O=C(COc1ccc2c(c1)CCC2)N(Cc1cccs1)c1ccn[nH]1 CHEMBL4064391 EC50 0.001 nM
O=C(/C=C/c1ccc2c(c1)OCO2)N(Cc1cccs1)c1ccn[nH]1 CHEMBL4069241 EC50 0.002 nM
Cc1ccc(/C=C/C(=O)N(Cc2cccs2)c2ccn[nH]2)cc1 CHEMBL4070838 EC50 0.004 nM
COc1cc(CN(CCN)C(=O)NC(C)c2ccccc2)ccc1OCc1ccccc1 CHEMBL5287633 IC50 0.05 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccn[nH]2)cc1 CHEMBL4087522 EC50 0.2 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2ncco2)cc1 CHEMBL4099556 EC50 0.3 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2c(C)n[nH]c2C)cc1 CHEMBL4075397 EC50 0.3 nM
O=S(=O)(c1ccc(-c2nnn[nH]2)cc1)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1 CHEMBL5275380 IC50 0.3 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2c[nH]nc2C)cc1 CHEMBL4072494 EC50 0.4 nM
FC(F)(F)c1ccccc1-c1cc(C(F)(F)F)c2[nH]c(C3=NOC4(CCCCC4)C3)nc2c1 CHEMBL1650511 IC50 0.413 nM
Cc1c(N(Cc2ccc(C(F)(F)C3CC3)c(Cl)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687372 IC50 0.6 nM
O=C(COc1ccc2c(c1)OCO2)N(Cc1cccs1)c1ccn[nH]1 CHEMBL4097005 EC50 0.6 nM
CCN(Cc1cccs1)C(=O)/C=C/c1ccc2c(c1)OCO2 CHEMBL4097943 EC50 0.7 nM
O=C([O-])c1ccc(S(=O)(=O)N(Cc2ccc(C(F)(F)C3CC3)c(F)c2)c2ncc3ccccc3c2C2CC2)cc1 CHEMBL3687381 IC50 0.8 nM
CCN(Cc1cccs1)C(=O)COc1ccc2c(c1)CCC2 CHEMBL4079591 EC50 0.8 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C2CC2)cc1 CHEMBL3682589 IC50 0.9 nM
O=C([O-])c1ccc(S(=O)(=O)N(Cc2ccc(C(F)(F)C3CC3)c(Cl)c2)c2ncc3ccccc3c2C(F)(F)F)cc1 CHEMBL3687404 IC50 0.9 nM
CC(C)(C)c1ccc(CN(c2ncc(C(F)(F)F)cc2Cl)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1 CHEMBL3353600 IC50 0.96 nM
Cc1c(N(Cc2ccc(C(F)(F)C3CC3)c(Cl)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(C2CC2)c2ccccc12 CHEMBL3687353 IC50 1.0 nM
Cc1c(N(Cc2ccc(C(F)(F)C3(C)CC3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687380 IC50 1.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2cc3c(F)cc(F)cc3s2)c2ncc3ccccc3c2C2CC2)cc1 CHEMBL3687356 IC50 1.1 nM
COc1ccc2oc(C(=O)N(Cc3cccs3)c3ccn[nH]3)cc2c1 CHEMBL4060261 EC50 1.1 nM
Cc1c(N(Cc2ccc(F)c(C(F)(F)F)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)sc2ccccc12 CHEMBL2324349 IC50 1.1 nM
O=C([O-])c1ccc(S(=O)(=O)N(Cc2ccc(C(F)(F)C3CC3)c(Cl)c2)c2ncc3ccccc3c2C2CC2)cc1 CHEMBL3687357 IC50 1.2 nM
Cc1c(N(Cc2ccc3c(c2)CCC3(C)C)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682568 IC50 1.3 nM
Cc1c(N(Cc2cc3c(F)cc(F)cc3s2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687365 IC50 1.3 nM
Cc1cc2ccccc2nc1N(Cc1ccc(C(F)(F)C2CC2)c(Cl)c1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687373 IC50 1.4 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)sc2ccccc12 CHEMBL3974529 IC50 1.4 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2cn[nH]c2)cc1 CHEMBL4105385 EC50 1.4 nM
Cc1c(N(Cc2ccc(C(F)(F)C3CC3)c(F)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687374 IC50 1.5 nM
COC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1Cl)C(F)(F)F CHEMBL3687393 IC50 1.6 nM
O=C([O-])c1ccc(S(=O)(=O)N(Cc2ccc(C(F)(F)C3CC3)c(F)c2)c2ncc3ccccc3c2C(F)(F)F)cc1 CHEMBL3687406 IC50 1.6 nM
Cc1c(N(Cc2ccc(C(F)(F)C3CCC3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687360 IC50 1.7 nM
COC(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1)(C(F)(F)F)C(F)(F)F CHEMBL3687392 IC50 1.7 nM
Cc1c(N(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682549 IC50 1.8 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)nc(C2CC2)c2ccccc12 CHEMBL3682543 IC50 1.9 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C(F)(F)F)cc1 CHEMBL3682590 IC50 2.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccon2)cc1 CHEMBL4064052 EC50 2.0 nM
CCN(Cc1cccs1)C(=O)/C=C/c1ccc(C)cc1 CHEMBL4063252 EC50 2.0 nM
Cc1c(N(C2CCc3cc(OC(F)(F)F)ccc32)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687351 IC50 2.1 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cn2)c2ncc3ccccc3c2C2CC2)cc1 CHEMBL3687325 IC50 2.2 nM
Cc1c(N(Cc2cc3c(Cl)cccc3s2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687367 IC50 2.2 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2Br)cc1 CHEMBL3687327 IC50 2.3 nM
COc1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)c(C)c2ccccc12 CHEMBL3682556 IC50 2.5 nM
COC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1F)C(F)(F)F CHEMBL3687390 IC50 2.6 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682539 IC50 2.7 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(C(C)C)c2ccccc12 CHEMBL3687396 IC50 2.8 nM
Cc1c(N(Cc2ccc(CC3CC3)c(F)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687342 IC50 2.9 nM
O=C([O-])c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2Cl)cc1 CHEMBL3682557 IC50 3.1 nM
Cc1c(N(Cc2cc3ccccc3s2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682578 IC50 3.1 nM
Cc1cccc2cnc(N(Cc3ccc(OC(F)(F)F)cc3)S(=O)(=O)c3ccc(C(=O)O)cc3)c(C)c12 CHEMBL3682614 IC50 3.1 nM
Cc1cc2ccccc2nc1N(Cc1ccc(C(F)(F)C2CC2)c(F)c1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687375 IC50 3.1 nM
CC(C)(c1ccc(CN(c2ncc(C(F)(F)F)cc2Cl)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1)C(F)(F)F CHEMBL3353601 IC50 3.3 nM
COC1(C(F)(F)F)CCc2cc(CN(c3ncc4ccccc4c3C)S(=O)(=O)c3ccc(C(=O)O)cc3)ccc21 CHEMBL3687394 IC50 3.5 nM
COc1nc(-c2ccccc2Cl)cc2nc(-c3c(Cl)c(C(C)(C)C)nn3C)[nH]c12 CHEMBL3967426 IC50 3.5 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)c(F)c2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682540 IC50 3.6 nM
COc1ccc(OCC(=O)N(Cc2cccs2)c2ccn[nH]2)cc1 CHEMBL4091381 EC50 3.7 nM
Cc1c(N(Cc2ccc(F)c(C(F)(F)F)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(C2CC2)c2ccccc12 CHEMBL3682609 IC50 3.8 nM
COc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687323 IC50 3.9 nM
Cc1c(N(Cc2ccc(CC3(C(F)(F)F)CC3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687364 IC50 3.9 nM
Cc1c(N(Cc2cc3cccc(Cl)c3s2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687370 IC50 3.9 nM
Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1 CHEMBL1289953 IC50 4.0 nM
Cc1cc2ccccc2nc1N(Cc1ccc(C(F)(F)C2CC2)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687354 IC50 4.0 nM
O=C(N[C@]1(c2ccc(OC(F)(F)F)cc2)CCOc2cccnc21)c1ccc2[nH]cnc2c1 CHEMBL5286610 IC50 4.0 nM
O=C1[C@@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc(Cl)cc3)N2C(=O)N1Cc1ccc(F)cc1 CHEMBL4647674 IC50 4.1 nM
Cc1cc2cccc(Cl)c2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3682610 IC50 4.3 nM
O=C(O)c1ccc(S(=O)(=O)N(c2ncc3ccccc3c2C2CC2)C2CCc3cc(OC(F)(F)F)ccc32)cc1 CHEMBL3687358 IC50 4.3 nM
Cc1c(N(Cc2cc(F)c3c(c2)CCC3)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687347 IC50 4.4 nM
O=C(c1sc(-c2ccccc2O)nc1O)N1CCCO1 CHEMBL5286892 IC50 4.5 nM
Cc1c(N(Cc2ccc(CC3CC3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682550 IC50 4.6 nM
Cc1c(N(Cc2ccc(C(F)(F)C3CC3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687362 IC50 4.6 nM
Cc1c(N(Cc2sc3ccccc3c2Cl)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687368 IC50 4.6 nM
CCOC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1)C(F)(F)F CHEMBL3682545 IC50 4.7 nM
Cc1c(N(Cc2ccc3c(c2)CCCC3)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682566 IC50 4.7 nM
COC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1)C(F)(F)F CHEMBL3682584 IC50 4.7 nM
Cc1c(N(Cc2ccc(F)c(C(F)(F)F)c2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682553 IC50 4.9 nM
Cc1cc2ccccc2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3682546 IC50 5.0 nM
CCOC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1F)C(F)(F)F CHEMBL3687391 IC50 5.0 nM
O=C([O-])c1ccc(S(=O)(=O)N(Cc2cc3c(F)cc(F)cc3s2)c2ncc3ccccc3c2C(F)(F)F)cc1 CHEMBL3687405 IC50 5.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)c(F)c1)c1ncccc1F)c1ccc(=O)[nH]c1 CHEMBL4237618 IC50 5.0 nM
CCn1/c(=N/S(=O)(=O)c2ccccc2)n(Cc2ccc(C(F)(F)F)c(F)c2)c2cc(C(F)(F)F)ccc21 CHEMBL5272167 IC50 5.0 nM
Cc1c(N(Cc2ccc3c(c2)OCC3(C)C)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3639814 IC50 5.3 nM
Cc1c(N(Cc2cc3cc(Cl)ccc3s2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687371 IC50 5.4 nM
CC(C)c1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687398 IC50 5.6 nM
COC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)O)cc2)cc1)C(F)(F)C(F)(F)F CHEMBL3687395 IC50 5.9 nM
Cc1c(N(Cc2cc3cc(F)cc(F)c3s2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687366 IC50 6.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1C(F)(F)F)c1ccc(=O)[nH]c1 CHEMBL4251427 IC50 6.0 nM
CCn1c(N(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2ccccc2)nc2cc(F)ccc21 CHEMBL5280890 IC50 6.0 nM
Cc1c(N(Cc2ccc(C(F)(F)F)c(F)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)sc2ccccc12 CHEMBL3353610 IC50 6.2 nM
CCc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687328 IC50 6.2 nM
O=C1N[C@H](Cc2ccccc2)C(=O)N2Cc3[nH]c4ccccc4c3C[C@@H]12 CHEMBL4649088 IC50 6.57 nM
Cc1cc2ccccc2nc1N(Cc1ccc2c(c1)CCCC2)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687352 IC50 6.9 nM
CC(C)c1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(C2CC2)c2ccccc12 CHEMBL3687402 IC50 6.9 nM
Cc1c(N(Cc2ccc(CC3CC3)cc2F)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687343 IC50 7.1 nM
CCOc1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(C)c2ccccc12 CHEMBL3687399 IC50 7.2 nM
CC(C)c1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(C(F)(F)F)c2ccccc12 CHEMBL3682592 IC50 7.4 nM
Cc1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)c(C)c2ccccc12 CHEMBL3682582 IC50 7.6 nM
O=C1[C@@H]2Cc3c([nH]c4ccccc34)[C@H](c3ccc(F)cc3)N2C(=O)N1c1cccc(C(F)(F)F)c1 CHEMBL4648953 IC50 7.67 nM
Cc1cc2ccccc2nc1N(Cc1ccc(CC2CC2)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687355 IC50 7.7 nM
COc1cc(CN(CCN)C(=O)O[C@@H](C)c2ccccc2)ccc1OCc1ccccc1 CHEMBL2441930 Kb 7.8 nM
CC1(c2ccc(CN(c3ncc(C(F)(F)F)cc3Cl)S(=O)(=O)c3ccc(C(=O)O)cc3)cc2)CC1 CHEMBL3353602 IC50 8.0 nM
CCN(Cc1cccs1)C(=O)COc1ccc(C)cc1 CHEMBL4096839 EC50 8.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)C2CC2)cc1 CHEMBL4071703 EC50 8.0 nM
CCN(Cc1cccs1)C(=O)COc1ccc(C)cc1O CHEMBL4087060 EC50 8.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1C(F)(F)F)c1ccc(O)cc1 CHEMBL4247840 IC50 8.0 nM
Cc1c(N(Cc2ccc3c(c2)CCC3)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682567 IC50 8.1 nM
CCc1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(C)c2ccccc12 CHEMBL3687385 IC50 8.1 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(C2CC2)c2c(C)cccc12 CHEMBL3687386 IC50 8.2 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353597 IC50 8.3 nM
Cc1c(N(Cc2ccc3c(c2)CC(C)(C)C3)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682569 IC50 8.3 nM
COc1cc(CN(CCN)C(=O)c2cccs2)ccc1OCc1ccccc1 CHEMBL2442052 Kb 8.4 nM
NC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C2CC2)cc1 CHEMBL3687412 IC50 8.5 nM
CCC(=O)c1sc(-c2cccc(F)c2)nc1O CHEMBL5269673 IC50 8.5 nM
Cc1c(N(Cc2ccc3ccccc3c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682555 IC50 8.6 nM
Cc1c(N(Cc2ccc(COC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687363 IC50 8.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)C[C@@H](O)c1cccc(Cl)c1O2 CHEMBL2443061 IC50 8.9 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(C(F)(F)F)cc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353594 IC50 8.9 nM
O=C(N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F)c1ccc(=O)[nH]c1 CHEMBL4243837 IC50 9.0 nM
CC(C)OP(=O)(OC(C)C)[C@@H](Cc1ccc(F)c(C(F)(F)F)c1)c1sc2ccccc2c1Br CHEMBL5274341 IC50 9.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(C2CCCC2)c2ccccc12 CHEMBL3687397 IC50 9.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)C[C@@H](O)c1cccc(F)c1O2 CHEMBL2443079 IC50 9.5 nM
Cc1cc2ccccc2nc1N(Cc1ccc(F)c(C(F)(F)C2CC2)c1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687379 IC50 9.6 nM
C[C@H](NC(=O)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)c(F)c1)C(F)(F)F CHEMBL3235983 IC50 10.0 nM
Cc1c(N(Cc2ccc3c(c2)COC3(C)C)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682577 IC50 10.0 nM
Cc1c(N(Cc2ccc(-c3ccccc3F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682580 IC50 10.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2nc(C3CC3)c3ccccc3c2C2CC2)cc1 CHEMBL3687403 IC50 10.0 nM
NC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C(F)(F)F)cc1 CHEMBL3687413 IC50 10.0 nM
CON(Cc1cccs1)C(=O)COc1ccc(C)cc1 CHEMBL4095201 EC50 10.0 nM
O=C(O)c1ccc(C(=O)N[C@@H](c2ccc(C(F)(F)F)cc2)c2ncccc2C(F)(F)F)nc1 CHEMBL4251467 IC50 10.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1F)c1ccc(=O)[nH]c1 CHEMBL4248077 IC50 10.0 nM
CCn1nnc(-c2sc(-c3cccc(F)c3)nc2O)n1 CHEMBL5270507 IC50 10.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(C(F)(F)F)cc2)c2ncc(Cl)cc2Cl)cc1 CHEMBL3353609 IC50 11.0 nM
Cc1c(N(Cc2cc(F)c(C(F)(F)F)s2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682570 IC50 11.0 nM
CCCc1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(C)c2ccccc12 CHEMBL3682585 IC50 11.0 nM
Cc1cc2c(Cl)cccc2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(=O)[O-])cc1 CHEMBL3682615 IC50 11.0 nM
Cc1c(N(Cc2cc3ccc(Cl)cc3s2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687369 IC50 11.0 nM
Cc1c(N(Cc2ccc(F)c(C(F)(F)C3CC3)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687378 IC50 11.0 nM
C=CCc1cc(OC)c(OC(C)C(O[C@H]2C[C@@H](C)CC[C@@H]2C(C)C)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4067554 EC50 11.0 nM
C[C@H](NC(=O)N1CCc2cccnc2[C@H]1c1ccc(C(F)(F)F)c(F)c1)C(F)(F)F CHEMBL3235984 IC50 12.0 nM
Cc1cc2ccccc2nc1N(Cc1ccc(F)c(C(F)(F)F)c1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3682547 IC50 12.0 nM
Cc1c(N(Cc2ccc(C3CC3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682558 IC50 12.0 nM
Cc1c(N(Cc2ccccc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(C2CC2)c2ccccc12 CHEMBL3682616 IC50 12.0 nM
Cc1c(N(Cc2cc3cccc(Cl)c3n2C)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3687338 IC50 12.0 nM
Cc1c(N(Cc2ccc3c(c2)c(Cl)cn3C)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687408 IC50 12.0 nM
O=C(c1sc(-c2cccc(F)c2)nc1O)N1CCCO1 CHEMBL5285661 IC50 12.0 nM
COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccccc2)N1Cc1ccccc1 CHEMBL4647444 IC50 12.3 nM
CCN(C(=O)c1ccccc1OCc1ccccc1C)[C@@H]1CCC[C@H](N)C1 CHEMBL2442021 Kb 12.7 nM
CCN(C(=O)c1ccccc1OCc1ccccc1Cl)[C@@H]1CCC[C@H](N)C1 CHEMBL2442017 Kb 13.0 nM
CONC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C)cc1 CHEMBL3682601 IC50 13.0 nM
O=C(O)c1ccc(C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)c2ncccc2F)nc1 CHEMBL4241349 IC50 13.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)CC(O)c1cccc(Cl)c1O2 CHEMBL2443076 IC50 13.3 nM
C[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cnc2ccccc2c1 CHEMBL3577885 IC50 13.8 nM
C[C@H](NC(=O)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1)C(F)(F)F CHEMBL3235969 IC50 14.0 nM
O=C(Nc1ccc(F)cc1)N1CCc2cccnc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235976 IC50 14.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(F)c(C(F)(F)F)c2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353599 IC50 14.0 nM
CC(=O)c1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682593 IC50 14.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)NC#N)cc2)ncc2ccccc12 CHEMBL3687410 IC50 14.0 nM
CCn1nnc(-c2sc(-c3ccccc3O)nc2O)n1 CHEMBL5290716 IC50 14.0 nM
FC(F)(F)c1ccccc1-c1ccc2[nH]c(/C=C/C3CCCCC3)nc2c1 CHEMBL1955989 IC50 15.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc3occc3c2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353606 IC50 15.0 nM
Cc1c(N(Cc2ccc(-c3cccc(F)c3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682581 IC50 15.0 nM
Cc1c(N(Cc2ccc3c(Cl)c[nH]c3c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682598 IC50 15.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(Br)c2ccccc12 CHEMBL3682606 IC50 15.0 nM
Cc1c(N(Cc2ccc(C(C)(O)C(F)(F)F)c(Cl)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687344 IC50 15.0 nM
COc1ccc(C(=O)N[C@@H](c2ccc(C(F)(F)F)cc2)c2ncccc2C(F)(F)F)cn1 CHEMBL4238921 IC50 15.0 nM
COC(=O)CC[C@H]1N[C@H](C(=O)NCc2ccc(F)cc2)Cc2c1[nH]c1ccccc21 CHEMBL4647464 IC50 15.46 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(F)c(C(F)(F)F)c2)c2ncc(Cl)cc2Cl)cc1 CHEMBL3353608 IC50 16.0 nM
Cc1c(N(Cc2ccc(Oc3ccccc3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682552 IC50 16.0 nM
Cc1cc2cccc(C)c2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(=O)[O-])cc1 CHEMBL3682618 IC50 16.0 nM
CCN(C(=O)c1ccccc1OCc1ccc(Cl)cc1)[C@@H]1CCC[C@H](N)C1 CHEMBL2442013 Kb 16.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)C[C@@H](O)c1cccc(Br)c1O2 CHEMBL2443063 IC50 16.6 nM
Cc1c(N(Cc2ccc(OC3CCCC3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682563 IC50 17.0 nM
Cc1cc2ccccc2nc1N(Cc1cccc(OC(F)(F)F)c1)S(=O)(=O)c1ccc(C(=O)[O-])cc1 CHEMBL3682619 IC50 17.0 nM
CCN(C(=O)c1ccccc1OCc1ccccc1F)[C@@H]1CCC[C@H](N)C1 CHEMBL2442019 Kb 17.8 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc3ccoc3c2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353607 IC50 18.0 nM
Cc1c(N(Cc2ccc3c(c2)CC(C)(C)O3)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682575 IC50 18.0 nM
CCONC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C)cc1 CHEMBL3687411 IC50 18.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4245257 IC50 18.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CCc3cccc(Br)c3O2)CC1 CHEMBL2443085 IC50 18.9 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)c(F)c1)c1ncccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4246904 IC50 19.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)CC(O)c1cccc(Br)c1O2 CHEMBL2443077 IC50 19.5 nM
Cc1c(N(Cc2ccc(OCC3CC3)c(Cl)c2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682565 IC50 20.0 nM
C=CCN(Cc1cccs1)C(=O)COc1ccc(C)cc1 CHEMBL4092493 EC50 20.0 nM
O=C(O)c1ccc(C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)c2ncccc2F)cc1 CHEMBL4250626 IC50 20.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1C(F)(F)F)c1ccc2ncccc2c1 CHEMBL4248426 IC50 20.0 nM
CCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21 CHEMBL2387541 IC50 20.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(OC(C)C)c2ccccc12 CHEMBL3682587 IC50 21.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(C(F)(F)F)c2ccccc12 CHEMBL3682591 IC50 21.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(N)=O)cc2)ncc2ccccc12 CHEMBL3682600 IC50 21.0 nM
Cc1c(N(Cc2cc3c(Cl)cccc3n2C)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3687337 IC50 21.0 nM
Cc1c(N(Cc2ccc3c(Cl)n[nH]c3c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687348 IC50 21.0 nM
Cc1cc2ccccc2nc1N(Cc1cccc(C(F)(F)C2CC2)c1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687377 IC50 21.0 nM
COCc1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(C)c2ccccc12 CHEMBL3687389 IC50 21.0 nM
Cn1ccc2c(Cl)cnc(N(Cc3ccc(OC(F)(F)F)cc3)S(=O)(=O)c3ccc(C(=O)[O-])cc3)c21 CHEMBL3682541 IC50 22.0 nM
O=C(N[C@@H](c1ccc(OC(F)(F)F)cc1)c1ncccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4242867 IC50 22.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)CC(O)c1cccc(F)c1O2 CHEMBL2443075 IC50 22.5 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2cc3ccccc3cn2)cc1 CHEMBL3639861 IC50 23.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccccc2)cc1 CHEMBL4091813 EC50 23.0 nM
O=C(Nc1cccnc1)N1CCc2cccnc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235979 IC50 24.0 nM
CCN(Cc1cccs1)C(=O)COc1cc(C)ccc1O CHEMBL4059464 EC50 24.0 nM
C[C@H](NC(=O)N1CCc2cccnc2[C@H]1c1ccc(C(F)(F)F)cc1)C(F)(F)F CHEMBL3235981 IC50 25.0 nM
CC(O)c1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682594 IC50 25.0 nM
Cc1c(N(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682542 IC50 26.0 nM
Cc1c(N(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682551 IC50 26.0 nM
Cc1c(N(Cc2ccc(OCC3CC3)c(F)c2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682564 IC50 26.0 nM
Cc1c(N(Cc2ccc(F)c(C(F)(F)F)c2)S(=O)(=O)N2CCC(C(=O)O)CC2)sc2ccccc12 CHEMBL5282082 IC50 26.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)CCN2CCC(c3ccccc3)CC2)sc2ccccc12 CHEMBL5285119 IC50 26.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccccc2C(F)(F)F)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353592 IC50 27.0 nM
N#Cc1ccc(C(=O)N[C@@H](c2ccc(C(F)(F)F)cc2)c2ncccc2C(F)(F)F)cc1 CHEMBL4247268 IC50 27.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)c(F)c1)c1ncccc1C(F)(F)F)c1ccccc1 CHEMBL4247395 IC50 27.0 nM
O=C(Nc1cccnc1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235965 IC50 28.0 nM
C=CCc1cc(OC)c(OC(C)C(O[C@@H]2C[C@H](C)CC[C@H]2C(C)C)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4076583 EC50 28.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(N2CCCC2)c2ccccc12 CHEMBL3682586 IC50 29.0 nM
Cc1c(N(Cc2ccc(OCC3CC3)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682559 IC50 30.0 nM
Cc1c(N(Cc2ccc(C(O)(C3CC3)C(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687349 IC50 30.0 nM
Cc1cccc2c(C)c(N(Cc3ccc(OC(F)(F)F)cc3)S(=O)(=O)c3ccc(C(=O)O)cc3)ncc12 CHEMBL3682613 IC50 31.0 nM
Cc1c(N(Cc2cccc(C(F)(F)C3CC3)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687376 IC50 31.0 nM
Cc1c(N(Cc2cc3ccccc3n2C)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3687331 IC50 32.0 nM
CCOC(=O)c1sc(-c2ccccc2)nc1O CHEMBL65312 IC50 32.0 nM
O=C(c1sc(-c2cccc(F)c2)nc1O)N1CCCCCO1 CHEMBL5267628 IC50 32.0 nM
Cc1c(N(Cc2ccc(OC3CC3)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682562 IC50 35.0 nM
Cc1c(N(Cc2ccc(C(C)(O)C(F)(F)C(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687346 IC50 35.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1C(F)(F)F)c1cccnc1 CHEMBL4249999 IC50 35.0 nM
O=C(Nc1ccc(F)cc1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL2032210 IC50 36.0 nM
O=C(NCc1ccc(F)cc1)[C@@H]1Cc2c([nH]c3ccccc23)CN1 CHEMBL4644158 IC50 36.85 nM
CC(C)(C)NC(=O)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235967 IC50 37.0 nM
Cc1c(N(Cc2ccc(OCC3CCC3)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682560 IC50 37.0 nM
Cc1c(N(Cc2ccc(C(F)(F)F)cn2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682571 IC50 38.0 nM
CCn1c(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)[O-])cc2)cc2ccccc21 CHEMBL3687332 IC50 38.0 nM
CCN(Cc1cccs1)C(=O)COc1ccc(Cl)cc1 CHEMBL4103845 EC50 39.0 nM
CCOC(=O)c1sc(-c2cccc(F)c2)nc1O CHEMBL5273282 IC50 39.0 nM
COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 CHEMBL2441929 EC50 40.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(F)cc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353598 IC50 40.0 nM
Cc1c(N(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682605 IC50 40.0 nM
CCCN(Cc1cccs1)C(=O)COc1ccc(C)cc1 CHEMBL4078818 EC50 40.0 nM
Cc1ccc2oc(C(=O)N(Cc3cccs3)c3ccn[nH]3)cc2c1 CHEMBL4091183 EC50 40.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2cccc(C(F)(F)F)c2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353593 IC50 41.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCc3cccc(Cl)c3O2)CC1 CHEMBL2443086 IC50 41.1 nM
O=S(=O)(c1ccc(CO)cc1)N(Cc1ccccc1)c1ncc(C(F)(F)F)cc1Cl CHEMBL3353573 IC50 42.0 nM
Cc1c(N(Cc2ccc(F)c(C(F)(F)F)n2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682544 IC50 43.0 nM
CC(C)NC(=O)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235968 IC50 44.0 nM
Cc1c(N(Cc2cc3cc(Cl)ccc3n2C)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682574 IC50 44.0 nM
COc1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(C)c2cccc(C)c12 CHEMBL3687400 IC50 44.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2cccc(Cl)c12 CHEMBL3687401 IC50 44.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CC1)CC(O)c1cccc(Br)c1O2 CHEMBL2443074 IC50 44.5 nM
CCn1ncc2cc(CN(c3ncc(C(F)(F)F)cc3Cl)S(=O)(=O)c3ccc(C(=O)O)cc3)ccc21 CHEMBL3353605 IC50 46.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)C[C@H](O)c1cccc(Cl)c1O2 CHEMBL2443060 IC50 46.3 nM
O=C(Nc1ccccc1F)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235959 IC50 48.0 nM
CC(C)c1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(C(C)C)c2ccccc12 CHEMBL3687324 IC50 48.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CCc3cccc(Cl)c3O2)CC1 CHEMBL2443084 IC50 48.5 nM
O=C(O)c1ccc(S(=O)(=O)N(CCCc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353589 IC50 49.0 nM
C[C@H](c1cc(F)cc(F)c1)N(C(=O)c1ccccc1O)[C@@H](C(N)=O)c1ccccc1 CHEMBL4791592 IC50 50.0 nM
C[C@H](NC(=O)N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1C(F)(F)F)C(F)(F)F CHEMBL4237740 IC50 51.0 nM
C[C@@H](NC(=O)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1)C(F)(F)F CHEMBL3235970 IC50 52.0 nM
Cc1c(N(Cc2cc3ccccc3cn2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682603 IC50 52.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccncc2)cc1 CHEMBL4094300 EC50 52.0 nM
C[C@H](NC(=O)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)nc1)C(F)(F)F CHEMBL3235982 IC50 53.0 nM
Cc1c(N(Cc2ccc3cc[nH]c3c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682596 IC50 54.0 nM
CCc1cc2ccccc2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3682621 IC50 54.0 nM
C=CCc1cc(OC)c(OC(C)C(OC2CCCCC2)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4076657 EC50 54.0 nM
Cc1c(N(Cc2ccc(C(C)(O)C(F)(F)F)c(F)c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687341 IC50 55.0 nM
CCN(C(=O)c1ccccc1OCc1ccccc1)[C@@H]1CCC[C@H](N)C1 CHEMBL2442022 Kb 56.3 nM
CNC(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353575 IC50 57.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2cccc(OC(F)(F)F)c2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353596 IC50 57.0 nM
Cc1c(N(Cc2ccc3c(Cl)cn(C)c3c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682599 IC50 57.0 nM
Cc1c(N(Cc2ccc3c(c2)OC(C)(C)C3)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682576 IC50 58.0 nM
C[C@H](NC(=O)N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1Br)C(F)(F)F CHEMBL4244629 IC50 59.0 nM
O=C1NC(c2cccc([N+](=O)[O-])c2)=CCN1c1ccccc1O CHEMBL258405 EC50 60.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)C[C@H](O)c1cccc(Br)c1O2 CHEMBL2443062 IC50 60.0 nM
C[C@H](c1ccc(F)cc1F)N(Cc1cccc(C(=O)O)c1)C(=O)c1cc2ccccc2cn1 CHEMBL3577904 IC50 60.0 nM
C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O CHEMBL190461 IC50 60.0 nM
CCn1nnc(-c2sc(-c3ccccc3C)nc2O)n1 CHEMBL5271247 IC50 60.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353572 IC50 61.0 nM
CCN(Cc1cccs1)C(=O)COc1ccc2c(c1)COC2 CHEMBL4060474 EC50 61.0 nM
CCn1nnc(-c2sc(-c3cccc(N)c3)nc2O)n1 CHEMBL5282352 IC50 61.0 nM
C[C@H](c1cccc(Cl)c1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cnc2ccccc2c1 CHEMBL3577902 IC50 62.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(C)(C)O)cc2)ncc2ccccc12 CHEMBL3682602 IC50 62.0 nM
Cc1c(N(Cc2cccc3ccccc23)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682554 IC50 65.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CC1)CC(O)c1cccc(Cl)c1O2 CHEMBL2443073 IC50 65.9 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2cc3ccccc3c(C3CC3)n2)cc1 CHEMBL3687387 IC50 66.0 nM
C=CCc1cc(OC)c(OC(C)C(OCCCCCCCCCC)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4077565 EC50 66.0 nM
CON(C)C(=O)c1sc(-c2ccccc2O)nc1O CHEMBL5291176 IC50 66.0 nM
CN(C)C(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353576 IC50 67.0 nM
N#CC1(c2ccc(CN(c3ncc(C(F)(F)F)cc3Cl)S(=O)(=O)c3ccc(C(=O)O)cc3)cc2)CC1 CHEMBL3353603 IC50 67.0 nM
Cc1c(N(Cc2ccc(-c3ccccc3)cn2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682572 IC50 67.0 nM
CCc1ccc(OCC(=O)N(CC)Cc2cccs2)cc1 CHEMBL4079334 EC50 67.0 nM
NC(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353574 IC50 70.0 nM
Cc1cc2ccc(F)cc2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687320 IC50 70.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)C(C)C)cc1 CHEMBL4089135 EC50 70.0 nM
CCn1c(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)[O-])cc2)cc2ccc(Cl)cc21 CHEMBL3687334 IC50 71.0 nM
CCN(C(=O)c1ccccc1OCc1ccccc1Cl)[C@H]1CCC[C@@H](N)C1 CHEMBL2442016 Kb 72.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc(Cl)c3sccc23)cc1 CHEMBL3687383 IC50 75.0 nM
O=C(N[C@@H](c1cnc2ccccc2c1)c1ncccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4246304 IC50 75.0 nM
Cc1ccc([C@H](NC(=O)c2ccc3cccnc3c2)c2ncccc2C(F)(F)F)cc1 CHEMBL4245611 IC50 75.0 nM
Cc1c(N(Cc2ccc3c(c2)CCC3(O)C(F)(F)F)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687345 IC50 78.0 nM
N#Cc1ccc(NC(=O)N2CCc3cccnc3[C@H]2c2ccc(C(F)(F)F)cc2)cc1 CHEMBL3235980 IC50 79.0 nM
Cc1c(N(CC2CCN(c3ccccc3)CC2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682579 IC50 79.0 nM
C[C@H](c1cc(F)cc(F)c1)N(C(=O)c1ccccc1)[C@@H](C(N)=O)c1ccccc1 CHEMBL3971179 IC50 80.0 nM
CCN(Cc1cccs1)C(=O)c1cc2cc(OC)ccc2o1 CHEMBL4087469 EC50 80.0 nM
CCOC(=O)c1sc(-c2ccc(F)cc2)nc1O CHEMBL5271941 IC50 80.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)nc2ccccc2c1Cl CHEMBL3682617 IC50 81.0 nM
O=C(c1sc(-c2ccccc2O)nc1O)N1CCCCO1 CHEMBL5279560 IC50 81.0 nM
C=CCc1cc(OC)c(OC(C)C(OC(C)C)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4065256 EC50 82.0 nM
N#Cc1cccc(NC(=O)N2CCc3ccccc3[C@H]2c2ccc(C(F)(F)F)cc2)c1 CHEMBL3235962 IC50 83.0 nM
Cc1c(N(Cc2cc3ccccc3n2C2CC2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3687339 IC50 83.0 nM
C=CCc1cc(OC)c(OC(C)C(OCCCCCCCC)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4076994 EC50 86.0 nM
C=CCc1cc(OC)c(O[C@@H](C)[C@@H](OCC)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4074380 EC50 87.0 nM
CCN(Cc1ccsc1)C(=O)COc1ccc(C)cc1 CHEMBL4105242 EC50 88.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cc2ccccc2cn1 CHEMBL3577889 IC50 90.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1ccccc1)[C@@H]1CCc2ccc(F)cc21 CHEMBL4759917 IC50 90.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CC1)CC(O)c1cccc(F)c1O2 CHEMBL2443072 IC50 90.1 nM
Cc1c(N(Cc2ccc(OCC3CCCC3)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682561 IC50 91.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)nc(-c2ccccc2)c2ccccc12 CHEMBL3682583 IC50 91.0 nM
Cc1cc2cc(F)ccc2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3687319 IC50 91.0 nM
Cc1c(N(Cc2ccc3ccn(C)c3c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682597 IC50 92.0 nM
Cc1cccc([C@H](NC(=O)c2ccc3cccnc3c2)c2ncccc2C(F)(F)F)c1 CHEMBL4239691 IC50 92.0 nM
Cc1c(N(Cc2ccccc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3682548 IC50 93.0 nM
CCN(Cc1cccs1)C(=O)CCc1ccc(C)cc1 CHEMBL4091126 EC50 93.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)C[C@H](O)c1cccc(F)c1O2 CHEMBL2443078 IC50 94.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cc2ccccn2n1 CHEMBL3577881 IC50 94.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc(Cl)c3ccccc23)cc1 CHEMBL3682607 IC50 94.0 nM
Cc1c(N(Cc2ccc(-c3ccccc3)nc2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682573 IC50 95.0 nM
CC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C)cc1 CHEMBL3687326 IC50 95.0 nM
COc1ccc([C@H](NC(=O)c2ccc3cccnc3c2)c2ncccc2C(F)(F)F)cc1 CHEMBL4238688 IC50 95.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccccc2OC(F)(F)F)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353595 IC50 96.0 nM
CON(C)C(=O)c1sc(-c2cccc(F)c2)nc1O CHEMBL5281532 IC50 96.0 nM
CCN(C(=O)c1ccccc1OCc1cccc(Cl)c1)C1CCCC(N)C1 CHEMBL2442015 Kb 96.6 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(C(C)O)c2ccccc12 CHEMBL3682595 IC50 97.0 nM
CCN(Cc1cccs1)C(=O)COc1cccc(C)c1 CHEMBL4077232 EC50 97.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CCc3cccc(F)c3O2)CC1 CHEMBL2443083 IC50 97.3 nM
C[C@H](c1cccc(Cl)c1)N(C(=O)c1ccccc1O)[C@@H](C(N)=O)c1ccccc1 CHEMBL3944840 IC50 100.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1ccccc1)[C@@H]1CCc2c(F)cc(F)cc21 CHEMBL4763262 IC50 100.0 nM
COc1ccc(/C=C/C(=O)N(C2CCCCC2)C2CCCCC2)cc1 CHEMBL5284149 EC50 100.0 nM
COc1cnc(-c2ccccn2)nc1CC(C)C CHEMBL5272743 EC50 100.0 nM
Cc1cc(NC(C)C)no1 CHEMBL2436830 EC50 100.0 nM
CNC(=O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C)cc1 CHEMBL3687409 IC50 103.0 nM
O=C(O)c1ccc(S(=O)(=O)N(CC2CCCCC2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353590 IC50 104.0 nM
CCn1c(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(C(=O)[O-])cc2)cc2cc(Cl)ccc21 CHEMBL3687333 IC50 105.0 nM
O=C1CC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)Oc2c(Br)cccc21 CHEMBL2443071 IC50 107.3 nM
Cc1ccc2c(C)c(N(Cc3ccc(OC(F)(F)F)cc3)S(=O)(=O)c3ccc(C(=O)O)cc3)ncc2c1 CHEMBL3682608 IC50 109.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)c(F)c1)c1ccccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4237383 IC50 109.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1cccnc1)[C@@H]1CCc2c(F)cc(Cl)cc21 CHEMBL4762495 IC50 110.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1cccnc1)[C@@H]1CCc2c(F)cc(F)cc21 CHEMBL4752955 IC50 110.0 nM
C[C@H](c1cc(F)cc(F)c1)N(C(=O)c1ccccc1N)[C@@H](C(N)=O)c1ccccc1 CHEMBL4780270 IC50 110.0 nM
O=C1CC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)Oc2c(Cl)cccc21 CHEMBL2443070 IC50 111.0 nM
O=C(Nc1nc2ccc(F)cc2s1)N1CCC2(CCc3cccc(Cl)c3O2)CC1 CHEMBL2443066 IC50 113.1 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2cc3c(Cl)cccc3cn2)cc1 CHEMBL3682588 IC50 115.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)O)cc2)nc(-c2cccnc2)c2ccccc12 CHEMBL3687384 IC50 116.0 nM
C[C@H](NC(=O)N[C@@H](c1ccc(C(F)(F)F)cc1)c1ncccc1F)C(F)(F)F CHEMBL4247847 IC50 119.0 nM
CCN(Cc1cccs1)C(=O)COc1ccc(OC)cc1 CHEMBL4102922 EC50 120.0 nM
CCN(Cc1cccs1)C(=O)c1cc2cc(C)ccc2o1 CHEMBL4093598 EC50 120.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1ccccc1)[C@@H]1CCc2c(F)cccc21 CHEMBL4749804 IC50 120.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1ccccc1)[C@@H]1CCc2ccc(Cl)cc21 CHEMBL4785984 IC50 120.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(-c3ccccc3)cc2Cl)cc1 CHEMBL3353582 IC50 122.0 nM
CC[C@H](c1ccc(F)cc1F)N(Cc1cccc(C(=O)O)c1)C(=O)c1cc2ccccn2n1 CHEMBL3577905 IC50 123.0 nM
O=C(N[C@@H](c1ccc(F)cc1)c1ncccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4247089 IC50 129.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2cc3ccccc3c(Br)n2)cc1 CHEMBL3682620 IC50 131.0 nM
COC(=O)c1sc(-c2ccccc2)nc1O CHEMBL5285498 IC50 131.0 nM
Cc1c(N(Cc2cc3cc(Cl)ccc3n2C2CC2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3687340 IC50 133.0 nM
Cc1ccc2cnc(N(Cc3ccc(OC(F)(F)F)cc3)S(=O)(=O)c3ccc(C(=O)O)cc3)c(C)c2c1 CHEMBL3682612 IC50 136.0 nM
CCN(Cc1ccoc1)C(=O)COc1ccc(C)cc1 CHEMBL4101022 EC50 136.0 nM
C=CCc1cc(OC)c(OC(C)C(OCC(C)C)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4073357 EC50 138.0 nM
CCCC(=O)c1sc(-c2cccc(F)c2)nc1O CHEMBL5266190 IC50 142.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cc2ccccc2s1 CHEMBL3577883 IC50 145.0 nM
Cc1nc2ccc(CN(c3ncc4ccccc4c3C)S(=O)(=O)c3ccc(C(=O)O)cc3)cc2s1 CHEMBL3687361 IC50 148.0 nM
CCCCC/C=C/C/C=C\C/C=C/C/C=C/CCCC(=O)NCCO CHEMBL375696 IC50 150.0 nM
CCCCCc1cc2c(c(O)c1C(=O)O)[C@@H]1C=C(C)CC[C@H]1C(C)(C)O2 CHEMBL465718 IC50 150.0 nM
C=C(C)[C@]12C[C@@H](C)[C@@]34OC(Cc5ccccc5)(O[C@@H]1C3C=C(COC(=O)Cc1ccc(O)c(OC)c1)C[C@]1(O)C(=O)C(C)=C[C@@H]41)O2 CHEMBL5269402 IC50 150.0 nM
C=CCc1cc(OC)c(OC(C)C(OCCOCCCC)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4072058 EC50 153.0 nM
O=C(NC(c1ccccc1)C(F)(F)F)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235971 IC50 154.0 nM
N#Cc1ccc(NC(=O)N2CCc3ccccc3[C@H]2c2ccc(C(F)(F)F)cc2)cc1 CHEMBL3235963 IC50 155.0 nM
Cc1nc2cc(CN(c3ncc4ccccc4c3C)S(=O)(=O)c3ccc(C(=O)O)cc3)ccc2s1 CHEMBL3687359 IC50 155.0 nM
O=C(N[C@@H](c1cccc(C(F)(F)F)c1)c1ncccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4242403 IC50 157.0 nM
CCCCCc1cc(O)c(C/C=C(\C)CCC=C(C)C)c(O)c1 CHEMBL497318 IC50 160.0 nM
CCCCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21 CHEMBL465 IC50 160.0 nM
CCOC(=O)c1sc(-c2ccc(C)cc2)nc1O CHEMBL5268431 IC50 160.0 nM
Cc1c(N(Cc2cnc3ccccc3c2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3687335 IC50 166.0 nM
O=C(c1sc(-c2cccc(F)c2)nc1O)N1CCCCO1 CHEMBL5271998 IC50 167.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1cccnc1N)[C@@H]1CCc2c(F)cc(Cl)cc21 CHEMBL4795385 IC50 170.0 nM
O=C(Nc1ccccn1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235964 IC50 171.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1Cl)N1CCC2(CCc3cccc(Cl)c3O2)CC1 CHEMBL2443089 IC50 177.8 nM
CCN(Cc1ccc(C)s1)C(=O)COc1ccc(C)cc1 CHEMBL4076572 EC50 178.0 nM
C[C@H](c1cc(F)cc(Cl)c1)N(C(=O)c1ccccc1)[C@@H](C(N)=O)c1ccccc1 CHEMBL3926952 IC50 180.0 nM
O=C1CC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)Oc2c(F)cccc21 CHEMBL2440148 IC50 182.1 nM
O=S(=O)(c1ccccc1)N(Cc1ccccc1)c1ncc(C(F)(F)F)cc1Cl CHEMBL3353569 IC50 183.0 nM
C[C@H](c1ccc(F)cc1F)N(Cc1cccc(C(=O)O)n1)C(=O)c1cc2ccccc2cn1 CHEMBL3577907 IC50 190.0 nM
CCN(Cc1cccs1)C(=O)COc1ccccc1C CHEMBL4091671 EC50 192.0 nM
Cc1c(N(Cc2nc3ccccc3o2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3682604 IC50 195.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2cccnc2)cc1 CHEMBL4077389 EC50 198.0 nM
O=C(Nc1ccc(F)cc1)N1CCc2nccnc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235978 IC50 200.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccccn2)cc1 CHEMBL4067773 EC50 200.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(Cl)cc2Cl)cc1 CHEMBL3353579 IC50 201.0 nM
CC[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cnc2ccccc2c1 CHEMBL3577900 IC50 202.0 nM
COC(=O)[C@@H](c1ccccc1)N(Cc1cccc(OC)c1)C(=O)c1ccccc1 CHEMBL3980601 IC50 210.0 nM
Cc1ncccc1C(=O)N([C@@H]1CCc2c(F)cc(Cl)cc21)[C@@H](C(N)=O)c1ccccc1 CHEMBL4750971 IC50 210.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2F)cc1 CHEMBL3353583 IC50 213.0 nM
CCN(C(=O)c1ccccc1OCc1ccc(Cl)cc1)[C@H]1CCC[C@@H](N)C1 CHEMBL2442014 Kb 214.0 nM
Cn1nnc(-c2sc(-c3cccc(F)c3)nc2O)n1 CHEMBL5278729 IC50 214.0 nM
O=C(NCCO)c1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353577 IC50 216.0 nM
O=C1CC2(CCN(C(=O)Nc3ccc(C(F)(F)F)cc3)CC2)Oc2c(Cl)cccc21 CHEMBL2443068 IC50 230.4 nM
C[C@H](c1ccc(F)cc1F)N(Cc1cccc(C(=O)O)c1)C(=O)c1cc2ccccn2n1 CHEMBL3577906 IC50 234.0 nM
CCN(Cc1cccs1)C(=O)COc1ccc(C(F)(F)F)cc1 CHEMBL4084970 EC50 236.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2cc3c(C4CC4)cccc3cn2)cc1 CHEMBL3687388 IC50 239.0 nM
CCn1nnc(-c2sc(-c3cccc(O)c3)nc2O)n1 CHEMBL5268891 IC50 239.0 nM
COc1cccc([C@@H](C)N(C(=O)c2ccccc2)[C@@H](C(N)=O)c2ccccc2)c1 CHEMBL3917717 IC50 240.0 nM
CCn1nnc(-c2sc(-c3cccc(OC)c3)nc2O)n1 CHEMBL5290167 IC50 245.0 nM
CCN(C(=O)c1ccccc1OCc1ccccc1C)[C@H]1CCC[C@@H](N)C1 CHEMBL2442020 Kb 246.0 nM
O=C(Nc1nc(C(F)(F)F)cs1)N1CCC2(CCc3cccc(Cl)c3O2)CC1 CHEMBL2443065 IC50 265.8 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1ccccc1)[C@@H]1CCc2ccccc21 CHEMBL4748099 IC50 270.0 nM
CCN(C(=O)c1ccccc1COc1ccccc1)[C@@H]1CCC[C@H](N)C1 CHEMBL2442026 Kb 280.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CCc3ccccc3O2)CC1 CHEMBL2443081 IC50 280.7 nM
CCn1nnc(-c2sc(-c3ccc(F)cc3)nc2O)n1 CHEMBL5279823 IC50 286.0 nM
O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2cc3c(Cl)cccc3c(Br)n2)cc1 CHEMBL3687322 IC50 287.0 nM
C[C@H](c1ccc(F)cc1F)N(Cc1cccc(C(=O)O)c1)C(=O)c1cnc2ccccc2c1 CHEMBL3577898 IC50 288.0 nM
CC(C)CC(=O)c1sc(-c2cccc(F)c2)nc1O CHEMBL5269450 IC50 289.0 nM
Cc1ccc(NC(=O)N2CCC3(CCc4cccc(Cl)c4O3)CC2)cc1 CHEMBL2443088 IC50 289.6 nM
O=C1CC2(CCN(C(=O)Nc3ccc(C(F)(F)F)cc3)CC2)Oc2c(F)cccc21 CHEMBL2443067 IC50 295.2 nM
CC(C)C(=O)c1sc(-c2cccc(F)c2)nc1O CHEMBL5280897 IC50 299.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1ccccc1)[C@@H]1CCc2c(F)cc(Cl)cc21 CHEMBL4749601 IC50 300.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccncc12 CHEMBL3687330 IC50 301.0 nM
O=C(N[C@H](c1ncccc1C(F)(F)F)C1CCCCC1)c1ccc2cccnc2c1 CHEMBL4245270 IC50 301.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cn2ccccc2n1 CHEMBL3576881 IC50 307.0 nM
COc1cccc(NS(=O)(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)c1 CHEMBL5281922 IC50 309.0 nM
O=C(N[C@@H](c1ccc(C(F)(F)F)cc1)c1cnccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4245344 IC50 311.0 nM
O=C(Nc1ccc(F)cc1)N1CC(F)(F)c2ccccc2C1c1ccc(C(F)(F)F)cc1 CHEMBL3235972 IC50 324.0 nM
CC[C@H](c1ccc(C)o1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cnc2ccccc2c1 CHEMBL3577903 IC50 328.0 nM
C=CCc1cc(OC)c(OC(C)C(OCCCCCC)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4084074 EC50 329.0 nM
C=CCc1cc(OC)c(OC(C)C(OCC)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4069984 EC50 332.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ncccc12 CHEMBL3687329 IC50 339.0 nM
NCCc1c[nH]c2ccc(OCc3ccccc3)cc12 CHEMBL1288652 IC50 340.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cc2ccccc2nn1 CHEMBL3577886 IC50 340.0 nM
NCCc1c[nH]c2ccc(Oc3ccccc3)cc12 CHEMBL5275778 IC50 340.0 nM
CCN(C(=O)c1ccccc1OCc1ccccc1F)[C@H]1CCC[C@@H](N)C1 CHEMBL2442018 Kb 367.0 nM
CCn1nnc(-c2sc(-c3cccc(C)c3)nc2O)n1 CHEMBL5269570 IC50 369.0 nM
COc1ncccc1C(=O)N([C@@H]1CCc2c(F)cc(Cl)cc21)[C@@H](C(N)=O)c1ccccc1 CHEMBL4785621 IC50 380.0 nM
O=C(N[C@@H](c1ccccc1)c1ncccc1C(F)(F)F)c1ccc2cccnc2c1 CHEMBL4246078 IC50 389.0 nM
Cc1ccccc1C(=O)N([C@H](C)c1cccc(Cl)c1)[C@@H](C(N)=O)c1ccccc1 CHEMBL3907933 IC50 390.0 nM
O=C(c1ccc2ncccc2c1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL4240425 IC50 390.0 nM
O=C(Nc1ccc(F)cc1)N1CCc2ncccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235973 IC50 391.0 nM
CCN(Cc1cccs1)C(=O)COc1ccc(C(C)C)cc1 CHEMBL4065047 EC50 397.0 nM
O=C(Nc1ccncc1)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235966 IC50 398.0 nM
C[C@H](c1cccc(Cl)c1)N(C(=O)c1ccccc1)[C@@H](C(N)=O)c1ccccc1 CHEMBL3898642 IC50 400.0 nM
Cc1ccc(OCC(=O)N(C)Cc2cccs2)cc1 CHEMBL4100340 EC50 400.0 nM
COCCN(Cc1cccs1)C(=O)COc1ccc(C)cc1 CHEMBL4086513 EC50 400.0 nM
CC1OC(=O)C2=C1N1CCc3ccccc3C1CC21SCCS1 CHEMBL5283551 EC50 400.0 nM
O=C(O)c1cccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)c1 CHEMBL3353571 IC50 406.0 nM
Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1 CHEMBL3900018 IC50 414.0 nM
C[C@H](c1cccc(Cl)c1)N(C(=O)c1ccccc1N)[C@@H](C(N)=O)c1ccccc1 CHEMBL3889978 IC50 420.0 nM
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 CHEMBL808 IC50 420.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccnn2C)cc1 CHEMBL4089781 EC50 422.0 nM
CCN(Cc1cccs1)C(=O)COc1ccc(F)cc1 CHEMBL4087468 EC50 422.0 nM
N#Cc1ccccc1NC(=O)N1CCc2ccccc2[C@H]1c1ccc(C(F)(F)F)cc1 CHEMBL3235961 IC50 424.0 nM
NCCN(Cc1cccs1)C(=O)c1ccccc1OCc1ccccc1 CHEMBL2442051 Kb 443.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1cc(C(=O)O)ccc1F)C(=O)c1cnc2ccccc2c1 CHEMBL3577893 IC50 446.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CCc3cc(F)cc(Cl)c3O2)CC1 CHEMBL2443064 IC50 457.2 nM
O=C(Nc1ccc(F)cc1)N1CCc2ccncc2C1c1ccc(C(F)(F)F)cc1 CHEMBL3235975 IC50 463.0 nM
CC(C)(C)c1ccc(NC(=O)N2CCN(c3ncccc3Cl)CC2)cc1 CHEMBL441472 IC50 475.0 nM
CCN(Cc1ccco1)C(=O)COc1ccc(C)cc1 CHEMBL4086590 EC50 489.0 nM
CCN(C(=O)c1ccccc1OCc1cccc(C#N)c1)C1CCCC(N)C1 CHEMBL2442011 Kb 491.0 nM
Cc1c(N(Cc2ccc3[nH]cc(Cl)c3c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687407 IC50 522.0 nM
N#Cc1ccc(NC(=O)N2CCC3(CCc4cccc(Cl)c4O3)CC2)cc1 CHEMBL2443087 IC50 543.7 nM
CCOC(=O)c1sc(-c2ccc(Cl)cc2)nc1O CHEMBL1377190 IC50 550.0 nM
Cc1c(N(Cc2ncc(CC3CC3)cn2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccccc12 CHEMBL3687336 IC50 563.0 nM
CCN(C(=O)/C=C/c1cccc([N+](=O)[O-])c1)c1ccccc1 CHEMBL5287298 IC50 575.0 nM
C=CCc1cc(OC)c(O[C@H](C)[C@H](OCC)c2ccc(O)c(OC)c2)c(OC)c1 CHEMBL4092140 EC50 583.0 nM
N[C@H]1CCC[C@@H](N(CC2CC2)C(=O)c2ccccc2OCc2ccccc2)C1 CHEMBL2442030 IC50 593.0 nM
Cc1c(N(Cc2ccc3cn[nH]c3c2)S(=O)(=O)c2ccc(C(=O)O)cc2)ncc2ccccc12 CHEMBL3687350 IC50 601.0 nM
O=C1CC2(CCN(C(=O)Nc3ccc(C(F)(F)F)cc3)CC2)Oc2c(Br)cccc21 CHEMBL2443069 IC50 656.9 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CCc3cc(F)ccc3O2)CC1 CHEMBL2443082 IC50 666.9 nM
CCN(Cc1cccs1)C(=O)COc1ccc2c(c1)CCCC2 CHEMBL4082377 EC50 689.0 nM
Cc1cc2ccc(Cl)cc2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3682611 IC50 695.0 nM
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL1094770 IC50 700.0 nM
CCCCCCCP(=O)(C(C)C)C(C)C CHEMBL5282883 EC50 700.0 nM
CCCCC/C=C/C/C=C\C/C=C/C/C=C/CCCC(=O)NCCc1ccc(O)c(O)c1 CHEMBL5284265 IC50 700.0 nM
Cc1cnc(N(Cc2ccccc2)S(=O)(=O)c2ccc(C(=O)O)cc2)c(Cl)c1 CHEMBL3353581 IC50 707.0 nM
NC(=O)[C@@H](c1ccccc1)N(C(=O)c1ccccc1)[C@@H]1CCc2c(Cl)cccc21 CHEMBL4758145 IC50 720.0 nM
Cc1cc(C(F)(F)F)cnc1N(Cc1ccccc1)S(=O)(=O)c1ccc(C(=O)O)cc1 CHEMBL3353584 IC50 736.0 nM
O=C(O)c1ccc(S(=O)(=O)N(CCc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cc1 CHEMBL3353588 IC50 762.0 nM
O=C(Nc1ccc(F)cc1)N1CCc2cncnc2C1c1ccc(C(F)(F)F)cc1 CHEMBL3235977 IC50 786.0 nM
N[C@H]1CCC[C@@H](N(C(=O)c2ccccc2OCc2ccccc2)C2CCC2)C1 CHEMBL2442033 Kb 794.0 nM
COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1 CHEMBL258502 IC50 800.0 nM
c1ccc(CN(CCc2c[nH]c3ccccc23)Cc2ccccc2)cc1 CHEMBL1779158 IC50 800.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cccc(-c2ccccc2)c1 CHEMBL3577880 IC50 837.0 nM
Cc1ccc(C(=O)N([C@H](C)c2cccc(Cl)c2)[C@@H](C(N)=O)c2ccccc2)cc1 CHEMBL3916922 IC50 850.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccn(C)n2)cc1 CHEMBL4099411 EC50 855.0 nM
Cc1cccc(CN(C(=O)c2ccccc2)[C@@H](C(N)=O)c2ccccc2)c1 CHEMBL3959823 IC50 870.0 nM
Cc1c(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(C(=O)[O-])cc2)ncc2ccn(C)c12 CHEMBL3687321 IC50 870.0 nM
CCN(Cc1cccs1)C(=O)C(C)Oc1ccc(C)cc1 CHEMBL4090221 EC50 889.0 nM
COc1cccc(CN(C(=O)c2ccccc2)[C@@H](C(N)=O)c2ccccc2)c1 CHEMBL3934736 IC50 900.0 nM
Cc1ccc(OCC(=O)N(CCO)Cc2cccs2)cc1 CHEMBL4064027 EC50 900.0 nM
Cc1ccc(OCC(=O)N(Cc2cccs2)CC(C)C)cc1 CHEMBL4073663 EC50 900.0 nM
C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCC)cc1O CHEMBL2387742 IC50 900.0 nM
CCOC(=O)Cc1sc(-c2ccccc2)nc1O CHEMBL5279232 IC50 950.0 nM
C[C@H](c1ccc(F)cc1)N(Cc1cccc(C(=O)O)c1)C(=O)c1cc2cc[nH]c2cn1 CHEMBL3577882 IC50 951.0 nM
CC(=O)c1sc(-c2cccc(F)c2)nc1O CHEMBL5284655 IC50 958.0 nM
CSc1cc(-c2ccc(Cl)cc2)[nH]n1 CHEMBL5282295 IC50 977.0 nM
Cn1ccc2c(N(Cc3ccc(OC(F)(F)F)cc3)S(=O)(=O)c3ccc(C(=O)O)cc3)ncc(Cl)c21 CHEMBL3687382 IC50 987.0 nM
COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O CHEMBL294199 IC50 1000.0 nM