Cc1cccc(-c2nc(Nc3ccncc3F)c3nc[nH]c3n2)n1 CHEMBL4209835 Ki(app) 0.14 nM
Cc1cccc(-c2nc(Nc3ccncc3F)c3cc[nH]c3n2)n1 CHEMBL4210246 Ki(app) 0.14 nM
CC(=O)Nc1cc(Nc2nc(-c3cccc(C(F)(F)F)n3)nc3[nH]ccc23)ccn1 CHEMBL4209583 Ki(app) 0.15 nM
Fc1cnccc1Nc1nc(-c2cccc(C(F)(F)F)n2)nc2[nH]ccc12 CHEMBL4217699 Ki(app) 0.22 nM
Cc1ccccc1-c1cc(Nc2ccnc3cc(-c4cnn(CCN(C)C)c4)ccc23)ccn1 CHEMBL4852453 IC50 0.32 nM
Cc1cccc(-c2nc(N)sc2-c2ccc3nccnc3c2)n1 CHEMBL519948 Ki 0.33 nM
Cc1cccc(-c2cc(Nc3ccnc4cc(-c5cnn(CCN(C)C)c5)ccc34)ccn2)c1 CHEMBL4858177 IC50 0.34 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccccc5)c4)ccnc3c2)cn1 CHEMBL4877947 IC50 0.35 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccoc5)c4)ccnc3c2)cn1 CHEMBL4846578 IC50 0.51 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccoc5)c4)ccnc3c2)cc1 CHEMBL4872884 IC50 0.54 nM
COc1ccc(NC(=S)n2cc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)n2)cc1 CHEMBL1835530 IC50 0.57 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5cc(F)ccc5F)c4)ccnc3c2)cc1 CHEMBL4861887 IC50 0.62 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5cccc(F)c5)c4)ccnc3c2)cn1 CHEMBL4872045 IC50 0.63 nM
Cc1ccccc1-c1cc(Nc2ccnc3cc(-c4ccc(S(C)(=O)=O)cc4)ccc23)ccn1 CHEMBL4874893 IC50 0.65 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccccc5F)c4)ccnc3c2)cc1 CHEMBL4867170 IC50 0.67 nM
Cc1nc(-c2nc(N)[nH]c2-c2ccc3nccnc3c2)ccc1F CHEMBL480742 Ki 0.7 nM
Cc1cccc(-c2ncn(CC(F)F)c2-c2ccc3ncc(C(N)=O)n3c2)n1 CHEMBL4455462 IC50 0.7 nM
Cc1cccc(-c2cc(Nc3ccnc4cc(-c5ccc(S(C)(=O)=O)cc5)ccc34)ccn2)c1 CHEMBL4851363 IC50 0.79 nM
N#Cc1cnc2ccc(-c3c(-c4ccc(F)c(Cl)c4)ncn3CCO)nn12 CHEMBL4514379 Ki(app) 0.8 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccccc5F)c4)ccnc3c2)cn1 CHEMBL4863867 IC50 0.82 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccccc5)c4)ccnc3c2)cc1 CHEMBL4877481 IC50 0.88 nM
NC(=O)c1cnc2ccc(-c3c(-c4ccc(F)cc4)ncn3CC(F)F)nn12 CHEMBL4440988 IC50 0.9 nM
Cc1cccc(-c2nc(Nc3ccncc3F)c3cccn3n2)n1 CHEMBL4205457 IC50 0.96 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)S(C)(=O)=O)cc1)c1ccccc1 CHEMBL1272128 IC50 1.0 nM
Cc1cccc(-n2ncc(C)c2-c2ccc3nc[nH]c(=O)c3c2)n1 CHEMBL2024688 IC50 1.0 nM
CCc1cc(-c2ccc3ncn(C)c(=O)c3c2)n(-c2cccc(C)n2)n1 CHEMBL2024689 IC50 1.0 nM
Cc1cnc(-c2cc(F)ccc2F)cc1Nc1ccnc2cn[nH]c12 CHEMBL4102696 pIC50 1.0 nM
CNC(=O)n1ncc2nccc(Nc3cc(-c4cc(F)ccc4F)ncc3C)c21 CHEMBL4101751 pIC50 1.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2cccc(C(F)F)n2)ccn1 CHEMBL4284170 IC50 1.0 nM
Cc1cccc(-c2ncn(CC(F)F)c2-c2ccc3nccn3c2)n1 CHEMBL4458215 IC50 1.0 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5cc(F)ccc5F)c4)ccnc3c2)cn1 CHEMBL4850787 IC50 1.03 nM
CC(=O)Nc1cc(Nc2nc(-c3cccc(C(F)(F)F)n3)nc3[nH]cnc23)ccn1 CHEMBL4205456 IC50 1.1 nM
Brc1cccc(-c2[nH]ncc2-c2ccnc3ccccc23)n1 CHEMBL341280 IC50 1.2 nM
Cc1cccc(-c2[nH]c(CNc3cc(C#N)ccc3N(C)C)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260904 IC50 1.3 nM
Cc1cccc(-c2nc(Nc3ccncc3)c3cccn3n2)n1 CHEMBL4206793 IC50 1.3 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5cccc(F)c5)c4)ccnc3c2)cc1 CHEMBL4874538 IC50 1.37 nM
CC(=O)Nc1cc(Nc2nc(-c3cccc(C(F)(F)F)n3)nn3cccc23)ccn1 CHEMBL4216706 IC50 1.4 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccsc5)c4)ccnc3c2)cn1 CHEMBL4875547 IC50 1.53 nM
Cc1cccc(-c2nc(Nc3ccnc4ccccc34)c3cccn3n2)n1 CHEMBL4205979 IC50 1.6 nM
N#Cc1cnc2ccc(-c3c(-c4ccc(F)cc4)ncn3CC(F)F)nn12 CHEMBL4584495 IC50 1.6 nM
Cc1ccc(-c2cc(Nc3ccnc4cc(-c5cnn(CCN(C)C)c5)ccc34)ccn2)cc1 CHEMBL4847382 IC50 1.65 nM
Fc1cnccc1Nc1nc(-c2ccccn2)nn2cccc12 CHEMBL4204772 IC50 1.7 nM
O=C(Nc1cc(Nc2c(Cl)cnc3c2OCO3)ccn1)C1CC1 CHEMBL3818173 IC50 1.9 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccc(F)cc5)c4)ccnc3c2)cc1 CHEMBL4853591 IC50 1.9 nM
CCn1ncc2nccc(Nc3cc(-c4cc(C)ccc4F)ncc3C)c21 CHEMBL4104104 pIC50 1.995 nM
CCc1cnn(-c2cccc(C)n2)c1-c1ccc2nc[nH]c(=O)c2c1 CHEMBL2024691 IC50 2.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 2.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2cccc(C(F)(F)F)n2)ccn1 CHEMBL4276907 IC50 2.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2cccc(C)n2)ccn1 CHEMBL4292047 IC50 2.0 nM
[2H]C([2H])([2H])Oc1ccc(-c2c(-c3ccnc(NC(C)=O)c3)[nH]c3cccnc23)nc1 CHEMBL4280731 IC50 2.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2ccc(Cl)cn2)ccn1 CHEMBL4280660 IC50 2.0 nM
CC(=O)Nc1nc(-c2ccc(F)c(C)n2)c(-c2ccc3ncnn3c2)[nH]1 CHEMBL517068 Ki 2.07 nM
O=C(CN1CCN(CCO)CC1)Nc1cc(Nc2nc(-c3cccc(C(F)(F)F)n3)nn3cccc23)ccn1 CHEMBL4214237 IC50 2.1 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(F)c(F)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835622 IC50 2.12 nM
COc1cccc(NC(=S)n2cc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)n2)c1 CHEMBL1835522 IC50 2.26 nM
Cc1cccc(-c2nn(C(=S)Nc3cccc(Cl)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835519 IC50 2.37 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C#N)c3CN(C)C)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260897 IC50 2.4 nM
COc1cc(NC(=S)n2cc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)n2)cc(OC)c1 CHEMBL1835630 IC50 2.49 nM
c1ccc(-c2nc(Nc3ccncc3)c3cccn3n2)nc1 CHEMBL4205311 IC50 2.5 nM
Cc1cccc(-c2n[nH]cc2-c2ccc(F)c(-c3cnn(CCO)c3)c2)n1 CHEMBL4303194 IC50 2.5 nM
COc1cccc2nccc(Nc3cc(-c4nc(C)ccc4F)ncc3C)c12 CHEMBL4094958 pIC50 2.512 nM
CNC(=O)n1ncc2nccc(Nc3ccnc(-c4cc(F)ccc4F)c3)c21 CHEMBL4060987 pIC50 2.512 nM
Cc1cccc(-c2[nH]c(CNc3cc(C#N)cc(N(C)C)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260900 IC50 2.6 nM
Cc1csc(-c2nc[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207988 IC50 2.7 nM
Cc1cccc(-c2nn(C(=S)Nc3ccccc3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835112 IC50 2.82 nM
Cc1cccc(-c2nn(C(=S)Nc3ccccc3Cl)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835535 IC50 2.83 nM
Cc1cccc(-c2[nH]ncc2-c2ccnc3ccccc23)n1 CHEMBL129677 IC50 2.9 nM
Cc1cccc(-c2[nH]c(CNc3cc(N(C)C)ccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260627 IC50 2.9 nM
CC(=O)Nc1nc(-c2cccc(C)n2)c(-c2ccc3ncnn3c2)[nH]1 CHEMBL450161 Ki 2.95 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(C#N)cc3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835532 IC50 2.95 nM
Cc1nc(-c2nc(N3CCN(S(C)(=O)=O)CC3)[nH]c2-c2ccc3ncnn3c2)ccc1F CHEMBL480583 Ki 3.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL1272238 IC50 3.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL1271736 IC50 3.0 nM
Cc1cccc(-n2nc(C)cc2-c2ccc3ncn(C)c(=O)c3c2)n1 CHEMBL2024687 IC50 3.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cn2)ccn1 CHEMBL4291307 IC50 3.0 nM
COc1ccc(-c2c(-c3ccnc(NC(C)=O)c3)[nH]c3cccnc23)cn1 CHEMBL4279160 IC50 3.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(N)=O CHEMBL5267945 IC50 3.0 nM
CC(C)C(=O)N[C@@H](CO)C(=O)O CHEMBL5285361 IC50 3.0 nM
Cc1cccc(-c2nn(C(=S)Nc3cccc(C(F)(F)F)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835521 IC50 3.01 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(C(F)(F)F)cc3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835529 IC50 3.04 nM
Cc1cccc(-c2[nH]c(CNc3cc(C#N)ccc3CN(C)C)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260905 IC50 3.1 nM
Cc1cnc(-c2cc(F)ccc2F)cc1Nc1ccnc2cnn(CC(C)O)c12 CHEMBL4085333 pIC50 3.162 nM
CNC(=O)n1ncc2nccc(Nc3ccnc(-c4cc(Cl)ccc4F)c3)c21 CHEMBL4063730 pIC50 3.162 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cnn(CC(N)=O)c34)c(C)cn2)c1 CHEMBL4075003 pIC50 3.162 nM
Fc1ccc(Cl)cc1-c1cc(Nc2ccncc2)c2cc[nH]c2n1 CHEMBL4447510 pIC50 3.162 nM
O=C(NCCCN1CCCC1=O)c1cnccc1Nc1nc(-c2cc(Br)ccc2F)nc2nccnc12 CHEMBL234655 IC50 3.2 nM
Cc1cccc(-c2nn(C(=S)Nc3cc(F)cc(F)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835623 IC50 3.2 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835531 IC50 3.3 nM
Cc1cccc(-c2[nH]c(CNc3cc(C#N)cc(CN4CCOCC4)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260903 IC50 3.3 nM
Cc1cccc(-c2nc(Nc3c(F)cncc3F)c3cccn3n2)n1 CHEMBL4211574 IC50 3.4 nM
Cc1cccc(-c2nn(C(=S)Nc3cccc(C(N)=O)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835525 IC50 3.45 nM
[2H]C([2H])([2H])n1ncc2cc(-c3nc(NCc4cccc(F)c4)[nH]c3-c3cccc(C)n3)ccc21 CHEMBL5279279 IC50 3.5 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(C)c(C)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835626 IC50 3.54 nM
Cc1cccc(-c2[nH]c(NCc3ccc(F)cc3F)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL5268868 IC50 3.6 nM
c1ccc(-c2nn3c(c2-c2ccnc4cc(OCCN5CCOCC5)ccc24)CCC3)nc1 CHEMBL260015 IC50 3.7 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(Cl)c(Cl)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835624 IC50 3.78 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(Cl)cc3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835527 IC50 3.87 nM
N[C@H]1CCN(Cc2ccn3nc(-c4ccccn4)nc(Nc4ccncc4F)c23)C[C@@H]1O CHEMBL4206220 IC50 3.9 nM
Cc1cc(C)cc(NC(=S)n2cc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)n2)c1 CHEMBL1835627 IC50 3.97 nM
Cc1cccc(-c2nn(C(=S)Nc3ccccc3OC(F)(F)F)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835621 IC50 3.98 nM
Cc1cccc(NC(=S)n2cc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)n2)c1 CHEMBL1835520 IC50 3.98 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cnn(C)c34)c(C)cn2)c1 CHEMBL4079857 pIC50 3.981 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(C)nc34)c(C)cn2)c1 CHEMBL4085263 pIC50 3.981 nM
O=c1[nH]c2cnccc2n1-c1cc(-c2cc(Cl)ccc2F)nc2[nH]ccc12 CHEMBL4470706 pIC50 3.981 nM
Cc1cccc(-c2n[nH]cc2-c2ccc3ncccc3n2)n1 CHEMBL185238 IC50 4.0 nM
COc1cccc(Nc2cc(Oc3cc(C)c(C)nc3-c3ccccn3)ccn2)c1 CHEMBL575721 IC50 4.0 nM
Cc1cccc(-c2nn(C(=S)Nc3ccccc3C)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835536 IC50 4.0 nM
C=Cn1cnc2ccc(-c3ccnn3-c3cccc(C)n3)cc2c1=O CHEMBL2024685 IC50 4.0 nM
Cc1cccc(-n2ncc(C)c2-c2ccc3ncn(C)c(=O)c3c2)n1 CHEMBL2024686 IC50 4.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL4748823 IC50 4.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(F)c3)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL4778963 IC50 4.0 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(F)cc3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835526 IC50 4.09 nM
Cc1cccc(-c2nn3c(c2-c2ccnc4ccc(C(N)=O)cc24)CCC3)n1 CHEMBL2364611 IC50 4.1 nM
Cc1cccc(-c2nn(C(=S)Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835628 IC50 4.12 nM
OC1(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)CCC(O)(C(F)(F)F)CC1 CHEMBL5202482 IC50 4.2 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(N)=O)c(OC)c2)cn1 CHEMBL5438171 IC50 4.2 nM
N[C@H]1CC[C@@H](NCc2ccn3nc(-c4ccccn4)nc(Nc4ccncc4F)c23)CC1 CHEMBL4214470 IC50 4.3 nM
CCc1cnn(-c2cccc(C)n2)c1-c1cc2cnccc2s1 CHEMBL3704651 IC50 4.3 nM
N#CC1CN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccc2F)C1 CHEMBL5199089 IC50 4.3 nM
COc1ccc(NC(=S)n2cc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)n2)cc1OC CHEMBL1835629 IC50 4.37 nM
N[C@@H]1CCN(Cc2ccn3nc(-c4ccccn4)nc(Nc4ccncc4F)c23)C[C@H]1O CHEMBL4217935 IC50 4.4 nM
Cc1cccc(-c2nn(C(=S)Nc3cccc(F)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835518 IC50 4.43 nM
Cc1cccc(-c2nn(C(=S)Nc3cccc(C#N)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835524 IC50 4.5 nM
CCOC(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208016 IC50 4.5 nM
Cc1cccc(-c2[nH]c(NCc3cccc(F)c3F)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL5273412 IC50 4.5 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)ccc1S(C)(=O)=O CHEMBL5204976 IC50 4.6 nM
Cc1cccc(-c2[nH]c(NCc3cccc(F)c3)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL5271258 IC50 4.7 nM
Cc1cccc(-c2[nH]c(CNc3cc(C#N)ccc3CN3CCOCC3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260907 IC50 4.8 nM
Cc1cccc(-c2[nH]c(CNc3cc(C#N)cc(CN(C)C)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260901 IC50 4.9 nM
c1ccc(-c2n[nH]cc2-c2ccnc3ccccc23)nc1 CHEMBL261454 Kd 5.0 nM
Cc1cccc(-c2c(-c3ccc4nccnc4c3)n(C)n(C)c2=O)n1 CHEMBL606632 Ki 5.0 nM
Cc1cccc(-n2nc3c(c2-c2ccc4nc[nH]c(=O)c4c2)CCC3)n1 CHEMBL2024693 IC50 5.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(Br)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260583 IC50 5.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C#N)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260591 IC50 5.0 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 Kd apparent 5.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2ccc(C)cn2)ccn1 CHEMBL4285292 IC50 5.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL4779584 IC50 5.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3C)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL4747557 IC50 5.0 nM
CC(C)(O)c1ccc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)cc1C(F)(F)F CHEMBL5199883 IC50 5.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1 CHEMBL5285746 IC50 5.0 nM
Cc1cccc(-c2[nH]c(NCc3cccc(F)c3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5283753 IC50 5.0 nM
Cc1cccc(-c2[nH]c(NCc3ccc(Cl)c(Cl)c3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5279947 IC50 5.0 nM
COc1cccc2nccc(Nc3cc(-c4cccc(C)n4)ncc3C)c12 CHEMBL4074485 pIC50 5.012 nM
CCNC(=O)n1ncc2nccc(Nc3ccnc(-c4cc(F)ccc4F)c3)c21 CHEMBL4075081 pIC50 5.012 nM
Cc1cccc(-c2nn(C(=S)Nc3cc(Cl)cc(Cl)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835625 IC50 5.08 nM
Cc1cccc(-c2[nH]c(NCc3ccccc3F)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5282597 IC50 5.1 nM
Cc1cccc(-c2[nH]c(NCc3ccc(F)c(F)c3)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL5274746 IC50 5.2 nM
Cc1cccc(-c2[nH]c(Cc3cccc(C(N)=O)c3)nc2-c2ccc3nccnc3c2)n1 CHEMBL492634 IC50 5.3 nM
Cc1cccc(-c2nn(C(=S)Nc3ccccc3F)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835534 IC50 5.39 nM
Cc1cccc(-c2[nH]c(NCc3ccc(F)c(F)c3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5289293 IC50 5.4 nM
Cc1csc(-c2nc(CNC(=O)OCC(C)C)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2208237 IC50 5.5 nM
OC1(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccc2F)COC1 CHEMBL5189063 IC50 5.5 nM
Cc1cccc(-c2[nH]c(NCc3cccc(Cl)c3F)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL5278659 IC50 5.5 nM
Fc1ccc(F)c(-c2cc(Nc3ccnc4cc(-c5cn[nH]c5)ccc34)ccn2)c1 CHEMBL4857294 IC50 5.55 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C#N)c3CN3CCCC3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260898 IC50 5.6 nM
COc1ccccc1NC(=S)n1cc(-c2ccc3ncnn3c2)c(-c2cccc(C)n2)n1 CHEMBL1835620 IC50 5.69 nM
Cc1csc(-c2nc(C(F)(F)F)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207996 IC50 5.8 nM
Cc1csc(-c2nc(C)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207989 IC50 5.8 nM
OC1(C(F)(F)F)CN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)C1 CHEMBL5178623 IC50 5.8 nM
Cc1cccc(-c2nc(N)sc2-c2ccc3ncccc3n2)n1 CHEMBL360034 IC50 6.0 nM
Cc1cc(Oc2ccnc(Nc3cccc(N4CCOCC4)c3)c2)c(-c2ccccn2)nc1C CHEMBL574413 IC50 6.0 nM
Cc1cccnc1-c1nc(N)sc1-c1ccc2ncccc2n1 CHEMBL576062 IC50 6.0 nM
CCc1cccc(-c2c(-c3ccc4nccnc4c3)n(C)n(C)c2=O)c1 CHEMBL594371 Ki 6.0 nM
Cc1cccc(-n2nccc2-c2ccc3nc[nH]c(=O)c3c2)n1 CHEMBL2024690 IC50 6.0 nM
Cc1cccc(-c2[nH]c(CNc3cc(F)cc(F)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260623 IC50 6.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(Cl)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260582 IC50 6.0 nM
COc1ccc(-c2c(-c3ccnc(NC(C)=O)c3)[nH]c3cccnc23)nc1 CHEMBL4288634 IC50 6.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(F)cc3)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL4780141 IC50 6.0 nM
Cc1cccc(-c2[nH]c(NCc3ccccc3F)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL5275540 IC50 6.0 nM
Cc1cccc(-c2nc3n(c2-c2cc4cnccc4s2)CCN3)n1 CHEMBL4457492 IC50 6.1 nM
Cn1cc(-c2ccc3c(Nc4ccnc(-c5cc(F)ccc5F)c4)ccnc3c2)cn1 CHEMBL4850436 IC50 6.18 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260567 Ki 6.296 nM
Fc1ccc(Cl)cc1-c1cc(Nc2ccnc3cn[nH]c23)ccn1 CHEMBL4073422 pIC50 6.31 nM
Cn1c(=O)n(-c2cc(-c3cc(Cl)ccc3F)nc3[nH]ccc23)c2ccncc21 CHEMBL4474551 pIC50 6.31 nM
Cc1ccc(NC(=S)n2cc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)n2)cc1 CHEMBL1835528 IC50 6.61 nM
Cc1cccc(-n2ncc(C)c2-c2cc3cnccc3s2)n1 CHEMBL3640035 IC50 6.65 nM
N#Cc1cnc2ccc(-c3c(-c4ccc(F)cc4)ncn3CCO)nn12 CHEMBL4452178 IC50 6.7 nM
Cc1cccc(-c2[nH]c(CNc3cccc(CN4CCOCC4)c3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260631 IC50 6.8 nM
Cc1cccc(-c2[nH]c(CNc3cc(C#N)ccc3CN3CCCC3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260906 IC50 6.8 nM
FC(F)(F)c1cccc(-c2nc(Nc3ccncc3)c3cccn3n2)n1 CHEMBL4202469 IC50 6.8 nM
Cn1nc(C(C)(C)O)c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccc21 CHEMBL5194314 IC50 6.8 nM
COc1ccccc1Nc1cc(Oc2cc(C)c(C)nc2-c2ccccn2)ccn1 CHEMBL575492 IC50 7.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)S(C)(=O)=O)cc1)c1ccccc1 CHEMBL1272182 IC50 7.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL1269806 IC50 7.0 nM
CCCCCCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2207995 IC50 7.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3Br)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260569 IC50 7.0 nM
CSc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260589 IC50 7.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)NCCN CHEMBL5287327 IC50 7.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)O CHEMBL5274165 IC50 7.0 nM
Cc1cccc(-c2nc(NCc3cccc(F)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087966 IC50 7.01 nM
CC(=O)Nc1nc(-c2ccc(F)c(C)n2)c(-c2ccc3nccnc3c2)[nH]1 CHEMBL519939 Ki 7.1 nM
COCC(=O)Nc1nc(-c2ccc(F)c(C)n2)c(-c2ccc3nccnc3c2)[nH]1 CHEMBL479262 Ki 7.2 nM
CCNC(=O)OCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208011 IC50 7.2 nM
Cc1cccc(-c2[nH]c(NCc3cccc(F)c3)nc2-c2ccc3c(cnn3C(F)F)c2)n1 CHEMBL5290805 IC50 7.2 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4ccnc(-c5ccsc5)c4)ccnc3c2)cc1 CHEMBL4847064 IC50 7.29 nM
CCCOC(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208019 IC50 7.3 nM
Cc1cccc(-c2[nH]c(NCc3ccc(Cl)cc3F)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL5275976 IC50 7.3 nM
Cc1cccc(-c2nc(NCc3ccc(F)c(F)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087983 IC50 7.43 nM
Cc1nc(-c2[nH]c(CNc3cccc(C#N)c3)nc2-c2ccc3ncnn3c2)ccc1F CHEMBL3634799 IC50 7.68 nM
COC(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208018 IC50 7.7 nM
Cc1cccc(-n2ncc(C)c2-c2cc3ccncc3s2)n1 CHEMBL3704654 IC50 7.94 nM
Fc1ccc(F)c(-c2cc(Nc3ccnc4cn[nH]c34)ccn2)c1 CHEMBL4064820 pIC50 7.943 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cnn(C[C@@H](C)O)c34)c(C)cn2)c1 CHEMBL4066402 pIC50 7.943 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cnn(C[C@H](C)O)c34)c(C)cn2)c1 CHEMBL4095435 pIC50 7.943 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(CCO)nc34)c(C)cn2)c1 CHEMBL4074026 pIC50 7.943 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(C[C@@H](C)O)nc34)c(C)cn2)c1 CHEMBL4077146 pIC50 7.943 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(C[C@H](C)O)nc34)c(C)cn2)c1 CHEMBL4093131 pIC50 7.943 nM
Cn1cnc2ccc(-c3c(-c4ccccn4)nn4c3CCC4)cc21 CHEMBL204170 IC50 8.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL1272291 IC50 8.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(Cl)c(Cl)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260620 IC50 8.0 nM
CCc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260585 IC50 8.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(F)c3)nc2-c2ccc3nsnc3c2)n1 CHEMBL4519261 IC50 8.0 nM
Cc1cccc(NCc2nc(-c3ccc4[nH]ncc4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL4759911 IC50 8.0 nM
Cc1csc(-c2nc(CN3CCOC3=O)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2208017 IC50 8.1 nM
CCCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2207991 IC50 8.1 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C#N)c3CN3CCOCC3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260899 IC50 8.1 nM
CCCC(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL1957675 IC50 8.2 nM
Cc1csc(-c2nc(C(C)C)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207992 IC50 8.2 nM
CC1(O)CCC(c2nn(C3CC3)cc2Oc2ccnc(Nc3ccnc(C(C)(C)O)c3)c2)CC1 CHEMBL4797447 IC50 8.2 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CC(O)(C(F)(F)F)C3)ccn2)ccn1 CHEMBL4782867 IC50 8.2 nM
Cc1csc(-c2nc(CCCCC(N)=O)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2208010 IC50 8.3 nM
Cc1cccc(-c2[nH]c(NCc3ccc(F)cc3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5276258 IC50 8.5 nM
Cc1csc(-c2nc(CNC(=O)OC(C)C)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2208022 IC50 8.6 nM
Cc1cccc(-c2nc(NCc3ccc(F)cc3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087972 IC50 8.61 nM
Cc1csc(-c2nc(C3CCCC3)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207998 IC50 8.7 nM
Cc1ccc(CNc2nc(-c3cccc(C)n3)c(-c3ccc4ncnn4c3)s2)cc1 CHEMBL2087974 IC50 8.75 nM
CCC(=O)Nc1nc(-c2ccc(F)c(C)n2)c(-c2ccc3nccnc3c2)[nH]1 CHEMBL521441 Ki 8.8 nM
Cc1csc(-c2nc(C3CC3)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207997 IC50 8.8 nM
Cc1cccc(-c2nc(NCc3cc(F)cc(F)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087984 IC50 8.92 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL1271796 IC50 9.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL1271853 IC50 9.0 nM
CCCC(=O)CCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208006 IC50 9.0 nM
Cc1csc(-c2nc(CC(C)C)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207993 IC50 9.0 nM
CCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2207990 IC50 9.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3Cl)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260568 IC50 9.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(F)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260581 IC50 9.0 nM
Cc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260584 IC50 9.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C(N)=O)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260592 IC50 9.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(F)c3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260614 IC50 9.0 nM
Cc1ccc(NCc2nc(-c3ccc4[nH]ncc4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL4798879 IC50 9.0 nM
CCCCOC(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208020 IC50 9.1 nM
NS(=O)(=O)c1cccc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)c1 CHEMBL4644348 IC50 9.1 nM
C[C@H](O)CNC(=O)c1cnccc1Nc1cc(-c2cc(Cl)ccc2F)nc2[nH]ccc12 CHEMBL4467267 pEC50 9.12 nM
CC(O)(c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)ccn1)C1CC1 CHEMBL5193583 IC50 9.2 nM
Cc1nc(-c2[nH]c(CNc3ccccc3)nc2-c2ccc3ncnn3c2)ccc1F CHEMBL3634711 IC50 9.23 nM
Cc1ccc(F)c(-c2[nH]c(CNc3cccc(C#N)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3634706 IC50 9.23 nM
Cc1cccc(-c2nc(NCc3cccc(C#N)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087971 IC50 9.26 nM
Cc1csc(-c2nc(CNC(=O)OCC(C)(C)C)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2208238 IC50 9.3 nM
Cc1cccc(-c2[nH]c(NCc3ccc(F)c(F)c3F)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5284635 IC50 9.6 nM
CCn1ncc2cc(-c3nc(NCc4cccc(F)c4)[nH]c3-c3cccc(C)n3)ccc21 CHEMBL5278109 IC50 9.7 nM
Cc1ccc(F)c(-c2[nH]c(CNc3ccccc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3634704 IC50 9.76 nM
C=Cc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3nc(C)ccc3F)[nH]2)c1 CHEMBL3634708 IC50 9.81 nM
Nc1nc(-c2ccc(F)cc2)c(-c2ccc3ncccc3n2)s1 CHEMBL361237 IC50 10.0 nM
c1ccc(-c2n[nH]cc2-c2ccc3ncccc3n2)nc1 CHEMBL183354 IC50 10.0 nM
Nc1nc(-c2cccc(Cl)c2)c(-c2ccc3ncccc3n2)s1 CHEMBL365663 IC50 10.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C(N)=O)c3)nc2-c2ccc3nccnc3c2)n1 CHEMBL229599 IC50 10.0 nM
CC(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Nc3ccc(N4CCOCC4)nc3)n2)s1 CHEMBL1808264 IC50 10.0 nM
Cc1cccc(-c2nn(C(=S)Nc3cccc(OC(F)(F)F)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835523 IC50 10.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(F)c(F)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260619 IC50 10.0 nM
CSc1ccccc1NCc1nc(-c2ccc3ncnn3c2)c(-c2cccc(C)n2)[nH]1 CHEMBL3260575 IC50 10.0 nM
CCn1cc2nccc(Nc3cc(-c4cc(C)ccc4F)ncc3C)c2n1 CHEMBL4082868 pIC50 10.0 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(CC(N)=O)nc34)c(C)cn2)c1 CHEMBL4075798 pIC50 10.0 nM
Fc1ccccc1-c1cc(Nc2ccncc2)c2cc[nH]c2n1 CHEMBL4576833 pKd 10.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(F)cc3)nc2-c2ccc3nsnc3c2)n1 CHEMBL4588407 IC50 10.0 nM
Cc1cccc(NCc2nc(-c3ccc4c(cnn4C)c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL4788508 IC50 10.0 nM
Cc1cccc2c(Nc3nc(Nc4cc(CN5CCNCC5)ccc4F)ncc3F)cnnc12 CHEMBL5189156 IC50 10.0 nM
Cc1cccc(-c2nc(Nc3ccncc3)c3ccccc3n2)n1 CHEMBL570533 Kd 10.0 nM
Cc1cccc(-c2nc(NCc3cccc(Cl)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087967 IC50 10.2 nM
Cc1cccc(-c2nc(NCc3ccccc3F)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087978 IC50 10.4 nM
Cc1nc(-c2[nH]c(CNc3cccc(C(N)=O)c3)nc2-c2ccc3ncnn3c2)ccc1F CHEMBL3634800 IC50 10.8 nM
Fc1ccc(F)c(-c2cc(Nc3ccnc4cc(-c5ccsc5)ccc34)ccn2)c1 CHEMBL4845722 IC50 10.95 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2ccccn2)c(=O)n1C CHEMBL593725 Ki 11.0 nM
CN(C)CCCOc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cn1 CHEMBL1829511 IC50 11.0 nM
CCCCCOC(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208021 IC50 11.0 nM
CCNC(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208014 IC50 11.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(CN(C)C)c3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260629 IC50 11.0 nM
CCc1ccccc1NCc1nc(-c2ccc3ncnn3c2)c(-c2cccc(C)n2)[nH]1 CHEMBL3260571 IC50 11.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(CC#N)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260593 IC50 11.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(Cl)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260599 IC50 11.0 nM
Cc1ccc(F)c(-c2[nH]c(CNc3cccc(C(N)=O)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3634707 IC50 11.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2ccc(OC(F)F)cn2)ccn1 CHEMBL4277338 IC50 11.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3nsnc3c2)n1 CHEMBL4453060 IC50 11.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(F)c3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL4794179 IC50 11.0 nM
Cc1cccc(-n2cc(-c3ccc4ncnn4c3)nc2CNc2ccccc2F)n1 CHEMBL5267324 IC50 11.0 nM
Cc1cccc(CNc2nc(-c3cccc(C)n3)c(-c3ccc4ncnn4c3)s2)c1 CHEMBL2087968 IC50 11.2 nM
Cc1cccc(-c2nc(NCc3ccccc3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087965 IC50 11.3 nM
COc1cccc(CNc2nc(-c3cccc(C)n3)c(-c3ccc4ncnn4c3)s2)c1 CHEMBL2087969 IC50 11.4 nM
OC1(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CC(F)(F)C4)ccn3)ccn2)CCOCC1 CHEMBL4791582 IC50 11.4 nM
Cc1cccc(-c2[nH]c(NCc3ccc(Cl)cc3F)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5277895 IC50 11.4 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(OCCN4CCOCC4)cc3)c2)nc1 CHEMBL205158 IC50 12.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C#N)c3)nc2-c2ccc3nccnc3c2)n1 CHEMBL387748 IC50 12.0 nM
Cc1cc(Oc2ccnc(Nc3ccc(C(=O)N(C)C)cc3)c2)c(-c2ccccn2)nc1C CHEMBL575923 IC50 12.0 nM
C=Cc1cccc(-c2c(-c3ccc4nccnc4c3)n(C)n(C)c2=O)c1 CHEMBL593708 Ki 12.0 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2cccc(Br)c2)c(=O)n1C CHEMBL595556 Ki 12.0 nM
Cc1cccc(-c2sc(NCc3cccc(C(N)=O)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL2088223 IC50 12.0 nM
CCNC(=O)CCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208008 IC50 12.0 nM
Cc1csc(-c2nc(C3CCCCC3)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207999 IC50 12.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3OC(F)(F)F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260574 IC50 12.0 nM
C=Cc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260590 IC50 12.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(Cl)c3Cl)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260615 IC50 12.0 nM
CCNS(=O)(=O)c1cccc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)c1 CHEMBL4649726 IC50 12.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)NC1COC1 CHEMBL5268400 IC50 12.0 nM
Cc1cccc(-c2nn(C(=S)Nc3ccccc3)cc2-c2ccnc3ccccc23)n1 CHEMBL1170377 IC50 12.0 nM
Cc1ccc(F)c(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3634705 IC50 12.1 nM
Cc1nc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)ccc1F CHEMBL3634712 IC50 12.5 nM
COc1cccc2nccc(Nc3cc(-c4cc(Cl)ccc4F)ncc3C)c12 CHEMBL4101991 pIC50 12.59 nM
COc1cccc2nccc(Nc3cc(-c4cc(C)ccc4F)ncc3C)c12 CHEMBL4097629 pIC50 12.59 nM
Cc1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccnc2cnn(CC(N)=O)c12 CHEMBL4072325 pIC50 12.59 nM
NC(=O)Cn1cc2nccc(Nc3ccnc(-c4cc(Cl)ccc4F)c3)c2n1 CHEMBL4067488 pIC50 12.59 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cnn(CCO)c34)c(C)cn2)c1 CHEMBL4087735 pIC50 12.59 nM
Cc1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccnc2cn(CC(N)=O)nc12 CHEMBL4069101 pEC50 12.59 nM
CCn1c(=O)n(-c2cc(-c3cc(Cl)ccc3F)ncc2C)c2ccncc21 CHEMBL4569690 pIC50 12.59 nM
O=c1[nH]c2cnccc2n1-c1cc(-c2ccc(F)cc2F)nc2[nH]ccc12 CHEMBL4555703 pIC50 12.59 nM
CNCCNC(=O)c1cnccc1Nc1cc(-c2ccc(F)cc2F)nc2[nH]ccc12 CHEMBL4470980 pIC50 12.59 nM
O=C(NC1CC1)c1cnccc1Nc1cc(-c2ccc(F)cc2F)nc2[nH]ccc12 CHEMBL4452818 pIC50 12.59 nM
CN(C)CCn1cc(-c2ccc3c(-c4cnc5ccc(-c6cc(F)ccc6F)cn45)ccnc3c2)cn1 CHEMBL4853270 IC50 12.74 nM
Cc1cccc(-n2nc3c(c2-c2cc4cnccc4s2)CCC3)n1 CHEMBL3704652 IC50 12.9 nM
Cc1cccc(-c2[nH]c(NCc3ccc(Cl)c(F)c3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5273695 IC50 12.9 nM
CS(=O)(=O)c1ccc(/C=C/C2CC(Nc3ccnc(-c4cc(F)ccc4F)c3)=CC=N2)cc1 CHEMBL4854949 IC50 12.94 nM
COc1cc(Nc2cc(Oc3ccc(C)nc3-c3ccccn3)ccn2)cc(OC)c1OC CHEMBL583964 IC50 13.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3ccccc3)cc2-c2ccc3nccnc3c2)n1 CHEMBL1824440 IC50 13.0 nM
Cc1cccc(-n2nccc2-c2ccc3ncn(C)c(=O)c3c2)n1 CHEMBL2024684 IC50 13.0 nM
CCCCNCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208005 IC50 13.0 nM
Cc1cccc(-c2[nH]c(COc3ccccc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260564 IC50 13.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260566 IC50 13.0 nM
CC(=O)c1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260594 IC50 13.0 nM
Cc1cccc(NCc2nc(-c3ccc4nsnc4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL4574187 IC50 13.0 nM
CC(C)N1CCN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)CC1 CHEMBL4633398 IC50 13.0 nM
N#Cc1ccc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)cc1N1CC(O)C1 CHEMBL4635820 IC50 13.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL4752915 IC50 13.0 nM
OC1(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)CCC(F)(F)CC1 CHEMBL5175843 IC50 13.0 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CCC(F)(F)CC3)ccn2)ccn1 CHEMBL4777294 IC50 13.2 nM
OC(c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CC(F)(F)C3)ccn2)ccn1)C(F)(F)F CHEMBL4788502 IC50 13.2 nM
Cc1cccc(-c2nc(NCc3cccc(C(N)=O)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2088219 IC50 13.6 nM
C=Cc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3ccc(F)c(C)n3)[nH]2)c1 CHEMBL3634801 IC50 13.7 nM
Cc1csc(-c2nc(C(C)(C)C)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2207994 IC50 14.0 nM
Cc1cc(C)cc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260625 IC50 14.0 nM
COc1cc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc(OC)c1 CHEMBL3260626 IC50 14.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3C)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260570 IC50 14.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3C(C)C)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260572 IC50 14.0 nM
COc1ccccc1NCc1nc(-c2ccc3ncnn3c2)c(-c2cccc(C)n2)[nH]1 CHEMBL3260573 IC50 14.0 nM
C=Cc1ccccc1NCc1nc(-c2ccc3ncnn3c2)c(-c2cccc(C)n2)[nH]1 CHEMBL3260576 IC50 14.0 nM
COc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260587 IC50 14.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3)nc2-c2ccc3nsnc3c2)n1 CHEMBL4464656 IC50 14.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3C)nc2-c2cc3cnccc3s2)n1 CHEMBL4474911 IC50 14.0 nM
CC1(O)CN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccc2C#N)C1 CHEMBL4641072 IC50 14.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL4756404 IC50 14.0 nM
CC1(C#N)CN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)C1 CHEMBL5203962 IC50 14.0 nM
CN(C)C(=O)N[C@@H](CO)C(=O)O CHEMBL5267264 IC50 14.0 nM
Cc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3nccnc3c2)n1 CHEMBL401570 IC50 14.3 nM
CN(C)CCn1cc(-c2ccc3c(Nc4ccnc(-c5ccc(F)cc5)c4)ccnc3c2)cn1 CHEMBL4867342 IC50 14.61 nM
C=C(C)[C@@H]1C/C=C(\C)C(=O)CCC2=C[C@@H]1OC2=O CHEMBL4533719 IC50 14.9 nM
Cc1cccc(-c2nn3c(c2-c2ccc4[nH]cnc4c2)CCC3)n1 CHEMBL382838 IC50 15.0 nM
CN(C)CCOc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL424676 IC50 15.0 nM
CCc1cccc(-c2[nH]c(CNc3cccc(C(N)=O)c3)nc2-c2ccc3nccnc3c2)n1 CHEMBL376119 IC50 15.0 nM
Cc1nc(-c2nc(N3CCOCC3)[nH]c2-c2ccc3ncnn3c2)ccc1F CHEMBL520104 Ki 15.0 nM
CN(C)CCCc1cccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)c1 CHEMBL567706 IC50 15.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1 CHEMBL1272020 IC50 15.0 nM
Cc1cccc(-c2[nH]c(CNc3cc(Cl)cc(Cl)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260624 IC50 15.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3NS(C)(=O)=O)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260579 IC50 15.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(NS(C)(=O)=O)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260596 IC50 15.0 nM
CC(=O)Nc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260597 IC50 15.0 nM
CNS(=O)(=O)c1cccc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)c1 CHEMBL4637746 IC50 15.0 nM
FC1(F)CN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)C1 CHEMBL5190833 IC50 15.0 nM
Cc1cccc(-c2nc(NCc3cc(Cl)cc(Cl)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2088213 IC50 15.1 nM
CC(=O)N1CCN(c2nc(-c3ccc(F)c(C)n3)c(-c3ccc4ncnn4c3)[nH]2)CC1 CHEMBL480582 Ki 15.2 nM
Cc1cccc(-c2[nH]c(CNc3cc(CN(C)C)ccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260628 IC50 15.3 nM
Cc1cccc(-c2nc(NCc3ccccc3Cl)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087979 IC50 15.5 nM
Cc1cccc(-c2nn(C(=S)Nc3ccc(C(N)=O)cc3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835533 IC50 15.6 nM
Cc1cccc(-c2nc(NCc3ccc(Cl)cc3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087973 IC50 15.8 nM
Cc1ccc(F)c(-c2cc(Nc3ccnc4cn[nH]c34)ccn2)c1 CHEMBL4092523 pIC50 15.85 nM
Cc1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccnc2cn[nH]c12 CHEMBL4084771 pIC50 15.85 nM
CNC(=O)n1ncc2nccc(Nc3cc(-c4cc(Cl)ccc4F)ncc3C)c21 CHEMBL4093090 pIC50 15.85 nM
CNC(=O)Cn1ncc2nccc(Nc3cc(-c4cc(C)ccc4F)ncc3C)c21 CHEMBL4103188 pIC50 15.85 nM
C[C@H](O)CNC(=O)c1cnccc1Nc1cc(-c2ccc(F)cc2F)nc2[nH]ccc12 CHEMBL4443611 pIC50 15.85 nM
Cc1cccc(-c2nc(Nc3ccncc3)c3c(C)csc3n2)n1 CHEMBL564250 IC50 16.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C(C)C)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260586 IC50 16.0 nM
Cc1ccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL3260601 IC50 16.0 nM
Cc1ccc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)cc1S(N)(=O)=O CHEMBL4646258 IC50 16.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(F)cc3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL4784124 IC50 16.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)NCC(N)=O CHEMBL5290769 IC50 16.0 nM
Oc1ccc(-c2ccc3c(Nc4ccnc(-c5cc(F)ccc5F)c4)ccnc3c2)cc1 CHEMBL4858091 IC50 16.24 nM
Cc1nc(-c2nc(N3CCN(C)CC3)[nH]c2-c2ccc3ncnn3c2)ccc1F CHEMBL480581 Ki 16.4 nM
COc1cc(CNc2nc(-c3cccc(C)n3)c(-c3ccc4ncnn4c3)s2)cc(OC)c1 CHEMBL2088218 IC50 16.5 nM
Cc1cccc(-c2nc(NCc3ccccc3C)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087980 IC50 16.9 nM
NC(=O)c1ccc(-c2nc(-c3ccccn3)c(-c3ccc4c(c3)OCO4)[nH]2)cc1 CHEMBL440084 Ki 17.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C\Nc1ccc(N(CCCN(C)C)C(C)=O)cc1 CHEMBL1271965 IC50 17.0 nM
CCCS(=O)(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208015 IC50 17.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(C)c(C)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260621 IC50 17.0 nM
COC(=O)c1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL3260595 IC50 17.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(F)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260598 IC50 17.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(Br)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260600 IC50 17.0 nM
Cc1cccc(-c2ncn(C)c2-c2ccc3nccn3c2)c1 CHEMBL4534989 IC50 17.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(F)c3)nc2-c2cc3cnccc3s2)n1 CHEMBL4576341 IC50 17.0 nM
c1cc(Oc2cn(C3CC3)nc2C2CCOCC2)cc(Nc2ccnc(NC3CCOCC3)c2)n1 CHEMBL4647548 IC50 17.0 nM
Cc1cccc(-c2[nH]c(NCc3ccc(Cl)c(Cl)c3)nc2-c2ccc3[nH]ncc3c2)n1 CHEMBL5270406 IC50 17.3 nM
Cc1cccc(-c2[nH]c(CNc3cc(C#N)cc(CN4CCCC4)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260902 IC50 17.8 nM
O=C(NC1CCOCC1)c1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL202887 IC50 18.0 nM
CN(C)CCNC(=O)Nc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL565814 IC50 18.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3cccc(C#N)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL3261096 IC50 18.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C)c3C)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260616 IC50 18.0 nM
O=C(Nc1ccccc1)c1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL4752410 IC50 18.0 nM
CS(=O)(=O)c1ccc(-c2ccc3nccc(Nc4ccnc(-c5cc(F)ccc5F)c4)c3c2)cc1 CHEMBL4875083 IC50 18.48 nM
Cc1cccc(-n2nc3c(c2-c2cc4ccncc4s2)CCC3)n1 CHEMBL3704655 IC50 18.9 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(CN4CCCC4)cc3)c2)nc1 CHEMBL205570 IC50 19.0 nM
ClCCOc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL204575 IC50 19.0 nM
COCCC(=O)Nc1nc(-c2ccc(F)c(C)n2)c(-c2ccc3nccnc3c2)[nH]1 CHEMBL480731 Ki 19.0 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2cccc(Cl)c2)c(=O)n1C CHEMBL592977 Ki 19.0 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2cccc(NS(C)(=O)=O)c2)c(=O)n1C CHEMBL607429 Ki 19.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL1272289 IC50 19.0 nM
COc1cccc(-c2nc(Nc3ccncc3)c3cccn3n2)n1 CHEMBL4218893 IC50 19.0 nM
Cc1cccc(NCc2nc(-c3cc4cnccc4s3)c(-c3cccc(C)n3)[nH]2)c1 CHEMBL4543738 IC50 19.0 nM
Cc1cccc(-c2nc(NCc3cccc(OC(F)(F)F)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087970 IC50 19.3 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3-c3ccc(F)cc3)ccn2)ccn1 CHEMBL4792452 IC50 19.7 nM
COc1cccc2nccc(Nc3ccnc(-c4cc(Cl)ccc4F)c3)c12 CHEMBL4077722 pIC50 19.95 nM
Cc1cnc(-c2cc(F)ccc2F)cc1Nc1ccnc2cn(CC(C)O)nc12 CHEMBL4088735 pIC50 19.95 nM
Fc1cc(F)c(-c2cc(Nc3ccncc3)c3cc[nH]c3n2)cc1Cl CHEMBL4437930 pEC50 19.95 nM
Cn1c(=O)n(-c2cc(-c3ccc(F)cc3F)nc3[nH]ccc23)c2ccncc21 CHEMBL4513488 pIC50 19.95 nM
O=C(NC1CC1)c1cnccc1Nc1cc(-c2cc(Cl)ccc2F)nc2[nH]ccc12 CHEMBL4483492 pIC50 19.95 nM
Nc1nc(-c2ccccn2)c(-c2ccc3ncccc3n2)s1 CHEMBL181361 IC50 20.0 nM
Cc1csc(-c2nc(Nc3ccncc3)c3ccccc3n2)n1 CHEMBL541777 IC50 20.0 nM
Cc1cccc(-c2c(-c3ccc4nccnc4c3)n(C)n(C)c2=O)c1 CHEMBL604261 Ki 20.0 nM
COc1cccc(-c2c(-c3ccc4nccnc4c3)n(C)n(C)c2=O)c1 CHEMBL606376 Ki 20.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3C#N)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260577 IC50 20.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)N[C@@H](C)CO CHEMBL5288333 IC50 20.0 nM
Fc1ccc(F)c(-c2cc(Nc3ccnc4ccccc34)ccn2)c1 CHEMBL4877712 IC50 20.12 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C(N)=O)c3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL389078 IC50 21.0 nM
Cc1cc(Oc2ccnc(Nc3ccc(S(N)(=O)=O)cc3)c2)c(-c2ccccn2)nc1C CHEMBL578235 IC50 21.0 nM
COc1cc(Nc2cc(Oc3ccc(C)nc3C)ccn2)cc(OC)c1OC CHEMBL574415 IC50 21.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(C(N)=O)cc3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL229597 IC50 21.0 nM
Cc1csc(-c2nc(C3CCOCC3)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2208001 IC50 21.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C#N)c3C#N)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260618 IC50 21.0 nM
Cc1cccc(-c2[nH]c(CSc3ccccc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260565 IC50 21.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3C)nc2-c2ccc3nsnc3c2)n1 CHEMBL4534375 IC50 21.0 nM
c1cc(Oc2cn(C3CC3)nc2C2CCOCC2)cc(Nc2cnn(C3CCOCC3)c2)n1 CHEMBL4648725 IC50 21.0 nM
O=C(N[C@@H](CO)C(=O)O)C1CC1 CHEMBL5290233 IC50 21.0 nM
Cc1cccc(-c2sc(NCc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL2088224 IC50 21.2 nM
Cc1cccc(-c2[nH]c(NCc3ccccc3F)nc2-c2ccc3[nH]nc(C)c3c2)n1 CHEMBL5282246 IC50 21.4 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3-c3ccc4c(c3)OCO4)ccn2)ccn1 CHEMBL4784194 IC50 21.7 nM
Cc1cccc(-c2nc(NCc3ccc(Cl)c(Cl)c3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087986 IC50 21.9 nM
COc1ccc(-c2ccc3c(Nc4ccnc(-c5cc(F)ccc5F)c4)ccnc3c2)cc1 CHEMBL4857030 IC50 21.93 nM
Cc1cccc(-c2nn3c(c2-c2ccc4ncn(C)c4c2)CCC3)n1 CHEMBL204966 IC50 22.0 nM
Cc1cccc(-c2nc(Nc3ccncc3)c3sccc3n2)n1 CHEMBL556871 IC50 22.0 nM
Cc1cccc(-c2cc(Nc3ccncc3)c3ccccc3n2)n1 CHEMBL560815 IC50 22.0 nM
Cc1ccc(Oc2ccnc(Nc3ccc(S(N)(=O)=O)cc3)c2)c(C)n1 CHEMBL585367 IC50 22.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3cccc(C#N)c3)cc2-c2ccc3ncccc3c2)n1 CHEMBL1766441 IC50 22.0 nM
Cc1cc(C)cc(CNc2nc(-c3cccc(C)n3)c(-c3ccc4ncnn4c3)s2)c1 CHEMBL2088215 IC50 22.0 nM
Cc1cccc(-c2[nH]c(CNC(=S)c3cccc(C(N)=O)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3261090 IC50 22.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)nc2)ccn1 CHEMBL4289841 IC50 22.0 nM
Cc1ccc(NCc2nc(-c3ccc4nsnc4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL4553389 IC50 22.0 nM
OC1(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)COC1 CHEMBL5173141 IC50 22.0 nM
Cc1cccc(-c2nc(NCc3cccc(C)c3C)sc2-c2ccc3ncnn3c2)n1 CHEMBL2088214 IC50 22.1 nM
Cc1cccc(-c2[nH]c(CNc3cccc(CN4CCCC4)c3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260630 IC50 22.1 nM
Cc1csc(-c2nc(C3CCC(=O)CC3)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2208000 IC50 23.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(OC(F)(F)F)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260588 IC50 23.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2cc3cnccc3s2)n1 CHEMBL4516224 IC50 23.0 nM
Cc1cccc(-n2nccc2-c2cc3cnccc3s2)n1 CHEMBL3704648 IC50 23.4 nM
Cc1cccc(-c2[nH]nc(C)c2-c2ccnc3ccccc23)n1 CHEMBL129153 IC50 24.0 nM
COc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL202891 IC50 24.0 nM
FC(F)(F)c1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL383523 IC50 24.0 nM
Cc1cccc(-c2[nH]c(NCc3cccc(C#N)c3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL226734 IC50 24.0 nM
CN(C)CCOc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL409525 IC50 24.0 nM
Cc1cccc(-c2[nH]c(NCc3ccc(C#N)cc3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL445934 IC50 24.0 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2cccc(CC#N)c2)c(=O)n1C CHEMBL593710 Ki 24.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL1271472 IC50 24.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3C)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL4780013 IC50 24.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)NC(CO)CO CHEMBL5095192 IC50 24.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)NC[C@H](C)O CHEMBL5289691 IC50 24.0 nM
COc1ccc(CNc2nc(-c3cccc(C)n3)c(-c3ccc4ncnn4c3)s2)cc1 CHEMBL2087975 IC50 24.3 nM
OC1(C(F)(F)F)CCN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CC(F)(F)C4)ccn3)ccn2)CC1 CHEMBL4780548 IC50 24.3 nM
Cc1cccc(-c2[nH]c(NCc3cccc(C#N)c3)nc2-c2ccc3c(cnn3C)c2)n1 CHEMBL5287255 IC50 24.4 nM
Cc1cccc(-c2sc(NCc3ccccc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL2088221 IC50 24.5 nM
CC(=O)COc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL202943 IC50 25.0 nM
Cc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)n1 CHEMBL537968 IC50 25.0 nM
Cc1cccc(-c2nc(C(C)C)[nH]c2-c2ccnc(-c3ccc(C(=O)NC4CCOCC4)cc3)c2)n1 CHEMBL585505 IC50 25.0 nM
Cc1cccc(-c2nn(CCC(=O)Nc3ccccc3)cc2-c2ccc3ncccc3c2)n1 CHEMBL1766450 IC50 25.0 nM
CCC(=O)NCCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208012 IC50 25.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(CC#N)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260609 IC50 25.0 nM
CC(=O)Nc1cc(Nc2nc(-c3cccc(C(F)(F)F)n3)nn3cccc23)c(F)cn1 CHEMBL4206910 IC50 25.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3)nc2-c2cc3cnccc3s2)n1 CHEMBL4447399 IC50 25.0 nM
Cc1cnc(-c2cc(Cl)ccc2F)cc1-n1c(=O)n(CC(N)=O)c2cnccc21 CHEMBL4564126 IC50 25.0 nM
OCCN1CCN(c2ccc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)cc2C(F)(F)F)CC1 CHEMBL5177566 IC50 25.0 nM
Cc1cccc(-c2sc(NCc3cccc(C#N)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL2088222 IC50 25.1 nM
Nc1nc(Nc2ccccc2)cc(-c2ccc3c(N)n[nH]c3c2)n1 CHEMBL1765876 pIC50 25.12 nM
CCc1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccnc2cccc(OC)c12 CHEMBL4066735 pIC50 25.12 nM
COc1cccc2nccc(Nc3ccnc(-c4cc(C)ccc4F)c3)c12 CHEMBL4070456 pIC50 25.12 nM
NC(=O)Cn1cc2nccc(Nc3ccnc(-c4cc(F)ccc4F)c3)c2n1 CHEMBL4082821 pIC50 25.12 nM
Fc1ccc(-c2cc(Nc3ccncc3)c3cc[nH]c3n2)c(F)c1 CHEMBL4446613 pEC50 25.12 nM
Cc1cccc(-c2nc(NCc3ccc(C(N)=O)cc3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2088220 IC50 25.7 nM
Cc1cccc(-c2[nH]c(Cc3cccc(C#N)c3)nc2-c2ccc3ncccc3c2)n1 CHEMBL1165374 IC50 26.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3cccc(C#N)c3)cc2-c2ccc3nccnc3c2)n1 CHEMBL1824442 IC50 26.0 nM
CC(=O)NCCCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208013 IC50 26.0 nM
Cc1csc(-c2nc(CN3CCCC3=O)[nH]c2-c2ccc3ncsc3c2)n1 CHEMBL2208003 IC50 26.0 nM
FC1(F)CC(c2nn(C3CC3)cc2Oc2ccnc(Nc3ccnc(N4CCOCC4)c3)c2)C1 CHEMBL4786439 IC50 26.0 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN[C@H](C)C5)nc4)c3n2)[C@@H](C)C1 CHEMBL5184000 IC50 26.0 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3-c3ccccc3)ccn2)ccn1 CHEMBL4777871 IC50 26.2 nM
COC(=O)c1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL203436 IC50 27.0 nM
O=C(O)c1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL568357 IC50 27.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3cccc(C#N)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL3261093 IC50 27.0 nM
Cc1cccc(-c2[nH]c(CNC(=S)c3ccccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3261088 IC50 27.0 nM
c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 CHEMBL513147 IC50 27.15 nM
OC1(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CC(F)(F)C4)ccn3)ccn2)CCC(F)(F)CC1 CHEMBL4797329 IC50 27.5 nM
Cc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL205156 IC50 28.0 nM
CCCC(=O)N(C)Cc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208004 IC50 28.0 nM
NS(=O)(=O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)ccc1F CHEMBL4646566 IC50 28.0 nM
CC(C)(O)C1CN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)C1 CHEMBL5207994 IC50 28.0 nM
CC(C)(O)c1cc2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccc2cn1 CHEMBL5175051 IC50 28.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN(C)C)cc1)c1ccccc1 CHEMBL1271470 IC50 29.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3ccccc3F)cc2-c2ccc3ncnn3c2)n1 CHEMBL3261095 IC50 29.0 nM
Cc1cccc(-c2nc(NCc3cccc(F)c3F)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087982 IC50 29.4 nM
CN(C)c1ccc(-c2ccc3c(Nc4ccnc(-c5cc(F)ccc5F)c4)ccnc3c2)cn1 CHEMBL4857982 IC50 29.4 nM
Cc1ccnc2ccc(-c3sc(N)nc3-c3ccccn3)nc12 CHEMBL182354 IC50 30.0 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(OCCn4ccnc4)cc3)c2)nc1 CHEMBL208437 IC50 30.0 nM
COc1ccc(Nc2cc(Oc3cc(C)c(C)nc3-c3ccccn3)ccn2)cc1 CHEMBL573287 IC50 30.0 nM
Cc1cccc2ccc(-c3sc(N)nc3-c3ccccn3)nc12 CHEMBL565643 IC50 30.0 nM
Cc1csc(-c2nc(CCCCC(=O)O)[nH]c2-c2ccc3c(c2)OCO3)n1 CHEMBL1957662 IC50 30.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3C(N)=O)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260578 IC50 30.0 nM
C=Cc1ccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL3260606 IC50 30.0 nM
COc1cc(-c2cnn3cc(-c4ccc(N5CCNCC5)cc4)cnc23)cc(OC)c1OC CHEMBL3341794 IC50 30.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3ccccc3)cc2-c2ccc3nsnc3c2)n1 CHEMBL4569982 IC50 30.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3cccc(F)c3)cc2-c2ccc3nsnc3c2)n1 CHEMBL4527908 IC50 30.0 nM
Cn1cc(-c2nn(C3CC3)cc2Oc2ccnc(Nc3ccnc(C(C)(C)O)c3)c2)cn1 CHEMBL4781586 IC50 30.2 nM
Cc1cccc(-c2nc(NCc3ccc(C#N)cc3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087977 IC50 30.8 nM
Cc1cccc(-c2n[nH]cc2-c2ccc(O)cc2)n1 CHEMBL118928 IC50 31.0 nM
Cc1cccc(-c2[nH]c(NCc3ccccc3F)nc2-c2ccc3[nH]nc([N+](=O)[O-])c3c2)n1 CHEMBL5289384 IC50 31.2 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3-c3ccc(C#N)cc3)ccn2)ccn1 CHEMBL4790322 IC50 31.4 nM
OC1(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CC(F)(F)C4)ccn3)ccn2)COC1 CHEMBL4791955 IC50 31.4 nM
COc1cccc2nccc(Nc3cc(-c4cccc(Cl)c4)ncc3C)c12 CHEMBL4078651 pIC50 31.62 nM
CNC(=O)Cn1cc2nccc(Nc3cc(-c4cc(C)ccc4F)ncc3C)c2n1 CHEMBL4064329 pIC50 31.62 nM
Cc1cnc(-c2cc(Cl)ccc2F)cc1-n1c(=O)n(C)c2cnccc21 CHEMBL4515962 pIC50 31.62 nM
CC(C)c1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL206544 IC50 32.0 nM
O=C(CCO)Nc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL585117 IC50 32.0 nM
CNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL497724 IC50 32.0 nM
CCNCc1ccc(N/C(=C2\C(=O)Nc3cc(C(=O)N(C)CC)ccc32)c2ccccc2)cc1 CHEMBL1271471 IC50 32.0 nM
CN1CCN(c2ccc(-c3cc(-c4c[nH]nc4-c4ccccn4)ccn3)cn2)CC1 CHEMBL1829512 IC50 32.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(C#N)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260607 IC50 32.0 nM
CC1(Cn2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)cn2)COC1 CHEMBL4637443 IC50 32.0 nM
ClCCOc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL261762 IC50 33.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(C(=O)NCCN(CC)CC)cc1)c1ccccc1 CHEMBL1271524 IC50 33.0 nM
COCCC(=O)Nc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL565645 IC50 34.0 nM
Cc1cccc(-c2cn(Cc3cccc(C#N)c3)nc2-c2ccc3ncccc3c2)n1 CHEMBL1164971 IC50 34.0 nM
Cc1cccc(-c2[nH]c(Cc3cccc(C(N)=O)c3)nc2-c2ccc3ncccc3c2)n1 CHEMBL1164957 IC50 34.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL496862 IC50 34.0 nM
Cc1ccc(NCc2nc(-c3ccc4c(cnn4C)c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL4740767 IC50 34.0 nM
Cc1cccc(-c2nc(NCc3cccc(Cl)c3Cl)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087985 IC50 34.3 nM
CC(O)(c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CC(F)(F)C3)ccn2)ccn1)C(F)(F)F CHEMBL4778362 IC50 34.6 nM
Cc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL226838 IC50 34.9 nM
N#Cc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL437118 IC50 35.0 nM
COCc1cccc(-c2c(-c3ccc4nccnc4c3)n(C)n(C)c2=O)c1 CHEMBL606919 Ki 35.0 nM
CN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL496861 IC50 35.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN(C)C)cc1)c1ccccc1 CHEMBL1272290 IC50 35.0 nM
Fc1ccc(Cl)cc1-c1nc(Nc2ccncc2)c2nccnc2n1 CHEMBL238125 IC50 35.0 nM
CC(=O)NCCNC(=O)c1cnccc1Nc1cc(-c2cc(Cl)ccc2F)ncc1C(C)C CHEMBL5285430 IC50 35.0 nM
Cc1cccc(-n2nc(C)c(C)c2-c2cc3cnccc3s2)n1 CHEMBL3704653 IC50 35.2 nM
Cc1cccc(-c2nc(NCc3ccccc3OC(F)(F)F)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087981 IC50 35.9 nM
Cc1cccc(-c2nn(CC(=O)Nc3cccc(C(N)=O)c3)cc2-c2ccc3ncnn3c2)n1 CHEMBL3261094 IC50 36.0 nM
Cc1cccc(-c2[nH]c(CNC(=S)c3cccc(C#N)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3261089 IC50 36.0 nM
FC1(F)CN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)CC1(F)F CHEMBL5169537 IC50 36.0 nM
O=S1(=O)CCN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccc2C(F)(F)F)CC1 CHEMBL5176877 IC50 36.0 nM
CNC(=O)CCCc1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208009 IC50 37.0 nM
Cc1cccc(-c2[nH]c(CNC(=O)c3ccccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3261084 IC50 37.0 nM
C=C(C)C(=O)N[C@@H](CO)C(=O)O CHEMBL5266024 IC50 37.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3ccccc3)cc2-c2ccc3nccnc3c2)n1 CHEMBL1824226 IC50 38.0 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)ccn1 CHEMBL4594432 IC50 38.2 nM
CC(=O)Nc1ccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL3260613 IC50 39.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3ccccc3)cc2-c2cc3cnccc3s2)n1 CHEMBL4576703 IC50 39.0 nM
CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)NCCNS(C)(=O)=O CHEMBL5291016 IC50 39.0 nM
Cc1cccc(-c2nn(C(=S)NC3CCN(C)CC3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835709 IC50 39.47 nM
COc1cccc2nccc(Nc3ccnc(-c4nc(C)ccc4F)c3)c12 CHEMBL4100266 pIC50 39.81 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(OCCN4CCCC4)cc3)c2)nc1 CHEMBL202994 IC50 40.0 nM
Cc1cccc(-c2nc(Nc3ccncn3)c3ccccc3n2)n1 CHEMBL571452 IC50 40.0 nM
COC(=O)Nc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL584928 IC50 40.0 nM
CC(=O)Nc1ccccc1NCc1nc(-c2ccc3ncnn3c2)c(-c2cccc(C)n2)[nH]1 CHEMBL3260580 IC50 40.0 nM
CSc1ccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL3260605 IC50 40.0 nM
COC(=O)c1cnccc1Nc1cc(-c2cc(Cl)ccc2F)ncc1C(C)C CHEMBL5287924 IC50 40.0 nM
Cc1cccc(-c2[nH]ncc2-c2ccc(F)cc2)n1 CHEMBL125846 IC50 41.0 nM
Cc1cccc(-c2nn3c(c2-c2ccc4ncn(CCCO)c4c2)CCC3)n1 CHEMBL204063 IC50 41.0 nM
CC[C@@H](CO)NC(=O)c1cnccc1Nc1cc(-c2cc(Cl)ccc2F)ncc1C(C)C CHEMBL5285227 IC50 41.0 nM
Cc1cccc(-c2[nH]c(NCc3ccccc3F)nc2-c2ccc3[nH]nc(F)c3c2)n1 CHEMBL5269616 IC50 41.3 nM
Cc1cc(F)cc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3634710 IC50 41.9 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(CN4CCOCC4)cc3)c2)nc1 CHEMBL1237161 IC50 42.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(C#N)cc3)nc2-c2ccc3nccnc3c2)n1 CHEMBL229546 IC50 42.0 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(CN4CCOCC4)cc3)c2)nc1 CHEMBL203162 IC50 42.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3ccccc3)cc2-c2ccc3nsnc3c2)n1 CHEMBL4594036 IC50 42.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(F)cc3)nc2-c2cc3cnccc3s2)n1 CHEMBL4533727 IC50 42.0 nM
Clc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL204838 IC50 43.0 nM
Cc1ccc(NCc2nc(-c3cc4cnccc4s3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL4519255 IC50 43.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3cccc(F)c3)cc2-c2ccnc3ccccc23)n1 CHEMBL4638285 IC50 43.0 nM
COc1cccc(CNc2nc(-c3cccc(C)n3)c(-c3ccc4ncnn4c3)s2)c1OC CHEMBL2088216 IC50 43.5 nM
COc1ccc(-c2cn(C)nc2-c2cccc(C)n2)cc1 CHEMBL129760 IC50 44.0 nM
COc1cc(Nc2cc(Oc3cc(C)c(C)nc3-c3ccccn3)ccn2)cc(OC)c1OC CHEMBL575099 IC50 44.0 nM
COc1ccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc1OC CHEMBL3260622 IC50 44.0 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CC(F)(F)C3)ccn2)ccn1 CHEMBL4791815 IC50 44.0 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3-c3cccc4c3OCCO4)ccn2)ccn1 CHEMBL4788673 IC50 44.2 nM
CCCCNC(=O)c1nc(-c2nc(C)cs2)c(-c2ccc3ncsc3c2)[nH]1 CHEMBL2208007 IC50 45.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C#N)c3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL387747 IC50 46.0 nM
CCc1cccc(-c2[nH]c(CNc3cccc(C(N)=O)c3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL229598 IC50 46.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(C#N)cc3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL229495 IC50 46.0 nM
CCc1cccc(-c2[nH]c(CNc3ccc(C(N)=O)cc3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL389079 IC50 46.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(C(C)C)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260602 IC50 46.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1C(N)=O CHEMBL4565968 IC50 46.0 nM
N#CC1CN(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)C1 CHEMBL5199037 IC50 46.0 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(CNC4CCOCC4)cc3)c2)nc1 CHEMBL204211 IC50 47.0 nM
CCc1cccc(-c2[nH]c(CNc3ccc(C#N)cc3)nc2-c2ccc3nccnc3c2)n1 CHEMBL229548 IC50 47.0 nM
CN(C)CCCCCOc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL411855 IC50 47.0 nM
Cc1cccc(-c2nn3c(c2-c2ccc(O)cc2)CCC3)n1 CHEMBL330814 IC50 47.0 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(CNC4CCCOC4)cc3)c2)nc1 CHEMBL566234 IC50 47.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CCN(C)C)cc1)c1ccccc1 CHEMBL1271577 IC50 47.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(NS(C)(=O)=O)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260612 IC50 47.0 nM
Cc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL1824446 IC50 47.0 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3C4COCC43)ccn2)ccn1 CHEMBL4795823 IC50 47.2 nM
COc1ccc(CNc2nc(-c3cccc(C)n3)c(-c3ccc4ncnn4c3)s2)cc1OC CHEMBL2088217 IC50 47.7 nM
Fc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL381948 IC50 48.0 nM
Cc1cccc(-c2nn3c(c2-c2ccnc4cc(Cl)ccc24)CCC3)n1 CHEMBL332344 IC50 48.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3cccc(C(N)=O)c3)cc2-c2ccc3nccnc3c2)n1 CHEMBL1824444 IC50 48.0 nM
Cc1cccc(-c2[nH]c(CNC(=S)c3ccccc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3261087 IC50 48.0 nM
COc1ccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL3260603 IC50 48.0 nM
Cc1cccc(-c2[nH]c(NCc3ccccc3F)nc2-c2ccc3[nH]cnc3c2)n1 CHEMBL5272038 IC50 48.2 nM
CN1CCN(C(=O)COc2ccc3c(-c4c(-c5ccccn5)nn5c4CCC5)ccnc3c2)CC1 CHEMBL409356 IC50 49.0 nM
Clc1cccc(-c2nc(Nc3ccncc3)c3ccccc3n2)c1 CHEMBL571451 IC50 49.0 nM
COc1cc(-c2cc(-c3cccc(N4CCNCC4)c3)cnc2N)cc(OC)c1OC CHEMBL3341944 IC50 49.0 nM
COc1cccc2nccc(Nc3cc(-c4cc(Cl)ccc4F)ncc3C3CC3)c12 CHEMBL4094260 pIC50 50.12 nM
NC(=O)Cn1ncc2nccc(Nc3ccnc(-c4cc(F)ccc4F)c3)c21 CHEMBL4089166 pIC50 50.12 nM
Cc1cccc(-c2nn3c(c2-c2ccc4ncn(CCCN5CCCCC5)c4c2)CCC3)n1 CHEMBL377711 IC50 51.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3cccc(C#N)c3)cc2-c2ccc3ncccc3c2)n1 CHEMBL1766454 IC50 51.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C\Nc1ccc(N(C)C(=O)CN(C)C)cc1 CHEMBL1272076 IC50 52.0 nM
COc1cc(-c2cncc(-c3ccc(N4C[C@@H](C)N(C)[C@@H](C)C4)cc3)c2C)cc(OC)c1C(N)=O CHEMBL4526828 IC50 52.0 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5[C@H](C)CN(C(=O)N6CCCC6)C[C@@H]5C)nc34)cn2)CCN1 CHEMBL5199417 IC50 52.0 nM
Cc1cccc(-c2nn3c(c2-c2ccc4ncn(CCCN(C)C)c4c2)CCC3)n1 CHEMBL441176 IC50 53.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3ccccc3F)cc2-c2ccnc3ccccc23)n1 CHEMBL4638492 IC50 53.0 nM
Cc1nc(-c2nc(N3CCCCC3)[nH]c2-c2ccc3ncnn3c2)ccc1F CHEMBL481546 Ki 53.2 nM
Clc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL121554 IC50 54.0 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2ccsc2)c(=O)n1C CHEMBL593951 Ki 54.0 nM
Cc1csc(-c2nc(-c3ccc(C(N)=O)cc3)[nH]c2-c2ccc3c(c2)OCO3)n1 CHEMBL1957649 IC50 54.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(C(N)=O)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260608 IC50 55.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3ccccc3F)cc2-c2ccc3nsnc3c2)n1 CHEMBL4461256 IC50 55.0 nM
Cc1cccc(-c2[nH]ncc2-c2ccc(Cl)cc2)n1 CHEMBL125738 IC50 57.0 nM
Cc1cccc(-c2[nH]c(CNC(=O)c3ccccc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3261083 IC50 57.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3ccccc3)cc2-c2ccnc3ccccc23)n1 CHEMBL4649639 IC50 57.0 nM
COc1cccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)c1OC CHEMBL3260617 IC50 58.0 nM
Fc1ccccc1-c1cc(-c2c[nH]nc2-c2ccccn2)ccn1 CHEMBL205427 IC50 59.0 nM
Nc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL585700 IC50 59.0 nM
CC(=O)c1ccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL3260610 IC50 59.0 nM
CSc1cccc(-c2c(-c3ccc4nccnc4c3)n(C)n(C)c2=O)c1 CHEMBL595578 Ki 60.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(OC(F)(F)F)cc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260604 IC50 60.0 nM
Cc1cccc(-c2nc(NCc3ccc(OC(F)(F)F)cc3)sc2-c2ccc3ncnn3c2)n1 CHEMBL2087976 IC50 60.9 nM
Cc1cccc(-c2cn(Cc3cccc(C(N)=O)c3)nc2-c2ccc3ncccc3c2)n1 CHEMBL1165063 IC50 61.0 nM
O=C(C1CC1)N1CC2(C1)CC(O)(c1cc(Nc3cc(Oc4cn(C5CC5)nc4C4CC(F)(F)C4)ccn3)ccn1)C2 CHEMBL4784622 IC50 61.3 nM
Cc1cccc(-c2nc(Nc3ccncc3C(=O)NC(C)C)c3cccn3n2)n1 CHEMBL4210079 IC50 62.0 nM
Cc1cc(Oc2ccnc(Nc3ccc(F)cc3)c2)c(-c2ccccn2)nc1C CHEMBL574199 IC50 63.0 nM
CCCC(=O)NCc1nc(-c2nc(C)cs2)c(-c2ccc3c(c2)OCO3)[nH]1 CHEMBL1957656 IC50 63.0 nM
FC(F)(F)c1cc(Nc2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CCOCC4)ccn3)ccn2)ccn1 CHEMBL5178134 IC50 63.0 nM
CN(C)CC(=O)Nc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL259821 IC50 64.0 nM
CCN(CC)CCNC(=O)c1ccc(N/C(=C2\C(=O)Nc3cc(C(=O)N(C)CC)ccc32)c2ccccc2)cc1 CHEMBL1271576 IC50 64.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CCN(C)C)cc1)c1ccccc1 CHEMBL1271631 IC50 64.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(OC)c1C(N)=O CHEMBL4468389 IC50 66.0 nM
Cc1cccc(-c2nn(C(=S)Nc3cccc(C(N)=O)c3)cc2-c2ccc3nc(C)nn3c2)n1 CHEMBL1835713 IC50 66.8 nM
Cc1cccc(-c2[nH]c(NCc3ccccc3F)nc2-c2ccc3[nH]nc(Cl)c3c2)n1 CHEMBL5281232 IC50 66.9 nM
Cn1cc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cn1 CHEMBL1828640 IC50 68.0 nM
Cc1cccc(-c2nn3c(c2-c2ccc4ncn(CCCN5CCOCC5)c4c2)CCC3)n1 CHEMBL381532 IC50 69.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C\Nc1ccc(CN2CCCCC2)cc1 CHEMBL1272021 IC50 69.0 nM
CCn1cnc2ccc(-c3ccnn3-c3cccc(C)n3)cc2c1=O CHEMBL2024692 IC50 69.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3cccc(C#N)c3)cc2-c2ccnc3ccccc23)n1 CHEMBL4649719 IC50 69.0 nM
OC1(c2cc(Nc3cc(Oc4cn(C5CC5)nc4C4CC(F)(F)C4)ccn3)ccn2)CN(CC(F)(F)F)C1 CHEMBL4781326 IC50 69.2 nM
CCc1cccc(-c2nn3c(c2-c2ccnc4ccccc24)CCC3)n1 CHEMBL122583 IC50 71.0 nM
O=C(CCO)N[C@@H](CO)C(=O)O CHEMBL5273556 IC50 71.0 nM
CN1CCCC1CCCOc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL406411 IC50 72.0 nM
Cc1cc(F)cc(-c2[nH]c(CNc3ccccc3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3634709 IC50 72.5 nM
CCc1cccc(-c2[nH]c(CNc3cccc(C#N)c3)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL229496 IC50 73.0 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2ccoc2)c(=O)n1C CHEMBL609582 Ki 73.0 nM
Cc1cccc(-c2nn3c(c2-c2ccc4ncn(CCCN5CCCC5)c4c2)CCC3)n1 CHEMBL206233 IC50 74.0 nM
CN1CCN(CCCOc2ccc3c(-c4c(-c5ccccn5)nn5c4CCC5)ccnc3c2)CC1 CHEMBL261674 IC50 74.0 nM
Cc1cccc(-c2[nH]c(CNc3ccc(C(N)=O)cc3)nc2-c2ccc3nccnc3c2)n1 CHEMBL229654 IC50 75.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3cccc(C(N)=O)c3)cc2-c2ccc3ncccc3c2)n1 CHEMBL1766444 IC50 75.0 nM
CN1CCN(c2ccc(-c3cnc4c(-c5ccnc6ccccc56)cnn4c3)cc2)CC1 CHEMBL2385596 IC50 75.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C)CC4)cc3)c2C)cc(OC)c1C(N)=O CHEMBL4435320 IC50 75.0 nM
O=C(O)[C@H](CO)NC(=O)N1CCCC1 CHEMBL5276114 IC50 75.0 nM
Fc1ccc(-c2n[nH]cc2-c2ccnc3ccccc23)nc1 CHEMBL340203 IC50 76.0 nM
Cc1cccc(-c2[nH]c(NCc3ccccc3F)nc2-c2ccc3[nH]nnc3c2)n1 CHEMBL5282344 IC50 76.5 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-n3cccn3)c2)nc1 CHEMBL1829504 IC50 77.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 77.0 nM
CC(C)(O)Cn1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)cn1 CHEMBL4640043 IC50 77.0 nM
Cc1cccc(-c2nn3c(c2-c2ccnc4ccccc24)CCC3)n1 CHEMBL119976 IC50 78.0 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2ccccc2)c(=O)n1C CHEMBL592999 Ki 78.0 nM
Cn1c(-c2ccc3nccnc3c2)c(-c2cccc(F)c2)c(=O)n1C CHEMBL593000 Ki 78.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3ccccc3)cc2-c2ccc3ncnn3c2)n1 CHEMBL3261091 IC50 78.0 nM
COC(=O)c1ccc(NCc2nc(-c3ccc4ncnn4c3)c(-c3cccc(C)n3)[nH]2)cc1 CHEMBL3260611 IC50 78.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3cccc(C#N)c3)cc2-c2cc3cnccc3s2)n1 CHEMBL4513885 IC50 78.0 nM
OCCCn1cnc2ccc(-c3c(-c4ccccn4)nn4c3CCC4)cc21 CHEMBL203619 IC50 79.0 nM
O=C(Nc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1)OCCO CHEMBL566439 IC50 79.0 nM
Oc1cc(Nc2ccnc3cc(-c4ccccc4)ccc23)ccc1Cl CHEMBL4873767 IC50 79.0 nM
COC(=O)N[C@@H](CO)C(=O)O CHEMBL5277114 IC50 79.0 nM
Cc1cccc(-c2cc(Nc3ccncc3)c3cc[nH]c3n2)n1 CHEMBL4572312 pIC50 79.43 nM
Cc1cccc(-c2nn3c(c2-c2ccc(O)cc2)C(C)C(C)(C)C3)n1 CHEMBL4277021 IC50 80.0 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-c3ccc(OCCC4CCCCC4)cc3)c2)nc1 CHEMBL379700 IC50 81.0 nM
Cc1cccc(-c2nn(CCC(=O)Nc3ccccc3)cc2-c2ccc3nccnc3c2)n1 CHEMBL1824438 IC50 82.0 nM
CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3-c3ccncc3)ccn2)ccn1 CHEMBL4777610 IC50 84.0 nM
CCN(C)CCOc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL411297 IC50 85.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3ccccc3F)cc2-c2ccc3ncnn3c2)n1 CHEMBL3261092 IC50 85.0 nM
Cc1cccc(-c2nn(C(=S)Nc3cccc(C#N)c3)cc2-c2ccc3nc(C)nn3c2)n1 CHEMBL1835712 IC50 85.3 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CC(=O)N(C)C)S(C)(=O)=O)cc1)c1ccccc1 CHEMBL1271683 IC50 86.0 nM
CC(=O)Nc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1 CHEMBL565815 IC50 87.0 nM
Cc1cccc(-c2nn(CC(=O)Nc3cccc(F)c3)cc2-c2ccc3nsnc3c2)n1 CHEMBL4471215 IC50 87.0 nM
COc1ccc(OC)c(/C=C/C(=O)Nc2sc3c(c2C#N)CCCC3)c1 CHEMBL5218580 IC50 87.0 nM
N#Cc1c(NC(=O)/C=C/c2ccc(O)cc2)sc2c1CCC2 CHEMBL5219198 IC50 87.0 nM
COc1ccc(OC)c(/C=C/C(=O)Nc2sc3c(c2C#N)CCC3)c1 CHEMBL5220468 IC50 87.0 nM
CCOc1ccc2c(-c3c(-c4cccc(C)n4)nn4c3CCC4)ccnc2c1 CHEMBL120587 IC50 88.0 nM
Cc1cccc(-c2nn(CCC(=S)Nc3ccccc3)cc2-c2ccc3ncccc3c2)n1 CHEMBL1766455 IC50 88.0 nM
c1ccc(-c2n[nH]cc2-c2ccnc(-n3ccnc3)c2)nc1 CHEMBL1829505 IC50 88.0 nM
Cc1cccc(-c2nn3c(c2-c2ccnc4ccc(Br)cc24)CCC3)n1 CHEMBL260923 IC50 89.0 nM
Cc1csc(-c2nc(N)[nH]c2-c2ccc3c(c2)OCO3)n1 CHEMBL1957670 IC50 90.0 nM
Cc1cccc(-c2[nH]c(CNC(=O)c3cccc(C#N)c3)nc2-c2ccc3ncnn3c2)n1 CHEMBL3261085 IC50 90.0 nM
COCCNC(=O)c1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 CHEMBL205151 IC50 91.0 nM
CCCCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL1271578 IC50 91.0 nM
CN(C)CCn1cc(-c2ccc3c(-n4ccc5cnc(-c6cc(F)ccc6F)nc54)ccnc3c2)cn1 CHEMBL4870460 IC50 91.72 nM
CCc1cccc(-c2[nH]c(CNc3ccc(C(N)=O)cc3)nc2-c2ccc3nccnc3c2)n1 CHEMBL226733 IC50 92.0 nM
Cc1cccc(-c2nc(C)cc(Nc3ccncc3)n2)n1 CHEMBL552232 IC50 93.0 nM
c1ccc(-c2n[nH]c(C3CC3)c2-c2ccnc3ccccc23)nc1 CHEMBL338196 IC50 94.0 nM
Cc1cccc(-c2nn(CC(=S)Nc3ccccc3)cc2-c2ccc3ncccc3c2)n1 CHEMBL1766453 IC50 94.0 nM
Cc1cccc(-n2nc(C)cc2-c2cc3cnccc3s2)n1 CHEMBL3704649 IC50 94.1 nM
Cc1cccc(-c2nn(C(=S)NC3CCN(Cc4ccccc4)CC3)cc2-c2ccc3ncnn3c2)n1 CHEMBL1835710 IC50 95.7 nM
Cc1cccc(-c2nn3c(c2-c2ccc(O)cc2)[C@H](C)C(C)(C)C3)n1 CHEMBL4285400 IC50 97.0 nM
CCc1cccc(-c2nn3c(c2-c2ccc(O)cc2)C(C)C(C)(C)C3)n1 CHEMBL4287654 IC50 98.0 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN(C)CC5)nc4)c3n2)[C@@H](C)C1 CHEMBL5186341 IC50 98.0 nM