC1 CHEMBL3687112 IC50 230.0 nM
Nc1ncc(-c2coc3ccccc23)cc1C(=O)Nc1ccncc1 CHEMBL3953224 IC50 230.0 nM
CCOc1ccc(-c2nc3c(NC)c(Br)cnc3[nH]2)cc1 CHEMBL2011904 IC50 231.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(OCCCN4CCOCC4)cc3)nc12 CHEMBL2011916 IC50 233.0 nM
CNC(=O)CCCCc1ccc(C(=O)Nc2sc(-c3ccncc3)nc2C(N)=O)cc1 CHEMBL3983696 IC50 240.0 nM
Nc1ncc(-c2ccc(CN3CCOCC3)s2)cc1C(=O)Nc1ccnnc1 CHEMBL3980829 IC50 240.0 nM
CC(=O)c1c[nH]c(-c2cnc(N)c(C(=O)Nc3ccncc3)c2)c1 CHEMBL3970040 IC50 240.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(C4CC4)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1 CHEMBL4226250 Kd 245.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 250.0 nM
N#Cc1ccc(Nc2cc(-c3ccc(OC4CCOCC4)c(C#N)c3)ccn2)nc1 CHEMBL3687154 IC50 250.0 nM
Nc1ncc(-c2ccc(CCC(=O)O)cc2)cc1C(=O)Nc1ccncc1 CHEMBL3975928 IC50 250.0 nM
Nc1ncc(-c2ccc(CN3CCOCC3)s2)cc1C(=O)Nc1ccncc1Cl CHEMBL3950028 IC50 250.0 nM
COc1ccc(-c2nc3cc(-c4ccc(C(=O)O)s4)cnc3[nH]2)cc1 CHEMBL3125738 IC50 256.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(C(=O)O)cc3)nc12 CHEMBL2011907 IC50 257.0 nM
N#Cc1cc(-c2ccnc(Nc3cncc(-c4cccnc4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687187 IC50 260.0 nM
COCCNCc1ccc(C(=O)Nc2sc(-c3ccncc3)nc2C(N)=O)cc1 CHEMBL3951517 IC50 260.0 nM
Cc1cnccc1NC(=O)c1cc(-c2ccc(CN3CCOCC3)s2)cnc1N CHEMBL3892127 IC50 260.0 nM
Cc1cnc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)nc1NCCCN(C)C(=O)C1CCC1 CHEMBL4227342 Kd 270.0 nM
CC(=O)N1CCC(c2ccc3oc4nc(N)c(C(=O)O)cc4c(=O)c3c2)CC1 CHEMBL4289613 IC50 270.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)OC(C)(C)C)CC5)ccn4)[nH]c3c2)n1 CHEMBL4545291 IC50 273.0 nM
CCc1cnc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)nc1NCCCN(C)C(=O)C1CCC1 CHEMBL4226837 Kd 275.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(C4CCNC4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687170 IC50 280.0 nM
Nc1ncc(-c2cn[nH]c2)cc1C(=O)Nc1ccncc1 CHEMBL3923200 IC50 280.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(CCC(F)(F)F)CC5)ccn4)[nH]c3c2)n1 CHEMBL4566710 IC50 281.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc4[nH]ncc4c3)nc12 CHEMBL2011921 IC50 288.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(C4CNC4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687167 IC50 290.0 nM
N#Cc1cc(-c2ccnc(Nc3cc(C4=CCCCO4)ccn3)c2)ccc1OC1CCOCC1 CHEMBL3687116 IC50 290.0 nM
Nc1nc2oc3ccc(C4CCSCC4)cc3c(=O)c2cc1C(=O)O CHEMBL4293403 IC50 290.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3991929 Kd apparent 299.0 nM
N#Cc1cc(-c2ccnc(Nc3nc(C4CC4)cs3)n2)ccc1OC1CCOCC1 CHEMBL3687117 IC50 300.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3sc(-c4ccncc4)nc3C(N)=O)cc2)CC1 CHEMBL3906947 IC50 300.0 nM
CC(C)c1ccc2c(=O)c3cc(C(=O)O)c(N)nc3oc2c1 CHEMBL4285560 IC50 300.0 nM
N#Cc1cc(-c2ccnc(Nc3ccc(C(F)(F)F)cn3)c2)ccc1OC1CCOCC1 CHEMBL3687156 IC50 310.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3sc(-c4ccncc4Br)nc3C(N)=O)cc2)CC1 CHEMBL3913460 IC50 310.0 nM
CN1CCN(C(=O)c2ccc(C(=O)Nc3sc(-c4ccncc4)nc3C(N)=O)cc2)CC1 CHEMBL3951104 IC50 310.0 nM
COc1ccc(-n2ccc3cnc(Nc4cc(OC)c(OC)c(OC)c4)nc32)cc1 CHEMBL1975927 pKi 316.23 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 316.23 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 316.23 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 316.23 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 316.23 nM
Cn1cccc1-c1cnc(N)c(C(=O)Nc2ccncc2)c1 CHEMBL3894537 IC50 320.0 nM
Cc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCCCNC(=O)C2CCC2)n1 CHEMBL5079920 IC50 321.0 nM
N#Cc1cc(-c2ccnc(Nc3cncc(N4CCOCC4)n3)c2)ccc1OC1CCOCC1 CHEMBL3687115 IC50 330.0 nM
Cc1cc(NC(=O)c2cc(-c3cnn(Cc4ccccc4)c3)cnc2N)ccn1 CHEMBL3975991 IC50 330.0 nM
Cn1ccc(-c2cnc(N)c(C(=O)Nc3ccncc3)c2)n1 CHEMBL3902251 IC50 330.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(OC)cc3)nc12 CHEMBL2011903 IC50 335.0 nM
O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br)C1CCC1 CHEMBL5085430 IC50 338.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(OC)c(OC)c3)nc12 CHEMBL2011913 IC50 345.0 nM
CN1CCN(c2ccnc(Nc3cc(-c4ccc(OC5CCOCC5)c(C#N)c4)ccn3)c2)CC1 CHEMBL3687114 IC50 350.0 nM
N#Cc1cc(-c2ccnc(Nc3nccnc3CO)c2)ccc1OC1CCOCC1 CHEMBL3687131 IC50 350.0 nM
Cc1cnccc1-c1nc(C(N)=O)c(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)s1 CHEMBL3934866 IC50 350.0 nM
NC(=O)Cn1cc(-c2cnc(N)c(C(=O)Nc3ccncc3)c2)cn1 CHEMBL3976366 IC50 360.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3sc(-c4ccncc4F)nc3C(N)=O)cc2)CC1 CHEMBL3944901 IC50 370.0 nM
Nc1ncc(-c2cnc3ccccn23)cc1C(=O)Nc1ccncc1 CHEMBL3976903 IC50 370.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 377.0 nM
N#Cc1cc(-c2ccnc(Nc3cn[nH]c3)c2)ccc1OCC1CCC1 CHEMBL3687139 IC50 380.0 nM
CNc1c(Cl)cnc2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc12 CHEMBL2011924 IC50 383.0 nM
CNc1c(Br)cnc2[nH]c(-c3ccc(N4CCCC4)cc3)nc12 CHEMBL2011914 IC50 388.0 nM
Nc1ncc(-c2ccc(CN3CCCCC3)s2)cc1C(=O)Nc1ccncc1 CHEMBL3961973 IC50 390.0 nM
Nc1ncc(-c2cc3ccccc3[nH]2)cc1C(=O)Nc1ccncc1 CHEMBL3925987 IC50 390.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 393.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 398.11 nM
CC(C)c1cc2c(=O)c3cc(C(=O)O)c(N)nc3oc2cc1F CHEMBL4284443 pIC50 398.11 nM
Cn1cccc1C(=O)Nc1sc(-c2ccncc2)nc1C(N)=O CHEMBL3925224 IC50 400.0 nM
Nc1ncc(-c2cccc(-n3cccn3)c2)cc1C(=O)Nc1ccncc1 CHEMBL3928914 IC50 400.0 nM
Nc1ncc(-c2ccc(C(=O)O)cc2)cc1C(=O)Nc1ccncc1 CHEMBL3937785 IC50 400.0 nM
CN(C)c1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1 CHEMBL4279379 IC50 400.0 nM
Cc1cc(-c2nc(C(N)=O)c(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)s2)ccn1 CHEMBL3896866 IC50 410.0 nM
Nc1ncc(-c2ccsc2)cc1C(=O)Nc1ccncc1 CHEMBL3964958 IC50 410.0 nM
Nc1ncc(-c2ccc[nH]2)cc1C(=O)Nc1ccncc1 CHEMBL3945410 IC50 410.0 nM
CNc1c(C#N)cnc2[nH]c(-c3ccc(OCCN4CCCCC4)cc3)nc12 CHEMBL2011901 IC50 426.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)c6ccco6)CC5)ccn4)[nH]c3c2)n1 CHEMBL4462056 IC50 429.0 nM
CC(=O)N1CCC(C(=O)NCCCNc2nc(Nc3cccc(F)c3)ncc2Br)CC1 CHEMBL2207183 IC50 430.0 nM
CCOc1cc(NC(=O)c2cc(-c3ccc(CN4CCOCC4)s3)cnc2N)ccn1 CHEMBL3899705 IC50 430.0 nM
Nc1nc2oc3ccc(C4CCC5(CC4)OCCO5)cc3c(=O)c2cc1C(=O)O CHEMBL4285588 IC50 440.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1Br)c1ccc(C(F)(F)F)cc1 CHEMBL2207220 IC50 450.0 nM
COC(=O)c1cnccc1NC(=O)c1cc(-c2ccc(CN3CCOCC3)s2)cnc1N CHEMBL3895236 IC50 450.0 nM
Nc1nc2oc3ccc(C4CCC(=O)CC4)cc3c(=O)c2cc1C(=O)O CHEMBL4281788 IC50 450.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 452.0 nM
COc1ccc(-c2nc3c(OCCCNC(=O)C4CCCC4)c(-c4csc(C(=O)O)c4)cnc3[nH]2)cc1 CHEMBL3125724 IC50 460.0 nM
N#Cc1cc(-c2ccnc(Nc3cnn(CCn4cccn4)c3)c2)ccc1OC1CCOCC1 CHEMBL3687179 IC50 460.0 nM
N#Cc1cc(-c2ccnc(Nc3cn[nH]c3)c2)ccc1OCC1CC1 CHEMBL3687134 IC50 460.0 nM
Brc1cnc2[nH]c(-c3ccc(OCCN4CCCCC4)cc3)nc2c1NCCC1CCNCC1 CHEMBL2011900 IC50 468.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 470.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 470.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 470.0 nM
Nc1nc2oc3ccc(C4=CCCCC4)cc3c(=O)c2cc1-c1nn[nH]n1 CHEMBL4291966 pIC50 489.78 nM
COCCn1cc(Nc2cc(-c3ccc(OCC4CCC4)c(C#N)c3)ccn2)cn1 CHEMBL3687140 IC50 490.0 nM
Nc1nc2oc3ccc(C4CCN(C=O)CC4)cc3c(=O)c2cc1C(=O)O CHEMBL4281733 IC50 490.0 nM
CCc1nc(Nc2ccc(N3CCOCC3)c(Cl)c2)nc2[nH]ccc12 CHEMBL2004118 pKi 501.19 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 501.19 nM
CN(C)CC1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL360847 pKi 501.19 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 501.19 nM
Nc1ncc(-c2c[nH]c3ccccc23)cc1C(=O)Nc1ccncc1 CHEMBL3931286 IC50 510.0 nM
CN(C)c1ccc2oc3nc(N)c(-c4nn[nH]n4)cc3c(=O)c2c1 CHEMBL4281345 pIC50 524.81 nM
Nc1nc2oc3ccc(N4CCOCC4)cc3c(=O)c2cc1-c1nn[nH]n1 CHEMBL4288542 pIC50 537.03 nM
Cc1coc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)n1 CHEMBL3687123 IC50 550.0 nM
CC(C)Cc1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1 CHEMBL4290544 IC50 550.0 nM
O=C(CCc1ccccc1)NCCCNc1nc(Nc2cccc(F)c2)ncc1Br CHEMBL2207179 IC50 560.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)C1CCCN1 CHEMBL3545328 Kd apparent 561.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 562.0 nM
CC(C)c1cc2c(=O)c3cc(C(=O)O)c(N)nc3oc2cn1 CHEMBL4287847 IC50 570.0 nM
CN(C)C(=O)CCCCCc1ccc(C(=O)Nc2sc(-c3ccncc3)nc2C(N)=O)cc1 CHEMBL3980051 IC50 580.0 nM
Nc1ncc(-c2ccoc2)cc1C(=O)Nc1ccncc1 CHEMBL3898836 IC50 610.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3sc(-c4ccnc(F)c4)nc3C(N)=O)cc2)CC1 CHEMBL3926136 IC50 630.0 nM
Nc1ncc(-c2cc3ccccc3s2)cc1C(=O)Nc1ccncc1 CHEMBL3958551 IC50 630.0 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 630.96 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 630.96 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 630.96 nM
CN1CCN(Cc2ccc(C(=O)Nc3sc(-c4ccncc4Cl)nc3C(N)=O)cc2)CC1 CHEMBL3922448 IC50 640.0 nM
NC(=O)c1nc(-c2ccncc2)sc1NC(=O)c1ccc(CN2CCOCC2)cc1 CHEMBL3946038 IC50 645.0 nM
COc1ccc(-c2nc3cc(-c4csc(C(C)=O)c4)cnc3[nH]2)cc1 CHEMBL3125734 IC50 650.0 nM
N#Cc1cc(-c2ccnc(Nc3ncccn3)c2)ccc1OC1CCOCC1 CHEMBL3687157 IC50 670.0 nM
Cc1cc(NC(=O)c2cc(-c3csc(CN4CCOCC4)c3)cnc2N)ccn1 CHEMBL3914197 IC50 670.0 nM
Nc1ncc(-c2cnn(CCO)c2)cc1C(=O)Nc1ccncc1 CHEMBL3897770 IC50 670.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 690.0 nM
COCCn1cc(-c2cnc(N)c(C(=O)Nc3ccncc3C)c2)cn1 CHEMBL3952415 IC50 690.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3nccc(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1 CHEMBL4228346 Kd 725.0 nM
COCCn1cc(-c2cnc(N)c(C(=O)Nc3ccncc3Cl)c2)cn1 CHEMBL3901749 IC50 740.0 nM
Nc1ncc(-c2cnn(CCN3CCOCC3)c2)cc1C(=O)Nc1ccncc1 CHEMBL3939553 IC50 740.0 nM
C#Cc1nc(Nc2cccc(CC(N)=O)c2)nc2[nH]cnc12 CHEMBL4786783 IC50 740.0 nM
Nc1nc2oc3ccc(C4=CCC5(CC4)OCCO5)cc3c(=O)c2cc1C(=O)O CHEMBL4278727 IC50 750.0 nM
Nc1nc2oc3ccc(C4CCOCC4)cc3c(=O)c2cc1C(=O)O CHEMBL4290024 IC50 750.0 nM
COc1ccc(-c2nc3c(OCCCNC(=O)C4CCCC4)c(Br)cnc3[nH]2)cc1 CHEMBL3125725 IC50 759.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 759.0 nM
Nc1nc2oc3ccc(N4CCOCC4)cc3c(=O)c2cc1C(=O)Nc1nn[nH]n1 CHEMBL4277887 IC50 760.0 nM
Cc1noc(-c2ccc3nc(Nc4cc(CN5CCNCC5)ccn4)[nH]c3c2)n1 CHEMBL4575832 IC50 764.0 nM
Nc1ncc(-c2ccc(N3CCNCC3)nc2)cc1C(=O)Nc1ccncc1 CHEMBL3936692 IC50 770.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1 CHEMBL4538174 IC50 770.0 nM
Nc1ncc(-c2cccc(-n3cccn3)c2)cc1C(=O)Nc1ccnnc1 CHEMBL3936393 IC50 790.0 nM
C=C(C)c1cc2c(=O)c3cc(C(=O)O)c(N)nc3oc2cc1F CHEMBL4292344 IC50 790.0 nM
N#Cc1ccc2c(c1)C(c1ccc3c(n1)CCCC3O)C(=O)N2 CHEMBL1985681 pKi 794.33 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 794.33 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 794.33 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cc(F)ccc1F CHEMBL1995811 pKi 794.33 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 800.0 nM
[C-]#[N+]c1cc(-c2ccnc(Nc3ccc(N4CCOCC4)cn3)c2)ccc1OCC1CCN(C(C)=O)CC1 CHEMBL3687147 IC50 810.0 nM
Nc1ncc(-c2ccc(CN3CCOCC3)s2)cc1C(=O)Nc1ccncn1 CHEMBL3938167 IC50 810.0 nM
O=C(NCCCNc1nc(Nc2ccccc2F)ncc1C1CC1)c1cccs1 CHEMBL2207189 IC50 820.0 nM
CC(C)CCc1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1 CHEMBL4295050 IC50 830.0 nM
Nc1nc2oc3ccc(C4CCS(=O)(=O)CC4)cc3c(=O)c2cc1C(=O)O CHEMBL4282790 IC50 830.0 nM
N#Cc1cc(-c2ccnc(Nc3cncc(C4=CCCCO4)n3)c2)ccc1OC1CCOCC1 CHEMBL3687122 IC50 850.0 nM
CC(C)c1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1 CHEMBL1096 IC50 850.0 nM
O=C(O)c1ccc(-c2cnc3[nH]c(-c4ccc(OCCN5CCCCC5)cc4)nc3c2)cc1 CHEMBL3125735 IC50 859.0 nM
CC(C)(C)c1cc(Nc2cc(-c3ccc(OC4CCOCC4)c(C#N)c3)ccn2)on1 CHEMBL3687173 IC50 860.0 nM
Nc1nc2oc3ccc(C4=CCOCC4)cc3c(=O)c2cc1C(=O)O CHEMBL4279336 IC50 860.0 nM
Nc1ncc(-c2ccc(CN3CCOCC3)s2)cc1C(=O)Nc1ccnc2ccoc12 CHEMBL3925708 IC50 890.0 nM
COc1ccc(NC(=O)c2cc(-c3ccc(CN4CCOCC4)s3)cnc2N)cc1 CHEMBL3972829 IC50 910.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccnc5)c4)c3c2)c1 CHEMBL5431124 IC50 951.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 970.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 Kd 970.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 1000.0 nM
C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 CHEMBL1976040 pKi 1000.0 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(F)ccc21 CHEMBL1993335 pKi 1000.0 nM
Nc1ncc(-c2ccc(CN3CCOCC3)s2)nc1C(=O)Nc1ccncc1 CHEMBL3924214 IC50 1000.0 nM
Cc1cnccc1NC(=O)c1cc(-c2ccc(-n3cccn3)cc2)cnc1N CHEMBL3911981 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM