Cc1cccc2c(=O)[nH]c(CCC(=O)Nc3ccc(C(=O)Nc4cccc5cccnc45)cc3)nc12 CHEMBL4069447 pIC50 0.1 nM
COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4cc(F)cc4c(=O)[nH]3)CC2)cn1 CHEMBL3805393 IC50 0.16 nM
COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4cc(F)cc4c(=O)[nH]3)CC2)cc1 CHEMBL3806163 IC50 0.17 nM
COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4c(C)ccc4c(=O)[nH]3)CC2)cc1 CHEMBL3805896 IC50 0.18 nM
COc1ccc(C(=O)C2CCN(C(=O)CCCc3nc4c(C)scc4c(=O)[nH]3)CC2)cc1C CHEMBL3804939 IC50 0.19 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3cnn(C)c3c2)CC1)c1ccc(C(=O)O)cc1 CHEMBL4634919 IC50 0.19 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)Nc1ccc(C(=O)Nc2cccc3cccnc23)cc1 CHEMBL4098188 IC50 0.2 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3c(C(=O)O)nn(C)c3c2)CC1)c1ccc(OC)cc1 CHEMBL4632401 IC50 0.25 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3cc(C(=O)O)n(C)c3c2)CC1)c1ccc(OC)cc1 CHEMBL4640008 IC50 0.26 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3ncn(C)c3c2)CC1)c1ccc(C(=O)O)cc1 CHEMBL4643690 IC50 0.27 nM
CC(C)n1cc(C(=O)C2CCN(C(=O)CCCc3nc4c(ccn4C)c(=O)[nH]3)CC2)cn1 CHEMBL3806049 IC50 0.28 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3c(cnn3C)c2)CC1)c1ccc(C(=O)O)cc1 CHEMBL4639702 IC50 0.29 nM
O=c1[nH]c(SCCN2CCN(CCSc3nc4ccccc4c(=O)[nH]3)CC2)nc2ccccc12 CHEMBL4638701 IC50 0.3 nM
N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)cc1Cl CHEMBL3110106 IC50 0.4 nM
CCN(C(=O)N1CCC(C(=O)c2ccc3c(c2)cc(C(=O)O)n3C)CC1)c1ccc(OC)cc1 CHEMBL4645574 IC50 0.44 nM
Cc1cc(N2C[C@@H](C)N[C@@H](C)C2)ncc1-c1ccc(-c2nc3c(ccn3C)c(=O)[nH]2)cc1 CHEMBL4101890 pIC50 0.4786 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 CHEMBL4458129 IC50 0.5 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C4CCNCC4)cc3)nc12 CHEMBL4567515 IC50 0.7 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cccnc45)C3)n2-c2ccc(C)s2)nc1 CHEMBL5070513 IC50 0.73 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn12 CHEMBL5199558 IC50 0.9 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nn12 CHEMBL5274873 IC50 0.9 nM
O=C(CCc1cccc(Cl)c1Cl)Nc1nnc2n1CCS2 CHEMBL2425812 IC50 1.0 nM
COc1ccc2c(c1)CC1(CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC3CC3)CC1)C2=O CHEMBL3966355 IC50 1.0 nM
N#Cc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)C3CCCNC43)CC2)nc1 CHEMBL5206816 IC50 1.0 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C4(O)CC4)cc3)cn12 CHEMBL5271127 IC50 1.0 nM
Cc1ccc2c(=O)[nH]c(-c3ccc([C@](C)(O)CCO)cc3)cn12 CHEMBL5272750 IC50 1.0 nM
N#Cc1ccc2c(c1)[nH]c(=O)n2[C@H]1C[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2Cl)C1 CHEMBL4095003 IC50 1.1 nM
CS(=O)(=O)c1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cccnc45)C3)n2-c2ccccc2F)nc1 CHEMBL4634146 IC50 1.1 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cccc5nc(C)cnc45)C3)n2-c2ccccc2F)nc1 CHEMBL5086139 IC50 1.1 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 CHEMBL4588170 IC50 1.4 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C(C)(C)OCCO)cc3)nc12 CHEMBL4551200 IC50 1.5 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cc(F)cc5nccnc45)C3)n2-c2ccccc2F)nc1 CHEMBL5085591 IC50 1.5 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cccc5ncc(C)nc45)C3)n2-c2ccccc2F)nc1 CHEMBL5093078 IC50 1.5 nM
Cc1csc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 CHEMBL5279709 IC50 1.5 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)OCCO)cc3)cn12 CHEMBL5281076 IC50 1.5 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cc(F)cnc45)C3)n2-c2ccc(C)s2)nc1 CHEMBL5091214 IC50 1.6 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccccn3)n2-c2ccccc2F)C1)c1cccc2nccnc12 CHEMBL5071436 IC50 1.6 nM
Cc1cccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cc(F)cc5nccnc45)C3)n2-c2ccccc2F)n1 CHEMBL5093991 IC50 1.6 nM
Cc1ccc2c(=O)[nH]c(-c3ccc([C@@](C)(O)CCO)cc3)cn12 CHEMBL5280682 IC50 1.6 nM
COc1ccc(-c2cc3c(c(=O)[nH]2)CCCN3C)cc1 CHEMBL3589282 IC50 1.7 nM
Cc1cccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cccc5nccnc45)C3)n2-c2ccccc2F)n1 CHEMBL5082525 IC50 1.7 nM
Cc1ccc2c(=O)[nH]c(-c3ccc([C@@](C)(O)CO)cc3)cn12 CHEMBL5269584 IC50 1.7 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(N4CCN(C)CC4)cc3)nc12 CHEMBL4584689 IC50 1.8 nM
CS(=O)(=O)c1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cccc5cccnc45)C3)n2-c2ccccc2F)nc1 CHEMBL4643373 IC50 1.8 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccccn3)n2-c2ccccc2F)C1)c1ccnc2cc(F)cnc12 CHEMBL4636903 IC50 1.8 nM
Cc1ccc2c(=O)[nH]c(-c3ccc(C4(O)COC4)cc3)cn12 CHEMBL5275576 IC50 1.8 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccc(OC(F)F)cn3)n2-c2ccccc2F)C1)c1cccc2nccnc12 CHEMBL5074738 IC50 1.9 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cccc5nccnc45)C3)n2-c2ccccc2F)nc1 CHEMBL5090849 pIC50 1.95 nM
COc1ccccc1NC(=O)c1ccc(NC(=O)CCc2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL2314698 IC50 2.0 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CCSC2 CHEMBL2431805 IC50 2.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc(N)c(-c4ncccn4)c3)CC2)[C@H]1c1ccccc1 CHEMBL3099716 IC50 2.0 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccc(OC(F)F)cn3)n2-c2ccccc2F)C1)c1ccnc2cc(F)cnc12 CHEMBL4640917 IC50 2.0 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccccn3)n2-c2ccccc2F)C1)c1cc(F)cc2nccnc12 CHEMBL5087403 IC50 2.0 nM
Cc1ccc2c(=O)[nH]c(-c3ccc([C@](C)(O)CO)cc3)cn12 CHEMBL5278616 IC50 2.0 nM
Oc1nc(-c2ccc(C(F)(F)F)cc2)nc2c1CSCC2 CHEMBL1086580 IC50 2.1 nM
Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C4CCN(C)CC4)cc3)nc12 CHEMBL4450725 IC50 2.2 nM
Cc1cccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cccnc45)C3)n2-c2ccccc2F)n1 CHEMBL4638483 IC50 2.2 nM
Cc1cccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cc(F)cnc45)C3)n2-c2ccccc2F)n1 CHEMBL4632685 IC50 2.2 nM
COc1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)CSCC3)CC1 CHEMBL4452246 IC50 2.3 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccccn3)n2-c2ccccc2F)C1)c1ccnc2cccnc12 CHEMBL4644156 IC50 2.4 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cccc5cccnc45)C3)n2-c2ccc(C)s2)nc1 CHEMBL5082704 IC50 2.4 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccc(OC(F)F)cn3)n2-c2ccccc2F)C1)c1cc(F)cc2nccnc12 CHEMBL5077466 IC50 2.4 nM
O=C(CCSc1nc2c(c(=O)[nH]1)CCCC2)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110119 IC50 2.5 nM
COc1ccc2c(c1)CC1(CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC(F)F)CC1)C2=O CHEMBL3895038 IC50 2.5 nM
c1ccc(C2=NC3=C(CCSC3)CN2)cc1 CHEMBL4069862 pIC50 2.512 nM
COc1ccc(N2CCN(c3nc4c(c(=O)[nH]3)CSCC4)CC2)cc1 CHEMBL4453770 IC50 2.6 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2Cl)C1)c1ccnc2cccnc12 CHEMBL4646640 IC50 2.6 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4cccc5nc(C)c(C)nc45)C3)n2-c2ccccc2F)nc1 CHEMBL5093410 IC50 2.6 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cccc(F)c23)nc2c1CCCC2 CHEMBL4454164 IC50 2.8 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccc(OC(F)F)cn3)n2-c2ccccc2F)C1)c1ccnc2cccnc12 CHEMBL4647488 IC50 2.9 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cc(F)cnc45)C3)n2-c2ccncc2)nc1 CHEMBL5082990 IC50 2.9 nM
CC(C)(O)c1ccc(-c2cn3cc(F)cc3c(=O)[nH]2)cc1 CHEMBL5269897 IC50 2.9 nM
O=C(CCc1c(Cl)cccc1Cl)Nc1nnc2n1CCS2 CHEMBL2425810 IC50 3.0 nM
Cc1cccc2c(O)nc(-c3ccc(O)cc3)nc12 CHEMBL125244 IC50 3.0 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1C CHEMBL3918110 IC50 3.0 nM
O=C(Nc1cccc2c(=O)[nH]ccc12)[C@H]1CCCNC1 CHEMBL5190651 IC50 3.0 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCC1 CHEMBL3952089 IC50 3.2 nM
Cc1cccc2c(O)nc(-c3ccc(N)cc3)nc12 CHEMBL541203 IC50 3.3 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cc(F)cc(F)c23)nc2c1CCCC2 CHEMBL4533577 IC50 3.3 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3nccs3)n2-c2ccccc2F)C1)c1ccnc2cccnc12 CHEMBL4639869 IC50 3.3 nM
Cc1cccc2c(=O)[nH]c(N3CCC4(CC3)C(=O)N(CCO)c3cc(F)cc(F)c34)nc12 CHEMBL4585076 IC50 3.4 nM
CC(C)(O)c1ccc(-c2cn3c(F)c(F)cc3c(=O)[nH]2)cc1 CHEMBL5284314 IC50 3.5 nM
CC(C)(C)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)cc1 CHEMBL4586580 IC50 3.6 nM
N#Cc1ccc2c(c1)[nH]c(=O)n2C12CC(c3nnc(-c4ccncn4)n3-c3ccccc3Cl)(C1)C2 CHEMBL4633567 IC50 3.6 nM
Cc1ncc2c(=O)[nH]c(-c3ccc(C(C)(C)C)cc3)cn12 CHEMBL5277254 IC50 3.8 nM
Cc1ccc2c(=O)[nH]c(CCCC(=O)N3CCC(Oc4ccc(C#N)cc4)CC3)nn12 CHEMBL3805627 IC50 3.9 nM
O=C(CN1CCC2(CC1)Cc1cc(F)ccc1C2=O)N(Cc1nc2c(c(=O)[nH]1)COCC2)CC1CC1 CHEMBL3889537 IC50 4.0 nM
CC(C)(C)c1ccc(-c2nc(O)c3c(n2)CCSC3)cc1 CHEMBL5286471 IC50 4.0 nM
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110117 IC50 4.1 nM
COc1ccc(NC(=O)c2ccc(NC(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)cc2)cc1 CHEMBL5176874 IC50 4.15 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cccnc45)C3)n2-c2ccccc2F)nc1 CHEMBL4643964 IC50 4.3 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cccnc45)C3)n2-c2cccnc2)nc1 CHEMBL5077896 IC50 4.5 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2ccc(C)s2)nc1 CHEMBL5078506 IC50 4.6 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCCO)cc(F)c13)[nH]c2=O CHEMBL4463639 IC50 4.7 nM
O=C1Nc2cccc(F)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4449621 IC50 4.7 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cccc4cccnc34)CC2)[C@H]1c1ccccc1 CHEMBL2381934 IC50 4.78 nM
COc1cccc(N2CCN(c3nc4c(c(=O)[nH]3)CSCC4)CC2)c1 CHEMBL4538780 IC50 4.8 nM
O=C1Nc2cccc(Cl)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4441837 IC50 4.9 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2Cl)C1)c1ccccn1 CHEMBL4641515 IC50 4.9 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(Cl)ccc43)CC2)[C@H]1c1ccccc1 CHEMBL3968203 IC50 4.98 nM
O=C(CCc1ccc(Cl)cc1Cl)Nc1nnc2n1CCS2 CHEMBL2425813 IC50 5.0 nM
O=C(CCc1ccccc1Cl)Nc1nnc2n1CCS2 CHEMBL2425809 IC50 5.0 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1 CHEMBL3945783 IC50 5.0 nM
O=C(c1ccccc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3916481 IC50 5.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(C)cc3)cc12 CHEMBL3763870 IC50 5.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 CHEMBL521686 IC50 5.2 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2ccccc2)nc1 CHEMBL5070921 IC50 5.2 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cccc(Cl)c23)nc2c1CCCC2 CHEMBL4441713 IC50 5.3 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cccnc45)C3)n2-c2ccncc2)nc1 CHEMBL5072185 IC50 5.4 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3ccnc4cccnc34)CC2)[C@H]1c1ccccc1 CHEMBL2381935 IC50 5.46 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(Br)cc3)nc12 CHEMBL3098937 IC50 5.5 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CS(C)(=O)=O)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4442053 IC50 5.5 nM
CC(C)(O)c1ccc(-c2cn3cccc3c(=O)[nH]2)cc1 CHEMBL5279214 IC50 5.5 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cc(Cl)ccc23)nc2c1CCCC2 CHEMBL4469043 IC50 5.8 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cccnc45)C3)n2-c2ccccn2)nc1 CHEMBL5089832 IC50 5.8 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cc(F)cnc45)C3)n2-c2cccnc2)nc1 CHEMBL5078858 IC50 5.8 nM
COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC3CC3)CC2)cc1 CHEMBL2419706 IC50 6.0 nM
O=C(c1ccc(F)cc1)C1CCN(C2CCN(Cc3nc4c(c(=O)[nH]3)COCC4)C2=O)CC1 CHEMBL3956961 IC50 6.0 nM
COCCOc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3956527 IC50 6.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC#N)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4532667 IC50 6.1 nM
CN1CCCc2c1cc(-c1ccc(Br)cc1)[nH]c2=O CHEMBL3589285 IC50 6.1 nM
CC(C)(O)c1ccc(-c2cn3c(F)ccc3c(=O)[nH]2)cc1 CHEMBL5276381 IC50 6.1 nM
O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccncc2)CC1 CHEMBL3110101 IC50 6.2 nM
COc1cc(F)c2c(c1)N(C)C(=O)C21CCN(c2nc3c(c(=O)[nH]2)CCCN3C)CC1 CHEMBL4470218 IC50 6.2 nM
c1ccc(-c2ncc3c(n2)CCSC3)cc1 CHEMBL4080549 pIC50 6.31 nM
COCCOc1cc(F)c2c(c1)N(C)C(=O)C21CCN(c2nc3c(c(=O)[nH]2)CCCN3C)CC1 CHEMBL4572668 IC50 6.4 nM
COc1ccccc1NC(=O)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5188771 IC50 6.45 nM
O=C1SCCc2nc(-c3ccc(C(F)(F)F)cc3)[nH]c(=O)c21 CHEMBL4059827 pIC50 6.457 nM
COc1cc(CCCOC(C)=O)cc(-c2cc(CCCOC(C)=O)cc(OC)c2O)c1O CHEMBL4239155 Kd 6.5 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 6.6 nM
Cc1ccc(-c2nc3c(C)cccc3c(=O)[nH]2)cc1 CHEMBL3098940 IC50 6.7 nM
O=C1N(CCO)c2cccc(Cl)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4483558 IC50 6.8 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1C CHEMBL3921853 IC50 7.0 nM
O=C(CN1CCC(C(=O)c2ccc(Cl)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3925030 IC50 7.0 nM
CC(C)(C)OC(=O)N1CCC2=C(C1)Nc1cccc3c(=O)[nH]nc2c13 CHEMBL3901232 IC50 7.0 nM
CC(C)(O)c1ccc(-c2nc3c(F)cc(F)cc3c(=O)[nH]2)cc1 CHEMBL4437173 IC50 7.0 nM
Cn1ccc2c(=O)[nH]c(N3CCC4(CC3)CN(CCO)c3cc(F)cc(F)c34)nc21 CHEMBL4441063 IC50 7.0 nM
O=C1Nc2cc(Cl)cc(Cl)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4469038 IC50 7.1 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccc(OC(F)F)cn3)n2-c2ccccc2F)C1)c1ccc(F)cn1 CHEMBL4640597 IC50 7.4 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2cccs2)CC1 CHEMBL2419698 IC50 7.5 nM
CN1CCCc2c1cc(-c1ccc(C(F)(F)F)cc1)[nH]c2=O CHEMBL3589283 IC50 7.5 nM
CC(C)(O)c1ccc(-c2nc3ccc(F)c(F)c3c(=O)[nH]2)cc1 CHEMBL4545573 IC50 7.5 nM
O=C1Nc2cc(F)cc(F)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4529394 IC50 7.5 nM
N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)cc1 CHEMBL3110100 IC50 7.6 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cc(F)ccc23)nc2c1CCCC2 CHEMBL4461426 IC50 7.6 nM
N#Cc1ccc(Oc2ccc(NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)cc2)cc1 CHEMBL5274581 IC50 7.6 nM
Cc1cc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn2c1 CHEMBL5280345 IC50 7.9 nM
O=C(CCC1CCCCC1)Nc1nnc2n1CCS2 CHEMBL2425801 IC50 8.0 nM
O=C(CN1CCC2(CC1)Cc1cc(F)ccc1C2=O)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3955207 IC50 8.0 nM
O=C(c1ccc(OC(F)(F)F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC2CC2)CC1 CHEMBL3891789 IC50 8.0 nM
O=C1N(CCO)c2cccc(F)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4577914 IC50 8.2 nM
CC(C)(O)c1ccc(-c2cn3c(CO)ccc3c(=O)[nH]2)cc1 CHEMBL5281885 IC50 8.2 nM
Cc1cccc2c(=O)[nH]c(N3CCC4(CC3)CN(CCO)c3cc(F)cc(F)c34)nc12 CHEMBL4566625 IC50 8.5 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cc(F)cnc45)C3)n2-c2ccccn2)nc1 CHEMBL5078964 IC50 8.5 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccc(OC4CC4)cn3)n2-c2ccccc2F)C1)c1ccccn1 CHEMBL5094240 IC50 8.6 nM
CC(C)(C)c1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL4290134 IC50 8.7 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)NCCc3nc4c(C(N)=O)cccc4[nH]3)cc1)C2=O CHEMBL4529965 IC50 8.8 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccc(OC(F)F)cn3)n2-c2ccccc2F)C1)c1ccccn1 CHEMBL4636717 IC50 8.8 nM
COCCNC(=O)c1ccc(-c2ccc3c(C)cc(=O)[nH]c3c2)c(Cl)c1 CHEMBL2381639 IC50 9.0 nM
Cc1cc(=O)[nH]c2cc(-c3ccccc3Cl)ccc12 CHEMBL2381634 IC50 9.0 nM
O=C(CCC1CCCC1)Nc1nnc2n1CCS2 CHEMBL2425800 IC50 9.0 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCCN(CCC4NC(=O)C5=C(CCOC5)N4)C3=O)CC2)cc1 CHEMBL4109152 IC50 9.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2ccccc2F)CC1 CHEMBL3945618 IC50 9.0 nM
CCOc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3903965 IC50 9.0 nM
CS(=O)(=O)c1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2ccccc2F)nc1 CHEMBL4640220 IC50 9.2 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](n4c(=O)[nH]c5cc(C#N)ccc54)C3)n2-c2ccccc2Cl)nc1 CHEMBL4633531 IC50 9.3 nM
CCOc1ccc(-c2nnc(C34CC(NC(=O)c5ccnc6cccnc56)(C3)C4)n2-c2ccncc2)nc1 CHEMBL5077379 IC50 9.4 nM
CC(C)(O)c1ccc(-c2cn3cc(Cl)cc3c(=O)[nH]2)cc1 CHEMBL5280167 IC50 9.4 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1 CHEMBL3897483 IC50 9.5 nM
O=C1N(CCO)c2cc(Cl)cc(Cl)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4461149 IC50 9.5 nM
CCOc1ccc(-c2nnc(C34CC(NC(=O)c5ccnc6cccnc56)(C3)C4)n2-c2cccnc2)nc1 CHEMBL5094543 IC50 9.6 nM
O=c1[nH]c2ccccc2n1[C@H]1C[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2Cl)C1 CHEMBL4074540 IC50 9.8 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCC(=O)O)cc(F)c13)[nH]c2=O CHEMBL4466181 IC50 9.9 nM
Cc1cccc2c(O)nc(-c3ccc(C(F)(F)F)cc3)nc12 CHEMBL346886 IC50 10.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)C[C@@H]2CCCO2)CC1 CHEMBL3892864 IC50 10.0 nM
C[C@@H](C1CC1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3940284 IC50 10.0 nM
O=C(CN1CCC(C(=O)c2ccc(OCC3CC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3928915 IC50 10.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3983088 IC50 10.2 nM
Cn1ccc2c(=O)[nH]c(N3CCC4(CC3)C(=O)N(CCO)c3cc(F)cc(F)c34)nc21 CHEMBL4460022 IC50 10.2 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cc(Cl)cc(Cl)c23)nc2c1CCCC2 CHEMBL4521982 IC50 10.4 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1Cl CHEMBL3905051 IC50 10.5 nM
CC(C)(O)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)cc1 CHEMBL4447252 IC50 10.5 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(N4CCOCC4)cc(F)c13)[nH]c2=O CHEMBL4446044 IC50 10.5 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2cc(F)cc(F)c23)nc2c1CCCC2 CHEMBL4448872 IC50 10.6 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC2CC2)CC1 CHEMBL2419705 IC50 10.7 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4439372 IC50 10.7 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](C(=O)Nc3cccc4cccnc34)CC2)[C@H]1c1ccccc1 CHEMBL2381960 IC50 10.9 nM
CCCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL2419702 IC50 11.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3ccnc4cccnc34)cc2)[C@H]1c1ccccc1 CHEMBL2381959 IC50 11.0 nM
CN(C)CCOc1cc(F)c2c(c1)N(C)C(=O)C21CCN(c2nc3c(c(=O)[nH]2)CCCN3C)CC1 CHEMBL4457037 IC50 11.1 nM
COCCN1C(=O)C2(CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)c2c(F)cc(F)cc21 CHEMBL4466701 IC50 11.7 nM
O=c1[nH]c(SCCN2CCN(CCCc3nc(-c4ccccc4)no3)CC2)nc2ccccc12 CHEMBL4648016 IC50 11.7 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2cccc(F)c23)nc2c1CCCC2 CHEMBL4560087 IC50 11.8 nM
O=C(CCc1ccccc1F)Nc1nnc2n1CCS2 CHEMBL2425808 IC50 12.0 nM
COc1ccc(-c2nc(O)c3cccc(C)c3n2)cc1 CHEMBL127101 IC50 12.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC(F)F)CC2)cc1 CHEMBL3935111 IC50 12.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3986246 IC50 12.0 nM
O=C(CN1CCC(C(=O)c2ccc(OCC3CCC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3944854 IC50 12.0 nM
O=C(CN1CCC(C(=O)c2ccc(OCCC3CC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3944401 IC50 12.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1C CHEMBL3967549 IC50 12.0 nM
CC(C)(O)c1ccc(-c2nc3c(Cl)cccc3c(=O)[nH]2)cc1 CHEMBL4514589 IC50 12.0 nM
CN1CCN(c2ccc(-c3nc4ccc(F)cc4c(=O)[nH]3)cc2)CC1 CHEMBL4455904 IC50 12.0 nM
O=C1Nc2cc(F)ccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4521841 IC50 12.0 nM
CC(C)Oc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2ccccc2F)nc1 CHEMBL5077249 IC50 12.0 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2ccc(Cl)s2)nc1 CHEMBL5078514 IC50 12.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC1COC1)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4581567 IC50 12.2 nM
CN1CCN(c2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)CC1 CHEMBL4582280 IC50 12.3 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCCN4CCCC4)cc(F)c13)[nH]c2=O CHEMBL4525942 IC50 12.4 nM
O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 CHEMBL5402698 IC50 12.4 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC(O)CO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4464007 IC50 12.5 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)Nc1ccc(-c2nnc(-c3ccccc3)o2)cc1 CHEMBL3110107 IC50 13.0 nM
CC[C@H](C)CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3964642 IC50 13.0 nM
CC[C@H](C)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3898270 IC50 13.0 nM
CC[C@@H](C)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL4109734 IC50 13.0 nM
CCCOc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3906833 IC50 13.0 nM
CC(C)(O)c1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL4475367 IC50 13.0 nM
CN(C)c1cc(F)c2c(c1)N(C)C(=O)C21CCN(c2nc3c(c(=O)[nH]2)CCCN3C)CC1 CHEMBL4442841 IC50 13.0 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2cccc(Cl)c2)nc1 CHEMBL5072993 IC50 13.0 nM
CCOc1ccc(-c2nnc(C34CC(NC(=O)c5ccnc6cccnc56)(C3)C4)n2-c2ccccn2)nc1 CHEMBL5072404 IC50 13.0 nM
O=C1Nc2cccc(Br)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4572625 IC50 13.4 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CCO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4445363 IC50 13.5 nM
O=c1[nH]c2ccccc2c2ccccc12 CHEMBL45245 pIC50 13.8 nM
CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 CHEMBL1173055 IC50 14.0 nM
O=C(CCc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 CHEMBL3110110 IC50 14.0 nM
CC(C)Oc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3947374 IC50 14.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)CCCC4)CC2)cc1 CHEMBL3933931 IC50 14.0 nM
C#CCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3965278 IC50 14.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2ccc(F)cc2F)CC1 CHEMBL3933577 IC50 14.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)(F)F)CC1 CHEMBL3941313 IC50 14.0 nM
COCCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(OC)cc2)CC1 CHEMBL3940683 IC50 14.0 nM
CC(C)(OCCO)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)cc1 CHEMBL4536612 IC50 14.0 nM
CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2ccccc2F)nc1 CHEMBL4633637 IC50 14.0 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccccn3)n2-c2ccccc2F)C1)c1ccc(F)cn1 CHEMBL4646010 IC50 14.0 nM
Cc1ccc(NC(=O)c2ccc(NC(=O)N3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)cc2)cc1 CHEMBL5174780 IC50 14.0 nM
Cc1ncc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn12 CHEMBL5289848 IC50 14.0 nM
O=C1Nc2cc(Cl)ccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4457667 IC50 14.4 nM
O=c1[nH]c(N2CCC3(CC2)COc2ccccc23)nc2c1CCCC2 CHEMBL4452289 IC50 14.6 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 15.0 nM
O=c1[nH]c(-c2ccc(Br)cc2)nc2c(O)cccc12 CHEMBL3827440 IC50 15.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1 CHEMBL3929005 IC50 15.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4ccc(Cl)c(C#N)c4)C3=O)CC2)cc1 CHEMBL3905010 IC50 15.0 nM
COc1ccc(C(=O)C2CCN(C3CCCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1 CHEMBL3930536 IC50 15.0 nM
COc1ccc(CN(Cc2nc3c(c(=O)[nH]2)COCC3)C(=O)CN2CCC(C(=O)c3ccc(F)cc3)CC2)cc1 CHEMBL3938947 IC50 15.0 nM
O=C(c1ccc(OC(F)(F)F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3975140 IC50 15.0 nM
CC#CCOc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC3CC3)CC2)cc1 CHEMBL3955426 IC50 15.0 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCCCC1 CHEMBL3939501 IC50 15.0 nM
COc1ccc(-n2c(SCCCN3C(=O)c4cccc5cccc(c45)C3=O)nnc2-c2ccncc2)cc1 CHEMBL4303453 IC50 15.0 nM
O=C1N(CCO)c2cc(F)cc(F)c2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4554146 IC50 15.1 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCCCC1 CHEMBL3893294 IC50 15.4 nM
CC1(C)CCC2=C(C1)c1n[nH]c(=O)c3cccc(c13)N2 CHEMBL3955370 IC50 15.6 nM
O=c1[nH]c(N2CCC3(CC2)CNc2cccc(Br)c23)nc2c1CCCC2 CHEMBL4556736 IC50 15.6 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccccc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL2419699 IC50 16.0 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCN(CC(=O)Nc4nnc5n4CCS5)C3=O)CC2)cc1 CHEMBL3964994 IC50 16.0 nM
C[C@H](c1ccccc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL4110589 IC50 16.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)CCCC4)CC3CC3)CC2)cc1 CHEMBL3961412 IC50 16.0 nM
N#Cc1ccc(CN(Cc2nc3c(c(=O)[nH]2)COCC3)C(=O)CN2CCC(C(=O)c3ccc(F)cc3)CC2)s1 CHEMBL3913243 IC50 16.0 nM
COc1cccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC(F)F)CC2)c1 CHEMBL3946798 IC50 16.0 nM
CCOc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1F CHEMBL3964683 IC50 16.0 nM
Cc1cccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccccn4)C3)n2-c2ccccc2F)n1 CHEMBL4641728 IC50 16.0 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2cc(Cl)cc(Cl)c23)nc2c1CCCC2 CHEMBL4591423 IC50 16.4 nM
CC(c1cccs1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3986804 IC50 16.5 nM
O=C(c1ccc(F)cc1)C1CCN([C@H]2CCN(Cc3nc4c(c(=O)[nH]3)COCC4)C2=O)CC1 CHEMBL3929392 IC50 17.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5c(c(=O)[nH]4)CCC5)C3=O)CC2)cc1 CHEMBL3927023 IC50 17.0 nM
O=C(c1ccc(C(F)(F)F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3952101 IC50 17.0 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2cccc(Cl)c23)nc2c1CCCC2 CHEMBL4535636 IC50 17.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCCN4CCOCC4)cc(F)c13)[nH]c2=O CHEMBL4544771 IC50 17.1 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCC1 CHEMBL3978133 IC50 17.5 nM
Cc1cc(=O)[nH]c2cc(-c3ccc(C(=O)NCCN4CCOCC4)cc3Cl)ccc12 CHEMBL2381638 Kd 18.0 nM
CC(C)CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL2419701 IC50 18.0 nM
COc1ccc2c(c1)CC1(CCN(C3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC1)C2=O CHEMBL3965681 IC50 18.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2nc3ccccc3s2)CC1 CHEMBL3956490 IC50 18.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3960803 IC50 18.0 nM
Cc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3943283 IC50 18.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)COCC4)CC2)cc1OC CHEMBL3977049 IC50 18.0 nM
O=C1Oc2ccccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4575275 IC50 18.3 nM
COc1cc(CCCO)cc(-c2cc(CCCO)cc(OC)c2O)c1O CHEMBL3594248 Kd 18.5 nM
N#Cc1cccc2c1C1(CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC1)CN2 CHEMBL4438002 IC50 18.5 nM
CN1CCN(CCOc2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)CC1 CHEMBL4441668 IC50 18.7 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1 CHEMBL3937313 IC50 19.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(CCF)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3922251 IC50 19.0 nM
COc1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)CCCC3)CC1 CHEMBL4454483 IC50 19.0 nM
Cc1c(F)ccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL3109648 pIC50 19.95 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)O)CC3)c(=O)c3ccccc32)cccc1C(F)(F)F CHEMBL3109647 pIC50 19.95 nM
C1=Cc2ccc(-c3ccc(CNCCN4CCOCC4)cc3)cc2NC1 CHEMBL4098578 pIC50 19.95 nM
O=C(CC1CCCCC1)Nc1nnc2n1CCS2 CHEMBL2425798 IC50 20.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc(C)c(C)c(=O)[nH]3)CC2)cc1 CHEMBL3901978 IC50 20.0 nM
CC(C)(C)CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3929923 IC50 20.0 nM
CC(C)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3907294 IC50 20.0 nM
O=C(CN1CCC(C(=O)c2ccc3c(c2)CCO3)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3939009 IC50 20.0 nM
COCCOC(C)(C)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)cc1 CHEMBL4440292 IC50 20.0 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(Cl)c1C#N CHEMBL4786379 IC50 20.0 nM
C[C@@H]1CN(c2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)C[C@H](C)N1 CHEMBL4539435 IC50 20.2 nM
O=c1[nH]c(N2CCC3(CC2)CNc2ccccc23)nc2c1CCCC2 CHEMBL4476087 IC50 20.7 nM
Cc1cc(=O)[nH]c2cc(-c3ccc(C(=O)O)cc3Cl)ccc12 CHEMBL2381637 IC50 21.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(CC(=O)Nc4nnc5n4CCS5)C3=O)CC2)cc1 CHEMBL3897864 IC50 21.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2cccc(F)c2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3937250 IC50 21.0 nM
C=CCc1cc(O)c(O)c(-c2cc(CC=C)cc(OC)c2O)c1 CHEMBL1958308 Kd 21.0 nM
CC(C)(O)c1ccc(-c2nc3cccc(F)c3c(=O)[nH]2)cc1 CHEMBL4548930 IC50 21.0 nM
O=C1OC2(CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC2)c2ccccc21 CHEMBL4442606 IC50 21.0 nM
Cc1cccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccc(F)cn4)C3)n2-c2ccccc2F)n1 CHEMBL4639146 IC50 21.0 nM
CN1CCC(Oc2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)CC1 CHEMBL4553990 IC50 21.2 nM
CN1CCCc2c1nc(N1CCC3(CC1)CN(CCO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4518341 IC50 21.4 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2ccccc12 CHEMBL2419892 IC50 21.5 nM
CC(C)(O)c1ccc(-c2nc3c(c(=O)[nH]2)COCC3)cc1 CHEMBL2419710 IC50 22.0 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccccn3)n2-c2ccccc2F)C1)c1ccccn1 CHEMBL4639723 IC50 22.0 nM
O=C(CN1CCC(C(=O)c2ccc(F)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL2419697 IC50 23.0 nM
O=C(c1ccc(Cl)cc1)C1CCN(C2CCN(Cc3nc4c(c(=O)[nH]3)COCC4)C2=O)CC1 CHEMBL3941919 IC50 23.0 nM
COc1cccc(CN(Cc2nc3c(c(=O)[nH]2)COCC3)C(=O)CN2CCC(C(=O)c3ccc(F)cc3)CC2)c1 CHEMBL3985156 IC50 23.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(N4CCNCC4)cc(F)c13)[nH]c2=O CHEMBL4574717 IC50 23.4 nM
O=c1[nH]c2sccc2c2ccccc12 CHEMBL3108871 pIC50 23.99 nM
CS(=O)(=O)c1ccc(-c2nnc(/C=C/c3nnc(-c4ccc(C#N)cc4)o3)n2-c2ccccc2Cl)nc1 CHEMBL2325503 IC50 25.0 nM
Oc1nc(-c2ccc(C(F)(F)F)cc2)nc2c(O)cccc12 CHEMBL151382 IC50 25.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5c(cnn5C)c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3945237 IC50 25.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL4113551 IC50 25.0 nM
Cc1ccccc1-n1c(/C=C/c2nnc(-c3ccc(C#N)cc3)o2)nnc1-c1ccc(S(C)(=O)=O)cn1 CHEMBL5276118 IC50 25.0 nM
O=C1Nc2ccccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4555506 IC50 25.1 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1ccccc1C#N CHEMBL4758600 IC50 25.1 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccnnc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4757303 IC50 25.1 nM
Cc1cccc(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)Nc4ccncc4)CC3)c(=O)c3c(C)cccc32)c1C#N CHEMBL4747523 IC50 25.1 nM
c1ccc(C2COCN2c2ccc(-c3cncc(-c4ncccn4)c3)cc2)cc1 CHEMBL4103924 pIC50 25.12 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4ncccn4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3099720 IC50 25.9 nM
O=C(CCC1CCCCCC1)Nc1nnc2n1CCS2 CHEMBL2425802 IC50 26.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc(C)c(C)c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3909379 IC50 26.0 nM
O=C1N(CCO)c2ccccc2C12CCN(c1nc3c(c(=O)[nH]1)CCCC3)CC2 CHEMBL4545585 IC50 26.0 nM
N#Cc1cccc2c1C1(CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC1)C(=O)N2 CHEMBL4462707 IC50 26.8 nM
O=c1[nH]c(N2CCC3(CC2)CN(CCO)c2ccccc23)nc2c1CCCC2 CHEMBL4579514 IC50 26.9 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3cc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL3946751 IC50 27.0 nM
CN1CCc2c1nc(N1CCC3(CC1)C(=O)N(CCO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4439240 IC50 27.6 nM
COc1ccc(-c2noc(CSc3nnc(C)n3-c3ccc(OC)cc3)n2)cc1 CHEMBL1898239 Kd 28.0 nM
CC(C)(C)c1ccc(-c2nc3c(sc4ccccc43)c(=O)[nH]2)cc1 CHEMBL3344072 IC50 28.6 nM
O=C(CN1CCC(C(=O)c2ccc(OC3CCOCC3)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3903427 IC50 29.0 nM
CC(C)C1CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3925115 IC50 29.0 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3nccs3)n2-c2ccccc2F)C1)c1ccccn1 CHEMBL4635489 IC50 29.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3C2)cc1 CHEMBL551505 IC50 29.2 nM
O=c1[nH]c(N2CCC3(CC2)NCc2ccccc23)nc2c1CCCC2 CHEMBL4456595 IC50 29.3 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC(=O)O)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4466165 IC50 29.8 nM
Cc1cccc2c(O)nc(-c3ccc([N+](=O)[O-])cc3)nc12 CHEMBL127396 IC50 30.0 nM
CC(C)(O)c1ccc(-c2nc3c(F)cccc3c(=O)[nH]2)cc1 CHEMBL4558610 IC50 30.0 nM
N#Cc1ccc2c(c1)[nH]c(=O)n2[C@H]1C[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2F)C1 CHEMBL4639158 IC50 30.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@@H]3[C@@H]4CC[C@@H](C4)[C@@H]3C2=O)cc1 CHEMBL1956162 pIC50 30.9 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccccn2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL2419700 IC50 31.0 nM
CC(C)(C)c1ccc(C(=O)Nc2nnc3n2CCS3)cc1 CHEMBL1594868 IC50 31.0 nM
CN1CCC(c2ccc(-c3nc4c(F)cc(F)cc4c(=O)[nH]3)cc2)CC1 CHEMBL4444673 IC50 31.0 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)Nc4ccncc4)CC3)c(=O)c3ccccc32)cccc1C(F)(F)F CHEMBL4794878 IC50 31.6 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)Nc4ccncc4)CC3)c(=O)c3c(Cl)cccc32)cccc1C(F)(F)F CHEMBL4754447 IC50 31.6 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1SCCC2 CHEMBL2419889 IC50 32.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccc(F)cc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3914416 IC50 32.0 nM
C[C@H](C1CC1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL4112739 IC50 32.0 nM
O=C(c1ccccn1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC2CC2)CC1 CHEMBL3984137 IC50 32.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(CC(F)(F)F)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4470270 IC50 32.4 nM
Cc1cccc(C)c1CCC(=O)Nc1nnc2n1CCS2 CHEMBL2425811 IC50 33.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(Cl)cc3)nc12 CHEMBL3098939 IC50 33.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(OCCN4CCCCC4)cc(F)c13)[nH]c2=O CHEMBL4471663 IC50 33.3 nM
Cn1c(=O)n([C@H]2C[C@H](c3nnc(-c4ccncn4)n3-c3ccccc3Cl)C2)c2ccc(C#N)cc21 CHEMBL4638887 IC50 34.0 nM
CCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL2419703 IC50 35.0 nM
CC(C)(C)c1ccc(-c2cn3cncc3c(=O)[nH]2)cc1 CHEMBL5275231 IC50 35.0 nM
O=c1[nH]c(N2CCC3(CC2)OCc2ccccc23)nc2c1CCCC2 CHEMBL4551975 IC50 35.7 nM
Cc1ccnc2c(NC(=O)c3ccc(N4C(=O)[C@@H]5[C@H](C4=O)[C@@H]4C=C[C@H]5C4)cc3)cccc12 CHEMBL1257010 IC50 36.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4ncc(C)c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3931845 IC50 36.0 nM
O=C(CN1CCC(C(=O)c2ccc(F)cc2)CC1)NCc1nc2c(c(=O)[nH]1)CCCC2 CHEMBL3966085 IC50 36.0 nM
COc1cc2ncnc(N3CCC(CN4Cc5ccccc5NC4=O)CC3)c2cc1OC CHEMBL4285233 IC50 36.0 nM
Cc1cc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn2n1 CHEMBL5284505 IC50 36.0 nM
COc1ccc(N2CCN(c3nc4c(c(=O)[nH]3)CC(F)(F)CC4)CC2)cc1 CHEMBL4461036 IC50 36.4 nM
COc1ccc(C(=O)Nc2ccc(C(=O)N(c3ccncn3)c3ccccc3Cl)cc2)cc1 CHEMBL3752492 IC50 37.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3C2)cc1 CHEMBL562310 IC50 38.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)C[C@H]2CCCO2)CC1 CHEMBL4110045 IC50 38.0 nM
O=C(c1cccc(OC(F)(F)F)c1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3976109 IC50 38.0 nM
O=c1[nH]c(-c2ccc(C3CCNCC3)cc2)nc2c(F)cc(F)cc12 CHEMBL4457148 IC50 38.0 nM
Cc1cc(=O)[nH]c2cc(-c3ccc(N)cc3Cl)ccc12 CHEMBL2381636 Kd 39.0 nM
O=C(CCc1ccccc1)Nc1nnc2n1CCS2 CHEMBL2425803 IC50 39.0 nM
O=C(CN1CCC(n2c(=O)[nH]c3ccccc32)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3902386 IC50 39.0 nM
CC(C)(O)c1ccc(-c2nc3ccc(Cl)cc3c(=O)[nH]2)cc1 CHEMBL4566814 IC50 39.0 nM
C[C@@H]1CN(c2cc(F)c3c(c2)N(C)C(=O)C32CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)C[C@H](C)O1 CHEMBL4449082 IC50 39.0 nM
CC(c1ccc(F)cc1F)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3987175 IC50 39.5 nM
COc1cccc(N2CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC2)c1 CHEMBL4076368 IC50 39.7 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)Nc3ccncc3)CC2)c(=O)c2ccccc21 CHEMBL4791639 IC50 39.8 nM
Cc1ccc(NC(=O)[C@H]2CC[C@H](Cn3c(=O)c4c(C)cccc4n(Cc4cccc(C(F)(F)F)c4C#N)c3=O)CC2)cn1 CHEMBL4763370 IC50 39.8 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3cnn(C)c3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4759993 IC50 39.8 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(F)cc3)nc12 CHEMBL3098938 IC50 40.0 nM
CC(C)(O)c1ccc(-c2nc3c(F)ccc(F)c3c(=O)[nH]2)cc1 CHEMBL4454894 IC50 40.0 nM
CN(C)c1ccc(-c2nc3c(c(=O)[nH]2)COCC3)cc1 CHEMBL2419899 IC50 41.0 nM
Cc1cccc2c(O)nc(-c3ccccc3)nc12 CHEMBL124749 IC50 41.0 nM
COc1ccc(-n2c(C)nnc2SCc2nc(-c3ccc(OC)c(OC)c3)no2)cc1 CHEMBL1867804 IC50 42.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2cccnc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3935482 IC50 42.0 nM
CS(=O)(=O)c1ccc(-c2nnc(SCc3nnc(-c4ccc(Cl)cc4)o3)n2-c2ccccc2Cl)nc1 CHEMBL2325500 IC50 43.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CN)cc3)nc12 CHEMBL3099815 IC50 43.0 nM
O=C(CN1CCC(c2noc3cc(F)ccc23)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3978546 IC50 43.0 nM
O=C(CN1CCC(C(=O)c2ccc3c(c2)OCO3)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3968547 IC50 43.0 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCN(Cc2ccccc2)C1 CHEMBL3939375 IC50 43.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 CHEMBL4524437 IC50 43.0 nM
Cc1cccc2c(=O)[nH]c(-c3ccc(CNC(=O)OCc4ccccc4)cc3)nc12 CHEMBL3098935 IC50 44.0 nM
Cc1ccc(-c2nc3c(O)cccc3c(=O)[nH]2)cc1 CHEMBL3827272 IC50 44.0 nM
Nc1ncnc2c1ncn2C1OC(C(=O)N2CCN(CC(=O)Nc3cccc4c3CNC4=O)CC2)[C@@H](O)[C@H]1O CHEMBL435073 pIC50 44.67 nM
O=C(NCc1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1)OCc1ccccc1 CHEMBL3828579 IC50 45.0 nM
COc1ccc(N2CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC2)cc1 CHEMBL4442353 IC50 45.5 nM
N#Cc1ccc2c(c1)oc(=O)n2[C@H]1C[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2Cl)C1 CHEMBL4634877 IC50 48.0 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4ncc(F)cn4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3913507 IC50 48.3 nM
O=c1[nH]c(-c2ccc(Cl)cc2)nc2c(O)cccc12 CHEMBL3099681 IC50 49.0 nM
CN1CCCc2c1nc(N1CCC3(CC1)C(=O)N(C)c1cc(N4CCCCC4)cc(F)c13)[nH]c2=O CHEMBL4467730 IC50 49.1 nM
CC1(C)OC(=O)N(c2ccc(-c3cnc(N)c(-c4ccc5nncn5n4)c3)cc2)[C@H]1c1ccccc1 CHEMBL3912260 IC50 49.3 nM
COc1ccccc1C1=CCN(c2nc3c(c(=O)[nH]2)CCCC3)CC1 CHEMBL4471982 IC50 49.7 nM
C[C@@H](c1ccccc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3919581 IC50 50.0 nM
CC(C)(O)c1ccc(-c2nc3cccc(Cl)c3c(=O)[nH]2)cc1 CHEMBL4457607 IC50 50.0 nM
O=c1[nH]nc2c3c(cccc13)N=C(CN1Cc3ccccc3C1)N2 CHEMBL3644587 IC50 50.0 nM
COc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4798387 IC50 50.1 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4759701 IC50 50.1 nM
Cc1c(F)ccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4788947 IC50 50.1 nM
N#Cc1ccc(-c2nnc(CSc3nnc(-c4ccncc4)n3-c3ccccc3Cl)o2)cc1 CHEMBL2325497 IC50 51.0 nM
Cc1cc(=O)[nH]c2cc(-c3ccccc3F)ccc12 CHEMBL2381633 IC50 52.0 nM
COc1ccc(-c2nc(O)c3ccccc3n2)cc1 CHEMBL336718 IC50 52.0 nM
CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1 CHEMBL372303 IC50 52.7 nM
CCc1cc(=O)[nH]c(CN2CCC(N3CCC(C(=O)c4ccc(OC)cc4)CC3)C2=O)n1 CHEMBL3900374 IC50 53.0 nM
COc1cc(-c2nnc(/C=C/c3nnc(-c4ccc(S(C)(=O)=O)cn4)n3-c3ccccc3Cl)o2)ccn1 CHEMBL2325502 IC50 54.0 nM
O=c1[nH]c(-c2ccc(Cl)cc2)nc2ccccc12 CHEMBL1163173 IC50 54.0 nM
O=c1[nH]c(-c2ccc(OC(F)(F)F)cc2)nc2c1COCC2 CHEMBL2419707 IC50 55.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(C2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3C2)cc1 CHEMBL4293376 IC50 56.0 nM
CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL2419704 IC50 57.0 nM
Oc1nc(N2CCN(c3ccccc3)CC2)nc2c1CCCC2 CHEMBL1609488 IC50 58.9 nM
Cc1ccc(-c2nc3c(c(=O)[nH]2)COCC3)cc1 CHEMBL2419896 IC50 62.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(Cl)cc3)nc12 CHEMBL3098936 IC50 62.0 nM
O=C(Nc1cccc2cccnc12)c1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@H]3C2)cc1 CHEMBL2016633 IC50 63.0 nM
CS(=O)(=O)c1ccc(-c2nc3c(c(=O)[nH]2)COCC3)cc1 CHEMBL2419709 IC50 63.0 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)Nc4ccncc4)CC3)c(=O)c3c(F)cccc32)cccc1C(F)(F)F CHEMBL4799048 IC50 63.1 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4761298 IC50 63.1 nM
O=C(CCc1ccccc1F)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419718 IC50 64.0 nM
COc1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)CC(F)(F)CC3)CC1 CHEMBL4475497 IC50 65.5 nM
CC1(C)OC(=O)N(c2ccc(-c3cc(-c4ncccn4)c[nH]c3=O)cc2)[C@H]1c1ccccc1 CHEMBL3946953 IC50 65.9 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2ccc(S(=O)(=O)N3CCOCC3)s2)CC1 CHEMBL3909888 IC50 66.0 nM
COc1ccccc1C1CCN(c2nc3c(c(=O)[nH]2)CCCC3)CC1 CHEMBL4444671 IC50 67.6 nM
C[C@@H](c1ccc(F)cc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3959094 IC50 68.0 nM
O=C(Nc1nnc2n1CCS2)C1CCCCC1 CHEMBL2425797 IC50 70.0 nM
O=c1[nH]c(N2CCN(Cc3ccncc3)CC2)nc2c1CCCC2 CHEMBL3593715 pIC50 70.79 nM
CC(C)c1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL2431867 IC50 72.0 nM
CN1CCc2c1nc(N1CCC3(CC1)CN(CCO)c1cc(F)cc(F)c13)[nH]c2=O CHEMBL4555632 IC50 73.6 nM
N#Cc1ccc(N2CCN([C@H]3C=C(c4cc5ncccc5c(=O)[nH]4)CC3)CC2)cc1 CHEMBL4776820 IC50 74.0 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1COCC2 CHEMBL2419893 IC50 75.0 nM
O=C(CCc1ccc(F)cc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419692 IC50 78.0 nM
O=C(CN1CCC(c2nnc(-c3ccc(F)cc3)o2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3941613 IC50 78.0 nM
Cc1ccc2c(c1C)c(=O)n(C[C@H]1CC[C@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4761086 IC50 79.4 nM
Cc1ccc(-c2nc3c(sc4ccccc43)c(=O)[nH]2)cc1 CHEMBL3344071 IC50 79.8 nM
CC(C)C1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3907218 IC50 80.0 nM
O=c1[nH]c(-c2ccc(Br)cc2)nc2c1COCC2 CHEMBL2419898 IC50 81.0 nM
[C-]#[N+]c1c(Cl)cccc1CN1CCC(N2CCC(C(=O)c3ccc(OC)cc3)CC2)C1=O CHEMBL3906478 IC50 81.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5ccsc5c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3926736 IC50 83.0 nM
COc1ccccc1C(=O)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC(F)F)CC1 CHEMBL3900771 IC50 85.0 nM
COc1ccc(-c2nc3c(c(=O)[nH]2)COCC3)cc1 CHEMBL2419900 IC50 86.0 nM
Oc1ccc(-c2nc(O)c3cccc(O)c3n2)cc1 CHEMBL127335 IC50 86.0 nM
COc1cccc2c(O)nc(-c3ccc(C(F)(F)F)cc3)nc12 CHEMBL123798 IC50 87.0 nM
O=C(CCc1ccco1)Nc1nnc2n1CCS2 CHEMBL2425816 IC50 88.0 nM
O=C(CCCC1CCCCC1)Nc1nnc2n1CCS2 CHEMBL2425804 IC50 89.0 nM
COc1ccc(-c2nnc(C3CCN(CC(=O)NCc4nc5c(c(=O)[nH]4)COCC5)CC3)o2)cc1 CHEMBL3935158 IC50 89.0 nM
CC(C)C1Cc2[nH]c(=O)c3cccnc3c2CO1 CHEMBL3736005 IC50 93.0 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3cnccn3)n2-c2ccccc2F)C1)c1ccccn1 CHEMBL5087490 IC50 93.0 nM
Cc1cccc2c1c(=O)n(C[C@H]1CC[C@@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL3109649 pIC50 100.0 nM
Cc1ccc2c(c1C)c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4786460 IC50 100.0 nM
O=c1[nH]c(-c2ccc(Br)cc2)nc2ccccc12 CHEMBL2058057 IC50 101.0 nM
O=C1NN=C2CCCc3[nH]c4cc(F)cc1c4c32 CHEMBL3929705 IC50 102.0 nM
CC(C)CC(=O)Nc1nnc2n1CCS2 CHEMBL1707591 IC50 103.0 nM
O=C1CC2(CCN(C(=O)CN3CCN(CCSc4nc5ccccc5c(=O)[nH]4)CC3)CC2)Oc2ccccc21 CHEMBL4632484 IC50 103.0 nM
O=C(CCc1ccccc1)N(Cc1nc2ccccc2c(=O)[nH]1)Cc1cccs1 CHEMBL2419711 IC50 106.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(Br)cc3)nc12 CHEMBL3827963 IC50 106.0 nM
Cn1ncnc1[C@@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@H]1c1ccc(F)cc1 CHEMBL3764816 pIC50 107.15 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)CCC4)CC2)cc1 CHEMBL3932754 IC50 110.0 nM
Cc1ccccc1NC(=O)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5172909 IC50 110.5 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1C CHEMBL4112659 IC50 112.0 nM
COc1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL4466835 IC50 112.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 120.0 nM
O=c1[nH]nc2c3c(cccc13)NC1=C2CCNC1 CHEMBL3978225 IC50 120.0 nM
N#Cc1ccc2c(c1)[nH]c(=O)n2[C@H]1CC[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2Cl)CC1 CHEMBL4102763 IC50 120.0 nM
COc1cccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)O)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4749857 IC50 125.9 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)O)CC3)c(=O)c3c(Cl)cccc32)cccc1C(F)(F)F CHEMBL4781804 IC50 125.9 nM
O=C1NC(c2ccc(C(F)(F)F)cc2)=NC2CSCC12 CHEMBL2419890 IC50 127.0 nM
COc1ccc(-c2nc(O)c3cccc(OC)c3n2)cc1 CHEMBL340481 IC50 128.0 nM
O=c1[nH]c2sccc2c2cc(O)ccc12 CHEMBL5077731 pIC50 128.82 nM
O=C1NN=C2CCCc3c2c2c1cccc2n3CCN1CCCCC1 CHEMBL3969049 IC50 130.0 nM
COc1ccc(-c2noc(CSc3nnc(C)n3-c3cccc(C)c3)n2)cc1 CHEMBL1724183 IC50 132.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3cc4c(c(=O)o3)COCC4)CC2)cc1 CHEMBL3981864 IC50 133.0 nM
O=C(CCc1ccncc1)Nc1nnc2n1CCS2 CHEMBL2425815 IC50 134.0 nM
CN1CCCc2c1cc(-c1ccc(Cl)cc1)[nH]c2=O CHEMBL3589284 IC50 134.0 nM
O=c1[nH]c(-c2ccsc2)nc2c1COCC2 CHEMBL2419895 IC50 136.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc(C)cc(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3902403 IC50 137.0 nM
O=C(CCc1cccnc1)Nc1nnc2n1CCS2 CHEMBL2425814 IC50 138.0 nM
COc1ccc2c(=O)[nH]c3sccc3c2c1 CHEMBL5084343 pIC50 138.04 nM
O=c1cc(-c2ccccc2)oc2ccccc12 CHEMBL275638 IC50 140.0 nM
O=c1cc(-c2ccc([N+](=O)[O-])cc2)oc2ccccc12 CHEMBL64780 IC50 140.0 nM
O=C1NN=C2CCCc3[nH]c4cccc1c4c32 CHEMBL3891329 IC50 140.0 nM
C[C@]12CCCN1CC1=NNC(=O)c3cc(F)cc4[nH]c2c1c34 CHEMBL4112930 IC50 140.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nc5sc(C)cc5c(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3967989 IC50 141.0 nM
COCCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(c2nnc(-c3ccccc3)o2)CC1 CHEMBL3973611 IC50 142.0 nM
CC1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3915929 IC50 143.0 nM
O=c1[nH]c(-c2ccc(Cl)cc2)nc2c1COCC2 CHEMBL2419897 IC50 148.0 nM
COc1ccc(N2CCN(c3nc4c(c(=O)[nH]3)COCC4)CC2)cc1 CHEMBL4446309 IC50 148.0 nM
Cc1cc(=O)[nH]c2cc(-c3cccc(F)c3)ccc12 CHEMBL2381632 IC50 150.0 nM
CC(C)(C)c1ccc(C2NC(=O)c3ccccc3N2)cc1 CHEMBL3594137 IC50 150.0 nM
O=C1NN=C2CCCc3c2c2c1cccc2n3CCN1CCCC1 CHEMBL3898162 IC50 150.0 nM
O=C1NN=C2CCCCc3[nH]c4cccc1c4c32 CHEMBL3969742 IC50 154.0 nM
N#Cc1cccnc1N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4ccccc34)c2)CC1 CHEMBL3740104 IC50 160.0 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CCCC2 CHEMBL2419891 IC50 163.0 nM
O=C1NN=C2CC(c3ccccc3)Cc3[nH]c4cccc1c4c32 CHEMBL3892363 IC50 164.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(C)cc3)nc12 CHEMBL3827329 IC50 167.0 nM
O=c1cc(-c2ccc(O)c(O)c2)oc2ccccc12 CHEMBL222556 IC50 170.0 nM
O=C(CN1CCC(c2nnc(-c3ccccc3)o2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3949450 IC50 170.0 nM
O=C(Nc1ccc(F)cc1)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5189723 IC50 171.0 nM
COc1ccc(-c2noc(CSc3nnc(-c4ccncc4)n3-c3ccc(OC)cc3)n2)cc1 CHEMBL1611739 IC50 175.0 nM
O=c1[nH]c(CN(Cc2cccs2)S(=O)(=O)Cc2ccccc2)nc2c1COCC2 CHEMBL3943146 IC50 177.0 nM
O=C(CCc1cccc(O)c1)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419694 IC50 178.0 nM
Cc1cc(=O)[nH]c2cc(-c3ccccc3)ccc12 CHEMBL2381630 IC50 180.0 nM
O=c1[nH]c2ccccc2c2c1sc1ccccc12 CHEMBL3344061 IC50 180.0 nM
Oc1nc(-c2ccccc2)nc2c(O)cccc12 CHEMBL341142 IC50 180.0 nM
CC1(C)OC(=O)N([C@H]2CC[C@H](NC(=O)c3cccc4cccnc34)CC2)[C@@H]1c1ccccc1 CHEMBL4110631 IC50 185.0 nM
O=C(CN1CCC(n2cc(-c3ccccc3)cn2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3949925 IC50 188.0 nM
CN1CCCc2c1cc(-c1ccccc1)[nH]c2=O CHEMBL3589281 IC50 189.0 nM
O=c1[nH]c(-c2ccc(O)cc2)nc2ccccc12 CHEMBL3289108 IC50 189.0 nM
CC1(C)OC(=O)N(c2ccc(C(=O)Nc3cccc4cccnc34)cc2)[C@H]1c1ccccc1 CHEMBL2381958 IC50 189.0 nM
Cc1ccc(-c2cc(=O)c3ccccc3o2)cc1 CHEMBL16861 IC50 190.0 nM
O=[N+]([O-])c1ccc(-c2nc(O)c3cccc(O)c3n2)cc1 CHEMBL338088 IC50 191.0 nM
O=c1[nH]c(SCCN2CCN(c3ccccn3)CC2)nc2ccccc12 CHEMBL4460557 IC50 193.0 nM
Cc1n[nH]c(C)c1CCC(=O)Nc1nnc2n1CCS2 CHEMBL2425789 IC50 195.0 nM
COc1ccc(-c2noc(CSc3nnc(C)n3-c3ccc(F)cc3)n2)cc1 CHEMBL1364326 IC50 197.0 nM
NC(=O)c1cccc2c1O/C(=C\c1ccc(C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)cc1)C2=O CHEMBL4474593 IC50 198.0 nM
c1ccc(C2=NC3=C(CN2)COCC3)cc1 CHEMBL4090855 pIC50 199.53 nM
Cc1cc(NCCc2ccc(O)cc2)c2nncn2n1 CHEMBL3238252 IC50 200.0 nM
COC(=O)c1ccc(-c2nc3c(c(=O)[nH]2)COCC3)cc1 CHEMBL2419708 IC50 202.0 nM
O=C(CC1CCOCC1)Nc1nnc2n1CCS2 CHEMBL2425799 IC50 202.0 nM
CC1(C)CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 CHEMBL3911687 IC50 203.0 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1C CHEMBL4113362 IC50 206.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccncc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 CHEMBL3924532 IC50 206.0 nM
O=C(CCc1ccccc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419712 IC50 216.0 nM
COc1ccc(C(=O)C2CCN([C@H]3CCCN(CCC4NC(=O)C5=C(CCOC5)N4)C3=O)CC2)cc1 CHEMBL3920028 IC50 218.0 nM
Nc1ccc(-c2nc(O)c3cccc(O)c3n2)cc1 CHEMBL126167 IC50 219.0 nM
O=C(Nc1nnc2n1CCS2)C1CCCC1 CHEMBL2425796 IC50 220.0 nM
O=C(N[C@H]1C[C@H](c2nnc(-c3ccccc3)n2-c2ccccc2F)C1)c1ccccn1 CHEMBL5081642 IC50 220.0 nM
C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(C(F)(F)F)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F CHEMBL5395820 IC50 227.0 nM
CC(C)c1ccc(C2NC(=O)c3ccccc3N2)cc1 CHEMBL3594136 IC50 230.0 nM
O=C(CCc1ccccc1F)N(Cc1ccc[nH]1)Cc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3934980 IC50 235.0 nM
O=C(Cc1ccccc1)Nc1nnc2n1CCS2 CHEMBL1446237 IC50 239.0 nM
O=C(CN1CCC(C(=O)N2CCc3c(Cl)cccc3C2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3930358 IC50 244.0 nM
O=C(Nc1nnc2n1CCS2)c1ccccc1 CHEMBL1714359 IC50 250.0 nM
Cc1c(C(N)=O)ccc2c1c(=O)n(C[C@H]1CC[C@H](C(=O)Nc3ccncc3)CC1)c(=O)n2Cc1cccc(C(F)(F)F)c1C#N CHEMBL4762657 IC50 251.2 nM
COc1ccc(C(=O)Nc2ccc(C(=O)NCC3(c4ccc(OC)cc4)CCOCC3)c(Cl)c2)cc1 CHEMBL3753510 pIC50 257.04 nM
O=C1NC2(CCN(c3nc4c(c(=O)[nH]3)CCCC4)CC2)c2ccccc21 CHEMBL4516906 IC50 258.0 nM
O=c1[nH]c(-c2ccc([N+](=O)[O-])cc2)nc2ccccc12 CHEMBL1164165 IC50 259.0 nM
O=c1[nH]c(-c2ccc(F)cc2)nc2c(O)cccc12 CHEMBL3828676 IC50 263.0 nM
O=C(Nc1nnc2n1CCS2)C1CCC1 CHEMBL2425795 IC50 264.0 nM
O=C(CN1CCC(c2n[nH]c3cc(F)ccc23)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3952800 IC50 270.0 nM
COc1ccc(-n2c(SCc3nc(-c4ccccc4)no3)nnc2-c2ccncc2)cc1 CHEMBL2016634 IC50 272.0 nM
Cc1nnc(SCc2nc(-c3ccc(Cl)cc3)no2)n1-c1ccc(F)cc1 CHEMBL1599148 IC50 281.0 nM
O=c1[nH]c(-c2ccccc2)cc2c1sc1ccccc12 CHEMBL3344065 IC50 283.0 nM
O=C(CCc1cccc(F)c1)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419691 IC50 284.0 nM
CC(C)n1cc2c(n1)CN(C(=O)c1cc(Cc3n[nH]c(=O)c4ccccc34)ccc1F)C2 CHEMBL4554200 IC50 289.8 nM
Cc1ccc(-c2nnc(CCc3nnc(-c4ccncc4)n3-c3ccccc3Cl)o2)cc1 CHEMBL2325499 IC50 290.0 nM
O=C(Nc1ccccc1F)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5179949 IC50 296.0 nM
CN1CCN(c2nc3c(c(=O)[nH]2)CCCC3)CC1 CHEMBL3593716 IC50 300.0 nM
O=C(CCCc1ccccc1)Nc1nnc2n1CCS2 CHEMBL2425805 IC50 303.0 nM
O=c1cc(-c2cccc(O)c2)oc2ccccc12 CHEMBL147552 IC50 310.0 nM
Cc1cc(=O)[nH]c2cc(-c3ccc(F)cc3)ccc12 CHEMBL2381631 IC50 310.0 nM
COc1ccc2c(C3CCN(CC(=O)NCc4nc5c(c(=O)[nH]4)COCC5)CC3)n[nH]c2c1 CHEMBL3928549 IC50 311.0 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)Nc3ccncc3)CC2)c(=O)c2ccncc21 CHEMBL4780670 IC50 316.2 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)Nc3ccncc3)CC2)c(=O)c2nc[nH]c21 CHEMBL4796484 IC50 316.2 nM
N#Cc1c(Cn2c(=O)n(C[C@H]3CC[C@H](C(=O)O)CC3)c(=O)c3c(F)cccc32)cccc1C(F)(F)F CHEMBL4764192 IC50 316.2 nM
C1CCC(CCCCNc2nnc3n2CCS3)CC1 CHEMBL4076784 pIC50 316.23 nM
O=C(CCc1ccccc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1ccc(Cl)s1 CHEMBL3936070 IC50 318.0 nM
O=C(OCc1ccccc1)N1CCN(CCSc2nc3ccccc3c(=O)[nH]2)CC1 CHEMBL4641894 IC50 318.0 nM
COc1ccc2c(c1)C(CC(=O)N1CCN(C(=O)c3ccccc3N3CCC(=O)NC3=O)CC1)CC2=O CHEMBL3577702 IC50 330.0 nM
N#Cc1ccc2c(c1)[nH]c(=O)n2-c1ccc(-c2nnc(-c3ccncn3)n2-c2ccccc2Cl)cc1 CHEMBL4064869 IC50 340.0 nM
O=C(CCc1ccc(O)cc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419695 IC50 341.0 nM
Cc1ccc(-c2cc3cnccc3c(=O)[nH]2)cc1 CHEMBL3589258 IC50 350.0 nM
CC(C)(C)c1ccc(C(=O)Nc2nnc3n2CCCS3)cc1 CHEMBL2425790 IC50 353.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)NCc3nc4c(c(=O)[nH]3)CCCCC4)CC2)cc1 CHEMBL3942774 IC50 353.0 nM
CC(C)c1ccc(C2NC(=O)c3cccnc3N2)cc1 CHEMBL268379 pIC50 354.81 nM
O=C(Nc1ccc(C(F)(F)F)cc1)c1ccc(NC(=O)N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1 CHEMBL5174447 IC50 366.5 nM
Oc1ccc2c(c1)sc1nncn12 CHEMBL5406267 IC50 370.0 nM
COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)CCCCC4)CC3CC3)CC2)cc1 CHEMBL3918346 IC50 371.0 nM
COc1ccc(C(=O)C2CCN([C@H]3CCN(CC(=O)Nc4nnc5n4CCS5)C3=O)CC2)cc1 CHEMBL3958005 IC50 374.0 nM
O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CCOC2 CHEMBL2419894 IC50 378.0 nM
COc1ccc(-c2cnn(C3CCN(CC(=O)NCc4nc5c(c(=O)[nH]4)COCC5)CC3)c2)cc1 CHEMBL3933643 IC50 386.0 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCN(Cc4nc5ccccc(=O)c5[nH]4)C3=O)CC2)cc1 CHEMBL4111286 IC50 390.0 nM
N#Cc1ccccc1Cn1c(=O)n(C[C@H]2CC[C@H](C(=O)Nc3ccncc3)CC2)c(=O)c2ncccc21 CHEMBL4761317 IC50 398.1 nM
O=C1NC(c2ccc(Cl)cc2)Nc2ccccc21 CHEMBL1448672 IC50 410.0 nM
O=c1[nH]c2ccccc2n1[C@H]1CC[C@H](c2nnc(-c3ccncn3)n2-c2ccccc2Cl)CC1 CHEMBL4084811 IC50 430.0 nM
CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCn2cc(nn2)-c2cc(C(=O)O)cc(c2)-c2cn(nn2)CC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CNC1=O CHEMBL5197192 Kd 440.0 nM
CN(C)c1ccc2c(-c3ccc(C(=O)NCCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]4CCn5cc(nn5)-c5cc(C(=O)O)cc(c5)C5=CN(CC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CNC4=O)NN5)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5277399 Kd 440.0 nM
O=C(NCc1ccccc1)Nc1nnc2n1CCS2 CHEMBL2425806 IC50 444.0 nM
COc1ccc(-c2cc(=O)c3ccc(O)cc3o2)cc1 CHEMBL16751 IC50 450.0 nM
COc1cccc2c(=O)[nH]c(-c3ccc(F)cc3)nc12 CHEMBL3827770 IC50 459.0 nM
COc1ccc(-n2c(SCc3nc(-c4ccc(C)cc4)no3)nnc2-c2ccncc2)cc1 CHEMBL1552719 IC50 460.0 nM
COc1ccc2c(c1)C(CC(=O)N[C@@H](CNC(=O)c1ccccc1N1CCC(=O)NC1=O)C(N)=O)CC2=O CHEMBL3577700 pIC50 467.74 nM
CN(C)CCn1c2c3c4c(cc(F)cc41)C(=O)NN=C3CC(C)(C)C2 CHEMBL3929889 IC50 480.0 nM
CCOc1ccc(-n2c(SCc3nc(-c4ccc(OC)cc4)no3)nnc2-c2ccncc2)cc1 CHEMBL1483505 IC50 509.0 nM
Cc1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL3289109 IC50 540.0 nM
Oc1nc(-c2ccccc2)nc2ccccc12 CHEMBL127066 IC50 540.0 nM
O=C1NC(c2ccccc2OCc2ccccc2)Nc2ccccc21 CHEMBL3594132 pIC50 575.44 nM
CC(C)(C)OC(=O)N1CCC2(CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)C2)C1 CHEMBL4159240 IC50 576.0 nM
O=c1[nH]c(SCCN2CCN(CCCOc3ccc(-c4ccccc4)cc3)CC2)nc2ccccc12 CHEMBL4642139 IC50 588.0 nM
Cc1ccc(-c2noc(CSc3nnc(C)n3-c3ccc(C)cc3)n2)cc1 CHEMBL1319888 IC50 589.0 nM
COc1ccc(C(=O)C2CCN([C@@H]3CCN(Cc4nc5c(c(=O)[nH]4)COCC5)C3=O)CC2)cc1 CHEMBL4107943 IC50 600.0 nM
CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCn2cc(nn2)CCCc2cn(nn2)CC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CNC1=O CHEMBL5173796 Kd 600.0 nM
O=c1cc(-c2cccc(O)c2)oc2cc(O)ccc12 CHEMBL253786 IC50 620.0 nM
O=c1[nH]c(-c2ccc3c(c2)OCO3)nc2ccccc12 CHEMBL4077094 IC50 620.0 nM
COc1ccc(-c2noc(CSc3nnc(C)n3-c3ccc(C)cc3)n2)cc1 CHEMBL1418516 IC50 629.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(CC(=O)Nc4nnc5ccccn45)C3=O)CC2)cc1 CHEMBL3969055 IC50 636.0 nM
Nc1ccc(-c2nc3ccccc3c(=O)[nH]2)cc1 CHEMBL3827921 IC50 690.0 nM
CC1(C)CC2=NNC(=O)c3cccc4c3c2c(n4CCN2CCCCC2)C1 CHEMBL3984980 IC50 700.0 nM
CC(C)(O)c1ccc(-c2nc3ccc(F)cc3c(=O)[nH]2)nc1 CHEMBL4585900 IC50 700.0 nM
CCc1c(C)nc(N2CCN(c3ccccc3F)CC2)nc1O CHEMBL2144572 IC50 720.0 nM
CC(c1nc2c(c(=O)[nH]1)COCC2)N(C)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL3942389 IC50 723.0 nM
O=C1NC(c2ccc(Cl)cc2)Nc2ncccc21 CHEMBL3594127 pIC50 758.58 nM
O=C(CN1CCC2(CCc3ccccc3C2=O)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3978051 IC50 760.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(Cc4nccc(=O)[nH]4)C3=O)CC2)cc1 CHEMBL3894926 IC50 764.0 nM
O=C(c1ccc(OCc2ccccc2)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC2CC2)CC1 CHEMBL3927814 IC50 764.0 nM
O=C(CCc1ccccc1O)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2419693 IC50 766.0 nM
COc1cc(Cl)c(C#N)cc1C(=O)NCCN1CCC(C(=O)c2ccc(F)cc2)CC1 CHEMBL2419696 IC50 770.0 nM
COc1ccc(-c2noc(CSc3nnc(-c4ccncc4)n3-c3ccccc3)n2)cc1 CHEMBL1443282 IC50 783.0 nM
O=C(CN1CCC(C(=O)N2CCc3ccccc3C2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 CHEMBL3969046 IC50 815.0 nM
COc1ccc(C2(CNC(=O)c3ccc(NC(=O)c4ccco4)cc3)CCOCC2)cc1 CHEMBL3753077 IC50 830.0 nM
CC1(C)CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 CHEMBL3972156 IC50 832.0 nM
COc1ccc(-c2noc(CSc3nnc(C)n3-c3ccccc3)n2)cc1OC CHEMBL2016863 IC50 861.0 nM
COc1cccc2c(O)nc(-c3ccc([N+](=O)[O-])cc3)nc12 CHEMBL125154 IC50 863.0 nM
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)ccc12 CHEMBL301624 IC50 870.0 nM
O=C1CCN(c2ccccc2C(=O)NCCc2ccc(Br)cc2)C(=O)N1 CHEMBL3577627 IC50 910.0 nM
O=c1[nH]c(CN(Cc2cccs2)S(=O)(=O)CCc2ccccc2)nc2c1COCC2 CHEMBL3913122 IC50 910.0 nM
CC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(C(F)(F)F)n21 CHEMBL3907010 IC50 930.0 nM
Cc1ccc2sc3nncn3c2c1 CHEMBL5398835 IC50 950.0 nM
CC(C)(C)OC(=O)N1CCC2(CC1)CCN(C(=O)c1cc(Cc3n[nH]c(=O)c4ccccc34)ccc1F)C2 CHEMBL4175833 IC50 953.0 nM
O=C(CCc1ccncc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1 CHEMBL2417574 IC50 958.0 nM
COc1ccc(C(=O)C2CCN(C3CCN(CC(=O)Nc4nncc5c4CCCO5)C3=O)CC2)cc1 CHEMBL3951549 IC50 970.0 nM
CC(C)CC(=O)Nc1nnc2n1CCCS2 CHEMBL2425792 IC50 980.0 nM
COc1ccc(C2NC(=O)c3ccccc3N2)cc1 CHEMBL138007 IC50 990.0 nM
O=C(CCc1ccccc1)N(Cc1nc2c(c(=O)[nH]1)COCC2)CC1CCCC1 CHEMBL3951890 IC50 995.0 nM
O=C(Nc1ccc(Br)cc1)c1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3C2)cc1 CHEMBL551249 EC50 1000.0 nM
COc1ccc2sc3nncn3c2c1 CHEMBL5402663 IC50 1000.0 nM
COc1cccc2sc3nncn3c12 CHEMBL5433172 IC50 1000.0 nM