Cn1cc(-c2nc3c(-c4ccnc(OC5CC5)c4)cnn3cc2OCC(C)(C)O)cn1 CHEMBL4791414 IC50 0.31 nM
COc1cn2ncc(-c3ccnc(OC(C)C)c3)c2nc1-c1cnn(C)c1 CHEMBL4758580 IC50 0.56 nM
COc1cn2ncc(-c3ccnc(OC4CCC4)c3)c2nc1-c1cnn(C)c1 CHEMBL4787891 IC50 0.61 nM
Cn1cc(-c2nc3c(-c4ccnc(OC5CC5)c4)cnn3cc2OCCC(C)(C)O)cn1 CHEMBL4751832 IC50 0.83 nM
CNc1nc2c(-c3ccnc(OC)c3)cnn2cc1OC CHEMBL4752199 IC50 1.0 nM
COc1cc(-c2cnn3cc(OC)c(C(C)C)nc23)ccn1 CHEMBL4748097 IC50 1.0 nM
COc1cc(-c2cnn3cc(OC)c(C4CCOC4)nc23)ccn1 CHEMBL4779273 IC50 1.1 nM
COc1cc(-c2cnn3cc(OC)c(C4CCCC4)nc23)ccn1 CHEMBL4782729 IC50 1.2 nM
c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385579 IC50 1.37 nM
CCc1cn2ncc(-c3ccnc(OC)c3)c2nc1NC CHEMBL4741185 IC50 1.5 nM
COc1cn2ncc(-c3ccnc(OC4CC4)c3)c2nc1-c1cnn(C)c1 CHEMBL4744618 IC50 1.6 nM
Cn1cc(-c2nc3c(-c4ccnc(OC5CC5)c4)cnn3cc2OCCCC(C)(C)O)cn1 CHEMBL4764221 IC50 2.0 nM
CNc1nc2c(-c3ccnc(OC)c3)cnn2cc1C CHEMBL4779579 IC50 2.9 nM
COc1cc(-c2cnn3cc(OC)c(-c4cc(C)no4)nc23)ccn1 CHEMBL4763627 IC50 2.9 nM
COc1cc(-c2cnn3cc(OC)c(C(C)(C)O)nc23)ccn1 CHEMBL4764416 IC50 3.3 nM
COc1cc(-c2cnn3cc(OC)c([C@@H]4COC(C)(C)C4)nc23)ccn1 CHEMBL4749061 IC50 3.6 nM
CNc1nc2c(-c3ccnc(OC)c3)cnn2cc1C1CC1 CHEMBL4744988 IC50 3.7 nM
CNc1ccn2ncc(-c3ccnc(OC)c3)c2n1 CHEMBL4795223 IC50 3.9 nM
COc1cc(-c2cnn3cc(OC)c(C)nc23)ccn1 CHEMBL4798505 IC50 5.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)nc2)ccn1 CHEMBL4289841 IC50 7.0 nM
COc1cn2ncc(-c3ccnc(OC(C)(C)C)c3)c2nc1-c1cnn(C)c1 CHEMBL4747422 IC50 7.0 nM
COc1cc(-c2cnn3cc(OC)c(N(C)C)nc23)ccn1 CHEMBL4777071 IC50 7.9 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(N)=O)c(OC)c2)cn1 CHEMBL5438171 IC50 14.5 nM
CN1CCN(c2ccc(-c3cnc4c(-c5ccnc6ccccc56)cnn4c3)cc2)CC1 CHEMBL2385596 IC50 15.0 nM
COc1cnc2c(-c3ccnc(OC)c3)cnn2c1 CHEMBL4750258 IC50 15.0 nM
COc1ccc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)cc1 CHEMBL2385600 IC50 16.0 nM
c1ccc2c(-c3cnn4cc(-c5ccc(N6CCOCC6)cc5)cnc34)ccnc2c1 CHEMBL2385582 IC50 26.0 nM
CCc1nc2c(-c3ccnc(OC)c3)cnn2cc1OC CHEMBL4763122 IC50 36.0 nM
c1cc(N2CCNCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385586 IC50 38.0 nM
COc1ccc(-c2c(-c3ccnc(NC(C)=O)c3)[nH]c3cccnc23)cn1 CHEMBL4279160 IC50 40.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1 CHEMBL4538174 Kd 54.0 nM
NC(=O)c1ccc(-c2nc(-c3ccccn3)c(-c3ccc4c(c3)OCO4)[nH]2)cc1 CHEMBL440084 IC50 66.0 nM
c1cc2cc(c1)-c1cnn3ccc(nc13)NCCOCCO2 CHEMBL4783244 IC50 75.0 nM
c1ccc(-c2nc(Nc3ccncc3)c3cccn3n2)nc1 CHEMBL4205311 IC50 77.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 80.0 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 CHEMBL478629 IC50 102.9 nM
Fc1cnccc1Nc1nc(-c2ccccn2)nn2cccc12 CHEMBL4204772 IC50 110.0 nM
COc1cc(CNC(=O)Nc2snc(OCc3cccnc3)c2C(N)=O)cc(OC)c1 CHEMBL4747912 IC50 110.0 nM
c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 CHEMBL513147 IC50 140.4 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 146.0 nM
CCCC1CC(=O)C2=C(C1)NC(C)=C(C(=O)OCC(C)C)C2c1ccc(C(C)(C)C)cc1 CHEMBL2180267 IC50 170.0 nM
CCCC1CC(=O)C2=C(C1)NC(C)=C(C(=O)OCC)C2c1ccc(C(C)(C)C)cc1 CHEMBL2180266 IC50 170.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)cc(F)c2n1 CHEMBL4786529 IC50 170.7 nM
c1ccc(-c2nn3c(c2-c2ccnc4cc(OCCN5CCOCC5)ccc24)CCC3)nc1 CHEMBL260015 IC50 190.0 nM
COc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 CHEMBL511563 IC50 236.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 250.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 250.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 260.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 270.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 300.0 nM
Cc1cccc(-c2nc(Nc3ccncc3F)c3cc[nH]c3n2)n1 CHEMBL4210246 IC50 310.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 320.0 nM
c1cc(-c2cnn3cc(-c4ccc(N5CCNCC5)cc4)cnc23)c2cccnc2c1 CHEMBL2385591 IC50 327.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 330.0 nM
OCCCn1cnc2ccc(-c3c(-c4ccccn4)nn4c3CCC4)cc21 CHEMBL203619 IC50 352.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cn2)ccn1 CHEMBL4291307 IC50 390.0 nM
Cn1cnc2ccc(-c3c(-c4ccccn4)nn4c3CCC4)cc21 CHEMBL204170 IC50 395.0 nM
c1ccc(-c2n[nH]cc2-c2ccnc3ccccc23)nc1 CHEMBL261454 IC50 400.0 nM
CCCC1CC(=O)C2=C(C1)NC(C)=C(C(=O)OC)C2c1ccc(-c2ccccc2)cc1 CHEMBL2180268 IC50 400.0 nM
CCOC(=O)C1=C(C)NC2=C(C(=O)CC(C)(C)C2)C1c1ccc(-c2ccccc2)cc1 CHEMBL2180273 IC50 460.0 nM
Cc1ccc(-c2cnc(N)c(C(=O)NC3CCCCC3)n2)cc1 CHEMBL4792978 IC50 490.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2cc(F)cc(F)c2n1 CHEMBL4778971 IC50 498.0 nM
CC1=C(C(=O)OCC(C)C)C(c2ccc(-c3ccccc3)cc2)C2=C(CC(C)(C)CC2=O)N1 CHEMBL2180281 IC50 530.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 540.0 nM
Cc1cccc(-c2nc(Nc3ccncc3)c3cccn3n2)n1 CHEMBL4206793 IC50 550.0 nM
COC(=O)C1=C(C)NC2=C(C(=O)CC(C)(C)C2)C1c1ccc(C(C)(C)C)cc1 CHEMBL2180618 IC50 560.0 nM
Cc1cccc(-c2nc(Nc3ccncc3F)c3cccn3n2)n1 CHEMBL4205457 IC50 570.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)ccc2n1 CHEMBL4788859 IC50 587.2 nM
COC(=O)C1=C(C)NC2=C(C(=O)CC(CC(C)C)C2)C1c1ccc(-c2ccccc2)cc1 CHEMBL2180270 IC50 590.0 nM
COC(=O)C1=C(C)NC2=C(C(=O)CC(C)(C)C2)C1c1ccc(C2CCCCC2)cc1 CHEMBL2180287 IC50 590.0 nM
Cc1cccc(-c2nn3c(c2-c2ccc4ncn(C)c4c2)CCC3)n1 CHEMBL204966 IC50 668.0 nM
Cc1cccc(-c2nn3c(c2-c2ccc4ncn(CCCO)c4c2)CCC3)n1 CHEMBL204063 IC50 690.0 nM
CC(c1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)c5ccccc45)cnn3c2)cc1)N1CCCC1 CHEMBL4283638 IC50 698.0 nM
Cc1cc(-c2cc(OC(=O)c3ccccc3)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL403989 Kd apparent 703.0 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC)c4)ccc32)cc1OC CHEMBL5401167 IC50 703.2 nM
COC(=O)C1=C(C)NC2=C(C(=O)CC(C)(C)C2)C1c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2180612 IC50 730.0 nM
CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2cccc(C)n2)ccn1 CHEMBL4292047 IC50 730.0 nM
CC1=C(C(=O)OCC(F)(F)F)C(c2ccc(-c3ccccc3)cc2)C2=C(CC(C)(C)CC2=O)N1 CHEMBL2180280 IC50 760.0 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NCC(F)(F)F)c(OC)c2)cn1 CHEMBL5404502 IC50 771.8 nM
CCC1CC(=O)C2=C(C1)NC(C)=C(C(=O)OC)C2c1ccc(-c2ccccc2)cc1 CHEMBL2177136 IC50 790.0 nM
C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 CHEMBL31965 Kd 800.0 nM
N[C@H]1CCN(Cc2ccn3nc(-c4ccccn4)nc(Nc4ccncc4F)c23)C[C@@H]1O CHEMBL4206220 IC50 810.0 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CCOC)c4)ccc32)cc1OC CHEMBL5395705 IC50 818.1 nM
Cc1cccc(-c2ncn(CC(F)F)c2-c2ccc3ncc(C(N)=O)n3c2)n1 CHEMBL4455462 IC50 820.0 nM
CCCC1=C(C(=O)OCC)C(c2ccc(-c3ccccc3)cc2)C2=C(CC(C)(C)CC2=O)N1 CHEMBL2180285 IC50 830.0 nM
COc1ccc(COC(=O)C2=C(C)NC3=C(C(=O)CC(C)(C)C3)C2c2ccc(-c3ccccc3)cc2)cc1 CHEMBL2180283 IC50 830.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 854.0 nM
COC(=O)C1=C(C)NC2=C(C(=O)CC(C)(C)C2)C1c1ccc(-c2ccc(C)cc2)cc1 CHEMBL2180611 IC50 860.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 863.0 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)O)c(OC)c2)cn1 CHEMBL5428147 IC50 868.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F CHEMBL1230020 Kd 890.0 nM
COC(=O)C1=C(C)NC2=C(C(=O)CC(C)(C)C2)C1c1ccc(-c2ccccc2C)cc1 CHEMBL2180614 IC50 890.0 nM
COC(=O)C1=C(C)NC2=C(C(=O)CC(C(C)C)C2)C1c1ccc(-c2ccccc2)cc1 CHEMBL2180269 IC50 940.0 nM
CC(=O)Nc1cc(Nc2nc(-c3cccc(C(F)(F)F)n3)nc3[nH]ccc23)ccn1 CHEMBL4209583 IC50 940.0 nM
CNc1ccn2ncc(-c3cccc(OC)c3)c2n1 CHEMBL4745367 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM