COC(=O)c1cccc2c1Oc1ccccc1N=C2 CHEMBL1084637 EC50 0.05 nM
NC(=O)c1cccc2c1Oc1ccccc1N=C2 CHEMBL1084640 pEC50 0.07586 nM
COC(=O)c1cccc2c1Cc1ccccc1N=C2 CHEMBL1085102 pEC50 0.1 nM
N#Cc1cccc2c1Oc1ccccc1C=N2 CHEMBL1256241 EC50 0.1 nM
NC(=O)c1cccc2c1Oc1ccccc1C=N2 CHEMBL1084097 EC50 0.11 nM
COC(=O)c1cccc2c1Oc1ccccc1C=N2 CHEMBL1084098 pEC50 0.1175 nM
N#Cc1cccc2c1Oc1ccccc1N=C2 CHEMBL1256240 EC50 0.15 nM
C1=Nc2ccccc2Oc2ccccc21 CHEMBL1085100 EC50 0.3 nM
COC(=O)c1ccc2c(c1)Cc1ccccc1C=N2 CHEMBL1085103 EC50 0.4 nM
COC(=O)c1cccc2c1Cc1ccccc1C=N2 CHEMBL1084639 pEC50 0.5754 nM
O=C(NC[C@@H](Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CCCC1 CHEMBL4208555 IC50 0.7 nM
N#CC(C#N)=Cc1ccccc1Cl CHEMBL1256101 EC50 0.9 nM
O=C(NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CCCC1 CHEMBL3907685 IC50 1.0 nM
C#CC(CC)(CC)NC(=O)c1cccnc1NC1CC(F)(F)C1 CHEMBL5408439 IC50 1.0 nM
Cn1cnc2ncn(Cc3nc([C@@H]4CO[C@@H](c5ccc(Cl)cc5)C4)no3)c(=O)c21 CHEMBL4849329 IC50 1.2 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(Cl)c(OCC(F)(F)F)c(Cl)c4)cs3)coc2n(C)c1=O CHEMBL3976535 IC50 1.45 nM
N#Cc1cccc2c1Cc1ccccc1N=C2 CHEMBL1256239 EC50 1.6 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2C(F)(F)F)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4865238 IC50 1.6 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(F)c(OCC(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3974013 IC50 1.68 nM
O=C(NCC(Cc1ccc(F)cc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CC1 CHEMBL3903533 IC50 2.0 nM
Oc1ccc2c(c1)Oc1ccccc1N=C2 CHEMBL1256339 EC50 2.1 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)cc(C(F)(F)F)c4)cs3)coc2n(C)c1=O CHEMBL3947821 IC50 2.15 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(C(F)(F)F)c4F)cs3)coc2n(C)c1=O CHEMBL3976217 IC50 2.21 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4F)cs3)csc2n(C)c1=O CHEMBL3905801 IC50 2.49 nM
NC(=O)c1cccc2c1Cc1ccccc1N=C2 CHEMBL1256242 EC50 2.5 nM
Cn1cnc2ncn(Cc3nc([C@H]4[C@@H]5CN(c6cccc(Cl)c6)C[C@@H]54)no3)c(=O)c21 CHEMBL4870870 IC50 2.9 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(F)cc(C(F)(F)F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3905460 IC50 2.93 nM
C1=Nc2ccccc2Cc2ccccc21 CHEMBL1085101 EC50 3.0 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(Cl)c(C(F)(F)F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3927494 IC50 3.18 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(Cl)c(OCC(C)C)c(Cl)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3920312 IC50 3.34 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)c(CCC(F)(F)F)c(F)c4)cs3)coc2n(C)c1=O CHEMBL3981050 IC50 3.38 nM
Brc1cccc2c1Cc1ccccc1N=C2 CHEMBL1256161 EC50 3.5 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)c(OCC(F)(F)F)c(Cl)c4)cs3)coc2n(C)c1=O CHEMBL3929233 IC50 3.54 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(F)c(OCC(C)(C)C)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3904770 IC50 3.63 nM
CCc1sc2c(c1CC(=O)Nc1nc(-c3cc(F)c(OCC(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3896353 IC50 3.98 nM
O=C(NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(F)cc2)CCCCC1 CHEMBL3982480 IC50 4.0 nM
O[C@@]1(C(F)(F)F)CCCC[C@@H]1Cc1ccc(F)cc1 CHEMBL5428371 IC50 4.0 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(C(F)(F)F)c(F)c3F)cs1)c(=O)n(C)c(=O)n2C CHEMBL3898239 IC50 4.02 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(F)c(C(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3899453 IC50 4.16 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)cc(C(F)(F)F)c4)cs3)nsc2n(C)c1=O CHEMBL3984932 IC50 4.4 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(F)c(C(F)(F)F)c3F)cs1)c(=O)n(C)c(=O)n2C CHEMBL3956560 IC50 4.52 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(F)c(OC(F)(F)F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3977240 IC50 4.84 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)nc(C3CC3)n2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4079886 IC50 5.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2Cl)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4103545 IC50 5.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Cc1csc(Cl)c1 CHEMBL5428179 IC50 5.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4)cs3)c(Cl)oc2n(C)c1=O CHEMBL3958126 IC50 5.06 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)cc(C(F)(F)F)c4)cs3)c(Cl)oc2n(C)c1=O CHEMBL3930651 IC50 5.15 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(OCC(F)(F)F)c(Cl)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3922771 IC50 5.29 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(C(F)(F)F)c4F)cs3)nsc2n(C)c1=O CHEMBL3944172 IC50 5.29 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4F)cs3)nsc2n(C)c1=O CHEMBL3945471 IC50 5.35 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)c(C(F)(F)F)c(F)c4)cs3)cccc2n(C)c1=O CHEMBL3947368 IC50 5.37 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4F)cs3)nsc2n(C)c1=O CHEMBL3941901 IC50 5.6 nM
COCCCOc1cccc(C2NC(=S)NC3=C2C(=O)c2ccccc23)c1 CHEMBL1939972 IC50 5.61 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)c(OCC(F)(F)F)c(F)c4)cs3)cccc2n(C)c1=O CHEMBL3906012 IC50 5.96 nM
COC(=O)c1ccc2c(c1)Oc1ccccc1N=C2 CHEMBL1085943 EC50 6.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2C#N)N1Sc1ccc(F)cc1 CHEMBL5402014 IC50 6.1 nM
CCCCOC(=O)c1cccc2c1Cc1ccccc1N=C2 CHEMBL1258323 EC50 6.2 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)(F)F)c(Cl)c4)cs3)nsc2n(C)c1=O CHEMBL3892326 IC50 6.28 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4F)cs3)cccc2n(C)c1=O CHEMBL3987145 IC50 6.49 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(C(F)(F)F)cc3F)cs1)c(=O)n(C)c(=O)n2C CHEMBL3920106 IC50 6.65 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4)cs3)nsc2n(C)c1=O CHEMBL3912738 IC50 6.74 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)c(OCC(F)(F)F)c(F)c4)cs3)ccnc2n(C)c1=O CHEMBL3948210 IC50 6.91 nM
O=C(NC(Sc1ccc(Cl)cc1)C(Cl)(Cl)Cl)c1ccccc1 CHEMBL1086371 IC50 7.0 nM
O=C(NCC(Cc1ccccc1)N1CCC(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CCCC1 CHEMBL3974466 IC50 7.0 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(F)c(C(F)(F)F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3936454 IC50 7.1 nM
Cn1cnc2ncn(Cc3nn([C@H]4C[C@H](c5ccc(Cl)cc5)C4)c(=O)o3)c(=O)c21 CHEMBL4865298 IC50 7.4 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4F)cs3)c(Cl)oc2n(C)c1=O CHEMBL3978811 IC50 7.58 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)(F)F)c(F)c4)cs3)c(Cl)oc2n(C)c1=O CHEMBL3939505 IC50 7.67 nM
COCCCNC(=O)c1cccc2c1Cc1ccccc1N=C2 CHEMBL1258324 EC50 7.7 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2F)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4092287 IC50 8.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)(F)F)c(F)c4)cs3)nsc2n(C)c1=O CHEMBL3892970 IC50 8.04 nM
CCCCOC(=O)c1cccc2c1Cc1ccccc1N=C2 CHEMBL1084638 pEC50 8.511 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(OC(F)(F)F)c(Cl)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3931880 IC50 8.54 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4)cs3)ccnc2n(C)c1=O CHEMBL3905406 IC50 8.92 nM
C1=Nc2ccccc2Sc2ccccc21 CHEMBL1256377 EC50 9.0 nM
O=C1NCCc2c1sc1ncn(Cc3nc(C[C@H](O)c4ccc(Cl)cc4)no3)c(=O)c21 CHEMBL4848526 IC50 9.0 nM
NC(=O)c1csc2ncn(Cc3nnn(C[C@H](O)c4cc5ccc(F)cc5s4)n3)c(=O)c12 CHEMBL5197125 IC50 9.0 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(Cl)c(OC(F)(F)F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3932546 IC50 9.04 nM
N#CC(Br)c1ccccc1 CHEMBL1085832 EC50 10.0 nM
COc1cccc([C@H]2NC(=S)NC3=C2C(=O)c2ccccc23)c1 CHEMBL1939828 EC50 10.0 nM
CC(C)C(NC(=O)c1cc(Cl)ccc1C(F)(F)F)C(=O)c1ccc([N+](=O)[O-])cc1 CHEMBL2071601 pIC50 10.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2C#N)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4098855 IC50 10.0 nM
O[C@]12CCCC[C@@H]1CCC[C@H]2Nc1ccc(F)cc1 CHEMBL4215994 IC50 10.0 nM
CNC(=O)c1sc2ncn(Cc3nc(C[C@H](O)c4ccc(Cl)cc4)no3)c(=O)c2c1C CHEMBL4866216 IC50 10.0 nM
Cc1c(C(N)=O)oc2ncn(Cc3nnn(C[C@H](O)c4cc5ccccc5s4)n3)c(=O)c12 CHEMBL5170316 IC50 10.0 nM
Cc1c(C(N)=O)oc2ncn(Cc3nnn(C[C@H](O)c4ccc(Cl)s4)n3)c(=O)c12 CHEMBL5196336 IC50 10.0 nM
Cc1oc2ncn(Cc3nnn(C[C@H](O)c4cc5ccc(F)cc5s4)n3)c(=O)c2c1C(N)=O CHEMBL5176405 IC50 10.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4F)cs3)c(Cl)oc2n(C)c1=O CHEMBL3949747 IC50 10.1 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)cc4F)cs3)nsc2n(C)c1=O CHEMBL3913924 IC50 10.57 nM
Cc1oc2ncn(Cc3nnn(C[C@H](O)c4cc5ccccc5s4)n3)c(=O)c2c1C(N)=O CHEMBL5187441 IC50 11.0 nM
Cn1nc2c(c1CC(=O)Nc1nc(-c3ccc(OC(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3900789 IC50 11.04 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)(F)F)c(F)c4)cs3)cccc2n(C)c1=O CHEMBL3964272 IC50 11.38 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)(F)F)c(F)c4)cs3)ccnc2n(C)c1=O CHEMBL3947801 IC50 11.45 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4)cs3)coc2n(C)c1=O CHEMBL3942587 IC50 11.88 nM
O=C(NCC(Cc1ccc(Br)cc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CCCC1 CHEMBL3983430 IC50 12.0 nM
NC(=O)c1csc2ncn(Cc3nnn(C[C@H](O)c4cc5cc(Cl)ccc5o4)n3)c(=O)c12 CHEMBL5202437 IC50 12.0 nM
NC(=O)c1csc2ncn(Cc3nnn(C[C@H](O)c4ccc5oc(F)cc5c4)n3)c(=O)c12 CHEMBL5205506 IC50 12.0 nM
Cc1oc2ncn(Cc3nnn(C[C@H](O)c4cc5cc(Cl)ccc5o4)n3)c(=O)c2c1C(N)=O CHEMBL5171677 IC50 12.0 nM
Cn1c(=O)c2c(cnn2CC(=O)Nc2nc(-c3cc(Cl)c(OCC(C)(C)C)c(Cl)c3)cs2)n(C)c1=O CHEMBL3914798 IC50 12.26 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(OC(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3904928 IC50 12.57 nM
COCCCOc1cccc([C@H]2NC(=S)NC3=C2C(=O)c2ccccc23)c1 CHEMBL1939826 IC50 13.0 nM
C[C@H]1CC[C@@H](C(=O)NCc2cc(-c3ccc(C(F)(F)F)nc3)ncn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4077957 IC50 13.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)c(Cl)cn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4086464 IC50 13.0 nM
Cc1c(C(N)=O)sc2ncn(Cc3nc(C[C@H](O)c4ccc(Cl)cc4)no3)c(=O)c12 CHEMBL4869839 IC50 13.0 nM
NC(=O)c1csc2ncn(Cc3nnn(C[C@H](O)c4cc5ccccc5s4)n3)c(=O)c12 CHEMBL5179888 IC50 13.0 nM
Cc1c(C(N)=O)oc2ncn(Cc3nnn(C[C@H](O)c4cc5cc(Cl)ccc5o4)n3)c(=O)c12 CHEMBL5209855 IC50 13.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4)cs3)cccc2n(C)c1=O CHEMBL3935137 IC50 13.38 nM
Cc1oc2c(c1CC(=O)Nc1nc(-c3cccc(C(F)(F)F)c3F)cs1)c(=O)n(C)c(=O)n2C CHEMBL3944579 IC50 13.59 nM
COc1ccc2c(c1)Oc1ccccc1N=C2 CHEMBL1256311 EC50 14.0 nM
O=C(NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CC1 CHEMBL3912566 IC50 14.0 nM
CC1(C)CCC[C@](O)(C(F)(F)F)[C@H]1Cc1ccc([N+](=O)[O-])cc1 CHEMBL5398163 IC50 14.0 nM
Cc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3298923 IC50 14.0 nM
Cc1c(C(=O)NCC(F)F)sc2ncn(Cc3nc(C[C@H](O)c4ccc(Cl)cc4)no3)c(=O)c12 CHEMBL4859608 IC50 15.0 nM
Cn1nc2c(c1CC(=O)Nc1nc(-c3ccc(C(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3981381 IC50 15.92 nM
Cc1ccnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c12 CHEMBL3787249 IC50 16.0 nM
NC(=O)c1sc2ncn(Cc3nc(C[C@H](O)c4ccc(Cl)cc4)no3)c(=O)c2c1Cl CHEMBL4850616 IC50 16.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Nc1ccc(F)cc1 CHEMBL4514203 IC50 16.0 nM
CCc1sc2c(c1CC(=O)Nc1nc(-c3ccc(C(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3894956 IC50 16.73 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Nc1ccc(Cl)cc1 CHEMBL5394758 IC50 17.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4F)cs3)onc2n(C)c1=O CHEMBL3894760 IC50 17.08 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4F)cs3)cccc2n(C)c1=O CHEMBL3943177 IC50 17.3 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4)cs3)coc2n(C)c1=O CHEMBL3920880 IC50 17.74 nM
Cn1c(=O)c2c(ccn2CC(=O)Nc2nc(-c3cc(Cl)c(OCCC(F)(F)F)c(Cl)c3)cs2)n(C)c1=O CHEMBL3976638 IC50 18.05 nM
CCc1sc2c(c1CC(=O)Nc1nc(-c3cc(F)c(OC(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3924373 IC50 18.12 nM
CC(C)COc1c(F)cc(-c2csc(NC(=O)Cc3coc4c3c(=O)n(C)c(=O)n4C)n2)cc1F CHEMBL3908909 IC50 18.2 nM
COC(=O)c1ccc2c(c1)N=Cc1ccccc1C2 CHEMBL1255996 EC50 19.0 nM
Cc1c(C(N)=O)sc2ncn(Cc3nc(C[C@H](O)c4cc5ccccc5o4)no3)c(=O)c12 CHEMBL4848827 IC50 19.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4F)cs3)ccnc2n(C)c1=O CHEMBL3979456 IC50 19.32 nM
Cc1cc(S(=O)(=O)N2CC[C@@H](F)[C@@H]2c2ccc(F)cc2)cc(C)c1F CHEMBL3754638 IC50 20.0 nM
Cn1cnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c21 CHEMBL3785736 IC50 20.0 nM
Fc1ccc(Nc2n[nH]c3cc(OC(F)(F)F)cnc23)cc1F CHEMBL4062193 IC50 20.0 nM
Cn1cnc2ncn(Cc3nn(C[C@H](F)c4ccc(Cl)cc4)c(=O)o3)c(=O)c21 CHEMBL4863686 IC50 20.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Oc1ccc(F)cc1 CHEMBL5439762 IC50 20.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4)cs3)cccc2n(C)c1=O CHEMBL3897802 IC50 20.09 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Nc1ccc(Cl)c(F)c1 CHEMBL5419744 IC50 21.0 nM
CC(C)[C@H](N)C(=O)OCn1c(-c2ccc(F)c(C(F)(F)F)c2F)cs/c1=N\C(=O)Cc1csc2c1c(=O)n(C)c(=O)n2C CHEMBL3926532 IC50 21.91 nM
NC(=O)c1csc2ncn(Cc3nnn(C[C@H](O)c4cc5cc(F)ccc5o4)n3)c(=O)c12 CHEMBL5185597 IC50 22.0 nM
CC(C)CNc1nc(N2CCN(CC3CCCOC3)CC2)ncc1C(=O)NCc1ccccc1 CHEMBL1818218 EC50 23.0 nM
Cc1cc(S(=O)(=O)N2CC(F)(F)C[C@@H]2c2ccc(F)cc2)cc(C)c1F CHEMBL3753942 IC50 23.0 nM
NC(=O)c1csc2ncn(Cc3nnn(C[C@H](O)c4cc(Cl)c(Cl)s4)n3)c(=O)c12 CHEMBL5181161 IC50 23.0 nM
FC(F)(F)c1ccccc1-c1cc2cn[nH]c2cc1Cl CHEMBL3298922 IC50 24.0 nM
COc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3299019 IC50 26.0 nM
FC(F)(F)c1ccccc1-c1cc2cn[nH]c2cc1OCC1CC1 CHEMBL3299022 IC50 26.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)cc4F)cs3)cccc2n(C)c1=O CHEMBL3897132 IC50 26.13 nM
Cn1nc2c(c1CC(=O)Nc1nc(-c3ccc(C(F)(F)F)cc3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3906234 IC50 26.56 nM
O=C(NCc1ccccc1)c1cnc(N2CCN(C(=O)c3c(F)cccc3F)CC2)nc1NC1CC1 CHEMBL1818214 EC50 27.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(OC(F)(F)F)c4)cs3)c(Cl)oc2n(C)c1=O CHEMBL3945044 IC50 27.41 nM
O=C(NC(Sc1ccc(Cl)cc1)C(Cl)(Cl)Cl)c1ccc(Br)cc1 CHEMBL1086588 IC50 28.0 nM
COc1ccc(C(=O)NC(Sc2ccc(Cl)cc2)C(Cl)(Cl)Cl)cc1 CHEMBL1086586 IC50 29.0 nM
O=C(CCl)c1ccccc1 CHEMBL105712 EC50 30.0 nM
COC(=O)c1cccc2c1N=Cc1ccccc1C2 CHEMBL1255995 EC50 31.0 nM
COC(=O)c1cccc2c1C=Nc1ccccc1C2 CHEMBL1255994 EC50 31.0 nM
Brc1ccc2c(c1)C=Nc1ccccc1C2 CHEMBL1255819 EC50 33.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)c(F)cn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4077623 IC50 33.0 nM
CC1(C)CCC[C@](O)(C(F)(F)F)[C@H]1Cc1ccc(F)cc1 CHEMBL5437183 IC50 33.0 nM
Cc1sc2c(c1CC(=O)Nc1nc(-c3ccc(Cl)c(Cl)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3956363 IC50 33.61 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)F)c(Cl)c4)cs3)cccc2n(C)c1=O CHEMBL3904057 IC50 34.03 nM
O=C(NC(Sc1ccc(Cl)cc1)C(Cl)(Cl)Cl)c1ccc([N+](=O)[O-])cc1 CHEMBL1086587 IC50 35.0 nM
FC(F)(F)Oc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3299024 IC50 36.0 nM
Cc1c(C(=O)NCC(C)(C)O)sc2ncn(Cc3nc(C[C@H](O)c4ccc(Cl)cc4)no3)c(=O)c12 CHEMBL4847955 IC50 37.0 nM
Fc1ccc(Nc2n[nH]c3cc(C(F)(F)F)cnc23)cc1F CHEMBL4103611 IC50 38.0 nM
Cn1c(=O)c2c(ccn2CC(=O)Nc2nc(-c3ccc(OC(F)(F)F)cc3)cs2)n(C)c1=O CHEMBL3931425 IC50 38.46 nM
CCOC(=O)CBr CHEMBL1085948 EC50 39.0 nM
CCOc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3299020 IC50 39.0 nM
CCN(CC)C(=O)c1cccc2c1Cc1ccccc1N=C2 CHEMBL1258325 EC50 40.0 nM
O=c1c2cccnc2ncn1Cc1nc(CCc2ccc(Cl)cc2)no1 CHEMBL3785110 IC50 41.0 nM
O=c1c2cccnc2ncn1Cc1nc(CC(F)c2ccc(Cl)cc2)no1 CHEMBL3785133 IC50 41.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Nc1ccc(Cl)c(Cl)c1 CHEMBL5422541 IC50 41.0 nM
CC(C)c1sc2c(c1CC(=O)Nc1nc(-c3ccc(C(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C CHEMBL3918948 IC50 41.31 nM
FC(F)(F)c1ccc2c(Nc3ccc(Cl)cc3)n[nH]c2c1 CHEMBL4095993 IC50 42.0 nM
CC(C)(C(=O)NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)c1ccccc1 CHEMBL3928226 IC50 43.0 nM
N#Cc1cc(C[C@@H]2CCCC[C@]2(O)C(F)(F)F)cs1 CHEMBL5413437 IC50 43.0 nM
CC(C)COc1ccc(-c2csc(NC(=O)Cc3cccc4c3c(=O)n(C)c(=O)n4C)n2)cc1 CHEMBL3981620 IC50 43.93 nM
CCC(=N\O)/C(C)=C/c1ccc(F)cc1 CHEMBL3697701 IC50 44.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1N1CCc2cc(F)ccc21 CHEMBL5419147 IC50 45.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)cc4)cs3)cccc2n(C)c1=O CHEMBL3902066 IC50 46.27 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C5CCCCC5)cc4)cs3)cccc2n(C)c1=O CHEMBL3968210 IC50 46.74 nM
O=c1c2[nH]cnc2ncn1Cc1nc(CCc2ccc(Cl)cc2)no1 CHEMBL5427438 IC50 47.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(C(F)(F)F)c4)cs3)cccc2n(C)c1=O CHEMBL3956711 IC50 47.37 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(OC(F)(F)F)c4)cs3)cccc2n(C)c1=O CHEMBL3920559 IC50 47.91 nM
Fc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3298251 IC50 48.0 nM
Cc1c(C(N)=O)sc2ncn(Cc3nc(C[C@H](O)c4cc(F)cc(F)c4)no3)c(=O)c12 CHEMBL4851706 IC50 48.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(Cl)c(C(F)(F)F)c4)cs3)cccc2n(C)c1=O CHEMBL3897467 IC50 48.18 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)cc4F)cs3)cccc2n(C)c1=O CHEMBL3939180 IC50 48.21 nM
CC(C)CNc1nc(N2CCN(Cc3ccccc3)CC2)ncc1C(=O)NCc1cccnc1 CHEMBL1818210 EC50 49.0 nM
Cn1c(=O)c2c(ccn2CC(=O)Nc2nc(-c3ccc(C(F)(F)F)c(F)c3)cs2)n(C)c1=O CHEMBL3937790 IC50 49.92 nM
CCc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3298924 IC50 50.0 nM
FC(F)Oc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3299025 IC50 50.0 nM
Clc1cccc(-c2nnnn2Cc2cccnc2)c1Cl CHEMBL377219 IC50 51.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(C)(C)C)cc4)cs3)cccc2n(C)c1=O CHEMBL3973094 IC50 51.68 nM
Cn1ncc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c21 CHEMBL3786037 IC50 52.0 nM
Fc1ccc(Nc2n[nH]c3cc(C(F)(F)F)ccc23)cc1F CHEMBL4098431 IC50 53.0 nM
O=C(NC[C@@H](Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CC1 CHEMBL4213371 IC50 53.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(Cl)c4)cs3)cccc2n(C)c1=O CHEMBL3951379 IC50 53.57 nM
Cc1oc2c(c1CC(=O)/N=c1\scc(-c3ccc(OC(F)(F)F)c(Cl)c3)n1COC(=O)CN)c(=O)n(C)c(=O)n2C CHEMBL3954164 IC50 54.29 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Nc1ccc(F)c(Cl)c1 CHEMBL5423752 IC50 55.0 nM
Cn1c(=O)c2c(CC(=O)Nc3ccn(-c4ccc(Cl)cc4)n3)cccc2n(C)c1=O CHEMBL3896592 IC50 55.02 nM
Cc1c(C(N)=O)sc2ncn(Cc3nc(C[C@H](O)c4ccc5c(c4)OCO5)no3)c(=O)c12 CHEMBL4868010 IC50 56.0 nM
CCc1ccc(-c2csc(NC(=O)Cc3cccc4c3c(=O)n(C)c(=O)n4C)n2)cc1 CHEMBL3968269 IC50 56.02 nM
O=c1c2cccnc2ncn1Cc1nc(CC(O)c2ccc(Cl)cc2)no1 CHEMBL3786639 IC50 58.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(Cl)c4F)cs3)cccc2n(C)c1=O CHEMBL3896060 IC50 58.55 nM
Cn1c(=O)c2c(CC(=O)Nc3ccn(-c4cccc(C(F)(F)F)c4)n3)cccc2n(C)c1=O CHEMBL3935604 IC50 58.94 nM
CC1(C)CCC[C@]2(C)[C@@H](C=O)C(C=O)=CC[C@@H]12 CHEMBL254550 EC50 59.0 nM
CC(C)c1ccc(-c2csc(NC(=O)Cc3cccc4c3c(=O)n(C)c(=O)n4C)n2)cc1 CHEMBL3914637 IC50 60.42 nM
FC(F)(F)c1ccccc1-c1cc2cn[nH]c2cc1C1CC1 CHEMBL3298926 IC50 61.0 nM
Cc1cc(S(=O)(=O)N2[C@H](CO)CC[C@@H]2c2ccc(F)cc2)cc(C)c1F CHEMBL3753909 IC50 63.0 nM
C/C(=C\c1noc(Cn2cnc3ncn(C)c3c2=O)n1)c1ccc(Cl)cc1 CHEMBL3786508 IC50 63.0 nM
N#Cc1ccc(CC(CNC(=O)C2(c3ccc(Cl)cc3)CCCC2)N2CCC(O)(C(F)(F)F)CC2)cc1 CHEMBL3954796 IC50 63.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Nc1cccc(F)c1 CHEMBL5413993 IC50 63.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ncn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4087767 IC50 64.0 nM
C[C@@H](C(=O)Nc1ccnc(-c2cnc(N3CCC[C@H]3C(F)(F)F)nc2)n1)n1cnc2c1c(=O)n(C)c(=O)n2C CHEMBL5436504 IC50 64.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(F)c4F)cs3)cccc2n(C)c1=O CHEMBL3958453 IC50 65.45 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(I)cc4)cs3)cccc2n(C)c1=O CHEMBL3948438 IC50 66.28 nM
COCCCOc1cccc([C@H]2NC(=S)Nc3c2oc2ncccc32)c1 CHEMBL3314489 IC50 67.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2ccnc(-c3cnc(C(F)(F)F)nc3)c2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4103225 IC50 69.0 nM
O=C1C2=C(NC(=S)NC2c2cccc(OCCCCO)c2)c2ccccc21 CHEMBL1939833 IC50 70.0 nM
Cc1cccc2ncn(CC(=O)NCCc3ccc(Cl)cc3)c(=O)c12 CHEMBL3787125 IC50 70.0 nM
CCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21 CHEMBL2387541 EC50 70.0 nM
CCCC(C)(C)C(=O)NC[C@@H](Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1 CHEMBL4211095 IC50 71.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(Br)cc4)cs3)cccc2n(C)c1=O CHEMBL3921886 IC50 73.35 nM
CCNc1cc(NC(=O)c2c(F)cccc2F)cc(C(F)(F)F)c1 CHEMBL3311192 IC50 74.0 nM
N#Cc1ccc(-c2n[nH]c3cc(OC(F)(F)F)ccc23)s1 CHEMBL4063630 IC50 74.0 nM
CNC(=O)c1sc2ncn(Cc3nc(C[C@H](O)c4ccc5c(c4)OCO5)no3)c(=O)c2c1C CHEMBL4854825 IC50 78.0 nM
CC(C)CNc1nc(N2CCN(Cc3ccccc3)CC2)ncc1C(=O)NCc1ccccc1 CHEMBL1818209 EC50 79.0 nM
CC(C)CCOc1ccc(-c2csc(NC(=O)Cc3cccc4c3c(=O)n(C)c(=O)n4C)n2)cc1 CHEMBL3891778 IC50 79.77 nM
Cc1cccc(N2CCN(C(=O)N[C@H](C(=O)c3ccc(C#N)cc3)C(C)(C)C)CC2)n1 CHEMBL5397673 IC50 80.0 nM
C#Cc1cccc(-c2nc3ccc(C(F)(F)F)cn3c2NC(C)C)c1 CHEMBL3938303 IC50 82.0 nM
O=C(NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)c1cc(C(F)(F)F)ccn1 CHEMBL4207671 IC50 83.0 nM
FC(F)(F)c1ccccc1-c1ccc2[nH]ncc2c1 CHEMBL3298242 IC50 84.0 nM
COc1cccc(C2NC(=S)N(C)C3=C2C(=O)c2ccccc23)c1 CHEMBL1939822 IC50 85.0 nM
C/C(=C\c1nc(Cn2cnc3ncccc3c2=O)no1)c1ccc(Cl)cc1 CHEMBL3787359 IC50 85.0 nM
Cc1oc2c(c1CC(=O)/N=c1\scc(-c3ccc(OC(F)(F)F)c(Cl)c3)n1COC(=O)[C@@H](N)C(C)C)c(=O)n(C)c(=O)n2C CHEMBL3987098 IC50 88.5 nM
CCCCCc1cc(O)c2c(c1)OC(C)(CCC=C(C)C)C=C2 CHEMBL422704 EC50 90.0 nM
CC(C)Nc1cc(NC(=O)c2c(F)cccc2F)cc(C(F)(F)F)c1 CHEMBL3309280 IC50 91.0 nM
Fc1ccc2[nH]c(-c3n[nH]c4cc(OC(F)(F)F)cnc34)cc2c1 CHEMBL4091459 IC50 91.0 nM
CC(C)(C(=O)NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C(F)(F)F CHEMBL4212575 IC50 91.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)c(C#N)cn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4085297 IC50 96.0 nM
Cc1ccc(-c2csc(NC(=O)Cc3cccc4c3c(=O)n(C)c(=O)n4C)n2)cc1 CHEMBL3985375 IC50 97.42 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(Cl)c(Cl)c4)cs3)cccc2n(C)c1=O CHEMBL3953065 IC50 98.32 nM
C#CCN1C(=O)/C(=C/C(C)=O)c2ccccc21 CHEMBL258455 EC50 100.0 nM
COC(=O)c1ccc2c(c1)C=Nc1ccccc1C2 CHEMBL1255904 EC50 100.0 nM
Cc1c(=O)n(Cc2ccccc2)c(=O)n2cc(C(=O)N3CC[C@@H](Oc4ccccc4C(F)(F)F)C3)sc12 CHEMBL3220449 IC50 100.0 nM
NC(=O)c1cccc(-c2cccc(OC(=O)NC3CCCCC3)c2)c1 CHEMBL184238 EC50 100.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Cc1ccc(Cl)nc1 CHEMBL5440987 IC50 100.0 nM
CC(C)(C)[C@H]1CC[C@H](C(=O)NCC(Cc2ccccc2)N2CCC(O)(C(F)(F)F)CC2)CC1 CHEMBL4204105 IC50 101.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(Cl)c4)cs3)cccc2n(C)c1=O CHEMBL3965541 IC50 102.5 nM
FC(F)c1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3298927 IC50 103.0 nM
N#Cc1ccc(N[C@@H]2CCCC[C@]2(O)C(F)(F)F)cc1 CHEMBL5394738 IC50 103.0 nM
O=C(NCc1ccccc1)c1cnc(N2CCN(CC3CCCOC3)CC2)nc1NC1CC1 CHEMBL1818217 EC50 109.0 nM
CCCNc1cc(NC(=O)c2c(F)cccc2F)cc(C(F)(F)F)c1 CHEMBL3311190 IC50 110.0 nM
Cc1cc(S(=O)(=O)N2CCC[C@@H]2c2ccc(F)cc2)cc(C)c1F CHEMBL3754351 IC50 110.0 nM
O=S(=O)(c1cc(Cl)c(F)c(Cl)c1)N1[C@H](CO)CC[C@@H]1c1ccc(F)cc1 CHEMBL3753452 IC50 110.0 nM
C#Cc1cccc(-c2nc3ccc(C(F)(F)F)cn3c2NC(C)(C)C)c1 CHEMBL3952379 IC50 110.0 nM
Fc1ccc(Nc2n[nH]c3cc(Cl)ccc23)cc1F CHEMBL4088258 IC50 111.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)nc3)ccn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4104134 IC50 113.0 nM
COc1cccc(C2NC(=S)NC3=C2C(=O)c2ccccc23)c1 CHEMBL1939978 IC50 128.0 nM
N#Cc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3299026 IC50 129.0 nM
CC1(C)CCC[C@]2(C)[C@@H](CC/C=C(/C=O)CC=O)[C@@H](C=O)CC[C@@H]12 CHEMBL1085849 EC50 130.0 nM
Cc1cc(S(=O)(=O)N2[C@H](CO)CC[C@@H]2c2ccc(F)cc2)cc(Cl)c1F CHEMBL3754449 IC50 130.0 nM
Fc1ccc(Nc2n[nH]c3cc(OC(F)(F)F)ccc23)cc1F CHEMBL4060024 IC50 131.0 nM
CC(C)Nc1c(-c2cccc(Cl)c2)nc2ccc(Br)cn12 CHEMBL3948176 IC50 132.0 nM
Fc1ccc(-c2n[nH]c3cc(OC(F)(F)F)cnc23)cc1F CHEMBL4073272 IC50 134.0 nM
O=c1c2ccnnc2ncn1Cc1nc(CCc2ccc(Cl)cc2)no1 CHEMBL3785216 IC50 136.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(Cl)ccc4F)cs3)cccc2n(C)c1=O CHEMBL3911625 IC50 138.1 nM
COCc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3299023 IC50 142.0 nM
CC(C)Nc1c(-c2cccc(Cl)c2)nc2ccc(C(F)(F)F)cn12 CHEMBL3968657 IC50 143.0 nM
CN(C(=O)n1nnc(Cc2ccc(-c3ccccc3)cc2)n1)C1CCCCC1 CHEMBL2376842 EC50 150.0 nM
Cc1c(=O)n(Cc2ccccc2)c(=O)n2cc(C(=O)N3CC[C@H](Oc4ccccc4C(F)(F)F)C3)sc12 CHEMBL3220450 IC50 150.0 nM
CC(Cc1nc(Cn2cnc3ncccc3c2=O)no1)c1ccc(Cl)cc1 CHEMBL3787353 IC50 150.0 nM
CC(C)N(CC(=O)NC[C@H]1CN(c2ccc(C(F)(F)F)cc2)CCO1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3898574 IC50 151.0 nM
O=c1c2cncnc2ncn1Cc1nc(CCc2ccc(Cl)cc2)no1 CHEMBL3786810 IC50 153.0 nM
O=C(NCc1cc(-c2ccc(C(F)(F)F)nc2)ncn1)[C@@H]1CCCN1S(=O)(=O)c1ccc(F)cc1 CHEMBL4104646 IC50 154.0 nM
O=c1c2cccnc2ncn1Cc1noc(CCc2ccc(Cl)cc2)n1 CHEMBL3787566 IC50 156.0 nM
N#Cc1ccc2c(c1)C=Nc1ccccc1C2 CHEMBL1256162 EC50 158.0 nM
CC(C)c1csc(C(=O)NCC(Cc2ccccc2)N2CCC(O)(C(F)(F)F)CC2)n1 CHEMBL4208667 IC50 159.0 nM
C/C(=C\c1nc(Cn2cnc3ncn(C)c3c2=O)no1)c1ccc(Cl)cc1 CHEMBL3786010 IC50 165.0 nM
CCCc1cc(O)c2c(c1)OC(C)(C)c1ccc(C)cc1-2 CHEMBL4170268 IC50 170.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3ccc(C(F)(F)F)nc3)ncn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4062110 IC50 179.0 nM
CCCCCc1cc(O)c2c(c1)OC(C)(C)c1ccc(C)cc1-2 CHEMBL74415 EC50 180.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)cn3)ncn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4066447 IC50 184.0 nM
Cc1cc(S(=O)(=O)N2[C@H](CO)CC[C@@H]2c2ccc(F)cc2)ccc1F CHEMBL3752532 IC50 190.0 nM
CC(C)N(CC(=O)NCC1CN(c2ccc(C(F)(F)F)cc2)CCO1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3899792 IC50 193.0 nM
CC(C)Nc1c(-c2cccc(Cl)c2)nc2ccc(Cl)cn12 CHEMBL3922867 IC50 195.0 nM
Cc1noc(C(C)C)c1C(=O)NC(C(=O)c1ccc(C#N)c(F)c1)C(C)(C)C CHEMBL2071599 pIC50 199.53 nM
CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(CO1)[C@@H]2CC/C=C(/C=O)CC=O CHEMBL1084611 EC50 200.0 nM
Cc1c(=O)n(Cc2ccccc2)c(=O)n2cc(C(=O)N3CCC(Oc4ccccc4F)CC3)sc12 CHEMBL3220451 IC50 200.0 nM
Cc1c(=O)n(Cc2ccccc2)c(=O)n2cc(C(=O)N3CCC(Oc4cccc(Cl)c4)CC3)sc12 CHEMBL3220452 IC50 200.0 nM
CCCNc1cc(NC(=O)c2ccccc2)cc(C(F)(F)F)c1 CHEMBL3311184 IC50 200.0 nM
COCCCOc1cccc(C2NC(=S)Nc3c2oc2c(F)cccc32)c1 CHEMBL3314488 IC50 200.0 nM
N#Cc1cccc2c(=O)n(CC(=O)NCCc3ccc(Cl)cc3)cnc12 CHEMBL3787289 IC50 201.0 nM
O=C1C2=C(NC(=S)NC2c2cccc(OCCO)c2)c2ccccc21 CHEMBL1939832 IC50 210.0 nM
Cn1cnc2ncn(Cc3noc(CCc4ccc(Cl)cc4)n3)c(=O)c21 CHEMBL3785390 IC50 211.0 nM
Cc1cc(Br)cn2c(NC(C)(C)C)c(-c3cccc(Cl)c3)nc12 CHEMBL3915061 IC50 221.0 nM
CCN(CC(=O)NCC1CN(c2ccc(C(F)(F)F)cc2)CCO1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3930110 IC50 226.0 nM
Cc1cc2nc(-c3cccc(Cl)c3)c(NC(C)(C)C)n2cc1Br CHEMBL3959298 IC50 229.0 nM
CC(C)N(CC(=O)NCC1CCCN(c2ccc(C(F)(F)F)cc2)C1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3890809 IC50 233.0 nM
C[C@@H]1CC[C@@H](C(=O)NCc2cc(-c3ccc(C(F)(F)F)nc3)ncn2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4083847 IC50 239.0 nM
O=C(O)c1cccc2c1Cc1ccccc1N=C2 CHEMBL1256310 EC50 245.0 nM
CN1C(=O)c2cccc(CC(=O)Nc3nc(-c4ccc(Cl)c(Cl)c4)cs3)c2C1=O CHEMBL1083803 IC50 250.0 nM
Cc1cc(-c2csc(NC(=O)Cc3cccc4c3C(=O)N(C)C4=O)n2)ccc1Cl CHEMBL1083804 IC50 250.0 nM
CN1C(=O)c2cccc(CC(=O)Nc3nc(-c4cc(F)c(C(F)(F)F)c(F)c4)cs3)c2C1=O CHEMBL1086092 IC50 250.0 nM
S=C=NCc1ccccc1 CHEMBL55285 EC50 250.0 nM
CC(C)C(NC(=O)N(C)C(C)(C)C)C(=O)c1ccc(Cl)cc1 CHEMBL2071586 pIC50 251.19 nM
CC(C)C(NC(=O)c1ccccc1)C(=O)c1ccc([N+](=O)[O-])cc1 CHEMBL2071491 pIC50 251.19 nM
Fc1ccc(-c2n[nH]c3cc(OC(F)(F)F)cnc23)cc1 CHEMBL4067095 IC50 257.0 nM
CC(C)(C)Nc1c(-c2cccc(Br)c2)nc2ccc(C(F)(F)F)cn12 CHEMBL3939108 IC50 264.0 nM
Cc1ccc2ncn(CC(=O)NCCc3ccc(Cl)cc3)c(=O)c2c1 CHEMBL3786110 IC50 265.0 nM
COC[C@@H]1CC[C@H](c2ccc(F)cc2)N1S(=O)(=O)c1cc(C)c(F)c(C)c1 CHEMBL3752891 IC50 270.0 nM
O=C(Cn1cnc2c(C(F)(F)F)cccc2c1=O)NCCc1ccc(Cl)cc1 CHEMBL3786619 IC50 286.0 nM
CC(C)Nc1cc(NC(=O)c2cccs2)cc(C(F)(F)F)c1 CHEMBL3311183 IC50 290.0 nM
Cc1cc(C)cc(S(=O)(=O)N2[C@H](CO)CC[C@@H]2c2ccc(F)cc2)c1 CHEMBL3754617 IC50 290.0 nM
Fc1c(-c2ccccc2C(F)(F)F)ccc2[nH]ncc12 CHEMBL3298250 IC50 296.0 nM
O=C1C2=C(NC(=S)NC2c2cccc(OCc3ccccn3)c2)c2ccccc21 CHEMBL3314486 IC50 300.0 nM
Fc1ccc(C(F)(F)F)c(-c2ccc3[nH]ncc3c2)c1 CHEMBL3298248 IC50 306.0 nM
CC(C)N(CC(=O)NC[C@@H]1CCCN(c2ccc(C(F)(F)F)cc2)C1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3908709 IC50 307.0 nM
O=C(NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)C1)C1(c2ccc(F)cc2)CCC1 CHEMBL4217137 IC50 309.0 nM
CCCCOc1cccc(C2NC(=S)NC3=C2C(=O)c2ccccc23)c1 CHEMBL1939836 IC50 310.0 nM
Fc1ccc(Oc2nccc3[nH]ccc23)cc1 CHEMBL3297778 IC50 310.0 nM
CC(C)C(NC(=O)c1cc(Cl)ccc1C(F)(F)F)C(=O)c1ccc(C#N)cc1 CHEMBL2071507 pIC50 316.23 nM
Fc1ccc(Oc2nccc3[nH]ccc23)c(F)c1 CHEMBL3298760 IC50 320.0 nM
O=C(O)c1cc([N+](=O)[O-])ccc1NCCCc1ccccc1 CHEMBL1256759 EC50 320.0 nM
C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2c(F)cnc(-c3cnc(C(F)(F)F)nc3)c2F)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL4064602 IC50 328.0 nM
COc1cc2ccnc(Oc3ccc(F)cc3)c2cc1OC CHEMBL3298322 IC50 330.0 nM
CC1(C)CCCC(O)(C(F)(F)F)C1Cc1ccc(Cl)cc1 CHEMBL5431800 IC50 340.0 nM
O=S(=O)(c1cc(Cl)c(F)c(Cl)c1)N1CCC[C@@H]1c1ccc(F)cc1 CHEMBL3754445 IC50 350.0 nM
Cc1ccc(C(=O)NC(Sc2ccc([N+](=O)[O-])cc2)C(Cl)(Cl)Cl)cc1 CHEMBL1086589 IC50 360.0 nM
C=CCCN=C=S CHEMBL3593942 EC50 360.0 nM
S=C=NCCc1ccccc1 CHEMBL151649 EC50 370.0 nM
Cc1cc(S(=O)(=O)N2C[C@H](F)C[C@@H]2c2ccc(F)cc2)cc(C)c1F CHEMBL3752895 IC50 380.0 nM
CN1C(=O)c2c(ncn2CC(=O)Nc2nc(-c3ccc(C(C)(C)C)cc3)cs2)N2CCN=C12 CHEMBL3894821 IC50 381.8 nM
CC(C)N(CC(=O)NCC1CN(c2ccc(C(F)(F)F)cn2)CCO1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3930699 IC50 385.0 nM
CCCNc1cc(NC(=O)c2cccs2)cc(C(F)(F)F)c1 CHEMBL3311182 IC50 390.0 nM
CC1(C)CCCC(O)(C(F)(F)F)C1Cc1ccc(C#N)cc1 CHEMBL5436178 IC50 390.0 nM
C=CCN=C=S CHEMBL233248 EC50 398.0 nM
CC(C)C(NC(=O)c1ccc(Cl)cc1)C(=O)c1ccc(C#N)cc1 CHEMBL2071502 pIC50 398.11 nM
CC(C)C(NC(=O)c1cnn(C(C)(C)C)c1C(F)(F)F)C(=O)c1ccc2nonc2c1 CHEMBL2071600 pIC50 398.11 nM
CC(C)(C)C(NC(=O)c1ccccc1)C(=O)c1ccc(Cl)cc1 CHEMBL2071592 pIC50 398.11 nM
CC(C)C(NC(=O)c1ccccc1)C(=O)c1ccc(Cl)cc1 CHEMBL2071494 pIC50 398.11 nM
Cn1c(=O)c2c(ccn2CC(=O)Nc2ccc(C(F)(F)F)cc2)n(C)c1=O CHEMBL1944838 IC50 400.0 nM
Cc1c(=O)n(Cc2ccccc2)c(=O)n2cc(C(=O)N3CCC(c4ccccc4F)CC3)sc12 CHEMBL3220453 IC50 400.0 nM
Fc1ccc(Oc2ncnc3[nH]ccc23)cc1 CHEMBL3298431 IC50 410.0 nM
CSCCCCN=C=S CHEMBL2151143 EC50 420.0 nM
C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCC)cc1O CHEMBL2387742 EC50 420.0 nM
CC(C)N(CC(=O)NCC1CCN(c2ccc(C(F)(F)F)cc2)C1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3983229 IC50 425.0 nM
CN(c1ccc(F)cc1)[C@@H]1CCCC[C@]1(O)C(F)(F)F CHEMBL5397630 IC50 430.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Nc1ccccc1 CHEMBL5426246 IC50 430.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Nc1ccc(F)cn1 CHEMBL5419942 IC50 440.0 nM
CSCCCN=C=S CHEMBL3186484 EC50 450.0 nM
Fc1ccc(-c2n[nH]c3cc(C(F)(F)F)cnc23)cc1F CHEMBL4102407 IC50 450.0 nM
CC1=CC(=O)c2c(O)cccc2C1=O CHEMBL295316 EC50 460.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Cc1ncc(Cl)s1 CHEMBL5440996 IC50 470.0 nM
O=C(NC[C@H](Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CC1 CHEMBL4208446 IC50 474.0 nM
C=CCSSSCC=C CHEMBL123040 EC50 490.0 nM
CCN(CC(=O)NCC1CCCN(c2ccc(C(F)(F)F)cc2)C1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3922391 IC50 494.0 nM
CN1C(=O)c2cccc(CC(=O)Nc3nc(-c4ccc(Cl)cc4)cs3)c2C1=O CHEMBL1085863 IC50 500.0 nM
CN1C(=O)c2cccc(CC(=O)Nc3nc(-c4cccc(C(F)(F)F)c4)cs3)c2C1=O CHEMBL1083798 IC50 500.0 nM
O=C1C2=C(NC(=S)NC2c2cccc(Br)c2)c2ccccc21 CHEMBL1939980 IC50 500.0 nM
CSCCCCCN=C=S CHEMBL3593947 EC50 500.0 nM
CCCC(=N\O)/C(C)=C/c1ccc(F)cc1 CHEMBL3697704 IC50 500.0 nM
CC(C)C(NC(=O)c1cnoc1C(C)(C)C)C(=O)c1ccc(C#N)cc1 CHEMBL2071509 pIC50 501.19 nM
CC(C)N(CC(=O)NC[C@H]1CCCN(c2ccc(C(F)(F)F)cc2)C1)S(=O)(=O)c1ccc(F)cc1 CHEMBL4110915 IC50 504.0 nM
O=C(O)/C=C1/C(=O)N(CC2CCCC2)c2c(F)cccc21 CHEMBL1084103 EC50 510.0 nM
CC(C)c1ccccc1-c1ccc2[nH]ncc2c1 CHEMBL3298240 IC50 514.0 nM
CC(C)N=C=S CHEMBL2208211 EC50 530.0 nM
C=CCCCN=C=S CHEMBL3593943 EC50 540.0 nM
FC(F)(F)c1ccc2c(Nc3ccc(Cl)nc3)n[nH]c2c1 CHEMBL4093377 IC50 550.0 nM
Cn1c(=O)c2c(CC(=O)/N=c3\scc(-c4ccc(F)c(C(F)(F)F)c4F)n3COP(=O)(O)O)csc2n(C)c1=O CHEMBL3915505 IC50 559.3 nM
CCC(=N\O)/C(C)=C/c1ccc(F)c(F)c1 CHEMBL3697714 IC50 574.0 nM
CSCCCCCCN=C=S CHEMBL574688 EC50 580.0 nM
CCc1ccccc1-c1ccc2[nH]ncc2c1 CHEMBL3298239 IC50 584.0 nM
CC1(C)C[C@H]2C=C(C=O)[C@]3(C=O)C[C@]3(C)[C@H]2C1 CHEMBL518292 EC50 590.0 nM
COCCCOc1cccc([C@H]2NC(=S)Nc3c2oc2ccccc32)c1 CHEMBL3314487 IC50 590.0 nM
O=C(Oc1ccc(Cl)cc1)N1CCN(c2ncccc2Cl)CC1 CHEMBL1076350 EC50 600.0 nM
CC(C)CN1C(=O)/C(=C/C(=O)O)c2cccc(Cl)c21 CHEMBL1084377 EC50 610.0 nM
CSCCCCCCCN=C=S CHEMBL3593948 EC50 610.0 nM
Fc1ccc(Oc2ncnc3[nH]cc(Cl)c23)c(F)c1 CHEMBL3298584 IC50 630.0 nM
COc1cc2ccnc(Oc3ccc(F)cc3F)c2cc1OC CHEMBL3297861 IC50 630.0 nM
CCN(CC(=O)NCC1CCN(c2ccc(C(F)(F)F)cc2)C1)S(=O)(=O)c1ccc(F)cc1 CHEMBL3913396 IC50 634.0 nM
O=C1C2=C(NC(=S)NC2c2cccc(O)c2)c2ccccc21 CHEMBL1939976 IC50 640.0 nM
Fc1ccc(Nc2n[nH]c3cc(C(F)(F)F)ncc23)cc1F CHEMBL4072845 IC50 645.0 nM
Cc1c[nH]c2ncnc(Oc3ccc(F)cc3F)c12 CHEMBL3298582 IC50 650.0 nM
NC(=O)/C=C1/C(=O)N(CC2CCCC2)c2c(F)cccc21 CHEMBL1084376 EC50 660.0 nM
O=C(NCC(Cc1ccccc1)N1CCC(C(F)(F)F)CC1)C1(c2ccc(F)cc2)CCCC1 CHEMBL4216712 IC50 673.0 nM
Cc1c(=O)n(Cc2ccccc2)c(=O)n2cc(C(=O)NCc3ccc4[nH]ccc4c3)sc12 CHEMBL3220224 IC50 680.0 nM
CCC(C)N=C=S CHEMBL3593576 EC50 680.0 nM
Cc1cccc2c(=O)n(CC(=O)NCCc3ccc(OC(F)F)cc3)cnc12 CHEMBL3787204 IC50 685.0 nM
N#Cc1ccc(-c2n[nH]c3cc(OC(F)(F)F)ccc23)cc1 CHEMBL4101680 IC50 686.0 nM
CC(C)CN=C=S CHEMBL3593941 EC50 690.0 nM
CCCCCc1cc(O)c(C/C=C(\C)CCC=C(C)C)c(O)c1 CHEMBL497318 EC50 700.0 nM
CCC(=N/O)/C(C)=C/c1ccc(F)cc1 CHEMBL3697710 IC50 701.0 nM
O=C1C2=C(NC(=S)NC2c2cccc(CO)c2)c2ccccc21 CHEMBL1939977 IC50 710.0 nM
Fc1ccc(Oc2ncnc3[nH]ccc23)c(F)c1 CHEMBL3298430 IC50 710.0 nM
O=C1C2=C(NC(=S)NC2c2cccc(OCc3cccnc3)c2)c2ccccc21 CHEMBL3314485 IC50 710.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Cc1ccncc1 CHEMBL5424148 IC50 722.0 nM
Fc1ccc2[nH]c(-c3n[nH]c4cc(OC(F)(F)F)ccc34)cc2c1 CHEMBL4100238 IC50 748.0 nM
Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 CHEMBL165 IC50 750.0 nM
CC1(C)CCCC(O)(C(F)(F)F)C1Cc1cccc(F)c1 CHEMBL5408516 IC50 750.0 nM
O=C1C2=C(NC(=S)N[C@@H]2c2ccccc2)c2ccccc21 CHEMBL1939984 IC50 770.0 nM
CC(C)CNc1cc(NC(=O)c2cccs2)cc(C(F)(F)F)c1 CHEMBL3311181 IC50 790.0 nM
CC(C)C(NC(=O)OC(C)(C)C)C(=O)c1ccc(Cl)cc1 CHEMBL2071588 pIC50 794.33 nM
CC(=O)/C=C1/C(=O)N(C)c2ccccc21 CHEMBL402589 EC50 800.0 nM
C=CC=O CHEMBL721 EC50 800.0 nM
CC(C)=CCC/C(C)=C/CC/C(C)=C/CSc1ccccc1C(=O)O CHEMBL23293 EC50 800.0 nM
Cc1cccc2c(=O)n(CC(=O)NCCc3ccc(Cl)cc3)cnc12 CHEMBL3787010 IC50 802.0 nM
O[C@]1(C(F)(F)F)CCCC[C@H]1Cc1ccc(Cl)cn1 CHEMBL5394183 IC50 810.0 nM
O=C(NCC(Cc1ccc(F)cc1)N1C2CCC1CC(O)(C(F)(F)F)C2)C1(c2ccc(F)cc2)CCCC1 CHEMBL4204223 IC50 825.0 nM
CC(C)CN1C(=O)/C(=C/C(=O)O)c2cccc(F)c21 CHEMBL1082283 EC50 830.0 nM
CC(=C\c1ccc(F)cc1)/C(=N\O)C(C)C CHEMBL3697707 IC50 850.0 nM
CC1(C(=O)NCC(Cc2ccccc2)N2CCC(O)(C(F)(F)F)CC2)CCCCC1 CHEMBL4203840 IC50 851.0 nM
CC(C)(C)Nc1c(-c2cccc(C#N)c2)nc2ccc(C(F)(F)F)cn12 CHEMBL3945305 IC50 854.0 nM
O=c1c2nccnc2ncn1Cc1nc(CCc2ccc(Cl)cc2)no1 CHEMBL3786920 IC50 918.0 nM
CN1C(=O)c2c(ncn2CC(=O)Nc2nc(-c3ccc(Br)cc3)cs2)N2CCN=C12 CHEMBL3924146 IC50 920.9 nM
CC(C)OC(=O)c1ccc2c(c1)C=Nc1ccccc1C2 CHEMBL1258208 EC50 933.0 nM
O=c1c2cccnc2ncn1Cc1noc(/C=C/c2ccc(Cl)cc2)n1 CHEMBL3787029 IC50 933.0 nM
CCCNc1cc(NC(=O)c2cccnc2)cc(C(F)(F)F)c1 CHEMBL3311186 IC50 940.0 nM
S=C1Nc2c(oc3ncccc23)C(c2cccc(OCc3cccnc3)c2)N1 CHEMBL3314490 IC50 940.0 nM
CC(C)Oc1cc2[nH]ncc2cc1-c1ccccc1C(F)(F)F CHEMBL3299021 IC50 970.0 nM
COCCCOc1cccc(C2NC(=S)NC3=C2C(=O)c2ccccc23)n1 CHEMBL3314484 IC50 970.0 nM
O=C(Oc1cccc(Cl)c1)N1CCN(c2ncccc2Cl)CC1 CHEMBL1081019 EC50 1000.0 nM
O=C(Oc1cccc(-c2ccccc2)c1)N1CCN(c2ncccc2C(F)(F)F)CC1 CHEMBL1081905 EC50 1000.0 nM
CCCCCCCC/C=C(\CCCCCCCC(=O)O)[N+](=O)[O-] CHEMBL550762 EC50 1000.0 nM
CCCCCCCCCC(=O)NC(C(=O)c1ccc(C#N)cc1)C(C)C CHEMBL2071513 pIC50 1000.0 nM
O=C(NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(C(F)(F)F)CC1 CHEMBL4216307 IC50 1000.0 nM
CC1(C)CCCC(O)(C(F)(F)F)C1Cc1ccc(F)cc1F CHEMBL5436224 IC50 1000.0 nM