COc1ccc(CN2C[C@@]3(CCC[C@](CC#N)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cc1 CHEMBL2323962 IC50 0.001 nM
C[C@]1(Cn2cnc3ccc(C#N)cc32)CCC[C@@]2(CN(Cc3ccccc3F)C(=O)O2)C1 CHEMBL2323961 IC50 0.001 nM
N#Cc1ccc2ncn(C[C@H]3CCC[C@]4(C3)CN(Cc3cccc(Br)c3)C(=O)O4)c2c1 CHEMBL2323960 IC50 0.001 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(C#N)cn4)C5)cn3)n2)s1 CHEMBL4096902 IC50 0.18 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5COCC4CN(c4ncc(C(F)(F)F)cn4)C5)cn3)n2)s1 CHEMBL4101768 IC50 0.19 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(Br)cn4)C5)cn3)n2)s1 CHEMBL4066531 IC50 0.21 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(C(F)(F)F)cn4)C5)cn3)n2)s1 CHEMBL3941914 IC50 0.22 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)CC4C(F)(F)F)cn3)n2)s1 CHEMBL4099293 IC50 0.29 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(Cl)cn4)C5)cn3)n2)s1 CHEMBL3971502 IC50 0.3 nM
N#Cc1ccc(S(=O)(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cc3)[C@](O)(CN)C2)c(Cl)c1 CHEMBL4456312 IC50 0.3 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(F)cn4)C5)cn3)n2)s1 CHEMBL4077638 IC50 0.31 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C/C(=N/OCC(F)(F)F)C5)cn3)n2)s1 CHEMBL3984947 IC50 0.36 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(S(C)(=O)=O)cn4)C5)cn3)n2)s1 CHEMBL4078117 IC50 0.39 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncccn4)C5)cn3)n2)s1 CHEMBL4095552 IC50 0.5 nM
CC(C)(C)CN1C[C@@]2(CCC[C@](C)(Cn3cnc4ccc(C#N)cc43)C2)OC1=O CHEMBL4469630 IC50 0.5 nM
N#Cc1ccc(S(=O)(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cn3)[C@](O)(CN)C2)c(Cl)c1 CHEMBL4547537 IC50 0.5 nM
N#Cc1ccc(S(=O)(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cn3)[C@@](O)(CN)C2)c(Cl)c1 CHEMBL4461475 IC50 0.5 nM
COC(=O)N1CCN(C(=O)c2ccc(Nc3nc(-c4sc(C)nc4C)cs3)nc2)C(C(F)(F)F)C1 CHEMBL3933401 IC50 0.57 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)C[C@@H]4C)cn3)n2)s1 CHEMBL4060956 IC50 0.62 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(CO)cn4)C5)cn3)n2)s1 CHEMBL4062935 IC50 0.65 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4cnc(C(F)(F)F)cn4)C5)cn3)n2)s1 CHEMBL4090714 IC50 0.71 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(CCN3CCCCC3)s2)cnn1-c1ccc(F)cc1 CHEMBL4459940 IC50 0.85 nM
Cc1nn(C)cc1-c1csc(Nc2ccc(C(=O)N3C4CCC3CN(c3ncc(C(F)(F)F)cn3)C4)cn2)n1 CHEMBL4084992 IC50 0.87 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ccc(Cl)cn4)C5)cn3)n2)s1 CHEMBL3950646 IC50 0.9 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CC5CCC(C4)N5c4ncc(C(F)(F)F)cn4)cn3)n2)s1 CHEMBL4083772 IC50 0.97 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)[C@H](C)C4)cn3)n2)s1 CHEMBL4091558 IC50 0.99 nM
CO/N=C1\C[C@H]2CC[C@@H](C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3915150 IC50 1.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(C(F)(F)F)cc3C#N)C[C@@]2(O)CO)cc1F CHEMBL4168219 IC50 1.0 nM
CC(C)(C)c1ccc2c(c1)CC[C@H]2NC(=O)Nc1cccc2[nH]ncc12 CHEMBL398338 IC50 1.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C/C(=N/OC[C@@H](O)C(F)(F)F)C5)cn3)n2)s1 CHEMBL3957347 IC50 1.1 nM
COc1ccccc1N1C[C@@]2(CCC[C@](C)(Cn3cnc4ccc(C#N)cc43)C2)OC1=O CHEMBL4521512 IC50 1.2 nM
CC(C)(C)c1cnc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cn1 CHEMBL4588831 IC50 1.2 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(CCN3CCCCC3)s2)cnn1-c1ccc(F)cn1 CHEMBL4578182 IC50 1.2 nM
N#Cc1ccc(S(=O)(=O)NCC[C@H](N)COc2ccc(C#N)c(F)c2)c(C(F)(F)F)c1 CHEMBL4749555 pIC50 1.259 nM
Cc1cc(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(C(F)(F)F)cn4)C5)cn3)n2)n(C)n1 CHEMBL4080527 IC50 1.3 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ccc(C(F)(F)F)nn4)C5)cn3)n2)s1 CHEMBL4069724 IC50 1.3 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ccc(C(F)(F)F)cn4)C5)cn3)n2)s1 CHEMBL4083195 IC50 1.4 nM
C[C@]1(Cn2cnc3ccc(C#N)cc32)CCC[C@@]2(CN(c3cnc(C4CC4)cn3)C(=O)O2)C1 CHEMBL4536058 IC50 1.5 nM
CCOc1cccc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)c1 CHEMBL4532369 IC50 1.6 nM
COC(=O)N1CC2CCC(C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3924485 IC50 1.7 nM
Cc1ccccc1N1C[C@@]2(CCC[C@](C)(Cn3cnc4ccc(C#N)cc43)C2)OC1=O CHEMBL4541827 IC50 1.7 nM
COC(=O)N1CC2CCCC(C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3985107 IC50 1.8 nM
Cc1nc(C(C)O)sc1-c1csc(Nc2ccc(C(=O)N3C4CCC3CN(c3ncc(C(F)(F)F)cn3)C4)cn2)n1 CHEMBL4077429 IC50 1.8 nM
CC(C)(O)c1cnc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cn1 CHEMBL4470585 IC50 1.8 nM
CCNC(=O)O[C@H]1C[C@H]2CC[C@@H](C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3985405 IC50 1.9 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1-c1ccc(F)cc1 CHEMBL4460657 IC50 1.9 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)[C@@H](C)C4)cn3)n2)s1 CHEMBL4063752 IC50 2.0 nM
N#Cc1ccc(S(=O)(=O)[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@]2(O)CO)cc1F CHEMBL4439448 IC50 2.0 nM
N#Cc1ccc(S(=O)(=O)[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3C#N)C[C@@]2(O)CO)cc1 CHEMBL4586959 IC50 2.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(CC(F)(F)F)C5)cn3)n2)s1 CHEMBL3979114 IC50 2.1 nM
CO[C@H]1C[C@H]2CC[C@@H](C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3906685 IC50 2.4 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)C[C@H]4C)cn3)n2)s1 CHEMBL4082835 IC50 2.4 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@]2(O)CO)cc1F CHEMBL4164465 IC50 2.5 nM
C[C@]1(Cn2cnc3ccc(C#N)cc32)CCC[C@@]2(CN(c3ccccc3Cl)C(=O)O2)C1 CHEMBL4514491 IC50 2.5 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(C4CCCCC4)C5)cn3)n2)s1 CHEMBL3908777 IC50 2.8 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C/C(=N/OCCCO)C5)cn3)n2)s1 CHEMBL3897222 IC50 2.9 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5COCC4CC(=O)C5)cn3)n2)s1 CHEMBL3906074 IC50 3.1 nM
CCOc1ccc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cn1 CHEMBL4588158 IC50 3.1 nM
CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(c2ccc(C3(C#N)CCOCC3)cc2)CC1 CHEMBL2323936 IC50 3.2 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CNCC4COC5)cn3)n2)s1 CHEMBL3942384 IC50 3.2 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ccc(Cl)cc4)C5)cn3)n2)s1 CHEMBL3979627 IC50 3.2 nM
N#Cc1ccc(S(=O)(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cc3)[C@](O)(CO)C2)c(Cl)c1 CHEMBL4439190 IC50 3.2 nM
N#Cc1ccc(S(=O)(=O)[C@H]2CN(S(=O)(=O)c3ccc(C#N)cc3Cl)C[C@@]2(O)CO)cc1 CHEMBL4547101 IC50 3.2 nM
Cc1nn(-c2ccc(F)cn2)cc1C(=O)Nc1nc(C2CCC2)c(CCN2CCCCC2)s1 CHEMBL4465116 IC50 3.3 nM
N#Cc1ccc(OCC2(O)CN(S(=O)(=O)c3ccc(Cl)cc3C#N)C2)cc1F CHEMBL3218116 IC50 3.4 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@]2(O)CN)cc1F CHEMBL4517101 IC50 3.5 nM
N#Cc1ccc(OCC2(O)CN(S(=O)(=O)c3ccc(Cl)cc3C#N)C2)cc1Cl CHEMBL3218117 IC50 3.6 nM
Cc1nc(C)c(-c2nsc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(C(F)(F)F)cn4)C5)cn3)n2)s1 CHEMBL4075898 IC50 3.7 nM
N#Cc1ccc(OCC2(O)CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C2)cc1F CHEMBL3218118 IC50 3.8 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccccc3C#N)C[C@@]2(O)CO)cc1F CHEMBL4454801 IC50 3.8 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ccc(C(F)(F)F)cc4)C5)cn3)n2)s1 CHEMBL4077357 IC50 3.9 nM
N#Cc1ccc(S(=O)(=O)N2CC(O)(COc3ccc(C#N)c(Cl)c3)C2)c(Cl)c1 CHEMBL3218119 IC50 4.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(C(N)=O)cn4)C5)cn3)n2)s1 CHEMBL4069627 IC50 4.2 nM
CCOc1cnc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cn1 CHEMBL4469982 IC50 4.2 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4CC(=NOCC(C)(C)O)C5)cn3)n2)s1 CHEMBL3968344 IC50 4.4 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C/C(=N/OC4CCN(C)CC4)C5)cn3)n2)s1 CHEMBL3914089 IC50 4.5 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C[C@@H](Oc4ncc(C(F)(F)F)cn4)C5)cn3)n2)s1 CHEMBL3924665 IC50 4.8 nM
N#Cc1ccc(S(=O)(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cn3)[C@](O)(CO)C2)c(Cl)c1 CHEMBL4437115 IC50 5.0 nM
CCOc1ccc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cc1 CHEMBL4579838 IC50 5.2 nM
C[C@]1(Cn2cnc3ccc(C#N)cc32)CCC[C@@]2(CN(c3ccccc3F)C(=O)O2)C1 CHEMBL4560266 IC50 5.2 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C/C(=N/OCCO)C5)cn3)n2)s1 CHEMBL3986034 IC50 6.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C[C@@H](OCCO)C5)cn3)n2)s1 CHEMBL3896628 IC50 6.2 nM
Cc1nn(C)cc1-c1nsc(Nc2ccc(C(=O)N3C4CCC3CN(c3ncc(C(F)(F)F)cn3)C4)cn2)n1 CHEMBL4077790 IC50 6.2 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C(C)CCCC4C)cn3)n2)s1 CHEMBL3954949 IC50 6.3 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4cnc(C(F)(F)F)nc4)C5)cn3)n2)s1 CHEMBL4103303 IC50 6.3 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C[C@@H](OC(=O)NCCF)C5)cn3)n2)s1 CHEMBL3915675 IC50 6.7 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)CC4)cn3)n2)s1 CHEMBL4090643 IC50 6.8 nM
CC(C)(C)c1cc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)no1 CHEMBL4476783 IC50 7.5 nM
N#Cc1ccc(S(=O)(=O)[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@]2(O)CO)cc1 CHEMBL4533534 IC50 7.9 nM
N#Cc1ccc(OC[C@@H](N)CCNS(=O)(=O)c2ccc(Cl)cc2C(F)(F)F)cc1F CHEMBL4797312 pIC50 7.943 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C/C(=N/O)C5)cn3)n2)s1 CHEMBL3976867 IC50 8.4 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)Nc4ccc(Cl)cc4)cn3)n2)s1 CHEMBL3979286 IC50 9.5 nM
Cc1nc(C)c(-c2csc(Nc3ccccn3)n2)s1 CHEMBL1327134 IC50 10.0 nM
CCOc1ccc2c(C(=O)N[C@H](c3ccccc3)C(F)(F)F)c(CN3CCC(N4CCCCC4)CC3)c(-c3cccc(C(F)(F)F)c3)nc2c1 CHEMBL4068023 IC50 10.0 nM
CCOC(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3932523 IC50 11.0 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1C1CCCCC1 CHEMBL4574043 IC50 11.0 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1-c1ccccc1 CHEMBL4538643 IC50 11.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cn3)C[C@@]2(O)CN)cc1F CHEMBL4550510 IC50 12.0 nM
CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(c2ccc(OC(C)C)cc2)CC1 CHEMBL2323945 IC50 12.6 nM
N#Cc1ccc(OCC2(O)CCN(S(=O)(=O)c3ccc(Cl)cc3Cl)CC2)cc1F CHEMBL3218112 IC50 12.9 nM
COc1cnc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cn1 CHEMBL4447221 IC50 14.0 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1C1CCC(F)(F)CC1 CHEMBL4531567 IC50 15.0 nM
COC(=O)C(C)(C)c1ccc(N2CCC(n3c(NC(C)C)nc4c(C(=O)N(C)C)c(Cl)c(Cl)cc43)CC2)cc1 CHEMBL2323944 IC50 15.8 nM
CC(C)(C)CN1C[C@@]2(CCC[C@H](Cn3cnc4ccc(C#N)cc43)C2)OC1=O CHEMBL4549613 IC50 16.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN1CCOCC1 CHEMBL2133556 IC50 18.0 nM
N#Cc1ccc(N)c(OC[C@@H](N)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)c1 CHEMBL4784771 pIC50 18.62 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C[C@@H](NC(=O)CC(F)(F)F)C5)cn3)n2)s1 CHEMBL3906180 IC50 19.0 nM
N#Cc1ccc(S(=O)(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cc3)[C@](O)(CO)C2)c(C(F)(F)F)n1 CHEMBL4441860 IC50 20.0 nM
N#Cc1ccc(S(=O)(=O)N2C[C@H](S(=N)(=O)c3ccc(Cl)cc3)[C@](O)(CO)C2)c(Cl)c1 CHEMBL4467225 IC50 20.0 nM
CN1CCN(c2nc3c(F)cccc3c(=O)n2-c2ccc(Oc3ccc(F)cc3)cc2)CC1 CHEMBL4437589 ECmax 20.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C2CCCCC2)n1CCCN1CCOCC1 CHEMBL3933812 Ki 21.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C#N)cn3)n2)s1 CHEMBL3900585 IC50 22.0 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1-c1ccc(C#N)cc1 CHEMBL4519618 IC50 22.0 nM
CC(=O)Nc1c(Cl)c(Cl)cc2c1nc(NC(C)C)n2C1CCN(c2ccc(C3(C#N)CCC3)cc2)CC1 CHEMBL5419607 IC50 22.65 nM
COc1cccc(Nc2nc(-c3sc(C)nc3C)cs2)n1 CHEMBL3925315 IC50 23.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CC(=O)C5)cn3)n2)s1 CHEMBL3927993 IC50 24.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C/C(=N/OCC(N)=O)C5)cn3)n2)s1 CHEMBL3942090 IC50 24.0 nM
N#Cc1ccc(S(=O)(=O)[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@H]2O)cc1 CHEMBL4468326 IC50 25.0 nM
COc1ccc(C#N)cc1OC[C@@H](N)CCNS(=O)(=O)c1ccc(Cl)cc1Cl CHEMBL4763693 pIC50 27.54 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)NC4CCCCC4)cn3)n2)s1 CHEMBL3975583 IC50 29.0 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1Cc1ccc(F)cc1 CHEMBL4526382 IC50 30.0 nM
Cc1nc(C)c(-c2csc(Nc3ccccc3)n2)s1 CHEMBL3977499 IC50 31.0 nM
CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(c2ccc(C(C)(C)C#N)cc2)CC1 CHEMBL2323935 IC50 31.6 nM
CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(c2ccc(C3CCCCC3)cc2)CC1 CHEMBL2323946 IC50 31.6 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C[C@@H](O)C5)cn3)n2)s1 CHEMBL3967702 IC50 32.0 nM
CC(=O)N1CC2CCC(C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3915493 IC50 32.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@H]2O)cc1 CHEMBL4465119 IC50 32.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@]2(O)CO)cc1F CHEMBL4173887 IC50 33.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(Br)cc3)n2)s1 CHEMBL424708 IC50 34.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cn3)C[C@@]2(O)CO)cc1F CHEMBL4437649 IC50 34.0 nM
COc1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3944251 IC50 35.0 nM
COC(=O)N1CCN(C(=O)c2ccc(Nc3nc(-c4sc(C)nc4C)cs3)nc2)CC1 CHEMBL3960867 IC50 37.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCCCC4)cn3)n2)s1 CHEMBL3946266 IC50 37.0 nM
CC(=O)Nc1c(Cl)c(Cl)cc2c1nc(NC(C)C)n2C1CCN(c2ccc(C3(C#N)CCCC3)cc2)CC1 CHEMBL5408079 IC50 37.96 nM
CN1CCN(c2nc3c(F)cccc3c(=O)n2-c2ccc(Oc3ccccc3)cc2)CC1 CHEMBL4449495 ECmax 39.0 nM
N#Cc1ccc(OC[C@@H](N)CCNS(=O)(=O)c2ccccc2C(F)(F)F)cc1F CHEMBL4795311 pIC50 39.81 nM
Cc1ccc(C#N)cc1OC[C@@H](N)CCNS(=O)(=O)c1ccc(Cl)cc1Cl CHEMBL4755223 pIC50 39.81 nM
O=C(N[C@H](c1ccccc1)C(F)(F)F)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12 CHEMBL4087716 IC50 40.0 nM
O=C(NC1(c2ccccc2)CC1)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2cc(Br)ccc12 CHEMBL4073922 IC50 40.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@H]2O)cc1F CHEMBL4172787 IC50 40.0 nM
N#Cc1ccc(S(=N)(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cc3)[C@](O)(CO)C2)c(Cl)c1 CHEMBL4473984 IC50 40.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C[C@@H](CO)C5)cn3)n2)s1 CHEMBL3977334 IC50 41.0 nM
N#Cc1ccc(F)c(OC[C@@H](N)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)c1 CHEMBL4761250 pIC50 41.69 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C(C)CC(=O)CC4C)cn3)n2)s1 CHEMBL3900878 IC50 46.0 nM
C[C@]1(Cn2cnc3ccc(C#N)cc32)CCC[C@@]2(CN(c3cccc(Cl)c3)C(=O)O2)C1 CHEMBL4465488 IC50 48.0 nM
C[C@]1(Cn2cnc3ccc(C#N)cc32)CCC[C@@]2(CNC(=O)O2)C1 CHEMBL4544597 IC50 49.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)N1CCN(C(=O)[C@H](CO)NS(=O)(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL4461515 EC50 49.0 nM
N#Cc1ccc(S(=O)(=O)N2CCC(O)(COc3ccc(C#N)c(F)c3)CC2)c(Cl)c1 CHEMBL3218113 IC50 49.1 nM
N#Cc1ccc(OCC2(O)CCN(S(=O)(=O)c3ccc(Cl)cc3Cl)CC2)cc1 CHEMBL3218114 IC50 49.7 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N(C)c4ccc(Cl)cc4)cn3)n2)s1 CHEMBL3971104 IC50 50.0 nM
C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 CHEMBL4065154 IC50 50.0 nM
COc1ccc2c(C(=O)N[C@H](c3ccccc3)C(F)(F)F)c(CN3CCC(N4CCCCC4)CC3)c(-c3cccc(C(F)(F)F)c3)nc2c1 CHEMBL4095413 IC50 50.0 nM
O=C(NC1(c2ccccc2)CC1)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12 CHEMBL4097859 IC50 50.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@H]2CO)cc1F CHEMBL4165555 IC50 50.0 nM
N#Cc1ccc(S(=O)(=O)[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@]2(O)CO)cc1 CHEMBL4534649 IC50 50.0 nM
CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(c2ccc(C(C)(C)C)cc2)CC1 CHEMBL2323947 IC50 50.1 nM
N#Cc1ccc(OC[C@@H](N)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)cc1F CHEMBL4753854 pIC50 50.12 nM
N#Cc1ccc(S(=O)(=O)N2CCC(O)(COc3ccc(C#N)c(F)c3)CC2)c(C#N)c1 CHEMBL3218115 IC50 50.5 nM
C/C=C/C=C/c1c(CC=C(C)C)cc2c(c1[C@H](Nc1ccccc1C(=O)O)[C@H]1c3c(CC=C(C)C)cc4c(c3[C@@H]3OC(=O)c5ccccc5N3[C@H]1/C=C/C)OC(C)(C)[C@H](O)C4=O)OC(C)(C)[C@@H](O)C2=O CHEMBL4633175 IC50 50.8 nM
COc1cc(OC)cc(C(=O)Nc2nc(-c3ccccc3)c(CCN3CCCCC3)s2)c1 CHEMBL4551456 IC50 51.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3)C[C@@]2(O)CO)cc1F CHEMBL4468250 IC50 53.0 nM
CC(C)(O)c1cnc(N2C[C@@]3(CC[C@@H](O)[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cn1 CHEMBL4870326 IC50 56.0 nM
N#Cc1ccc(Cl)c(OC[C@@H](N)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)c1 CHEMBL4777668 pIC50 57.54 nM
O=C(N[C@H](c1ccccc1)C(F)(F)F)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2cc(Br)ccc12 CHEMBL4078886 IC50 60.0 nM
O=C(N[C@H](c1ccccc1)C(F)(F)F)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccc(Br)cc12 CHEMBL4103166 IC50 60.0 nM
CCOc1ccc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)nn1 CHEMBL4519711 IC50 60.0 nM
Cc1cnc(N2C[C@@]3(CCC[C@](C)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cn1 CHEMBL4447940 IC50 60.0 nM
N#Cc1ccc2ncn(C[C@H]3CCC[C@]4(C3)CN(c3ccccc3Cl)C(=O)O4)c2c1 CHEMBL4535351 IC50 63.0 nM
N#Cc1ccc(OC[C@@H](N)CCNS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1F CHEMBL4747177 pIC50 63.1 nM
N#Cc1cccc(OCC(N)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)c1 CHEMBL4740898 pIC50 63.1 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)CC4CO)cn3)n2)s1 CHEMBL4072343 IC50 64.0 nM
CCOc1cccc(N2C[C@@]3(CCC[C@H](Cn4cnc5ccc(C#N)cc54)C3)OC2=O)c1 CHEMBL4556983 IC50 74.0 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1C(C)(C)C CHEMBL4519974 IC50 78.0 nM
CC(C)Nc1nc2ccc(C#N)cc2n1C1CCN(c2ccc(C(C)(C)C#N)cc2)CC1 CHEMBL5423651 IC50 78.92 nM
CC(=O)N[C@H]1C[C@H]2CC[C@@H](C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3933578 IC50 80.0 nM
C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 CHEMBL4084542 IC50 80.0 nM
CCOc1ccc2c(C(=O)NC3(c4ccccc4)CC3)c(CN3CCC(N4CCCCC4)CC3)c(-c3cccc(C(F)(F)F)c3)nc2c1 CHEMBL4104743 IC50 80.0 nM
Cc1nc(-c2ccccc2)oc1C(=O)Nc1nc(C2CCC2)c(N2CCN(C)CC2)s1 CHEMBL4462976 IC50 81.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN1CCCCC1 CHEMBL3928900 IC50 82.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(-c3ccccc3)c(C3CCN(C)CC3)s2)c1 CHEMBL4579045 IC50 84.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)c1 CHEMBL4446542 IC50 84.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(-c3ccccc3)c(CCCN(C)C)s2)c1 CHEMBL4586243 IC50 86.0 nM
C[C@]1(Cn2cnc3ccc(C#N)cc32)CCC[C@@]2(CN(c3ccc(F)cc3)C(=O)O2)C1 CHEMBL4590243 IC50 96.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(-c3ccccc3)c(CCCN3CCOCC3)s2)c1 CHEMBL4467623 IC50 99.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3[N+](=O)[O-])cc2)CC1 CHEMBL3613642 Kb 100.0 nM
Cc1nc(C)c(-c2csc(Nc3cccc(C#N)n3)n2)s1 CHEMBL3960032 IC50 100.0 nM
O=C(N[C@@H](c1ccccc1)C(F)(F)F)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12 CHEMBL4105593 IC50 100.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@H]2O)cc1F CHEMBL4162110 IC50 100.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(C(F)(F)F)cc3)C[C@@]2(O)CO)cc1F CHEMBL4453088 IC50 100.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(-c3ccccc3)c(CCCN3CCCCC3)s2)c1 CHEMBL4589218 IC50 120.0 nM
N#Cc1ccc(OCC(N)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)cc1F CHEMBL4749498 pIC50 125.89 nM
Cc1ccc(N2CCC(n3c(NC(C)C)nc4c(C(=O)N(C)C)c(Cl)c(Cl)cc43)CC2)cc1 CHEMBL2323948 IC50 126.0 nM
Cc1cccc(N2CCC(n3c(NC(C)C)nc4c(C(=O)N(C)C)c(Cl)c(Cl)cc43)CC2)c1 CHEMBL2323949 IC50 126.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(CCO)CCO CHEMBL3908106 IC50 130.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C2CCN(C(=O)OCc3ccccc3)CC2)n1CCCN1CCOCC1 CHEMBL3979302 Ki 130.0 nM
CNC(C)CCn1c(C(C)(C)C)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3969322 Ki 130.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CCC(C)N1CCOCC1 CHEMBL3939775 Ki 130.0 nM
CC(C)[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 CHEMBL4097174 IC50 130.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4F)cs3)nsc2n(C)c1=O CHEMBL3945471 IC50 131.9 nM
CCOc1ccc(N2C[C@@]3(CCC[C@H](Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cc1 CHEMBL4471311 IC50 140.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(-c3ccccc3)c(N3CCN(C)CC3)s2)c1 CHEMBL4553265 IC50 144.0 nM
N#Cc1ccc(OCC2(O)CCN(S(=O)(=O)c3ccc(Cl)cc3Cl)C2)cc1F CHEMBL4160589 IC50 150.0 nM
N#Cc1ccc(OC[C@@]2(O)CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@H]2O)cc1F CHEMBL4165961 IC50 150.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)cc4F)cs3)nsc2n(C)c1=O CHEMBL3913924 IC50 152.9 nM
CN1CCN(c2nc3c(F)cccc3c(=O)n2-c2ccc(SC(F)(F)F)cc2)CC1 CHEMBL4474443 ECmax 156.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)(F)F)c(F)c4)cs3)ccnc2n(C)c1=O CHEMBL3947801 IC50 158.4 nM
N#Cc1ccc(S(=O)(=O)[C@@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@]2(O)CO)cc1 CHEMBL4444971 IC50 159.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccn2)n1CCCN1CCOCC1 CHEMBL3971714 Ki 160.0 nM
CNCCCn1c(-c2ccccc2)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3945641 Ki 160.0 nM
CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 CHEMBL4069979 IC50 160.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4)cs3)nsc2n(C)c1=O CHEMBL3912738 IC50 161.7 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C CHEMBL3899055 Ki 169.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CC(C)(C)CN1CCOCC1 CHEMBL3976956 Ki 170.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CN(c4ncc(C(=O)O)cn4)C5)cn3)n2)s1 CHEMBL4076956 IC50 170.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)(F)F)c(F)c4)cs3)nsc2n(C)c1=O CHEMBL3892970 IC50 172.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(C(F)(F)F)nc3)C[C@@]2(O)CO)cc1F CHEMBL4459916 IC50 175.0 nM
CC(=O)Nc1c(Cl)c(Cl)cc2c1nc(NC(C)C)n2C1CCN(c2ccc(C(C)(C)C#N)cc2)CC1 CHEMBL5425542 IC50 181.7 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cn3)C[C@]2(O)CO)cc1F CHEMBL4440858 IC50 190.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN1CCNC(=O)C1 CHEMBL3982928 Ki 196.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CCCN1CCOCC1 CHEMBL3945194 Ki 197.0 nM
N#Cc1ccc(OCC(N)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)cc1 CHEMBL4787004 pIC50 199.53 nM
CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(c2ccccc2)CC1 CHEMBL2323942 IC50 200.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)NCc4ccc(Cl)cc4)cn3)n2)s1 CHEMBL3950242 IC50 200.0 nM
C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(Cl)c2)nc2ccccc12)c1ccccc1 CHEMBL4062863 IC50 200.0 nM
N#Cc1ccc(O[C@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@@H]2CO)cc1F CHEMBL4162218 IC50 200.0 nM
CC(C)Nc1nc2c(C(=O)N(C)C)ncnc2n1C1CCN(c2ccc(N3c4ccccc4C(C)(C)c4ccccc43)cc2)CC1 CHEMBL5405879 IC50 205.9 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)cc(C(F)(F)F)c4)cs3)nsc2n(C)c1=O CHEMBL3984932 IC50 236.5 nM
Cc1nc(C)c(-c2csc(Nc3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cn3)n2)s1 CHEMBL3898828 IC50 240.0 nM
Cc1nc(C)c(-c2csc(Nc3cc(C#N)ccn3)n2)s1 CHEMBL3971734 IC50 240.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)C1CCCC1 CHEMBL3901340 IC50 240.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CC(F)(F)CN1CCOCC1 CHEMBL3959234 Ki 240.0 nM
N#Cc1ccc2ncn(C[C@H]3CCC[C@]4(C3)CN(c3cccc(Cl)c3)C(=O)O4)c2c1 CHEMBL4581258 IC50 240.0 nM
CN1CCN(c2sc(NC(=O)c3cc(-c4ccccc4)cs3)nc2C2CCC2)CC1 CHEMBL4459428 IC50 240.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(C3CC3)c(N3CCN(C)CC3)s2)c1 CHEMBL4434654 IC50 240.0 nM
COc1ccc2c(C(=O)NC3(c4ccccc4)CC3)c(CN3CCC(N4CCCCC4)CC3)c(-c3cccc(C(F)(F)F)c3)nc2c1 CHEMBL4094483 IC50 250.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)c1ccno1 CHEMBL3956059 Ki 251.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(S(F)(F)(F)(F)F)cc3)cc2)CC1 CHEMBL3613639 IC50 260.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CCC(C)N1CCNCC1 CHEMBL3949591 IC50 260.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(OC(F)(F)F)c(Cl)c4)cs3)nsc2n(C)c1=O CHEMBL3892326 IC50 278.7 nM
CN1CCN(c2nc3c(F)cccc3c(=O)n2-c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL4560730 EC50 280.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)CC1CCN(C)CC1 CHEMBL3973124 Ki 282.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(S(=O)(=O)Nc4ccc(Cl)cc4)cn3)n2)s1 CHEMBL3970031 IC50 290.0 nM
CNCC(C)(C)Cn1c(C(C)(C)C)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3982533 Ki 290.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(-c3cccnc3)c(N3CCN(C)CC3)s2)c1 CHEMBL4441221 IC50 290.0 nM
Cc1ccccc1N1C[C@@]2(CCC[C@H](Cn3cnc4ccc(C#N)cc43)C2)OC1=O CHEMBL4571300 IC50 310.0 nM
COc1cc(OC)cc(C(=O)Nc2nc(-c3ccccc3)c(CN3CCCCC3)s2)c1 CHEMBL4463312 IC50 310.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NCCCN(C)S(=O)(=O)c1ccc(Cl)cc1Cl CHEMBL4585693 ECmax 312.0 nM
CN1CCN(c2nc3c(F)cccc3c(=O)n2-c2ccc(Cc3ccccc3)cc2)CC1 CHEMBL4542977 ECmax 312.0 nM
N#Cc1ccc(OC[C@@H](N)CCNS(=O)(=O)c2ccc(C(F)(F)F)cc2Cl)cc1F CHEMBL4754934 pIC50 316.23 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)nc(-c2ccccc2)n1CCCN1CCOCC1 CHEMBL3954209 Ki 320.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)c1ccncc1 CHEMBL3968858 Ki 320.0 nM
C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccc(Cl)cc2)nc2ccccc12)c1ccccc1 CHEMBL4082016 IC50 320.0 nM
N#Cc1ccc(OC2CCN(S(=O)(=O)c3ccc(Cl)cc3Cl)C2)cc1F CHEMBL4176167 IC50 320.0 nM
Cc1c(C(=O)Nc2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1CCCN1CCOCC1 CHEMBL3891829 IC50 340.0 nM
COc1ccccc1N1C[C@@]2(CCC[C@H](Cn3cnc4ccc(C#N)cc43)C2)OC1=O CHEMBL4450392 IC50 340.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)CC(C)(C)CN(C)C CHEMBL3943630 Ki 352.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN1CCNCC1 CHEMBL3920603 Ki 355.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2cccnc2)n1CCCN1CCOCC1 CHEMBL3972010 Ki 379.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3F)cc2)CC1 CHEMBL3613640 IC50 380.0 nM
CCOC(=O)CCn1c(C(C)(C)C)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3978892 Ki 380.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CCS(=O)(=O)N1CCOCC1 CHEMBL3945104 Ki 380.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(C)(C)C)cc3)cc2)CC1 CHEMBL3613628 IC50 390.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCN1CCOCC1 CHEMBL3900869 IC50 400.0 nM
C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccc(C(F)(F)F)cc2)nc2ccccc12)c1ccccc1 CHEMBL4100026 IC50 400.0 nM
COc1ccnc(Nc2nc(-c3sc(C)nc3C)cs2)c1 CHEMBL3916322 IC50 410.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCNS(C)(=O)=O CHEMBL3980974 Ki 427.0 nM
CNCC(F)(F)Cn1c(C(C)(C)C)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3922814 Ki 450.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CC(C)(C)CN1CCNCC1 CHEMBL3931771 Ki 450.0 nM
Cc1c(C(=O)Nc2cccc(Cl)c2)cc(-c2ccccc2)n1CCCN1CCOCC1 CHEMBL3953092 Ki 453.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)C1CCC1 CHEMBL3931352 Ki 472.0 nM
Cc1nc(C)c(-c2csc(Nc3cccnc3)n2)s1 CHEMBL1374508 IC50 490.0 nM
O=C(NCc1ccccc1)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12 CHEMBL4072053 IC50 500.0 nM
Cc1cccc(-c2nc3ccccc3c(C(=O)N[C@@H](C)c3ccccc3)c2CN2CCC(N3CCCCC3)CC2)c1 CHEMBL4105323 IC50 500.0 nM
Cc1c(C(=O)Nc2cccc(C(C)C)c2)cc(-c2ccccc2)n1CCCN1CCOCC1 CHEMBL3950968 Ki 519.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(Cl)c(C(F)(F)F)c4)cs3)cccc2n(C)c1=O CHEMBL3897467 IC50 520.2 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C[C@@H](N)C5)cn3)n2)s1 CHEMBL3905564 IC50 530.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CCC(=O)N1CCNCC1 CHEMBL3981914 Ki 530.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3C(F)(F)F)cc2)CC1 CHEMBL3613641 IC50 540.0 nM
N#Cc1ccc2ncn(C[C@H]3CCC[C@]4(C3)CN(c3ccccc3F)C(=O)O4)c2c1 CHEMBL4520028 IC50 540.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(F)c(C(F)(F)F)c4F)cs3)nsc2n(C)c1=O CHEMBL3941901 IC50 553.1 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CCC(=O)N1CCOCC1 CHEMBL3912047 Ki 560.0 nM
CC(=O)Nc1ccc(C(=O)N(C)CCCn2c(-c3ccccc3)cc(C(=O)Nc3cccc(C(F)(F)F)c3)c2C)cc1 CHEMBL3933378 Ki 560.0 nM
CC(=O)N(C)CCCn1c(-c2ccccc2)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3965039 IC50 590.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cc(-c2ccccc2)nn1CCCN1CCOCC1 CHEMBL3917468 Ki 590.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(C(C)(C)C)n1CCS(=O)(=O)N1CCNCC1 CHEMBL3893583 Ki 590.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)C(C)C CHEMBL3947902 Ki 590.0 nM
CCCCCc1cc(O)c2c(c1)OC(C)(CCC=C(C)C)C=C2 CHEMBL422704 EC50 600.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN CHEMBL3910256 Ki 605.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4)cs3)ccnc2n(C)c1=O CHEMBL3905406 IC50 619.5 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C5CCC4CNC5)cn3)n2)s1 CHEMBL3952172 IC50 620.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCC(=O)CC4)cn3)n2)s1 CHEMBL3983567 IC50 620.0 nM
CN1CCN(c2nc3cc(F)ccc3c(=O)n2-c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL4465567 ECmax 625.0 nM
CCOC(=O)c1ccc(-n2c(N3CCN(C)CC3)nc3c(F)cccc3c2=O)cc1 CHEMBL4440011 ECmax 625.0 nM
N#Cc1ccc(OC[C@@H](N)CCNS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1F CHEMBL4788545 pIC50 630.96 nM
N#Cc1ccc(OC[C@@H](N)CCNS(=O)(=O)c2ccccc2OC(F)(F)F)cc1F CHEMBL4800371 pIC50 630.96 nM
CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1-c1ccc(N2CCCCC2)cc1 CHEMBL2323940 IC50 631.0 nM
N#Cc1ccc(S(=O)(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cc3)[C@](O)(CO)C2)cn1 CHEMBL4453093 IC50 631.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)CC(C)C CHEMBL3899580 IC50 640.0 nM
Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@@H]5CC[C@H]4C[C@H](O)C5)cn3)n2)s1 CHEMBL3897681 IC50 650.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)CC1CC1 CHEMBL3967340 Ki 655.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)c1cnc2ccccc2n1 CHEMBL3970612 Ki 662.0 nM
Cc1c(C(=O)Nc2ccccc2)cc(-c2ccccc2)n1CCCN1CCOCC1 CHEMBL1702623 Ki 678.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)OC(C)(C)C CHEMBL3920416 Ki 701.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)C1CC1 CHEMBL3917457 Ki 707.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2)CC1 CHEMBL3613629 IC50 710.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)C(Cl)(Cl)Cl CHEMBL3981972 Ki 713.0 nM
COCCCn1c(-c2ccccc2)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3986869 Ki 714.0 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1C CHEMBL4534599 IC50 730.0 nM
O=S(=O)(c1ccc(Cl)cc1Cl)N1CCN(Cc2ccccc2)CC1 CHEMBL2324348 EC50 770.0 nM
CNC(=O)N1CC2CCC(C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 CHEMBL3943456 IC50 770.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)CC[C@H](O)[C@H](O)CO CHEMBL3916329 Ki 771.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccncc2)n1CCCN1CCOCC1 CHEMBL3909002 Ki 780.0 nM
N#Cc1ccc(OCC(O)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)cc1F CHEMBL4741577 pIC50 794.33 nM
N#Cc1ccc(S(=O)(=O)NCC[C@H](N)COc2ccc(C#N)c(F)c2)cc1 CHEMBL4765224 pIC50 794.33 nM
O=C(Nc1ccc(S(=O)(=O)N2CCN(C3CCCC3)CC2)cc1)c1ccc(C(F)(F)F)cc1 CHEMBL3613638 IC50 800.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)c1cccc(N(C)C)c1 CHEMBL3894060 Ki 816.0 nM
N#Cc1ccc2ncn(C[C@H]3CCC[C@]4(C3)CN(c3ccccc3)C(=O)O4)c2c1 CHEMBL4549957 IC50 820.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(C(F)(F)F)c4F)cs3)nsc2n(C)c1=O CHEMBL3944172 IC50 825.8 nM
CN1CCN(c2sc(NC(=O)c3ccc(-c4ccccc4)o3)nc2C2CCC2)CC1 CHEMBL4550407 IC50 830.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)c1cccs1 CHEMBL3939486 Ki 844.0 nM
COc1ccc(OC)c(CC(=O)N(C)CCCn2c(-c3ccccc3)cc(C(=O)Nc3cccc(C(F)(F)F)c3)c2C)c1 CHEMBL3908494 Ki 850.0 nM
CN1CCN(c2nc3c(F)cccc3c(=O)n2-c2ccc(OC3CCOCC3)cc2)CC1 CHEMBL4455286 EC50 870.0 nM
CC(=O)Nc1c(Cl)c(Cl)cc2c1nc(NC(C)C)n2C1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL5400287 IC50 879.1 nM
Cc1c(C(=O)Nc2nc(C3CCC3)c(N3CCN(C)CC3)s2)cnn1C1CCOCC1 CHEMBL4470016 IC50 880.0 nM
C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCC)cc1O CHEMBL2387742 EC50 900.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(C(F)(F)F)c(F)c4F)cs3)cccc2n(C)c1=O CHEMBL3987145 IC50 902.6 nM
CCN(CC)C1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2)CC1 CHEMBL3613636 IC50 910.0 nM
CC(C)c1ccc(-n2c(N3CCN(C)CC3)nc3c(F)cccc3c2=O)cc1 CHEMBL4516018 EC50 910.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3N)cc2)CC1 CHEMBL3613643 IC50 930.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(-c4ncccc4Cl)cc3)cc2)CC1 CHEMBL3613627 IC50 930.0 nM
COC(=O)NCCCn1c(-c2ccccc2)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3952145 Ki 936.0 nM
Cn1c(=O)c2c(CC(=O)Nc3nc(-c4ccc(Br)cc4)cs3)cccc2n(C)c1=O CHEMBL3921886 IC50 969.3 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)c1cccnc1 CHEMBL3945336 Ki 978.0 nM
Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN(C)C(=O)c1ccc2ccccc2n1 CHEMBL3962053 Ki 984.0 nM
COC(=O)CCCN(C)CCCn1c(-c2ccccc2)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1C CHEMBL3922305 Ki 988.0 nM
Cc1c(C(=O)Nc2nc3ccccc3s2)cc(-c2ccccc2)n1CCCN1CCOCC1 CHEMBL3893687 Ki 992.0 nM
CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(Cc2ccccc2)CC1 CHEMBL2323939 IC50 1000.0 nM
CC(C)(NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 CHEMBL4079837 IC50 1000.0 nM
N#Cc1ccc(OC[C@@H]2CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C[C@H]2O)cc1F CHEMBL4175922 IC50 1000.0 nM
N#Cc1ccc(OC[C@H](N)CCNS(=O)(=O)c2ccc(Cl)cc2Cl)cc1F CHEMBL4746378 pIC50 1000.0 nM
Cc1ccccc1S(=O)(=O)NCC[C@H](N)COc1ccc(C#N)c(F)c1 CHEMBL4741595 pIC50 1000.0 nM
NC(CCNS(=O)(=O)c1ccc(Cl)cc1Cl)COc1cccc(F)c1 CHEMBL4784636 pIC50 1000.0 nM