CS(=O)(=O)Nc1cc(C#N)cc(-c2c[nH]c3ncc(-c4cccc(C(=O)NC5CC5)c4)cc23)c1 CHEMBL4760558 IC50 0.12 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cc(C#N)cc(NS(C)(=O)=O)c5)c4c3)cc2)CC1 CHEMBL4749291 IC50 0.13 nM
CNC(=O)c1cccc(-c2cnc3[nH]cc(-c4cc(C#N)cc(NS(C)(=O)=O)c4)c3c2)c1 CHEMBL4762464 IC50 0.18 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cc(C#N)cc(NS(=O)(=O)C6CC6)c5)c4c3)cc2)CC1 CHEMBL4759123 IC50 0.19 nM
CS(=O)(=O)Nc1cc(C#N)cc(-c2c[nH]c3ncc(-c4cccc(C(=O)N5CCCC5)c4)cc23)c1 CHEMBL4744045 IC50 0.21 nM
CN1CCN(C(=O)c2ccc(-c3cnc4[nH]cc(-c5cc(C#N)cc(NS(C)(=O)=O)c5)c4c3)cc2)CC1 CHEMBL4751494 IC50 0.21 nM
CS(=O)(=O)Nc1cc(C#N)cc(-c2c[nH]c3ncc(-c4cccc(C(=O)N5CCCCC5)c4)cc23)c1 CHEMBL4788405 IC50 0.22 nM
CN(C)C1CCN(C(=O)c2cccc(-c3cnc4[nH]cc(-c5cc(C#N)cc(NS(C)(=O)=O)c5)c4c3)c2)C1 CHEMBL4788976 IC50 0.22 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cc(C#N)c6[nH]ncc6c5)c4c3)cc2)CC1 CHEMBL4797452 IC50 0.23 nM
CN1CCN(C(=O)c2cccc(-c3cnc4[nH]cc(-c5cc(C#N)cc(NS(C)(=O)=O)c5)c4c3)c2)CC1 CHEMBL4791330 IC50 0.25 nM
CNC(=O)c1cccc(-c2cnc3[nH]cc(-c4cc(C#N)c(Cl)c(NS(C)(=O)=O)c4)c3c2)c1 CHEMBL4756005 IC50 0.3 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.314 nM
CC(C)(Oc1ccc(-c2cnc3[nH]cc(-c4cc(C#N)cc(NS(C)(=O)=O)c4)c3c2)cc1)C(=O)O CHEMBL4788688 IC50 0.33 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cc(C#N)c(Cl)c(NS(C)(=O)=O)c5)c4c3)cc2)CC1 CHEMBL4760435 IC50 0.43 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ncc6c5)c4c3)cc2)CC1 CHEMBL4754003 IC50 0.44 nM
CC(C)(C(=O)O)c1ccc(-c2cnc3[nH]cc(-c4cc(C#N)cc(NS(C)(=O)=O)c4)c3c2)cc1 CHEMBL4797770 IC50 0.47 nM
CN1CCC(n2cc(-c3cnc4[nH]cc(-c5cc(C#N)c(Cl)c(NS(C)(=O)=O)c5)c4c3)cn2)CC1 CHEMBL4780310 IC50 0.68 nM
Cn1cc(-c2ccc(-c3cnc4[nH]cc(-c5cc(C#N)cc(NS(C)(=O)=O)c5)c4c3)cc2)cn1 CHEMBL4781043 IC50 0.8 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cccc(C#N)c5)c4c3)cc2)CC1 CHEMBL4743105 IC50 0.91 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCC(N)CC2)cc1 CHEMBL3684049 IC50 1.3 nM
CC(C)=CC(=O)Nc1sc(Nc2ccc3cc(CO)ccc3c2)nc1C(N)=O CHEMBL3684025 IC50 1.6 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 IC50 2.0 nM
Cc1nccn1Cc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3684056 IC50 2.3 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cncn2)cc1 CHEMBL3684039 IC50 2.5 nM
CN(C)[C@H]1CCN(Cc2ccc(C(=O)Nc3sc(Nc4ccc5ccccc5c4)nc3C(N)=O)cc2)C1 CHEMBL3684048 IC50 2.6 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCN(CCO)CC2)cc1 CHEMBL3684034 IC50 2.7 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cc2nn[nH]n2)cc1 CHEMBL3684051 IC50 2.9 nM
COc1ccc(C#N)cc1-c1ccnc(Nc2ccc(N3CCN(C)CC3)c(OC)c2)c1 CHEMBL2312144 IC50 3.0 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)cc1 CHEMBL3684045 IC50 3.0 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CC[C@H](N)C2)cc1 CHEMBL3684047 IC50 3.0 nM
NC(=O)c1nc(Nc2ccc3ncccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)cc1 CHEMBL3684063 IC50 3.0 nM
Cc1cn(Cc2ccc(C(=O)Nc3sc(Nc4ccc5ccccc5c4)nc3C(N)=O)cc2)cn1 CHEMBL3684057 IC50 3.1 nM
CN1CCCN(Cc2ccc(C(=O)Nc3sc(Nc4ccc5ccccc5c4)nc3C(N)=O)cc2)CC1 CHEMBL3684038 IC50 3.2 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCC(O)CC2)cc1 CHEMBL3684031 IC50 3.4 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cnc(CO)c2)cc1 CHEMBL3684061 IC50 3.5 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CNCCO)cc1 CHEMBL3684029 IC50 3.7 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]cnc6c5)c4c3)cc2)CC1 CHEMBL4778005 IC50 3.8 nM
COc1ccc(Cl)cc1-c1ccnc(Nc2ccc(N3CCN(C)CC3)c(OC)c2)c1 CHEMBL2312145 IC50 4.0 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#CCCO CHEMBL3684050 IC50 4.0 nM
CN1CCN(c2ccc(C(=O)Nc3sc(Nc4ccc5ncccc5c4)nc3C(N)=O)cc2)CC1 CHEMBL3683994 IC50 4.1 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCNC(=O)C2)cc1 CHEMBL3684033 IC50 4.2 nM
CC#CC(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O CHEMBL3684030 IC50 4.4 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#CCO CHEMBL3684046 IC50 4.5 nM
NC(=O)c1nc(Nc2cccc3ncccc23)sc1NC(=O)c1ccc(Cn2ccnc2)cc1 CHEMBL3684066 IC50 4.8 nM
COc1ccc(C#N)cc1-c1ccnc(Nc2ccc(N3CCN(C)CC3)cc2)c1 CHEMBL2312143 IC50 5.0 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CC[C@H](O)C2)cc1 CHEMBL3684042 IC50 5.0 nM
O=C1Nc2cc(CS(=O)(=O)c3c(Cl)cccc3Cl)ccc2S/C1=C\c1ccc(O)c([N+](=O)[O-])c1 CHEMBL5437737 IC50 5.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3sc(Nc4ccc5ccccc5c4)nc3C(N)=O)cc2)CC1 CHEMBL3683991 IC50 5.1 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 CHEMBL2436978 IC50 5.2 nM
NCc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3683993 IC50 5.3 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cc(CO)nn2)cc1 CHEMBL3684072 IC50 5.3 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 5.4 nM
COc1cc(Nc2ncc(Cl)c(-c3cccc(CC#N)c3)n2)ccc1N1CCN(C)CC1 CHEMBL2312140 IC50 5.4 nM
NC(=O)c1nc(Nc2ccc3cc(CO)ccc3c2)sc1NC(=O)c1ccsc1 CHEMBL3684007 IC50 5.5 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CC[C@@H](O)C2)cc1 CHEMBL3684041 IC50 5.5 nM
NC(=O)c1nc(Nc2cccc3cccnc23)sc1NC(=O)c1ccc(Cn2ccnc2)cc1 CHEMBL3684071 IC50 5.5 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CC(O)C2)cc1 CHEMBL3684040 IC50 5.6 nM
CN(c1ccc2ncccc2c1)c1nc(C(N)=O)c(NC(=O)c2csc(CN3CCOCC3)c2)s1 CHEMBL3684004 IC50 5.7 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CCO)cc1 CHEMBL3684016 IC50 5.8 nM
NC(=O)c1nc(Nc2ccc3cc(CO)ccc3c2)sc1NC(=O)C1CC1 CHEMBL3684024 IC50 5.8 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283353 IC50 5.8 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cnnn2)cc1 CHEMBL3684044 IC50 5.9 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cnc([N+](=O)[O-])c2)cc1 CHEMBL3684058 IC50 5.9 nM
COc1cc(Nc2cc(-c3cccc(C#N)c3)ccn2)ccc1N1CCN(C)CC1 CHEMBL2312142 IC50 6.0 nM
C#CC(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O CHEMBL3684043 IC50 6.0 nM
COc1ccc2cc(Nc3nc(C(N)=O)c(NC(=O)c4ccc(Cn5ccnc5)cc4)s3)ccc2c1 CHEMBL3639829 IC50 6.1 nM
Cc1nnc(Cc2ccc(C(=O)Nc3sc(Nc4ccc5ccccc5c4)nc3C(N)=O)cc2)o1 CHEMBL3684069 IC50 6.2 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCCCC2CO)cc1 CHEMBL3684037 IC50 6.8 nM
Cc1nnnn1Cc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3684060 IC50 7.1 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cccc(NS(C)(=O)=O)c5)c4c3)cc2)CC1 CHEMBL4758384 IC50 7.1 nM
CC(C)=CC(=O)Nc1sc(Nc2ccc3ccc(F)cc3c2)nc1C(N)=O CHEMBL3684020 IC50 7.2 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(N2CCN(CCO)CC2)cc1 CHEMBL3684035 IC50 7.2 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc[nH]1 CHEMBL3684000 IC50 7.5 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)s1 CHEMBL3684064 IC50 7.7 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cnc6[nH]ncc6c5)c4c3)cc2)CC1 CHEMBL4741790 IC50 7.9 nM
Nc1ncc(Br)c2ccc(-c3ccnc(F)c3)nc12 CHEMBL4471729 pIC50 7.943 nM
COc1ccc(C#N)cc1-c1ccnc(Nc2ccc(N3CCOCC3)c(OC)c2)c1 CHEMBL2312148 IC50 8.0 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(NCCN2CCCCC2)cc1 CHEMBL3683989 IC50 8.0 nM
CC(C)Nc1cc(Nc2ccn3nccc3n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4641090 IC50 8.0 nM
CN1CCN(Cc2cc(C(=O)Nc3sc(Nc4cccc5ncccc45)nc3C(N)=O)cs2)CC1 CHEMBL3684005 IC50 8.2 nM
NCCNc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3684036 IC50 8.4 nM
NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)cc1 CHEMBL3684073 IC50 8.4 nM
CN(C)CCNc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3683987 IC50 8.6 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCOCC2)cc1 CHEMBL3683992 IC50 8.6 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1csc(Cn2ccnc2)c1 CHEMBL3684070 IC50 8.7 nM
c1ccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)cc1 CHEMBL3102859 IC50 9.2 nM
NC(=O)c1nc(Nc2cccc3ncccc23)sc1NC(=O)c1ccsc1 CHEMBL3684002 IC50 9.4 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2[N+](=O)[O-])cc1 CHEMBL3684055 IC50 9.5 nM
COc1ccc2cc(Nc3nc(C(N)=O)c(NC(=O)c4ccc(N)cc4)s3)ccc2c1 CHEMBL3684022 IC50 9.7 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#CCCCn1ccnc1 CHEMBL3684054 IC50 9.7 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 9.9 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 10.0 nM
CS(=O)(=O)c1ccc(-c2cc(-c3ccc(O)cc3)cnc2N)cc1 CHEMBL3754283 pIC50 10.0 nM
NC(=O)c1nc(Nc2ccc3cc(F)ccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)cc1 CHEMBL3684062 IC50 10.1 nM
CN1CCN(c2ccc(C(=O)Nc3sc(Nc4ccc5ccccc5c4)nc3C(N)=O)cc2)CC1 CHEMBL3683988 IC50 10.2 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cccn2)cc1 CHEMBL3684052 IC50 10.3 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(NCCO)cc1 CHEMBL3683986 IC50 10.6 nM
CC(O)CNc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3683999 IC50 10.7 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#CCCCn1cncn1 CHEMBL3684053 IC50 10.7 nM
COc1ccc(C#N)cc1-c1ccnc(Nc2ccc(N3CCC(N(C)C)CC3)c(F)c2)c1 CHEMBL2312154 IC50 11.0 nM
COc1ccc(C#N)cc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)c1 CHEMBL2312147 IC50 11.0 nM
Cc1ccc(C(=O)Nc2sc(Nc3ccc4cc(CO)ccc4c3)nc2C(N)=O)s1 CHEMBL3684028 IC50 11.1 nM
NC(=O)c1nc(Nc2ccc3cnccc3c2)sc1NC(=O)c1ccsc1 CHEMBL3684003 IC50 12.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL274654 Kd apparent 12.0 nM
CC(=O)Nc1cccc(-c2c[nH]c3ncc(-c4ccc(CN5CCN(C)CC5)cc4)cc23)c1 CHEMBL4795159 IC50 12.0 nM
CC(C)=CC(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O CHEMBL3684010 IC50 12.7 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(N2CCC(O)CC2)cc1 CHEMBL3684013 IC50 12.7 nM
NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)C1CC1 CHEMBL3684018 IC50 12.8 nM
NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)c1ccc(NCCO)cc1 CHEMBL3684019 IC50 12.9 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc(Cl)cc5)c4c3)cc2)CC1 CHEMBL4757719 IC50 14.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccccc5)c4c3)cc2)CC1 CHEMBL4753491 IC50 14.0 nM
COc1ccc2cc(Nc3nc(C(N)=O)c(NC(=O)c4ccc(NCCO)cc4)s3)ccc2c1 CHEMBL3684015 IC50 14.8 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cnc([N+](=O)[O-])n2)cc1 CHEMBL3684059 IC50 14.8 nM
Nc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cn1 CHEMBL3754515 IC50 15.0 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C1CC1 CHEMBL3684012 IC50 15.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cccc(N)c5)c4c3)cc2)CC1 CHEMBL4787455 IC50 15.0 nM
C[C@H](O)CNc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3684026 IC50 15.1 nM
COc1ccc2cc(Nc3nc(C(N)=O)c(NC(=O)C=C(C)C)s3)ccc2c1 CHEMBL3684023 IC50 15.2 nM
CN1CCN(c2ccc(C(=O)Nc3sc(Nc4cccc5ncccc45)nc3C(N)=O)cc2)CC1 CHEMBL3683995 IC50 15.6 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2C(=O)CSC2=O)cc1 CHEMBL3684065 IC50 15.9 nM
CN1CCN(C/C=C/C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)CC1 CHEMBL3684032 IC50 16.0 nM
O[C@H]1CC[C@@H](Oc2cccc3cnc(Nc4ccc5nc[nH]c5c4)nc23)CC1 CHEMBL4776173 IC50 16.6 nM
C[C@@H](O)CNc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3684027 IC50 16.8 nM
NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)c1ccsc1 CHEMBL3684009 IC50 16.9 nM
CN1CCN(c2ccc(C(=O)Nc3sc(N(C)c4ccc5ncccc5c4)nc3C(N)=O)cc2)CC1 CHEMBL3683997 IC50 17.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc(NS(C)(=O)=O)cc5)c4c3)cc2)CC1 CHEMBL4749390 IC50 18.0 nM
Cc1noc(Cc2ccc(C(=O)Nc3sc(Nc4ccc5ccccc5c4)nc3C(N)=O)cc2)n1 CHEMBL3684068 IC50 18.5 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc(F)cc5)c4c3)cc2)CC1 CHEMBL4798207 IC50 19.0 nM
CN1CCN(c2ccc(C(=O)Nc3sc(Nc4cccc5cccnc45)nc3C(N)=O)cc2)CC1 CHEMBL3683996 IC50 19.1 nM
NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)CCCCCN1CCOCC1 CHEMBL3684021 IC50 19.5 nM
CC(=O)Nc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3683983 IC50 19.8 nM
COc1ccc(Cl)cc1-c1ccnc(Nc2ccc(CCN3CCOCC3)cc2)c1 CHEMBL2312155 IC50 20.0 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)CCCCCN1CCOCC1 CHEMBL3684011 IC50 20.2 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(N)cc1 CHEMBL3683990 IC50 20.3 nM
COc1ccc(C(=O)Nc2sc(Nc3ccc4ncccc4c3)nc2C(N)=O)cc1 CHEMBL3683984 IC50 21.5 nM
NC(=O)c1nc(Nc2ccc3cc(F)ccc3c2)sc1NC(=O)c1ccc(NCCO)cc1 CHEMBL3684014 IC50 22.5 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1cc2sccc2[nH]1 CHEMBL3684001 IC50 22.7 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd apparent 23.0 nM
NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(NCCO)c(N)c1 CHEMBL3684017 IC50 24.4 nM
CC(=O)Nc1ccc(C(=O)Nc2sc(Nc3cccc4ccccc34)nc2C(N)=O)cc1 CHEMBL3683982 IC50 24.7 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 25.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1ccc(F)cc1 CHEMBL5181357 IC50 26.0 nM
NC(=O)c1nc(Nc2ccnc3ccccc23)sc1NC(=O)c1ccc(Cn2ccnc2)cc1 CHEMBL3684067 IC50 26.5 nM
CNC(=O)c1cccc(-c2c[nH]c3ncc(-c4ccc(CN5CCN(C)CC5)cc4)cc23)c1 CHEMBL4761756 IC50 27.0 nM
Cc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1N CHEMBL3683985 IC50 27.2 nM
CN(CCO)c1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1 CHEMBL3683998 IC50 27.4 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 28.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cccc6ccccc56)c4c3)cc2)CC1 CHEMBL4745045 IC50 31.0 nM
CN1CCN(c2ccc(C(=O)Nc3sc(N(C)c4ccc5ccccc5c4)nc3C(N)=O)cc2)CC1 CHEMBL3684006 IC50 36.3 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 Kd apparent 38.0 nM
CC(C)NC(=O)c1ccc(-c2cnc(N)c(-c3ccc(C#N)cc3)c2)cc1 CHEMBL4558962 pIC50 39.81 nM
COc1ccc(Cl)cc1-c1ccnc(Nc2ccc(N3CCOCC3)c(OC)c2)c1 CHEMBL2312150 IC50 41.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1ccc(OC(F)F)cc1 CHEMBL5198084 IC50 41.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(F)c1C(N)=O CHEMBL4548795 IC50 41.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cccc(C(=O)N(C)C)c5)c4c3)cc2)CC1 CHEMBL4746089 IC50 43.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 45.0 nM
COc1cccc(Cn2c(=O)oc3cc(-c4cnc5[nH]ccc5c4)ccc32)c1 CHEMBL5204762 IC50 50.0 nM
COc1cc(Nc2nc(C(N)=O)c(NC(=O)c3ccsc3)s2)cc2ccccc12 CHEMBL3684008 IC50 51.3 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 53.0 nM
COc1cc(Nc2cc(-c3cccc(C#N)c3)ccn2)ccc1N1CCOCC1 CHEMBL2312146 IC50 55.0 nM
CCc1nnc(-c2c(OC)cc(-c3cnc4cc(-c5cnn(C)c5)ccn34)cc2OC)o1 CHEMBL5407103 IC50 56.0 nM
COc1cc(C#N)cc(-c2ccnc(Nc3ccc(N4CCOCC4)c(OC)c3)c2)c1 CHEMBL2312153 IC50 63.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1ccc(C(F)(F)F)cc1 CHEMBL5196290 IC50 66.0 nM
COc1cccc(CN2CCOc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)c1 CHEMBL4879278 IC50 67.0 nM
O=Cc1cccc(CN2CCOc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)c1 CHEMBL5176397 IC50 67.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4877347 IC50 67.7 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 69.0 nM
COc1cccc(CN2CCc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)c1 CHEMBL5183702 IC50 72.0 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5093741 IC50 87.0 nM
N#Cc1ccc(CN2CCOc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)cc1 CHEMBL5187616 IC50 87.0 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 Kd apparent 89.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 90.0 nM
O=c1oc2cc(-c3cnc4[nH]ccc4c3)ccc2n1Cc1cccc(F)c1 CHEMBL5176051 IC50 90.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1cccc([N+](=O)[O-])c1 CHEMBL5199307 IC50 93.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 94.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4517408 IC50 96.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 97.0 nM
COc1cc(CN2CCOc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)cc(OC)c1 CHEMBL5178816 IC50 99.0 nM
Cc1ccc(C(=O)Nc2sc(Nc3ccccc3)nc2C(N)=O)cc1 CHEMBL3764451 Ki 100.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 107.0 nM
O=c1oc2cc(-c3cnc4[nH]ccc4c3)ccc2n1Cc1ccc(F)cc1 CHEMBL5177071 IC50 110.0 nM
COc1cccc(CN2CCOc3cc(-c4cnc(N)c(C#N)c4)ccc3C2=O)c1 CHEMBL5209377 IC50 113.0 nM
COc1ccc(F)cc1-c1ccnc(Nc2ccc(N3CCOCC3)c(OC)c2)c1 CHEMBL2312151 IC50 118.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 121.0 nM
COc1cccc(CNC(=O)c2ccc(-c3cnc4[nH]ccc4c3)cc2OC)c1 CHEMBL5191656 IC50 125.0 nM
CC(C)(O)c1cnc(N)c2nc(-c3ccnc(F)c3)ccc12 CHEMBL4527085 pIC50 125.89 nM
CC(C)Nc1cc(Nc2nc3ccnn3cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4634922 IC50 130.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 140.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 140.0 nM
COc1cccc(CN2CCOc3cc(-c4c[nH]c5ncccc45)ccc3C2=O)c1 CHEMBL5185269 IC50 149.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 150.0 nM
Nc1ncnc2ccc(-c3ccnc(F)c3)nc12 CHEMBL3262590 IC50 150.0 nM
N#Cc1cc(-c2ccc3c(c2)oc(=O)n3Cc2ccc(F)cc2)cnc1N CHEMBL5186920 IC50 156.0 nM
N#Cc1ccc(-c2cnc3[nH]cc(NC(=O)c4cccnc4)c3c2)cc1 CHEMBL516312 Kd 160.0 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1 CHEMBL377300 Kd 160.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1ccc(F)c(Cl)c1 CHEMBL5190863 IC50 174.0 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 180.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 184.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 210.0 nM
COc1cc(Nc2cc(-c3cccc(CC#N)c3)ccn2)ccc1N1CCN(C)CC1 CHEMBL2312141 Kd 220.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 221.0 nM
O=c1oc2cc(-c3c[nH]c4ncccc34)ccc2n1Cc1ccc(F)cc1 CHEMBL5182938 IC50 228.0 nM
Nc1ccc(-c2ccc3c(c2)oc(=O)n3Cc2ccc(F)cc2)cn1 CHEMBL5208784 IC50 234.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 251.0 nM
COc1ccc(CN2CCOc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)cc1 CHEMBL5178448 IC50 254.0 nM
Cc1c(Cl)cccc1-c1ccc(C(=O)Nc2ccc(S(N)(=O)=O)cc2)o1 CHEMBL3752265 IC50 260.0 nM
COc1cccc(Cn2c(=O)oc3cc(-c4ccc5c(c4)CCN5)ccc32)c1 CHEMBL5173514 IC50 265.0 nM
COc1ccc(CN2CCOc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)cc1OC CHEMBL5187557 IC50 266.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 270.0 nM
COc1ccc(C(F)(F)F)cc1-c1ccnc(Nc2ccc(N3CCOCC3)c(OC)c2)c1 CHEMBL2312152 IC50 275.0 nM
O=c1oc2cc(-c3cnc4[nH]ccc4c3)ccc2n1Cc1cccc(OC(F)(F)F)c1 CHEMBL5206353 IC50 289.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 310.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 310.0 nM
COc1cccc(CN2CCOc3ccc(-c4cnc5[nH]ccc5c4)cc3C2=O)c1 CHEMBL5181741 IC50 319.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1cc(F)ccc1F CHEMBL5199647 IC50 324.0 nM
Cc1cccc(Cn2c(=O)oc3cc(-c4cnc5[nH]ccc5c4)ccc32)c1 CHEMBL5183306 IC50 356.0 nM
O=C(c1cccc(CNc2n[nH]c3cccc(Cl)c23)c1)N1CCN(C(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL5393904 IC50 367.3 nM
COc1cccc(CN2CC(C)(C)Oc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)c1 CHEMBL5195806 IC50 368.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 Kd apparent 385.0 nM
CN1CCN(c2ccc(NC(=O)c3ccc(-c4cc(Cl)ccc4Cl)o3)cc2)CC1 CHEMBL3754324 IC50 394.0 nM
COc1cccc(Cn2c(=O)oc3cc(-c4ccc(N)nc4)ccc32)c1 CHEMBL5193748 IC50 412.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 430.0 nM
COC(=O)c1cccc(CN2CCOc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)c1 CHEMBL5191012 IC50 460.0 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 Kd 480.0 nM
COc1cccc(CN2CCCc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)c1 CHEMBL5178737 IC50 483.0 nM
COc1cc(CN2CCOc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)ccc1F CHEMBL5173480 IC50 526.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1cccc(-c2ccccc2)c1 CHEMBL5192015 IC50 545.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 Kd apparent 565.0 nM
COc1cccc(CN2Cc3cc(-c4cnc5[nH]ccc5c4)ccc3C2=O)c1 CHEMBL5191005 IC50 597.0 nM
COc1cc(-c2ccc3c(c2)oc(=O)n3Cc2ccc(F)cc2)cnc1N CHEMBL5189810 IC50 610.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1cccc(C(F)(F)F)c1 CHEMBL5174748 IC50 612.0 nM
COc1cccc(CN2CCOc3cc(-c4ccc(N)nc4)ccc3C2=O)c1 CHEMBL4868359 IC50 656.0 nM
Nc1ncnn2c(-c3ccc4c(c3)oc(=O)n4Cc3ccc(F)cc3)ccc12 CHEMBL5208862 IC50 663.0 nM
COC(=O)Nc1cc(-c2cc(C)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5195653 IC50 690.0 nM
COc1cc(Cn2c(=O)oc3cc(-c4cnc5[nH]ccc5c4)ccc32)ccc1F CHEMBL5200231 IC50 719.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 Kd apparent 746.0 nM
O=C1c2ccc(-c3cnc4[nH]ccc4c3)cc2OCCN1Cc1cc(C(F)(F)F)ccc1F CHEMBL5175869 IC50 770.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 801.0 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 810.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 Kd 820.0 nM
O=c1oc2cc(-c3ccnc4[nH]ncc34)ccc2n1Cc1ccc(F)cc1 CHEMBL5178825 IC50 910.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 950.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM