C[C@@H](CCCn1ccc2cc(-c3ncc4c(n3)NC(=O)CO4)c(F)cc2c1=O)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5400567 IC50 0.11 nM
Nc1nc(-c2cc3ccn(CCC[C@H](COC(F)F)Nc4cn[nH]c(=O)c4C(F)(F)F)c(=O)c3cc2F)ncc1C(F)(F)F CHEMBL5397180 IC50 0.14 nM
O=C([C@@H](O)CCNc1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5394931 IC50 0.141 nM
O=C(CCCN(c1ccccc1)c1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5413717 IC50 0.151 nM
CCN(CCCC(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)c1cc(C(F)(F)F)c(=O)[nH]n1 CHEMBL5415829 IC50 0.179 nM
O=c1[nH]ncc(N[C@H](CCCn2ccc3cc(-c4ncc(C(F)F)cn4)c(F)cc3c2=O)COC(F)F)c1C(F)(F)F CHEMBL5393845 IC50 0.179 nM
C[C@@H](CCCn1ccc2cc(-c3ncc(C(F)(F)F)c(N4C[C@@H](O)[C@@H]4C)n3)c(F)cc2c1=O)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5422715 IC50 0.185 nM
C[C@@H](CCCn1ccc2cc(-c3ncc(Cl)c(N)n3)c(F)cc2c1=O)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5407242 IC50 0.188 nM
C[C@@H](CCCn1ccc2cc(-c3ncc(C(F)(F)F)c(N4CC(C#N)C4)n3)c(F)cc2c1=O)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5421106 IC50 0.188 nM
CCC(CC)N1CCN(C(=O)c2cc(Cn3c(=O)[n-]c(=O)c4ccccc43)ccc2F)CC1=O CHEMBL5403305 IC50 0.21 nM
O=C(CC[C@@H]1CCCN1c1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5419793 IC50 0.212 nM
C[C@@H](COCCC(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5095043 Kd 0.22 nM
O=C(CCC1Cc2ccccc2N1c1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5422627 IC50 0.232 nM
CN(CCCC(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)c1cc(C(F)(F)F)c(=O)[nH]n1 CHEMBL5409582 IC50 0.233 nM
O=C(CCCNc1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5425262 IC50 0.263 nM
O=C(CCCCc1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5409458 IC50 0.288 nM
O=C(c1cccc(Cc2cc(C(F)(F)F)c(=O)[nH]n2)c1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5417113 IC50 0.405 nM
C[C@@H](COCCC(=O)N1CCN2c3ncc(C(F)(F)F)cc3NC(=O)C2C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5209116 IC50 0.584 nM
CN1C(=O)[C@@H]2CN(C(=O)CCOC[C@@H]3CCN3c3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 CHEMBL5177385 IC50 0.6114 nM
C=CN1C(=O)[C@@H]2CN(C(=O)CCOC[C@H](C)Nc3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 CHEMBL5181016 IC50 0.648 nM
O=C(CC[C@@H]1CCCCN1c1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5407196 IC50 0.671 nM
CC(COCCC(=O)N1CCN2c3ncc(C(F)(F)F)cc3NC2C1)Oc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5190796 IC50 0.802 nM
[2H]C([2H])([2H])N1C(=O)C2CN(C(=O)CCOC[C@H](C)Oc3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 CHEMBL5183629 IC50 0.806 nM
CN1C(=O)[C@H]2CN(C(=O)CCOC[C@@H]3CCN3c3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 CHEMBL5202833 IC50 0.87 nM
C[C@@H](COCCC(=O)N1CCN2c3ncc(C(F)(F)F)cc3N(C)C(=O)C2C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5174619 IC50 0.966 nM
C[C@@H](COCCC(=O)N1CCN2c3ncc(Cl)cc3OCC[C@@H]2C1)Oc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5173659 IC50 1.006 nM
C=CN1C(=O)[C@H]2CN(C(=O)CCOC[C@H](C)Nc3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 CHEMBL5180425 IC50 1.173 nM
C[C@@H](COCCC(=O)N1CCN2c3ncc(C(F)(F)F)cc3OC[C@@H]2C1)Oc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5183278 IC50 1.243 nM
C[C@@H](COCCC(=O)N1CCN2c3ncc(Cl)c(C(F)(F)F)c3OCC[C@@H]2C1)Oc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5193823 IC50 2.031 nM
C[C@@H](COCCC(=O)N1CCN2c3ncc(C(F)(F)F)cc3NCCC2C1)Oc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5204396 IC50 3.106 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 CHEMBL5402698 IC50 7.3 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(C(F)(F)F)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5395820 IC50 7.6 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(Br)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5410175 IC50 11.1 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ccc(C(F)(F)F)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5414515 IC50 14.5 nM
COc1ccc(NC(=O)c2ccc(NC(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)cc2)cc1 CHEMBL5176874 IC50 15.0 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ccc4c(c3)OC(F)(F)O4)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5398173 IC50 19.4 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(S(C)(=O)=O)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5436756 IC50 29.2 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(C#N)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5407189 IC50 34.5 nM
O=C(C1CN(CCNc2cn[nH]c(=O)c2C(F)(F)F)C1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 CHEMBL5429007 IC50 39.3 nM
Cc1cnc(N2CCN(C(=O)C3CN(C[C@H](C)Nc4cn[nH]c(=O)c4C(F)(F)F)C3)CC2)nc1 CHEMBL5425015 IC50 42.4 nM
COc1ccc(OC)c2c1sc1nnc(N)n12 CHEMBL5404785 pIC50 83.18 nM
CC1CN(c2ncc(C(F)(F)F)cn2)CC(C)N1C(=O)C1CN(C[C@H](C)Nc2cn[nH]c(=O)c2C(F)(F)F)C1 CHEMBL5417413 IC50 110.0 nM
C[C@@H](CN1CC(C(=O)N2C3CC2CN(c2ncc(C(F)(F)F)cn2)C3)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5432380 IC50 116.0 nM
C[C@@H]1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(-c3nccs3)n21 CHEMBL5420649 IC50 149.0 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn12 CHEMBL5199558 IC50 330.0 nM