N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)cc1 CHEMBL3110100 IC50 0.1 nM
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccc(Cl)cc2)CC1 CHEMBL3110122 IC50 0.1 nM
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110117 IC50 0.1 nM
COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4c(C)ccc4c(=O)[nH]3)CC2)cc1 CHEMBL3805896 IC50 0.18 nM
N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)cc1Cl CHEMBL3110106 IC50 0.2 nM
N#Cc1cccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)c1 CHEMBL3110104 IC50 0.2 nM
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2cccc(Cl)c2)CC1 CHEMBL3110103 IC50 0.2 nM
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccccn2)CC1 CHEMBL3110102 IC50 0.2 nM
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccncc2)CC1 CHEMBL3110101 IC50 0.2 nM
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1 CHEMBL3110121 IC50 0.2 nM
O=C(CCSc1nc2c(c(=O)[nH]1)CCCC2)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110119 IC50 0.2 nM
COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4cc(F)cc4c(=O)[nH]3)CC2)cc1 CHEMBL3806163 IC50 0.2 nM
COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4cc(F)cc4c(=O)[nH]3)CC2)cn1 CHEMBL3805393 IC50 0.24 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3c(c2)cc(C(=O)O)n3C)CC1)c1ccc(OC)cc1 CHEMBL4645574 IC50 0.26 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3cnn(C)c3c2)CC1)c1ccc(C(=O)O)cc1 CHEMBL4634919 IC50 0.27 nM
N#Cc1cc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)ccc1Cl CHEMBL3110105 IC50 0.3 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc4[nH]c(=O)n(-c5ncccn5)c4c3)CC2)[C@H]1c1ccccc1 CHEMBL3917693 IC50 0.316 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3cc(C(=O)O)n(C)c3c2)CC1)c1ccc(OC)cc1 CHEMBL4640008 IC50 0.36 nM
C[C@H]1OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(C#N)ccc43)CC2)[C@H]1c1ccccc1 CHEMBL4115425 IC50 0.375 nM
COc1ccc(C(=O)C2CCN(C(=O)CCCc3nc4c(C)scc4c(=O)[nH]3)CC2)cc1C CHEMBL3804939 IC50 0.4 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3ncn(C)c3c2)CC1)c1ccc(C(=O)O)cc1 CHEMBL4643690 IC50 0.41 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3c(cnn3C)c2)CC1)c1ccc(C(=O)O)cc1 CHEMBL4639702 IC50 0.5 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3c(C(=O)O)nn(C)c3c2)CC1)c1ccc(OC)cc1 CHEMBL4632401 IC50 0.52 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn12 CHEMBL5199558 IC50 0.6 nM
CNC(=O)[C@H](CNC(=O)CCn1c(=O)[nH]c(=O)c2ccccc21)NC(=O)c1cnc2ccccc2c1 CHEMBL5401025 pIC50 0.7943 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 CHEMBL4458129 IC50 0.8 nM
Cc1ccc2c(=O)[nH]c(-c3ccc([C@](C)(O)CCO)cc3)cn12 CHEMBL5272750 IC50 0.8 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nn12 CHEMBL5274873 IC50 0.8 nM
CC(C)n1cc(C(=O)C2CCN(C(=O)CCCc3nc4c(ccn4C)c(=O)[nH]3)CC2)cn1 CHEMBL3806049 IC50 0.81 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4c(F)c(C#N)ccc43)CC2)[C@H]1c1ccccc1 CHEMBL2381946 IC50 1.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(C#N)ccc43)CC2)[C@H]1c1ccccc1 CHEMBL2381942 IC50 1.0 nM
O=C(CCCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110118 IC50 1.0 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C4(O)CC4)cc3)cn12 CHEMBL5271127 IC50 1.0 nM
Oc1nc(-c2ccc(C(F)(F)F)cc2)nc2c1CSCC2 CHEMBL1086580 IC50 1.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@@H](c3cnc4ccn(-c5ncccn5)c4c3)CC2)[C@H]1c1ccccc1 CHEMBL3912956 IC50 1.01 nM
COc1ccc(-c2cc3c(c(=O)[nH]2)CCCN3C)cc1 CHEMBL3589282 IC50 1.1 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 CHEMBL4588170 IC50 1.2 nM
CC(C)(O)c1ccc(-c2cn3c(F)c(F)cc3c(=O)[nH]2)cc1 CHEMBL5284314 IC50 1.2 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C4CCNCC4)cc3)nc12 CHEMBL4567515 IC50 1.3 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc(N)c(-c4ncccn4)c3)CC2)[C@H]1c1ccccc1 CHEMBL3099716 IC50 1.47 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(Br)cnc43)CC2)[C@H]1c1ccccc1 CHEMBL3927399 IC50 1.48 nM
CN1CCCc2c1cc(-c1ccc(C(F)(F)F)cc1)[nH]c2=O CHEMBL3589283 IC50 1.5 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(N4CCN(C)CC4)cc3)nc12 CHEMBL4584689 IC50 1.5 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C(C)(C)OCCO)cc3)nc12 CHEMBL4551200 IC50 1.6 nM
Cc1ccc2c(=O)[nH]c(-c3ccc([C@@](C)(O)CO)cc3)cn12 CHEMBL5269584 IC50 1.9 nM
CC(C)(O)c1ccc(-c2cn3cc(F)cc3c(=O)[nH]2)cc1 CHEMBL5269897 IC50 1.9 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(c2ccncn2)CC1 CHEMBL4098952 pIC50 1.995 nM
Cc1cc(OCC(=O)NCCNC(=O)c2cccc(COc3ccccc3C(N)=O)c2)c2c3c(c(=O)oc2c1)CCC3 CHEMBL5414217 pIC50 1.995 nM
O=C(CCCc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110116 IC50 2.0 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)Nc4ccncc4)CC3)c(=O)c3ccccc32)cccc1C(F)(F)F CHEMBL4794878 IC50 2.0 nM
Cc1cccc(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)Nc4ccncc4)CC3)c(=O)c3c(C)cccc32)c1C#N CHEMBL4747523 IC50 2.0 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(Cl)c1C#N CHEMBL4786379 IC50 2.0 nM
Cc1csc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 CHEMBL5279709 IC50 2.0 nM
Cc1ccc2c(=O)[nH]c(-c3ccc([C@@](C)(O)CCO)cc3)cn12 CHEMBL5280682 IC50 2.1 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C4CCN(C)CC4)cc3)nc12 CHEMBL4450725 IC50 2.2 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)OCCO)cc3)cn12 CHEMBL5281076 IC50 2.3 nM
Cc1cc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn2c1 CHEMBL5280345 IC50 2.3 nM
COc1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)CSCC3)CC1 CHEMBL4452246 IC50 2.5 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccnnc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4757303 IC50 2.5 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3cnn(C)c3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4759993 IC50 2.5 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C4(O)COC4)cc3)cn12 CHEMBL5275576 IC50 2.5 nM
CC(C)(O)c1ccc(-c2cn3cc(Cl)cc3c(=O)[nH]2)cc1 CHEMBL5280167 IC50 2.5 nM
Cn1cnc(C(=O)N2CCN(C(=O)c3ccc(Nc4nc5ccccc5n5nnnc45)cc3)CC2)c1 CHEMBL4060134 pIC50 2.512 nM
Cc1ccc2c(=O)[nH]c(-c3ccc([C@](C)(O)CO)cc3)cn12 CHEMBL5278616 IC50 2.6 nM
CC(C)(O)c1ccc(-c2cn3cccc3c(=O)[nH]2)cc1 CHEMBL5279214 IC50 2.7 nM
Cc1ncc2c(=O)[nH]c(-c3ccc(C(C)(C)C)cc3)cn12 CHEMBL5277254 IC50 2.9 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cnccc43)CC2)[C@H]1c1ccc(F)cc1 CHEMBL3899350 IC50 2.95 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(C#N)c(F)cc43)CC2)[C@H]1c1ccccc1 CHEMBL2381945 IC50 3.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cnccc43)CC2)[C@H]1c1ccccc1 CHEMBL2381939 IC50 3.0 nM
C[C@@]1(c2ccccc2)CN([C@H]2CC[C@@H](n3c(=O)[nH]c4cc(C#N)ccc43)CC2)C(=O)O1 CHEMBL3963667 IC50 3.0 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)Nc4ccncc4)CC3)c(=O)c3c(Cl)cccc32)cccc1C(F)(F)F CHEMBL4754447 IC50 3.2 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4759701 IC50 3.2 nM
Cc1c(F)ccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4788947 IC50 3.2 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1ccccc1C#N CHEMBL4758600 IC50 3.2 nM
CC(C)(C)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)cc1 CHEMBL4586580 IC50 3.3 nM
COc1ccc(N2CCN(c3nc4c(c(=O)[nH]3)CSCC4)CC2)cc1 CHEMBL4453770 IC50 3.4 nM
CC(C)(O)c1ccc(-c2cn3c(F)ccc3c(=O)[nH]2)cc1 CHEMBL5276381 IC50 3.4 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(C#N)ccc43)CC2)[C@H]1c1ccc(F)cc1 CHEMBL3936768 IC50 3.42 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCCO)cc(F)c13)[nH]c2=O CHEMBL4463639 IC50 3.5 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4c(C#N)cccc43)CC2)[C@H]1c1ccccc1 CHEMBL2381943 IC50 3.56 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC#N)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4532667 IC50 3.7 nM
Cn1ccc2c(=O)[nH]c(N3CCC4(CC3)CN(CCO)c3cc(F)cc(F)c34)nc21 CHEMBL4441063 IC50 3.8 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 CHEMBL5402698 IC50 3.8 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccnc4cc(F)cnc34)CC2)[C@H]1c1ccccc1 CHEMBL2381936 IC50 3.86 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3csc(-c4ncccn4)n3)CC2)[C@H]1c1ccccc1 CHEMBL3962475 IC50 3.94 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(C(=O)c2c[nH]cn2)CC1 CHEMBL4094551 pIC50 3.981 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4ccncc43)CC2)[C@H]1c1ccccc1 CHEMBL2381938 IC50 4.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cccnc43)CC2)[C@H]1c1ccccc1 CHEMBL2381937 IC50 4.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccnc4cccnc34)CC2)[C@H]1c1ccccc1 CHEMBL2381935 IC50 4.0 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)Nc3ccncc3)CC2)c(=O)c2ccccc21 CHEMBL4791639 IC50 4.0 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)Nc4ccncc4)CC3)c(=O)c3c(F)cccc32)cccc1C(F)(F)F CHEMBL4799048 IC50 4.0 nM
COc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4798387 IC50 4.0 nM
Cc1ccc(NC(=O)[C@H]2CC[C@H](Cn3c(=O)c4c(C)cccc4n(Cc4cccc(C(F)(F)F)c4C#N)c3=O)CC2)cn1 CHEMBL4763370 IC50 4.0 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4761298 IC50 4.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCC(=O)O)cc(F)c13)[nH]c2=O CHEMBL4466181 IC50 4.2 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CS(C)(=O)=O)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4442053 IC50 4.3 nM
COc1cc(F)c2c(c1)N(C)C(=O)C21CCN(c2nc3c(c(=O)[nH]2)CCCN3C)CC1 CHEMBL4470218 IC50 4.4 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cccc(F)c23)nc2c1CCCC2 CHEMBL4454164 IC50 4.4 nM
O=C1N(CCO)c2cccc(Cl)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4483558 IC50 4.4 nM
Cn1ccc2c(=O)[nH]c(N3CCC4(CC3)C(=O)N(CCO)c3cc(F)cc(F)c34)nc21 CHEMBL4460022 IC50 4.5 nM
COCCOc1cc(F)c2c(c1)N(C)C(=O)C21CCN(c2nc3c(c(=O)[nH]2)CCCN3C)CC1 CHEMBL4572668 IC50 4.8 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CCSC2 CHEMBL2431805 pIC50 4.898 nM
CC1(c2ccccc2)CN([C@H]2CC[C@@H](n3c(=O)[nH]c4cc(C#N)ccc43)CC2)C(=O)O1 CHEMBL3915681 IC50 4.9 nM
CN(C)CCOc1cc(F)c2c(c1)N(C)C(=O)C21CCN(c2nc3c(c(=O)[nH]2)CCCN3C)CC1 CHEMBL4457037 IC50 4.9 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cncnc43)CC2)[C@H]1c1ccccc1 CHEMBL2381941 IC50 5.0 nM
CC(C)(C)c1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL4290134 IC50 5.0 nM
N#Cc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)C3CCCNC43)CC2)nc1 CHEMBL5206816 IC50 5.0 nM
CC1(c2ccc(-c3nc4ccccc4c(=O)[nH]3)cc2)NC(=O)NC1=O CHEMBL5275705 IC50 5.0 nM
Cc1cccc2c(=O)[nH]c(CCC(=O)Nc3ccc(C(=O)Nc4cccc5cccnc45)cc3)nc12 CHEMBL4069447 IC50 5.1 nM
CC1(C)OC(=O)N(C2CCC(c3cnc4[nH]ccc4c3)CC2)[C@H]1c1ccccc1 CHEMBL3902790 IC50 5.17 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3csc(-c4ccccc4)n3)CC2)[C@H]1c1ccccc1 CHEMBL3912818 IC50 5.18 nM
Cc1cccc2c(=O)[nH]c(N3CCC4(CC3)C(=O)N(CCO)c3cc(F)cc(F)c34)nc12 CHEMBL4585076 IC50 5.3 nM
O=C1Nc2cc(Cl)cc(Cl)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4469038 IC50 5.3 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(Cl)ccc43)CC2)[C@H]1c1ccccc1 CHEMBL3968203 IC50 5.33 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cc(F)cc(F)c23)nc2c1CCCC2 CHEMBL4533577 IC50 5.4 nM
Cc1cccc2c(=O)[nH]c(N3CCC4(CC3)CN(CCO)c3cc(F)cc(F)c34)nc12 CHEMBL4566625 IC50 5.5 nM
O=C1Nc2cccc(F)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4449621 IC50 5.8 nM
O=C1Nc2cccc(Br)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4572625 IC50 5.8 nM
CC(C)c1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL2431867 IC50 6.0 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1C CHEMBL3918110 IC50 6.0 nM
CN1CCCc2c1cc(-c1ccc(Br)cc1)[nH]c2=O CHEMBL3589285 IC50 6.1 nM
CN1CCC(Oc2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)CC1 CHEMBL4553990 IC50 6.1 nM
O=c1[nH]c(SCCN2CCN(CCSc3nc4ccccc4c(=O)[nH]3)CC2)nc2ccccc12 CHEMBL4638701 IC50 6.1 nM
COc1cccc(N2CCN(c3nc4c(c(=O)[nH]3)CSCC4)CC2)c1 CHEMBL4538780 IC50 6.2 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)NCCc3nc4c(C(N)=O)cccc4[nH]3)cc1)C2=O CHEMBL4529965 IC50 6.3 nM
CN(C)c1cc(F)c2c(c1)N(C)C(=O)C21CCN(c2nc3c(c(=O)[nH]2)CCCN3C)CC1 CHEMBL4442841 IC50 6.3 nM
Cc1ccc2c(c1C)c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4786460 IC50 6.3 nM
Cc1c(F)ccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL3109648 IC50 6.3 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(c2ccncc2)CC1 CHEMBL4080918 pIC50 6.31 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cccc(Cl)c23)nc2c1CCCC2 CHEMBL4441713 IC50 6.4 nM
O=C1Nc2cc(F)cc(F)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4529394 IC50 6.4 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cnc(Cl)cc43)CC2)[C@H]1c1ccccc1 CHEMBL3926356 IC50 6.52 nM
O=C1N(CCO)c2cccc(F)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4577914 IC50 6.8 nM
CC1(C)OC(=O)N(C2CC=C(c3cc4ccncc4[nH]c3=O)CC2)[C@H]1c1ccccc1 CHEMBL3892522 IC50 6.91 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc(N)c(C#N)c3)CC2)[C@H]1c1ccccc1 CHEMBL3099718 IC50 6.98 nM
O=C(CCc1cccc(Cl)c1Cl)Nc1nnc2n1CCS2 CHEMBL2425812 IC50 7.0 nM
N#CCOC(=O)c1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL2431803 IC50 7.0 nM
CC(C)(O)c1ccc(-c2nc3ccc(F)c(F)c3c(=O)[nH]2)cc1 CHEMBL4545573 IC50 7.0 nM
CC(C)(O)c1ccc(-c2nc3c(F)cc(F)cc3c(=O)[nH]2)cc1 CHEMBL4437173 IC50 7.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cnc(C#N)cc43)CC2)[C@H]1c1ccccc1 CHEMBL3902644 IC50 7.42 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)n3ccc4cccnc43)CC2)[C@H]1c1ccccc1 CHEMBL3927898 IC50 7.46 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CCO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4445363 IC50 7.5 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cc(Cl)cc(Cl)c23)nc2c1CCCC2 CHEMBL4521982 IC50 7.5 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](N3Cc4cc(C#N)ccc4NC3=O)CC2)[C@H]1c1ccccc1 CHEMBL3912326 IC50 7.63 nM
CN1CCN(c2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)CC1 CHEMBL4582280 IC50 7.7 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC1COC1)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4581567 IC50 7.8 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4439372 IC50 7.9 nM
CN1CCN(CCOc2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)CC1 CHEMBL4441668 IC50 7.9 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)O)CC3)c(=O)c3ccccc32)cccc1C(F)(F)F CHEMBL3109647 IC50 7.9 nM
O=C1CCCN1c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4083872 pIC50 7.943 nM
O=C1COCCN1c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4089774 pIC50 7.943 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(c2ncccn2)CC1 CHEMBL4087470 pIC50 7.943 nM
Cn1ccc(C(=O)N2CCN(C(=O)c3ccc(Nc4nc5ccccc5n5nnnc45)cc3)CC2)n1 CHEMBL4096094 pIC50 7.943 nM
O=C(CCn1c(=O)[nH]c(=O)c2ccccc21)NCCNC(=O)c1cnc2ccccc2c1 CHEMBL5398050 pIC50 7.943 nM
COc1ccccc1NC(=O)c1ccc(NC(=O)CCc2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL2314698 IC50 8.0 nM
COc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4749857 IC50 8.1 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cc(Cl)ccc23)nc2c1CCCC2 CHEMBL4469043 IC50 8.4 nM
Cc1ccc2c(=O)[nH]c(CCCC(=O)N3CCC(Oc4ccc(C#N)cc4)CC3)nn12 CHEMBL3805627 IC50 8.5 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC(O)CO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4464007 IC50 8.9 nM
N#Cc1cccnc1N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4ccccc34)c2)CC1 CHEMBL3740104 IC50 9.0 nM
O=C1N(CCO)c2cc(Cl)cc(Cl)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4461149 IC50 9.0 nM
O=C(Nc1cccc2c(=O)[nH]ccc12)[C@H]1CCCNC1 CHEMBL5190651 IC50 9.0 nM
COc1ccc(-c2nc(O)c3ccccc3n2)cc1 CHEMBL336718 IC50 9.0 nM
C[C@]1(c2ccccc2)CN([C@H]2CC[C@H](n3c(=O)[nH]c4cnccc43)CC2)C(=O)O1 CHEMBL4108027 IC50 9.01 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)Nc1ccc(C(=O)Nc2cccc3cccnc23)cc1 CHEMBL4098188 IC50 9.1 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cnn4cccnc34)CC2)[C@H]1c1ccccc1 CHEMBL3942458 IC50 9.18 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCCN4CCOCC4)cc(F)c13)[nH]c2=O CHEMBL4544771 IC50 9.2 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2cccc(F)c23)nc2c1CCCC2 CHEMBL4560087 IC50 9.2 nM
CC1(C)OC(=O)N([C@@H]2CC=C(c3cnc4ccn(-c5ncccn5)c4c3)CC2)[C@H]1c1ccccc1 CHEMBL4115067 IC50 9.26 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1 CHEMBL3945783 IC50 9.5 nM
CC(C)(O)c1ccc(-c2cn3c(CO)ccc3c(=O)[nH]2)cc1 CHEMBL5281885 IC50 9.8 nM
N#Cc1cccc2c1C1(CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC1)CN2 CHEMBL4438002 IC50 9.9 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cccc4cccnc34)CC2)[C@H]1c1ccccc1 CHEMBL2381934 IC50 10.0 nM
COc1ccc2c(c1)CC1(CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC3CC3)CC1)C2=O CHEMBL3966355 IC50 10.0 nM
COc1ccc2c(c1)CC1(CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC(F)F)CC1)C2=O CHEMBL3895038 IC50 10.0 nM
CC(=O)N(C)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4101869 pIC50 10.0 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(C(=O)c2cc[nH]n2)CC1 CHEMBL4068794 pIC50 10.0 nM
CC(C)(OCCO)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)cc1 CHEMBL4536612 IC50 10.0 nM
O=C1N(CCO)c2cc(F)cc(F)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4554146 IC50 10.0 nM
O=C1Nc2cccc(Cl)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4441837 IC50 10.2 nM
COCCN1C(=O)C2(CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)c2c(F)cc(F)cc21 CHEMBL4466701 IC50 10.3 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL521686 IC50 10.4 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4ncccc43)CC2)[C@H]1c1ccccc1 CHEMBL2381940 IC50 10.7 nM
CC(C)(O)c1ccc(-c2nc3c(Cl)cccc3c(=O)[nH]2)cc1 CHEMBL4514589 IC50 11.0 nM
O=C1Nc2cc(F)ccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4521841 IC50 11.0 nM
CC(C)(C)c1ccc(-c2nc(O)c3c(n2)CCSC3)cc1 CHEMBL5286471 IC50 11.0 nM
O=c1[nH]c(-c2ccc(Br)cc2)nc2ccccc12 CHEMBL2058057 IC50 11.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCCN4CCCC4)cc(F)c13)[nH]c2=O CHEMBL4525942 IC50 11.1 nM
C[C@@H]1CN(c2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)C[C@H](C)N1 CHEMBL4539435 IC50 11.1 nM
O=C1Nc2cc(Cl)ccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4457667 IC50 11.1 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cc(-c4ncccn4)c[nH]c3=O)CC2)[C@H]1c1ccccc1 CHEMBL3904622 IC50 11.4 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccnc(-c4ccccc4)n3)CC2)[C@H]1c1ccccc1 CHEMBL3933484 IC50 11.4 nM
CC1(C)OC(=O)N(C2CCC(c3cc4ccncc4[nH]c3=O)CC2)[C@H]1c1ccccc1 CHEMBL3897296 IC50 11.5 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4ccccc43)CC2)C1c1ccccc1 CHEMBL3936168 IC50 11.8 nM
CC1(C)OC(=O)N(c2ccc(-c3cc4ccncc4[nH]c3=O)cc2)[C@H]1c1ccccc1 CHEMBL3930085 IC50 11.8 nM
O=C(CCc1c(Cl)cccc1Cl)Nc1nnc2n1CCS2 CHEMBL2425810 IC50 12.0 nM
Cc1cc(NCCc2ccc(O)cc2)c2nncn2n1 CHEMBL3238252 IC50 12.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CN(C)C)cc3)cc12 CHEMBL3763641 IC50 12.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CN4CCOCC4)cc3)cc12 CHEMBL3765008 IC50 12.0 nM
COc1ccc2c(c1)CC1(CCN([C@H]3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC1)C2=O CHEMBL3952773 IC50 12.0 nM
CN1CCN(c2ccc(-c3nc4ccc(F)cc4c(=O)[nH]3)cc2)CC1 CHEMBL4455904 IC50 12.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCCN4CCCCC4)cc(F)c13)[nH]c2=O CHEMBL4471663 IC50 12.0 nM
Cc1ncc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn12 CHEMBL5289848 IC50 12.0 nM
NS(=O)(=O)c1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL5277753 IC50 12.0 nM
CC(C)(O)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)cc1 CHEMBL4447252 IC50 12.5 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cccc5nccnc45)C3)n2-c2ccccc2F)nc1 CHEMBL5090849 pIC50 12.59 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1 CHEMBL3897483 IC50 12.8 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(N4CCNCC4)cc(F)c13)[nH]c2=O CHEMBL4574717 IC50 12.8 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CN4CCC(N(C)C)CC4)cc3)cc12 CHEMBL3765269 IC50 13.0 nM
Cc1cc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn2n1 CHEMBL5284505 IC50 13.0 nM
COc1ccc(NC(=O)c2ccc(NC(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)cc2)cc1 CHEMBL5176874 IC50 13.5 nM
CN1CCCc2c1nc(N1CCC3(CC1)CN(CCO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4518341 IC50 13.6 nM
Cn1cc2cccc(C(=O)N[C@H]3CC[C@H](N4C(=O)OC(C)(C)[C@@H]4c4ccccc4)CC3)c2n1 CHEMBL3918037 IC50 13.7 nM
O=C(CCc1ccccc1Cl)Nc1nnc2n1CCS2 CHEMBL2425809 IC50 14.0 nM
CC(C)(O)c1ccc(-c2nc3c(F)cccc3c(=O)[nH]2)cc1 CHEMBL4558610 IC50 14.0 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2cc(F)cc(F)c23)nc2c1CCCC2 CHEMBL4448872 IC50 14.0 nM
Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1 CHEMBL3137320 Kd 14.0 nM
CN1CCc2c1nc(N1CCC3(CC1)C(=O)N(CCO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4439240 IC50 14.1 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc(N)c(-c4nccc(C(=N)N)n4)c3)CC2)[C@H]1c1ccccc1 CHEMBL3893214 IC50 14.3 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(N4CCOCC4)cc(F)c13)[nH]c2=O CHEMBL4446044 IC50 14.9 nM
CC(C)(O)c1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL4475367 IC50 15.0 nM
O=c1[nH]c(-c2ccc(C3CCNCC3)cc2)nc2c(F)cc(F)cc12 CHEMBL4457148 IC50 15.0 nM
O=C1OCCN1c1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL5270676 IC50 15.0 nM
Cc1cn(CC(=O)N[C@@H](CCCCn2cc(-c3ccncc3F)nn2)C(N)=O)c(=O)[nH]c1=O CHEMBL5424788 Kd 15.0 nM
COc1ccc2c(c1)C(CC(=O)NCCNC(=O)CCn1c(=O)[nH]c(=O)c3ccccc31)CC2=O CHEMBL5418588 IC50 15.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2cccs2)CC1 CHEMBL2419698 IC50 15.4 nM
COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC3CC3)CC2)cc1 CHEMBL2419706 IC50 15.5 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)O)CC3)c(=O)c3c(Cl)cccc32)cccc1C(F)(F)F CHEMBL4781804 IC50 15.8 nM
Cc1ccc2c(c1C)c(=O)n(C[C@H]1CC[C@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4761086 IC50 15.8 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(C(=O)c2ncccn2)CC1 CHEMBL4079594 pIC50 15.85 nM
CC(=O)N1CCN(C(=O)c2ccc(Nc3nc4ccccc4n4nnnc34)cc2)CC1 CHEMBL4098529 pIC50 15.85 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](C(=O)Nc3cccc4cccnc34)CC2)[C@H]1c1ccccc1 CHEMBL2381960 IC50 16.0 nM
O=C(CSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110115 IC50 16.0 nM
CN(C)Cc1ccc(-c2cc3c(F)cccc3c(=O)[nH]2)cc1 CHEMBL3763480 IC50 16.0 nM
C[C@H](C1CC1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL4112739 IC50 16.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(OCCN(C)C)cc3)cc12 CHEMBL3959757 IC50 16.0 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C(=O)N4CCN(C)CC4)nc3)cc12 CHEMBL3951809 IC50 16.0 nM
CC1(C)OC(=O)N(C2CC=C(c3cnc(N)c(-c4ncccn4)c3)CC2)C1c1ccccc1 CHEMBL3978474 IC50 16.0 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cccc(Br)c23)nc2c1CCCC2 CHEMBL4556736 IC50 16.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4cnnc(Cl)c4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3935903 IC50 16.2 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC(F)(F)F)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4470270 IC50 16.2 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2cccc(Cl)c23)nc2c1CCCC2 CHEMBL4535636 IC50 16.6 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cc(F)ccc23)nc2c1CCCC2 CHEMBL4461426 IC50 16.7 nM
N#Cc1cccc2c1C1(CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC1)C(=O)N2 CHEMBL4462707 IC50 16.8 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CN4CCN(C)CC4)cc3)cc12 CHEMBL3764244 IC50 17.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CN4CCNCC4)cc3)cc12 CHEMBL3764967 IC50 17.0 nM
O=C(CN1CCC2(CC1)Cc1cc(F)ccc1C2=O)N(Cc1nc2c(c(=O)[nH]1)COCC2)CC1CC1 CHEMBL3889537 IC50 17.0 nM
Cc1cccc2c(=O)[nH]c(-c3cnc(N4CCN(C)CC4)nc3)cc12 CHEMBL3957840 IC50 17.0 nM
CN(C)CCOc1ccc(-c2cc3ccccc3c(=O)[nH]2)cc1 CHEMBL3894241 IC50 17.0 nM
CC(C)(O)c1ccc(-c2nc3cccc(F)c3c(=O)[nH]2)cc1 CHEMBL4548930 IC50 17.0 nM
CC1(c2ccccc2)CN([C@H]2CC[C@H](n3c(=O)[nH]c4cnccc43)CC2)C(=O)O1 CHEMBL3952354 IC50 17.2 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3ccnc4cccnc34)cc2)[C@H]1c1ccccc1 CHEMBL2381959 IC50 18.0 nM
CN(C)Cc1ccc(-c2cc3ccccc3c(=O)[nH]2)cc1 CHEMBL3764754 IC50 18.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC(F)F)CC2)cc1 CHEMBL3935111 IC50 18.0 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2cc(Cl)cc(Cl)c23)nc2c1CCCC2 CHEMBL4591423 IC50 18.2 nM
COc1cccc2c(=O)[nH]c(-c3ccc(CN(C)C)cc3)cc12 CHEMBL3764757 IC50 19.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc4cc[nH]c4c3)CC2)[C@H]1c1ccccc1 CHEMBL3986563 IC50 19.0 nM
O=C1N(CCO)c2ccccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4545585 IC50 19.0 nM
Cc1ccc(-c2nc3c(sc4ccccc43)c(=O)[nH]2)cc1 CHEMBL3344071 IC50 19.4 nM
COc1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)CC(F)(F)CC3)CC1 CHEMBL4475497 IC50 19.4 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1C CHEMBL3921853 IC50 19.5 nM
CC(=O)Nc1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4073498 pIC50 19.95 nM
COCCN(C)C(=O)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4066552 pIC50 19.95 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(C(=O)C2CC2)CC1 CHEMBL4096495 pIC50 19.95 nM
O=C(Cc1n[nH]c(=O)c2ccccc12)OCC(=O)N1CCN(c2ccccn2)CC1 CHEMBL5404185 pIC50 19.95 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cccnc43)CC2)C1c1ccccc1 CHEMBL3970313 IC50 20.1 nM
COc1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)CCCC3)CC1 CHEMBL4454483 IC50 20.5 nM
O=C(C[C@H]1CCCN1Cc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110114 IC50 21.0 nM
CN1CCCc2c1cc(-c1ccc(Cl)cc1)[nH]c2=O CHEMBL3589284 IC50 21.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CN4CC(N(C)C)C4)cc3)cc12 CHEMBL3764573 IC50 21.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)CCCC4)CC2)cc1 CHEMBL3933931 IC50 21.0 nM
O=C(CN1CCC(C(=O)c2ccc(OCCC3CC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3944401 IC50 21.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(N4CCN(C)CC4)nc3)cc12 CHEMBL3980436 IC50 21.0 nM
CC(C)(C)c1ccc(-c2cn3ccnc3c(=O)[nH]2)cc1 CHEMBL5274180 IC50 21.0 nM
O=C(Nc1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1)c1cccs1 CHEMBL3431396 IC50 21.0 nM
CC(C)(C)c1ccc(-c2nc3c(sc4ccccc43)c(=O)[nH]2)cc1 CHEMBL3344072 IC50 21.3 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(N4CCCCC4)cc(F)c13)[nH]c2=O CHEMBL4467730 IC50 21.3 nM
Cc1ccc(-c2nc3c(O)cccc3c(=O)[nH]2)cc1 CHEMBL3827272 IC50 22.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5c(cnn5C)c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3945237 IC50 22.0 nM
CCCOc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3906833 IC50 23.0 nM
O=C(CN1CCC(C(=O)c2ccc(OCC3CC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3928915 IC50 23.0 nM
CC(C)(O)c1ccc(-c2nc3ccc(Cl)cc3c(=O)[nH]2)cc1 CHEMBL4566814 IC50 23.0 nM
COC(=O)c1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL5267866 IC50 23.0 nM
COc1ccc(Cl)cc1N(CC(=O)N[C@H]1CC[C@H](n2c(=O)[nH]c3ccccc32)CC1)S(=O)(=O)c1ccccc1 CHEMBL2381947 IC50 24.0 nM
O=C(CCc1ccc(Cl)cc1Cl)Nc1nnc2n1CCS2 CHEMBL2425813 IC50 24.0 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCCN(CCC4NC(=O)C5=C(CCOC5)N4)C3=O)CC2)cc1 CHEMBL4109152 IC50 24.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)C[C@@H]2CCCO2)CC1 CHEMBL3892864 IC50 24.0 nM
CN1CCN(c2ccc(-c3cc4ccccc4c(=O)[nH]3)cn2)CC1 CHEMBL3978937 IC50 24.0 nM
O=C(C1CC1)N1CCN(c2ncc(-c3cc4c(O)cccc4c(=O)[nH]3)cn2)CC1 CHEMBL3957681 IC50 24.0 nM
COCCOC(C)(C)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)cc1 CHEMBL4440292 IC50 24.0 nM
CC1(C)OC(=O)N([C@@H]2CC=C(c3cc(-c4ncccn4)c[nH]c3=O)CC2)[C@H]1c1ccccc1 CHEMBL4108736 IC50 24.1 nM
CC1(C)OC(=O)N(C2CCN(c3cnc4ccn(-c5ncccn5)c4c3)CC2)[C@H]1c1ccccc1 CHEMBL3962794 IC50 24.3 nM
CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 CHEMBL1173055 IC50 25.0 nM
O=C(CN1CCC2(CC1)Cc1cc(F)ccc1C2=O)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3955207 IC50 25.0 nM
Cc1c(C(N)=O)ccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4762657 IC50 25.1 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(c2cccnc2)CC1 CHEMBL4079993 pIC50 25.12 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(C(=O)C2CCOCC2)CC1 CHEMBL4066095 pIC50 25.12 nM
Cn1cncc1C(=O)N1CCN(C(=O)c2ccc(Nc3nc4ccccc4n4nnnc34)cc2)CC1 CHEMBL4088369 pIC50 25.12 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cnc(C(F)(F)F)cc43)CC2)[C@H]1c1ccccc1 CHEMBL3948690 IC50 25.8 nM
COCCOc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3956527 IC50 26.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(C(=O)N4CCN(C)CC4)nc3)cc12 CHEMBL3891929 IC50 26.0 nM
CC(C)(O)c1ccc(-c2nc3c(F)ccc(F)c3c(=O)[nH]2)cc1 CHEMBL4454894 IC50 26.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccc4cc[nH]c4n3)CC2)[C@H]1c1ccccc1 CHEMBL3905472 IC50 26.4 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc4[nH]c(=O)n(-c5ncccn5)c4c3)CC2)[C@@H]1c1ccccc1 CHEMBL4109303 IC50 26.8 nM
O=C(N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1)[C@@H]1CCCN(Cc2nc3ccccc3c(=O)[nH]2)C1 CHEMBL3110113 IC50 27.0 nM
O=C(c1ccc(F)cc1)C1CCN(C2CCN(Cc3nc4c(c(=O)[nH]3)COCC4)C2=O)CC1 CHEMBL3956961 IC50 27.0 nM
CCOc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3903965 IC50 27.0 nM
CC(C)(C)c1ccc(-c2cn3cncc3c(=O)[nH]2)cc1 CHEMBL5275231 IC50 27.0 nM
O=C1Nc2ccccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4555506 IC50 27.6 nM
O=C(CCC1CCCC1)Nc1nnc2n1CCS2 CHEMBL2425800 IC50 28.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3986246 IC50 28.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)CCC4)CC2)cc1 CHEMBL3932754 IC50 28.5 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC(=O)O)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4466165 IC50 28.5 nM
O=c1[nH]c(N2CCC3(CC2)CNc2ccccc23)nc2c1CCCC2 CHEMBL4476087 IC50 28.5 nM
N#Cc1ccc2c(c1)[nH]c(=O)n2[C@H]1C[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2Cl)C1 CHEMBL4095003 pIC50 28.84 nM
CC#CCOc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC3CC3)CC2)cc1 CHEMBL3955426 IC50 29.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1Cl CHEMBL3905051 IC50 29.0 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(CN4CCN(C)CC4)cc3)cc12 CHEMBL3967859 IC50 29.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(C2CCN(Cc3nc4c(c(=O)[nH]3)COCC4)C2=O)CC1 CHEMBL3941919 IC50 30.0 nM
O=C(CN1CCC(C(=O)c2ccc(OCC3CCC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3944854 IC50 30.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(C)cc3)cc12 CHEMBL3763870 IC50 30.0 nM
O=C1Oc2ccccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4575275 IC50 30.2 nM
O=C(CCSc1nccc(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110120 IC50 31.0 nM
COc1ccccc1NC(=O)[C@H]1CC[C@H](NC(=O)CCc2nc3ccccc3c(=O)[nH]2)CC1 CHEMBL3110108 IC50 31.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)CCCC4)CC3CC3)CC2)cc1 CHEMBL3961412 IC50 31.0 nM
O=C(c1ccccc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3916481 IC50 31.0 nM
COc1cc2ncnc(N3CCC(CN4Cc5ccccc5NC4=O)CC3)c2cc1OC CHEMBL4285233 IC50 31.0 nM
CN1CCC(c2ccc(-c3nc4c(F)cc(F)cc4c(=O)[nH]3)cc2)CC1 CHEMBL4444673 IC50 31.0 nM
O=c1[nH]c(N2CCC3(CC2)OCc2ccccc23)nc2c1CCCC2 CHEMBL4551975 IC50 31.5 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(C2CCOCC2)CC1 CHEMBL4069265 pIC50 31.62 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCN(c2ccccn2)CC1 CHEMBL4104232 pIC50 31.62 nM
CNC(=O)[C@H](CNC(=O)c1cccc(COc2ccccc2C(N)=O)c1)NC(=O)COc1cc(C)cc2oc(=O)c3c(c12)CCC3 CHEMBL5412890 pIC50 31.62 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cc(-c4ncccn4)c[nH]c3=O)CC2)C1c1ccccc1 CHEMBL3937817 IC50 31.8 nM
O=C(CCC1CCCCC1)Nc1nnc2n1CCS2 CHEMBL2425801 IC50 32.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(Br)cc3)nc12 CHEMBL3098937 IC50 32.0 nM
Cc1cccc2c(O)nc(-c3ccc([N+](=O)[O-])cc3)nc12 CHEMBL127396 IC50 32.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3csc(Br)n3)CC2)[C@H]1c1ccccc1 CHEMBL3934977 IC50 32.1 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3nnc(-c4ccccc4)o3)CC2)[C@@H]1c1ccccc1 CHEMBL4109213 IC50 32.2 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1 CHEMBL3929005 IC50 33.0 nM
COc1ccc2c(c1)CC1(CCN(C3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC1)C2=O CHEMBL3965681 IC50 33.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1C CHEMBL3967549 IC50 33.0 nM
CN1CCN(c2ncc(-c3cc4ccccc4c(=O)[nH]3)cn2)CC1 CHEMBL3942785 IC50 33.0 nM
O=C1OC2(CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC2)c2ccccc21 CHEMBL4442606 IC50 33.7 nM
O=C1SCCc2nc(-c3ccc(C(F)(F)F)cc3)[nH]c(=O)c21 CHEMBL4059827 pIC50 33.88 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5c(c(=O)[nH]4)CCC5)C3=O)CC2)cc1 CHEMBL3927023 IC50 34.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cc4ccncc4[nH]3)CC2)[C@H]1c1ccccc1 CHEMBL3896548 IC50 34.0 nM
COc1ccccc1NC(=O)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5188771 IC50 34.8 nM
Cc1cccc2c(O)nc(-c3ccc(N)cc3)nc12 CHEMBL541203 IC50 35.0 nM
Cc1ccc(-c2nc3c(C)cccc3c(=O)[nH]2)cc1 CHEMBL3098940 IC50 35.0 nM
CC(C)Oc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3947374 IC50 35.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC2CC2)CC1 CHEMBL2419705 IC50 35.0 nM
COCCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(OC)cc2)CC1 CHEMBL3940683 IC50 35.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3960803 IC50 35.0 nM
CC(C)(O)c1ccc(-c2nc3cccc(Cl)c3c(=O)[nH]2)cc1 CHEMBL4457607 IC50 35.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 CHEMBL4524437 IC50 35.0 nM
COc1ccc(N2CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC2)cc1 CHEMBL4442353 IC50 35.0 nM
COc1ccccc1C1=CCN(c2nc3c(c(=O)[nH]2)CCCC3)CC1 CHEMBL4471982 IC50 35.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(Cl)cc3)nc12 CHEMBL3098939 IC50 36.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4ccc(Cl)c(C#N)c4)C3=O)CC2)cc1 CHEMBL3905010 IC50 36.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1 CHEMBL3937313 IC50 36.0 nM
C[C@@H]1CN(c2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)C[C@H](C)O1 CHEMBL4449082 IC50 36.0 nM
COc1ccc(-c2nc(O)c3cccc(C)c3n2)cc1 CHEMBL127101 IC50 37.0 nM
O=C(CCc1nc2c(c(=O)[nH]1)CCCN2)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110112 IC50 37.0 nM
O=C(c1ccc(F)cc1)C1CCN([C@H]2CCN(Cc3nc4c(c(=O)[nH]3)COCC4)C2=O)CC1 CHEMBL3929392 IC50 37.0 nM
O=C(CN1CCC(C(=O)c2ccc(Cl)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3925030 IC50 37.0 nM
CC[C@H](C)CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3964642 IC50 37.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3983088 IC50 37.0 nM
O=C(c1ccc(OC(F)(F)F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC2CC2)CC1 CHEMBL3891789 IC50 37.0 nM
O=c1[nH]c(SCCN2CCN(CCCc3nc(-c4ccccc4)no3)CC2)nc2ccccc12 CHEMBL4648016 IC50 37.4 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCN(CC(=O)Nc4nnc5n4CCS5)C3=O)CC2)cc1 CHEMBL3964994 IC50 38.0 nM
CC[C@H](C)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3898270 IC50 38.0 nM
CCOc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1F CHEMBL3964683 IC50 38.0 nM
CN1CCN(c2ccc(-c3cc4c(Cl)cccc4c(=O)[nH]3)cn2)CC1 CHEMBL3953295 IC50 39.0 nM
COc1ccc(-c2cc3c(C)cccc3c(=O)[nH]2)nc1 CHEMBL3962607 IC50 39.0 nM
Cc1ccc(NC(=O)c2ccc(NC(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)cc2)cc1 CHEMBL5174780 IC50 39.0 nM
CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1 CHEMBL372303 IC50 39.2 nM
COc1cccc(N2CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC2)c1 CHEMBL4076368 IC50 39.4 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)O)CC3)c(=O)c3c(F)cccc32)cccc1C(F)(F)F CHEMBL4764192 IC50 39.8 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc(C)c(C)c(=O)[nH]3)CC2)cc1 CHEMBL3901978 IC50 40.0 nM
O=C(CN1CCC(C(=O)c2ccc3c(c2)CCO3)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3939009 IC50 40.0 nM
Cc1cccc2c(O)nc(-c3ccccc3)nc12 CHEMBL124749 IC50 42.0 nM
C[C@@H](C1CC1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3940284 IC50 42.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1OC CHEMBL3977049 IC50 42.0 nM
CN1CCN(C(=O)c2ccc(-c3cc4c(O)cccc4c(=O)[nH]3)cn2)CC1 CHEMBL3982661 IC50 42.0 nM
CC1(c2ccccc2)CN([C@H]2CC[C@H](n3c(=O)[nH]c4ccccc43)CC2)C(=O)O1 CHEMBL3939673 IC50 42.8 nM
COc1ccc(C(=O)C2CCN(C3CCN(CC(=O)Nc4nnc5n4CCS5)C3=O)CC2)cc1 CHEMBL3897864 IC50 43.0 nM
C#CCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3965278 IC50 43.0 nM
CC[C@@H](C)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL4109734 IC50 43.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2ccccc2F)CC1 CHEMBL3945618 IC50 43.0 nM
O=C(c1ccc(OC(F)(F)F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3975140 IC50 43.0 nM
O=c1[nH]c(N2CCC3(CC2)COc2ccccc23)nc2c1CCCC2 CHEMBL4452289 IC50 43.4 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(F)cc3)nc12 CHEMBL3098938 IC50 44.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3nnc(-c4ccccc4)o3)CC2)[C@H]1c1ccccc1 CHEMBL3933998 IC50 45.2 nM
CS(=O)(=O)c1ccc(-c2nnc(/C=C/c3nnc(-c4ccc(C#N)cc4)o3)n2-c2ccccc2Cl)nc1 CHEMBL2325503 IC50 46.0 nM
O=c1[nH]c(-c2ccc(Cl)cc2)nc2c(O)cccc12 CHEMBL3099681 IC50 46.0 nM
COc1ccc(C(=O)C2CCN(C3CCCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1 CHEMBL3930536 IC50 46.0 nM
CCCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL2419702 IC50 46.0 nM
Cc1ccccc1-n1c(/C=C/c2nnc(-c3ccc(C#N)cc3)o2)nnc1-c1ccc(S(C)(=O)=O)cn1 CHEMBL5276118 IC50 46.0 nM
Cc1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL16861 pIC50 46.77 nM
CC1(C)OC(=O)N([C@H]2CC=C(c3cc(-c4ncccn4)c[nH]c3=O)CC2)[C@H]1c1ccccc1 CHEMBL3970873 IC50 46.8 nM
O=c1[nH]c(-c2ccc(Br)cc2)nc2c(O)cccc12 CHEMBL3827440 IC50 47.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc(C)c(C)c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3909379 IC50 47.0 nM
Cc1cnc(C(=O)NCCNC(=O)Cn2[nH]c(=O)c3ccccc3c2=O)cn1 CHEMBL5427001 IC50 47.0 nM
CC(c1cccs1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3986804 IC50 47.5 nM
Cc1cccc2c(O)nc(-c3ccc(C(F)(F)F)cc3)nc12 CHEMBL346886 IC50 48.0 nM
CN1CCN(Cc2ccc(-c3cc4ccc(F)cc4c(=O)[nH]3)cc2)CC1 CHEMBL3951529 IC50 48.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4ncccn4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3099720 IC50 49.0 nM
COc1cccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC(F)F)CC2)c1 CHEMBL3946798 IC50 49.0 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2ccccc23)nc2c1CCCC2 CHEMBL4579514 IC50 49.3 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2ccccc12 CHEMBL2419892 IC50 50.0 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110110 IC50 50.0 nM
O=c1[nH]nc2c3c(cccc13)N=C(CN1Cc3ccccc3C1)N2 CHEMBL3644587 IC50 50.0 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCOCC1 CHEMBL4087876 pIC50 50.12 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCNCC1 CHEMBL4077695 pIC50 50.12 nM
Cc1cccc2c(=O)[nH]c(-c3cnc(N4CCN(C(=O)C5CC5)CC4)nc3)cc12 CHEMBL3891325 IC50 51.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3coc(-c4ccccc4)n3)CC2)[C@H]1c1ccccc1 CHEMBL3946239 IC50 51.9 nM
Cc1cccc2c(O)nc(-c3ccc(O)cc3)nc12 CHEMBL125244 IC50 52.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4ccc5nncn5n4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3912260 IC50 52.1 nM
Oc1nc(-c2ccc(C(F)(F)F)cc2)nc2c(O)cccc12 CHEMBL151382 IC50 53.0 nM
N#Cc1ccc(CN(Cc2nc3c(c(=O)[nH]2)COCC3)C(=O)CN2CCC(C(=O)c3ccc(F)cc3)CC2)s1 CHEMBL3913243 IC50 53.0 nM
CN1CCc2c1nc(N1CCC3(CC1)CN(CCO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4555632 IC50 53.5 nM
O=C(CN1CCC(C(=O)c2ccc(F)cc2)CC1)NCc1nc2c(c(=O)[nH]1)CCCC2 CHEMBL3966085 IC50 55.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)(F)F)CC1 CHEMBL3941313 IC50 55.0 nM
O=[N+]([O-])c1ccc(-c2nc(O)c3cccc(O)c3n2)cc1 CHEMBL338088 IC50 58.0 nM
Oc1nc(-c2ccccc2)nc2ccccc12 CHEMBL127066 IC50 59.0 nM
CC(C)(C)CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3929923 IC50 60.0 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)Nc1ccc(-c2nnc(-c3ccccc3)o2)cc1 CHEMBL3110107 IC50 63.0 nM
C[C@H](c1ccccc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL4110589 IC50 63.0 nM
CN(C)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL1516121 pIC50 63.1 nM
O=C(c1ccc(Nc2nc3ccccc3n3nnnc23)cc1)N1CCCCC1 CHEMBL4075167 pIC50 63.1 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)Nc3ccncc3)CC2)c(=O)c2ccncc21 CHEMBL4780670 IC50 63.1 nM
O=C(NCCNC(=O)c1n[nH]c(=O)c2ccccc12)c1cccc(CN2C(=O)CNC2=O)c1 CHEMBL5394271 pIC50 63.1 nM
O=C(CN1CCC(C(=O)c2ccc(F)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL2419697 IC50 64.0 nM
Cc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3943283 IC50 64.0 nM
COc1ccccc1C1CCN(c2nc3c(c(=O)[nH]2)CCCC3)CC1 CHEMBL4444671 IC50 65.4 nM
O=c1cc(-c2ccc([N+](=O)[O-])cc2)oc2ccccc12 CHEMBL64780 IC50 66.0 nM
COc1ccc(CN(Cc2nc3c(c(=O)[nH]2)COCC3)C(=O)CN2CCC(C(=O)c3ccc(F)cc3)CC2)cc1 CHEMBL3938947 IC50 66.0 nM
CN(C)c1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL2431868 pIC50 66.07 nM
O=C(CN1CCC(C(=O)c2ccc(OC3CCOCC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3903427 IC50 67.0 nM
COc1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL4466835 IC50 67.6 nM
CC(C)CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL2419701 IC50 70.0 nM
COc1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL16312 pIC50 70.79 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4ncc(C)c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3931845 IC50 72.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(CCF)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3922251 IC50 72.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CNC(=O)OCc4ccccc4)cc3)nc12 CHEMBL3098935 IC50 73.0 nM
COc1cccc2c(O)nc(-c3ccc(C(F)(F)F)cc3)nc12 CHEMBL123798 IC50 73.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2nc3ccccc3s2)CC1 CHEMBL3956490 IC50 73.0 nM
O=C(c1ccc(C(F)(F)F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3952101 IC50 73.0 nM
Cc1ccc2c(c1)NC(=O)C2CC(=O)NCCNC(=O)CCn1c(=O)[nH]c(=O)c2ccccc21 CHEMBL5430269 IC50 75.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4nccc(C#N)n4)c[nH]c3=O)cc2)[C@H]1c1ccccc1 CHEMBL3978820 IC50 75.8 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(C(=O)N4CCN(CC5CC5)CC4)cn3)cc12 CHEMBL3964953 IC50 76.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3nc4ccccc4[nH]3)CC2)[C@H]1c1ccccc1 CHEMBL3949580 IC50 76.8 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4ncccn4)c[nH]c3=O)cc2)[C@H]1c1ccccc1 CHEMBL3946953 IC50 76.9 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2ccc(F)cc2F)CC1 CHEMBL3933577 IC50 77.0 nM
COc1ccc(-c2noc(CSc3nnc(C)n3-c3ccc(OC)cc3)n2)cc1 CHEMBL1898239 Kd 79.0 nM
COc1ccc(N2CCN(c3nc4c(c(=O)[nH]3)CC(F)(F)CC4)CC2)cc1 CHEMBL4461036 IC50 79.6 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccccc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL2419699 IC50 82.0 nM
Nc1ccc(-c2nc(O)c3cccc(O)c3n2)cc1 CHEMBL126167 IC50 83.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2cccc(F)c2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3937250 IC50 84.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4ncc(F)cn4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3913507 IC50 85.0 nM
CC1(C)OC(=O)N([C@@H]2CC=C(c3cnc4cc[nH]c4c3)CC2)[C@H]1c1ccccc1 CHEMBL4111046 IC50 88.6 nM
COc1cccc([C@@H]2N(c3ccc(C(=O)Nc4cccc5cccnc45)cc3)C(=O)OC2(C)C)c1 CHEMBL3907867 IC50 89.9 nM
O=c1[nH]c2ccccc2c2c1sc1ccccc12 CHEMBL3344061 IC50 90.0 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CCCC2 CHEMBL2419891 IC50 93.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4c(F)cc(F)cc43)CC2)[C@H]1c1ccccc1 CHEMBL3970169 IC50 93.0 nM
COc1cccc(CN(Cc2nc3c(c(=O)[nH]2)COCC3)C(=O)CN2CCC(C(=O)c3ccc(F)cc3)CC2)c1 CHEMBL3985156 IC50 94.0 nM
CC(C)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3907294 IC50 95.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4ccccn4)c[nH]c3=O)cc2)[C@H]1c1ccccc1 CHEMBL3903856 IC50 95.3 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5sc(C)cc5c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3967989 IC50 96.0 nM
CN1CCCc2c1cc(-c1ccccc1)[nH]c2=O CHEMBL3589281 IC50 97.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3cc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3946751 IC50 100.0 nM
Cc1cc(N2C[C@@H](C)N[C@@H](C)C2)ncc1-c1ccc(-c2nc3c(ccn3C)c(=O)[nH]2)cc1 CHEMBL4101890 IC50 100.0 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)Nc3ccncc3)CC2)c(=O)c2nc[nH]c21 CHEMBL4796484 IC50 100.0 nM
O=c1[nH]c(-c2ccc(F)cc2)nc2c(O)cccc12 CHEMBL3828676 IC50 101.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cn4ccccc4n3)CC2)[C@@H]1c1ccccc1 CHEMBL4111057 IC50 101.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(F)cc3)cc12 CHEMBL3763316 IC50 104.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL4113551 IC50 104.0 nM
O=C(c1ccccn1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC2CC2)CC1 CHEMBL3984137 IC50 105.0 nM
CC1(C)OC(=O)N(c2ccc(-n3c(=O)[nH]c4ccncc43)cc2)[C@H]1c1ccccc1 CHEMBL3949034 IC50 105.0 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1SCCC2 CHEMBL2419889 IC50 110.0 nM
O=c1[nH]c2ccccc2c2ccccc12 CHEMBL45245 IC50 110.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(Br)cc3)nc12 CHEMBL3827963 IC50 111.0 nM
O=c1cc(-c2ccc(-c3nnn[nH]3)cc2)oc2ccccc12 CHEMBL2431804 IC50 114.0 nM
CC1(C)OC(=O)N(c2ccc(-n3c(=O)[nH]c4cnccc43)cc2)[C@H]1c1ccccc1 CHEMBL3893116 IC50 114.0 nM
CCc1cc(=O)[nH]c(CN2CCC(N3CCC(C(=O)c4ccc(OC)cc4)CC3)C2=O)n1 CHEMBL3900374 IC50 115.0 nM
Cc1ccccc1[C@@H]1N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)C(=O)OC1(C)C CHEMBL3920080 IC50 116.0 nM
O=c1[nH]c(N2CCC3(CC2)NCc2ccccc23)nc2c1CCCC2 CHEMBL4456595 IC50 118.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccccn2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL2419700 IC50 120.0 nM
Cc1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL1503900 pIC50 125.89 nM
CC(C)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4064332 pIC50 125.89 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2ccccc2F)nc1 CHEMBL4633637 pIC50 125.89 nM
CNC(=O)[C@H](CNC(=O)Cn1[nH]c(=O)c2ccccc2c1=O)NC(=O)c1cnc(C)cn1 CHEMBL5432829 pIC50 125.89 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)Nc3ccncc3)CC2)c(=O)c2ncccc21 CHEMBL4761317 IC50 125.9 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)cc2c(Cl)cccc12 CHEMBL3763182 IC50 128.0 nM
O=C(CN1CCC(C(=O)c2ccc3c(c2)OCO3)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3968547 IC50 129.0 nM
C[C@@H]1OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(C#N)ccc43)CC2)C1c1ccccc1 CHEMBL3920654 IC50 129.0 nM
COc1ccc([C@@H]2N(c3ccc(C(=O)Nc4cccc5cccnc45)cc3)C(=O)OC2(C)C)cc1 CHEMBL3902356 IC50 130.0 nM
Cc1ccccc1NC(=O)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5172909 IC50 130.5 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3C2)cc1 CHEMBL562310 IC50 131.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(C2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3C2)cc1 CHEMBL4293376 IC50 131.0 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)cc1)C2=O CHEMBL4474593 IC50 131.0 nM
CC(C)n1cc2c(n1)CN(C(=O)c1cc(Cc3n[nH]c(=O)c4ccccc34)ccc1F)C2 CHEMBL4554200 IC50 133.3 nM
Oc1nc(N2CCN(c3ccccc3)CC2)nc2c1CCCC2 CHEMBL1609488 IC50 135.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccc(F)cc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3914416 IC50 138.0 nM
O=c1[nH]c(-c2ccc(Cl)cc2)nc2ccccc12 CHEMBL1163173 IC50 140.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccc[nH]3)CC2)[C@H]1c1ccccc1 CHEMBL3925312 IC50 142.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(C#N)cnc43)CC2)[C@H]1c1ccccc1 CHEMBL2381944 IC50 143.0 nM
N#Cc1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL2431802 pIC50 144.54 nM
CN1CCN(C(=O)c2ccc(-c3cc(=O)c4ccccc4o3)cc2)CC1 CHEMBL2431801 pIC50 144.54 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3ccc(N)nc3)CC2)[C@H]1c1ccccc1 CHEMBL3098146 IC50 148.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)C[C@H]2CCCO2)CC1 CHEMBL4110045 IC50 148.0 nM
CC1(C)CC(=O)Nc2cc(NC(=O)c3cc(-c4ccc5nc(N)ncc5c4)ccc3F)ccc21 CHEMBL3099719 IC50 150.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4cccnc4)c[nH]c3=O)cc2)[C@H]1c1ccccc1 CHEMBL3926435 IC50 150.0 nM
CN(C)Cc1ccc(-c2cc3c(Cl)cccc3c(=O)[nH]2)cc1 CHEMBL3764050 IC50 151.0 nM
COc1cccc(C2N(c3ccc(C(=O)Nc4cccc5cccnc45)cc3)C(=O)OC2(C)C)c1 CHEMBL3935830 IC50 152.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(C)cc3)nc12 CHEMBL3827329 IC50 153.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(Cl)cc3)nc12 CHEMBL3098936 IC50 155.0 nM
CC(c1ccc(F)cc1F)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3987175 IC50 155.0 nM
O=C(c1cccc(OC(F)(F)F)c1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3976109 IC50 155.0 nM
Oc1ccc(-c2nc(O)c3cccc(O)c3n2)cc1 CHEMBL127335 IC50 156.0 nM
N#Cc1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4078510 pIC50 158.49 nM
Cc1ccnc2c(NC(=O)c3ccc(N4C(=O)[C@@H]5[C@H](C4=O)[C@@H]4C=C[C@H]5C4)cc3)cccc12 CHEMBL1257010 IC50 160.0 nM
COC(=O)c1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL2431800 IC50 162.0 nM
[C-]#[N+]c1c(Cl)cccc1CN1CCC(N2CCC(C(=O)c3ccc(OC)cc3)CC2)C1=O CHEMBL3906478 IC50 162.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4ncco4)c[nH]c3=O)cc2)[C@H]1c1ccccc1 CHEMBL3935338 IC50 167.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@H]3C2)cc1 CHEMBL2016633 IC50 170.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc(N)c(-c4ncccn4)c3)CC2)[C@@H]1c1ccccc1 CHEMBL4114342 IC50 174.0 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(C(F)(F)F)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5395820 IC50 174.0 nM
O=c1[nH]c(-c2ccccc2)cc2c1sc1ccccc12 CHEMBL3344065 IC50 181.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)[C@H]1c1cccc(F)c1 CHEMBL3922327 IC50 193.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4cccnc4)cnc3F)cc2)[C@H]1c1ccccc1 CHEMBL3898370 IC50 193.0 nM
Oc1nc(-c2ccccc2)nc2c(O)cccc12 CHEMBL341142 IC50 195.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cc(-c4ncccn4)c[nH]c3=O)CC2)[C@@H]1c1ccccc1 CHEMBL4115129 IC50 195.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)[C@H]1c1ccccc1 CHEMBL2381958 IC50 198.0 nM
O=c1[nH]c2sccc2c2ccccc12 CHEMBL3108871 pIC50 199.53 nM
COCCNC(=O)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4068660 pIC50 199.53 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccncc3)CC2)[C@H]1c1ccccc1 CHEMBL3957419 IC50 205.0 nM
O=C(CN1CCC(c2noc3cc(F)ccc23)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3978546 IC50 207.0 nM
O=c1cc(-c2ccccc2)oc2ccc(F)cc12 CHEMBL61745 pIC50 208.93 nM
C[C@@H](c1ccccc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3919581 IC50 209.0 nM
COc1ccccc1NC(=O)c1ccc(NC(=O)CCc2nc3ccccc3c(=O)[nH]2)cc1C CHEMBL3110124 IC50 210.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5ccsc5c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3926736 IC50 211.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2cccnc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3935482 IC50 214.0 nM
O=C(Nc1ccc(F)cc1)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5189723 IC50 214.0 nM
O=c1[nH]c(SCCN2CCN(c3ccccn3)CC2)nc2ccccc12 CHEMBL4460557 IC50 218.0 nM
O=c1cc(-c2ccc(O)c(O)c2)oc2ccccc12 CHEMBL222556 pIC50 218.78 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4cc(Cl)cnn4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3970582 IC50 220.0 nM
COc1ccccc1C(=O)N[C@H]1CC[C@H](N2C(=O)OC(C)(C)[C@@H]2c2ccccc2)CC1 CHEMBL3910878 IC50 220.0 nM
COc1ccc(N2CCN(c3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL4446309 IC50 220.0 nM
O=C(CN1CCC(n2c(=O)[nH]c3ccccc32)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3902386 IC50 222.0 nM
Cn1cc2c(C(=O)N[C@H]3CC[C@H](N4C(=O)OC(C)(C)[C@H]4c4ccccc4)CC3)cccc2n1 CHEMBL4115561 IC50 222.0 nM
Cn1cc(C(=O)N[C@H]2CC[C@H](N3C(=O)OC(C)(C)[C@@H]3c3ccccc3)CC2)c2ccccc21 CHEMBL3976861 IC50 225.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)[C@H]1c1ccccn1 CHEMBL3940865 IC50 228.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccnc4[nH]ccc34)CC2)[C@H]1c1ccccc1 CHEMBL3919133 IC50 228.0 nM
C[C@]12CCCN1CC1=NNC(=O)c3cc(F)cc4[nH]c2c1c34 CHEMBL4112930 IC50 230.0 nM
O=c1cc(-c2ccc(Cl)cc2)oc2ccccc12 CHEMBL16783 IC50 233.0 nM
CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL2419704 IC50 241.0 nM
O=C1CCN(c2ccccc2C(=O)NCCc2nc(-c3ccccn3)no2)C(=O)N1 CHEMBL3577624 pIC50 245.47 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cnccc43)CC2)[C@@H]1c1ccccc1 CHEMBL4111810 IC50 249.0 nM
c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL1510453 pIC50 251.19 nM
C[C@@H](c1ccc(F)cc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3959094 IC50 256.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccncn3)CC2)[C@H]1c1ccccc1 CHEMBL3922372 IC50 260.0 nM
O=C1NC(c2ccc(C(F)(F)F)cc2)=NC2CSCC12 CHEMBL2419890 IC50 262.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)C1c1ccccc1F CHEMBL3895579 IC50 263.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3c[nH]c(=O)c(-c4ncccn4)c3)CC2)[C@H]1c1ccccc1 CHEMBL3926404 IC50 267.0 nM
C[C@]1(c2ccccc2)CN([C@H]2CC[C@H](n3c(=O)[nH]c4cc(C#N)ccc43)CC2)C(=O)O1 CHEMBL4107480 IC50 270.0 nM
O=C(CCc1ccccc1F)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419718 IC50 271.0 nM
CCOC(=O)c1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL2431799 IC50 272.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)[C@H]1c1ccncc1 CHEMBL3950367 IC50 272.0 nM
O=c1cc(-c2ccc(F)cc2)oc2ccccc12 CHEMBL53738 pIC50 275.42 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1C CHEMBL4112659 IC50 278.0 nM
O=c1cc(-c2cccc(O)c2)oc2cc(O)ccc12 CHEMBL253786 IC50 280.0 nM
CC1(C)OC(=O)N(c2ccc(-n3cc(-c4ncccn4)ccc3=O)cc2)[C@H]1c1ccccc1 CHEMBL3955689 IC50 280.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc(C)cc(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3902403 IC50 286.0 nM
COc1ccc2c(c1)C(CC(=O)NCCNC(=O)c1ccccc1N1CCC(=O)NC1=O)CC2=O CHEMBL3577701 pIC50 288.4 nM
COc1ccc2c(c1)C(CC(=O)N1CCN(C(=O)c3ccccc3N3CCC(=O)NC3=O)CC1)CC2=O CHEMBL3577702 pIC50 288.4 nM
CC(C)(C)c1ccc(C(=O)Nc2nnc3n2CCS3)cc1 CHEMBL1594868 IC50 299.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(F)cc3)nc12 CHEMBL3827770 IC50 299.0 nM
O=C(CCc1ccc(F)cc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419692 IC50 299.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3C2)cc1 CHEMBL551505 IC50 303.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)[C@H]1c1ccc(F)cc1 CHEMBL3960652 IC50 307.0 nM
O=c1cc(-c2cccc(O)c2)oc2ccccc12 CHEMBL147552 IC50 310.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)C1c1ccccn1 CHEMBL3912864 IC50 310.0 nM
O=c1cc(-c2ccc(Br)cc2)oc2ccccc12 CHEMBL294099 IC50 313.0 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL3109649 pIC50 316.23 nM
O=c1cc(-c2ccccc2)oc2ccccc12 CHEMBL275638 IC50 320.0 nM
Cn1ncnc1[C@@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@H]1c1ccc(F)cc1 CHEMBL3764816 IC50 322.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cccc4cccnc34)CC2)[C@@H]1c1ccccc1 CHEMBL4110631 IC50 323.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3cc4c(c(=O)o3)COCC4)CC2)cc1 CHEMBL3981864 IC50 328.0 nM
O=C1CCN(c2ccccc2C(=O)NCc2ccc(-n3cccn3)cc2)C(=O)N1 CHEMBL3577625 IC50 330.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@@H]3[C@@H]4CC[C@@H](C4)[C@@H]3C2=O)cc1 CHEMBL1956162 IC50 343.0 nM
COc1ccc(-c2nc(O)c3cccc(OC)c3n2)cc1 CHEMBL340481 IC50 346.0 nM
Cc1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL3289109 IC50 346.0 nM
O=C1CCN(c2ccccc2C(=O)NCCc2ccc(Br)cc2)C(=O)N1 CHEMBL3577627 pIC50 346.74 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cnn(-c4ccccc4)c3)CC2)[C@H]1c1ccccc1 CHEMBL3935281 IC50 350.0 nM
O=c1cc(-c2ccc3c(c2)OCO3)oc2ccccc12 CHEMBL483633 IC50 360.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@@H](c3cnc(N)c(-c4ncccn4)c3)CC2)[C@H]1c1ccccc1 CHEMBL3099717 IC50 370.0 nM
COc1ccc2c(c1)C(CC(=O)N[C@@H](CNC(=O)c1ccccc1N1CCC(=O)NC1=O)C(N)=O)CC2=O CHEMBL3577700 IC50 370.0 nM
O=c1[nH]c(N2CCN(Cc3ccncc3)CC2)nc2c1CCCC2 CHEMBL3593715 IC50 370.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4ncccc43)CC2)[C@@H]1c1ccccc1 CHEMBL4113700 IC50 371.0 nM
CC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(C(F)(F)F)n21 CHEMBL3907010 IC50 372.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4ncccn4)cnc3F)cc2)[C@H]1c1ccccc1 CHEMBL3925784 IC50 378.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)[C@H]1c1cccnc1 CHEMBL3939156 IC50 392.0 nM
CC(C)CC(=O)Nc1nnc2n1CCS2 CHEMBL1707591 IC50 395.0 nM
O=C(OCc1ccccc1)N1CCN(CCSc2nc3ccccc3c(=O)[nH]2)CC1 CHEMBL4641894 IC50 398.0 nM
Clc1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL1446017 pIC50 398.11 nM
O=C(O)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4064899 pIC50 398.11 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)CCC2c2ccc(F)cc2)cc1 CHEMBL2381956 IC50 400.0 nM
Cn1nc(-c2ccc(NC(=O)CCc3nc4ccccc4c(=O)[nH]3)cc2)c2ccccc21 CHEMBL3110127 IC50 400.0 nM
COc1ccccc1N(C)C(=O)c1ccc(NC(=O)CCc2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL3110125 IC50 400.0 nM
Nc1ncnc2c1ncn2C1OC(C(=O)N2CCN(CC(=O)Nc3cccc4c3CNC4=O)CC2)[C@@H](O)[C@H]1O CHEMBL435073 pIC50 407.38 nM
COc1ccccc1C(=O)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3900771 IC50 420.0 nM
O=c1[nH]c(-c2ccc3c(c2)OCO3)nc2ccccc12 CHEMBL4077094 IC50 430.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4ccccn4)cnc3F)cc2)[C@H]1c1ccccc1 CHEMBL3973361 IC50 447.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)n(CC(F)F)c4cnccc43)CC2)[C@H]1c1ccccc1 CHEMBL3906166 IC50 457.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cccnc43)CC2)[C@@H]1c1ccccc1 CHEMBL4110429 IC50 470.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3nnc(-c4ccccc4)o3)CC2)C1c1ccccc1 CHEMBL3906673 IC50 473.0 nM
COc1cccc2c(O)nc(-c3ccccc3)nc12 CHEMBL126871 IC50 475.0 nM
COc1ccc(C(=O)C2CCN([C@H]3CCCN(CCC4NC(=O)C5=C(CCOC5)N4)C3=O)CC2)cc1 CHEMBL3920028 IC50 483.0 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CCOC2 CHEMBL2419894 IC50 485.0 nM
O=C(CN1CCC(c2nnc(-c3ccc(F)cc3)o2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3941613 IC50 487.0 nM
CC1(C)OC(=O)N(c2ccn3c(Nc4ccnc5cccnc45)nnc3c2)[C@H]1c1ccccc1 CHEMBL3921450 IC50 503.0 nM
O=C(Nc1ccccc1F)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5179949 IC50 506.5 nM
CC1(C)OC(=O)N([C@H]2CC[C@@H](c3c[nH]c(=O)c(-c4ncccn4)c3)CC2)[C@H]1c1ccccc1 CHEMBL3953487 IC50 511.0 nM
O=C1NC2(CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC2)c2ccccc21 CHEMBL4516906 IC50 514.0 nM
C=CCc1cc(O)c(O)c(-c2cc(CC=C)cc(OC)c2O)c1 CHEMBL1958308 Kd 520.0 nM
O=c1[nH]c(-c2ccc(O)cc2)nc2ccccc12 CHEMBL3289108 IC50 528.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)CC[C@@H]2c2ccccc2)cc1 CHEMBL2381950 IC50 540.0 nM
COc1ccc(-c2nnc(C3CCN(CC(=O)NCc4nc5c(c(=O)[nH]4)COCC5)CC3)o2)cc1 CHEMBL3935158 IC50 548.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cnc4ccccc4c3)CC2)[C@@H]1c1ccccc1 CHEMBL4115081 IC50 548.0 nM
COc1ccc(C(=O)Nc2ccc(C(=O)N(c3ccncn3)c3ccccc3Cl)cc2)cc1 CHEMBL3752492 pIC50 549.54 nM
O=C(Nc1ccc(C(F)(F)F)cc1)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5174447 IC50 550.5 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)C1c1cccc(F)c1 CHEMBL3913326 IC50 551.0 nM
O=C1CC2(CCN(C(=O)CN3CCN(CCSc4nc5ccccc5c(=O)[nH]4)CC3)CC2)Oc2ccccc21 CHEMBL4632484 IC50 552.0 nM
COc1ccc(-c2noc(CSc3nnc(-c4ccncc4)n3-c3ccc(OC)cc3)n2)cc1 CHEMBL1611739 IC50 559.0 nM
COc1ccc(-c2cc(=O)c3ccc(O)cc3o2)cc1 CHEMBL16751 IC50 560.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2ccc(S(=O)(=O)N3CCOCC3)s2)CC1 CHEMBL3909888 IC50 561.0 nM
COc1ccc(C2(CNC(=O)c3ccc(NC(=O)c4ccco4)cc3Cl)CCOCC2)cc1 CHEMBL3752386 pIC50 562.34 nM
NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12 CHEMBL1094636 IC50 570.0 nM
O=C1CCN(c2ccccc2C(=O)NCCc2ccc(Cl)cc2)C(=O)N1 CHEMBL3577628 IC50 570.0 nM
Cc1cc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nn2n1 CHEMBL5284305 IC50 570.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)CCCCC4)CC2)cc1 CHEMBL3942774 IC50 575.0 nM
NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCCC(c3ccccc3)C2)c1 CHEMBL4085694 pIC50 575.44 nM
O=c1cc(-c2ccccc2)oc2ccc(Cl)cc12 CHEMBL293478 pIC50 588.84 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](N3C(=O)C(F)(F)c4ccccc43)CC2)[C@H]1c1ccccc1 CHEMBL3893898 IC50 617.0 nM
CC(C)(C)c1ccc(C2NC(=O)c3ccccc3N2)cc1 CHEMBL3594137 IC50 620.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4ccccn4)cnn3)cc2)[C@H]1c1ccccc1 CHEMBL3933300 IC50 621.0 nM
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)ccc12 CHEMBL301624 IC50 630.0 nM
Fc1ccc(Nc2nc3ccccc3n3nnnc23)cc1 CHEMBL4086359 pIC50 630.96 nM
COc1ccc(C2N(c3ccc(C(=O)Nc4cccc5cccnc45)cc3)C(=O)OC2(C)C)cc1 CHEMBL3889842 IC50 631.0 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)NCc3ccccc3)CC2)c(=O)c2ccccc21 CHEMBL4751197 IC50 631.0 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)Nc1ccc(-c2c[nH]c(-c3ccccc3)n2)cc1 CHEMBL3110130 IC50 640.0 nM
O=c1[nH]c(SCCN2CCN(CCCOc3ccc(-c4ccccc4)cc3)CC2)nc2ccccc12 CHEMBL4642139 IC50 673.0 nM
O=C1CCN(c2ccccc2C(=O)NCCc2ccc(Cl)cc2Cl)C(=O)N1 CHEMBL3577626 pIC50 676.08 nM
COc1ccc(C2(CNC(=O)c3ccc(NC(=O)c4ccc(C)o4)cc3)CCOCC2)cc1 CHEMBL3752054 IC50 690.0 nM
Cc1cc(N2C(=O)OC(C)(C)[C@@H]2c2ccccc2)ccc1C(=O)Nc1ccnc2cccnc12 CHEMBL3890044 IC50 693.0 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1C CHEMBL4113362 IC50 711.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)CCCCC4)CC3CC3)CC2)cc1 CHEMBL3918346 IC50 714.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3ncc4cc(C#N)ccc43)CC2)[C@H]1c1ccccc1 CHEMBL3940510 IC50 714.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccccc3)CC2)[C@H]1c1ccccc1 CHEMBL3986106 IC50 755.0 nM
O=C(CN1CCC(C(=O)N2CCc3c(Cl)cccc3C2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3930358 IC50 761.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)C1c1ccncc1 CHEMBL3901845 IC50 767.0 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5ncccc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4776820 IC50 769.0 nM
C[C@@]1(c2ccccc2)CN([C@H]2CC[C@H](n3c(=O)[nH]c4cnccc43)CC2)C(=O)O1 CHEMBL3905345 IC50 772.0 nM
Oc1nc(-c2ccc(F)cc2)nc2ccccc12 CHEMBL18688 IC50 781.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cc(C4=NCCCN4)c[nH]c3=O)CC2)[C@H]1c1ccccc1 CHEMBL3895512 IC50 783.0 nM
Nc1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL3827921 IC50 786.0 nM
CCC1(CC)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)[C@H]1c1ccccc1 CHEMBL3895243 IC50 786.0 nM
O=c1cc(-c2ccc(O)cc2)oc2ccccc12 CHEMBL327209 IC50 788.0 nM
O=C(CCc1nc2ncccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110111 IC50 800.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)OC3(CCC3)C2c2ccccc2)cc1 CHEMBL3911267 IC50 822.0 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(CC(=O)Nc4nnc5n4CCS5)C3=O)CC2)cc1 CHEMBL3958005 IC50 830.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccncc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3924532 IC50 845.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cccc4[nH]ncc34)CC2)[C@H]1c1ccccc1 CHEMBL3980346 IC50 848.0 nM
O=C(O)c1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL165822 IC50 850.0 nM
Cc1cc(=O)[nH]c2cc(-c3ccccc3F)ccc12 CHEMBL2381633 IC50 860.0 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)Nc1ccc(-c2nc3ccccc3o2)cc1 CHEMBL3110129 IC50 860.0 nM
CC1(C)OC(=O)N(c2ccc(-n3c(=O)[nH]c4ccccc43)cc2)[C@H]1c1ccccc1 CHEMBL3921472 IC50 863.0 nM
COc1cccc2c(O)nc(-c3ccc([N+](=O)[O-])cc3)nc12 CHEMBL125154 IC50 873.0 nM
NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCN(c3ccc(Cl)cc3)CC2)c1 CHEMBL4068366 IC50 900.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CN)cc3)nc12 CHEMBL3099815 IC50 907.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3ncc4cc(C#N)ccc43)CC2)[C@@H]1c1ccccc1 CHEMBL4112337 IC50 915.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4nccc(C#N)n4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3940611 IC50 920.0 nM
CC1(C)OC(=O)N(c2ccc(N3C(=O)Cc4ccccc43)cc2)[C@H]1c1ccccc1 CHEMBL3906527 IC50 973.0 nM