CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(N[C@@H](C)C(C)(C)C)c2n1 CHEMBL4249882 Ki 0.047 nM
Cc1cc(-c2cnn3c(CC[C@H]4C[C@@](C)(O)C4)cc(Oc4cccnc4)nc23)ccc1C(=O)NC1CC1 CHEMBL4877547 Kd 0.071 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3911532 Ki 0.084 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(N3CC(C)(C)C3)c2n1 CHEMBL4245639 Ki 0.088 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL3927553 Ki 0.094 nM
Cc1cc(-c2cnn3c(NC[C@H]4C[C@@](C)(O)C4)cc(Oc4cccnc4)nc23)ccc1C(=O)NC1CC1 CHEMBL4469414 Ki 0.1 nM
COc1cc(C(=O)N2CC3(COC3)C2)ccc1Nc1nc2ccc(-c3ccc(NC(=O)Cc4ccc(F)cc4)cc3)cn2n1 CHEMBL4632740 IC50 0.1 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(N3CC4(CCOCC4)C3)c2n1 CHEMBL4239476 Ki 0.11 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL3924132 Ki 0.11 nM
CCOc1cc(-c2nnc(C)n2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL4247121 Ki 0.12 nM
CCOc1cc(-c2nnc(CCN(C)C)n2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL4240502 Ki 0.12 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)C4CCCC4)CC3)c2n1 CHEMBL4845775 Kd 0.12 nM
COc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL3932996 Ki 0.13 nM
COc1cc(C(=O)N2C[C@@H]3C[C@H]2CO3)ccc1Nc1nc2ccc(-c3ccc(NC(=O)Cc4ccc(F)cc4)cc3)cn2n1 CHEMBL4636046 IC50 0.15 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)C4CCCCC4)CC3)c2n1 CHEMBL4875028 Kd 0.15 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(C)c(=O)n([C@H]3CC[C@@H](NC(=O)C4CCCC4)CC3)c2n1 CHEMBL4870223 Kd 0.17 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(C)c(=O)n([C@H]3CC[C@@H](NC(=O)C4CCCCC4)CC3)c2n1 CHEMBL4858486 Kd 0.17 nM
COc1cc(-c2nnc3n2CCC3)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL4251352 Ki 0.19 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N[C@@H](C)C(C)(C)C)c2n1 CHEMBL3809829 Ki 0.2 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(-c4ccncc4)cc32)ccc1C(=O)NC1CC1 CHEMBL3951371 IC50 0.2 nM
Cc1cc(-n2cnc3c(NCC4CCOCC4)cc(Oc4cccc(F)c4F)cc32)ccc1C(=O)NC1CC1 CHEMBL3928754 IC50 0.2 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccccc4O)cc32)ccc1C(=O)NC1CC1 CHEMBL3961628 IC50 0.2 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(N3CC(C)(C#N)C3)c2n1 CHEMBL4249151 Ki 0.2 nM
O=C(Cc1ccc(F)cc1)Nc1ccc(-c2ccc3nc(Nc4ccc(C(=O)N5CCOCC5)cc4OCC(F)(F)F)nn3c2)cc1 CHEMBL4638914 IC50 0.2 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)nc(Cc4ccccc4)cn23)ccc1C(=O)NC1CC1 CHEMBL4642174 IC50 0.2 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)C(C)(C)C)CC3)c2n1 CHEMBL4846040 Kd 0.2 nM
COc1ccc(Oc2cc(NCCC(F)(F)F)c3ncc(-c4ccc(C(=O)NC5CC5)c(C)c4)n3n2)c(F)c1F CHEMBL4456085 IC50 0.25 nM
CCC(=O)N[C@H]1CC[C@@H](n2c(=O)c(C)cc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)CC1 CHEMBL4869527 Kd 0.29 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)cc(C(C)(O)c4cccc(F)c4O)nn23)ccc1C(=O)NC1CC1 CHEMBL3354568 IC50 0.3 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCC4CCOCC4)cc(Oc4ccccc4O)nn23)cc1 CHEMBL3410078 IC50 0.3 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccccc4O)cc32)cc1C CHEMBL3965128 IC50 0.3 nM
C=C(c1ccc(OC)c(F)c1)c1cc(NCCC(F)(F)F)c2ncc(-c3ccc(C(=O)NC4CC4)c(C)c3)n2n1 CHEMBL4632416 IC50 0.3 nM
Cc1cc(-c2cnc3c(NC[C@H]4C[C@@](C)(O)C4)cc(Oc4cccnc4)nn23)ccc1C(=O)NC1CC1 CHEMBL4645348 IC50 0.3 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)c4ccccc4)CC3)c2n1 CHEMBL4868353 Kd 0.3 nM
COc1cc(S(C)(=O)=O)ccc1Nc1nc2ccc(-c3ccc(NC(=O)[C@H](C)c4ccc(F)cc4)cc3)cn2n1 CHEMBL4303241 IC50 0.34 nM
CCOc1cc(-c2nnc3n2CCC3)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1 CHEMBL4250961 Ki 0.38 nM
COc1ccc(C(=O)c2cc(NCCC(F)(F)F)c3ncc(-c4ccc(C(=O)NC5CC5)c(C)c4)n3n2)cc1F CHEMBL3354567 IC50 0.4 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(Oc4cccc(F)c4F)nc23)ccc1C(=O)NC1CC1 CHEMBL3818646 IC50 0.4 nM
Cc1cc(-n2cnc3c(NCC4CCOCC4)cc(Oc4cccc(F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3932181 IC50 0.4 nM
COc1ccc(Oc2cc(NCC3CCOCC3)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1F CHEMBL3912382 IC50 0.4 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4F)cc32)ccc1C(=O)NC1CC1 CHEMBL3941964 IC50 0.4 nM
COc1ccc(Oc2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)cc4)c3c2)cc1F CHEMBL3923628 IC50 0.4 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4O)cc32)ccc1C(=O)NC1CC1 CHEMBL3918586 IC50 0.4 nM
COc1ccc(Oc2cc(NCCC(F)(F)F)n3ncc(-c4ccc(C(=O)NC5CC5)c(C)c4)c3n2)c(F)c1F CHEMBL4640247 IC50 0.4 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)C4CC4)CC3)c2n1 CHEMBL4860430 Kd 0.41 nM
CCC(=O)N[C@H]1CC[C@@H](n2c(=O)ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)CC1 CHEMBL4866294 Kd 0.41 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3809252 Ki 0.44 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccccc4)cc32)ccc1C(=O)NC1CC1 CHEMBL3916360 IC50 0.5 nM
COc1cc(C(=O)N2CC(F)C2)ccc1Nc1nc2ccc(-c3ccc(NC(=O)[C@H](C)c4ccc(F)cc4)cc3)cn2n1 CHEMBL4642491 IC50 0.5 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)nc(Oc4ccccc4)cn23)ccc1C(=O)NC1CC1 CHEMBL4634949 IC50 0.5 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)C(C)C)CC3)c2n1 CHEMBL4867504 Kd 0.5 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)C45CC6CC(CC(C6)C4)C5)CC3)c2n1 CHEMBL4873395 Kd 0.56 nM
COc1ccc(C(F)(F)c2cc(NCCC(F)(F)F)c3ncc(-c4ccc(C(=O)NC5CC5)c(C)c4)n3n2)cc1 CHEMBL3354995 IC50 0.6 nM
Cc1cc(F)cc(Oc2cc(NCC3CCOCC3)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)c1 CHEMBL3951894 IC50 0.6 nM
Cc1ccc(F)cc1Oc1cc(NCC2CCOCC2)c2ncn(-c3ccc(C(=O)NC4CC4)c(C)c3)c2c1 CHEMBL3976909 IC50 0.6 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(O)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3920978 IC50 0.6 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@](C)(O)CC2)c2cc[nH]c2n1 CHEMBL4476012 IC50 0.6 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)cc(C4(c5cc(F)ccc5O)CC4)nn23)ccc1C(=O)NC1CC1 CHEMBL4634997 IC50 0.6 nM
CCc1cccc(CC)c1NC(=O)c1ccn2c1CCc1cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc1-2 CHEMBL4449557 IC50 0.6 nM
CCC(=O)N[C@H]1CC[C@@H](n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4C)nc32)CC1 CHEMBL4869142 Kd 0.63 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)cc(C(F)(F)c4cccc(F)c4)nn23)ccc1C(=O)NC1CC1 CHEMBL3354569 IC50 0.7 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)cc(C4(c5cccc(F)c5F)CC4)nn23)ccc1C(=O)NC1CC1 CHEMBL3354996 IC50 0.7 nM
CC(C)(Nc1cc(NCC2CCOCC2)c2ncc(-c3ccc(C(=O)NC4CC4)cc3)n2n1)C(F)(F)F CHEMBL3410084 IC50 0.7 nM
O=C(N[C@@H](c1ccccn1)C1CC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422092 Ki(app) 0.7 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(Nc4cccc(F)c4)nc23)ccc1C(=O)NC1CC1 CHEMBL3819019 IC50 0.7 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3907929 IC50 0.7 nM
COc1ccc(Oc2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1F CHEMBL3930776 IC50 0.7 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccccc4O)cc32)cc1C CHEMBL3977649 IC50 0.7 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)c(F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3972126 IC50 0.7 nM
Cc1cc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(O)c(F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3958776 IC50 0.7 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2cc[nH]c2n1 CHEMBL4450891 IC50 0.7 nM
C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F CHEMBL4546504 IC50 0.7 nM
CCC(=O)N[C@H]1CC[C@@H](n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)CC1 CHEMBL4857210 Kd 0.7 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(C)=O)CC3)c2n1 CHEMBL4861308 Kd 0.72 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(Oc4ccccc4)nc23)ccc1C(=O)NC1CC1 CHEMBL3819210 Ki 0.77 nM
COc1cc(-c2cnn(C)c2C)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3900491 Ki 0.78 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(N3CCCC3)c2n1 CHEMBL4248872 Ki 0.82 nM
C=CC(=O)Nc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-n1ccc(C(=O)Nc3c(CC)cccc3CC)c1CC2 CHEMBL5094006 Ki 0.83 nM
COc1ccc(Oc2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)c(F)c1 CHEMBL3930381 IC50 0.9 nM
Cc1cc(-c2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)ccc1C(=O)NC1CC1 CHEMBL3963282 IC50 0.9 nM
CNC(=O)c1ccc(-c2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1C CHEMBL3971110 IC50 0.9 nM
COc1ccc(Cc2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1F CHEMBL3922470 IC50 0.9 nM
COc1ncc2cc1NS(=O)(=O)c1ccc(F)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3c(C)c-2sc13 CHEMBL4878958 Kd 0.9 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(Nc4ccccc4F)nc23)ccc1C(=O)NC1CC1 CHEMBL3819328 IC50 0.94 nM
CCc1cccc(CC)c1NC(=O)c1nn(C)c2c1CCc1cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC(F)(F)F)nc1-2 CHEMBL1236095 Ki 0.99 nM
Cc1cc(N2CCOCC2)ccc1Nc1nc(NC2CCC(O)CC2)c2nc[nH]c2n1 CHEMBL2047951 IC50 1.0 nM
FC(F)(F)Oc1cc(N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047952 IC50 1.0 nM
CCOc1cc(N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047956 IC50 1.0 nM
COc1cc(N2CCNCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047958 IC50 1.0 nM
CC(C)CNc1nc(-c2cccc3ncccc23)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3422104 IC50 1.0 nM
CC(C)CNc1nc(C#CCCCC#N)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3976059 IC50 1.0 nM
CC(C)CNc1nc(-c2ccc([S+]([O-])C3CC3)cc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3942039 IC50 1.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC4CC4)c3)ccc2cn1 CHEMBL3929046 IC50 1.0 nM
COc1cc(-c2nncn2C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3891051 IC50 1.0 nM
COCc1ncc(-c2ccc(Nc3cc4cc(-c5cnn(CC(C)(C)O)c5)ccc4cn3)c(OC)c2)n1C CHEMBL3951011 IC50 1.0 nM
COc1cc(-c2ncnn2C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3906542 IC50 1.0 nM
COc1cc(C(=O)N2CC3(CCOC3)C2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3961626 IC50 1.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1cc2nc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3932702 IC50 1.0 nM
COc1cc(-c2nncn2C)ccc1Nc1cc2nc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3968964 IC50 1.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2nc(-c3cnn(CC4(O)CCC4)c3)ccc2cn1 CHEMBL3894315 IC50 1.0 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4F)cc32)cc1C CHEMBL3912122 IC50 1.0 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(C#N)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3963669 IC50 1.0 nM
Cc1cc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(O)cc4F)cc32)ccc1C(=O)NC1CC1 CHEMBL3890351 IC50 1.0 nM
COc1cc(-c2cnn(C)c2CO)ccc1Nc1ncc2ccnc(NCC3(C)CCOC3)c2n1 CHEMBL3913772 IC50 1.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2ccnc(NCC3(C)CCOC3)c2n1 CHEMBL3928170 IC50 1.0 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc(OC2CCOCC2)c2cc[nH]c2n1 CHEMBL4472951 IC50 1.0 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CCOC(C)(C)C2)c2cc[nH]c2n1 CHEMBL4558047 IC50 1.0 nM
N#Cc1ccccc1Nc1nc2ccc(-c3ccc(NC(=O)Cc4ccccc4)cc3)cn2n1 CHEMBL4581793 IC50 1.0 nM
COc1cc(N2CCOC2=O)ccc1Nc1nc2ccc(-c3ccc(NC(=O)[C@H](C)c4ccc(F)cc4)cc3)cn2n1 CHEMBL4646001 IC50 1.0 nM
CCc1cccc(CC)c1NC(=O)c1ccn(-c2nc(Nc3ccc(N4CCN(CC(=O)N(C)C)CC4)cc3OC)nc3[nH]ccc23)c1 CHEMBL5092826 IC50 1.0 nM
CCc1cccc(CC)c1NC(=O)c1ccn(-c2nc(Nc3ccc(N4CCC(O)(CN5CCN(C)CC5)CC4)cc3OC)nc3[nH]ccc23)c1 CHEMBL5093015 IC50 1.0 nM
O=C(NCC1(N2CCOCC2)CCCCC1)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1 CHEMBL3422080 IC50 1.1 nM
O=C(N[C@H](c1ncccn1)C1CCCC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422095 IC50 1.1 nM
Cc1cc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(F)c(F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3984609 IC50 1.1 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)cc4)cc32)ccc1C(=O)NC1CC1 CHEMBL3963313 IC50 1.1 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)cc4F)cc32)ccc1C(=O)NC1CC1 CHEMBL3939360 IC50 1.1 nM
Cc1cc(-c2cnn3c(NC[C@H]4C[C@H](O)C4)cc(Oc4cccnc4)nc23)ccc1C(=O)NC1CC1 CHEMBL4526755 IC50 1.1 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NC(=O)c4cccc5ccccc45)CC3)c2n1 CHEMBL4859914 Kd 1.1 nM
O=C(N[C@H](c1ccccn1)C1CCCC1)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1 CHEMBL3422086 IC50 1.2 nM
O=C(N[C@H](c1ccccn1)C1CC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422091 IC50 1.2 nM
COC(=O)CCC#Cc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3974177 IC50 1.2 nM
Cc1ccc(F)cc1Nc1cc(NCC2CCOCC2)c2ncn(-c3ccc(C(=O)NC4CC4)c(C)c3)c2c1 CHEMBL3936009 IC50 1.2 nM
CCc1n[nH]c(CC)c1NC(=O)c1ccn2c1CCc1cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc1-2 CHEMBL5419030 IC50 1.2 nM
N#Cc1ccc(-c2cc(NCC3CCOCC3)c3ncc(-c4ccc(C(=O)NC5CC5)cc4)n3n2)c(N)c1 CHEMBL3410073 IC50 1.3 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC3CCCCC3)c2n1 CHEMBL3808500 Ki 1.3 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(OC(F)F)cc4)cc32)ccc1C(=O)NC1CC1 CHEMBL3982746 IC50 1.3 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc(OC2CCCC2)c2cc[nH]c2n1 CHEMBL4585148 IC50 1.3 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc(OC2CCCCC2)c2cc[nH]c2n1 CHEMBL4530475 IC50 1.3 nM
COc1cc(N2CCN(C(=O)CO)CC2)ccc1Nc1nc(O[C@H]2CCOC(C)(C)C2)c2cc[nH]c2n1 CHEMBL4521278 IC50 1.3 nM
O=C(N[C@H](c1ccccn1)C1CC1)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1 CHEMBL3422084 IC50 1.4 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(F)c(F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3939373 IC50 1.4 nM
CC(C)CNc1nccn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3410060 IC50 1.4 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc2ccc(-c3ccc(NC(=O)Cc4ccc(F)cc4)cc3)cn2n1 CHEMBL4638962 IC50 1.4 nM
COc1cc(S(C)(=O)=O)ccc1Nc1nc2ccc(-c3ccc(NC(=O)Cc4ccc(F)cc4)cc3)cn2n1 CHEMBL4632648 IC50 1.4 nM
O=C(N[C@H](CC1CC1)c1ccccn1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422099 IC50 1.5 nM
Cc1ccc(F)cc1Nc1cc(NCCC(F)(F)F)c2ncn(-c3ccc(C(=O)NC4CC4)c(C)c3)c2c1 CHEMBL3922224 IC50 1.5 nM
Cc1cc(-n2cnc3c(NCC4CCOCC4)cc(-c4ccccc4CO)cc32)ccc1C(=O)NC1CC1 CHEMBL3966584 IC50 1.5 nM
COc1cc(C(=O)N2CC(F)C2)ccc1Nc1nc2ccc(-c3ccc(NC(=O)Cc4ccc(F)cc4)cc3)cn2n1 CHEMBL4645182 IC50 1.5 nM
CCC(=O)N[C@H]1CC[C@@H](n2c(=O)cc(CC)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)CC1 CHEMBL4874692 Kd 1.5 nM
CC(C)C[C@H](NC(=O)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1)c1ccccn1 CHEMBL3422097 IC50 1.7 nM
O=C(NC1CC1)c1ccc(-c2cnn3c(NCC4CCOCC4)nc(Oc4ccccc4)nc23)cc1Cl CHEMBL3818403 IC50 1.7 nM
CC(C)CNc1nc(C#CCc2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3965241 IC50 1.7 nM
Cc1cc(N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047943 IC50 1.8 nM
O=C(N[C@H](c1ccccn1)C1CCCC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422093 IC50 1.8 nM
CNC(=O)CCC#Cc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3982814 IC50 1.8 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(-c4ccccc4CO)cc32)ccc1C(=O)NC1CC1 CHEMBL3933630 IC50 1.8 nM
Cc1cc(F)cc(Oc2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)c1 CHEMBL3918654 IC50 1.8 nM
COc1ccc(C(O)c2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1F CHEMBL3915482 IC50 1.8 nM
Cc1cc(-c2cnn3c(NC[C@H]4CC[C@@H](O)CC4)cc(Oc4cccnc4)nc23)ccc1C(=O)NC1CC1 CHEMBL4579057 IC50 1.8 nM
CC[C@@H](NC(=O)c1ccc2[nH]nc(-c3ccc(OC4CCN(C)CC4)cc3)c2c1)c1ccccc1Cl CHEMBL3422063 IC50 1.9 nM
C/C=C(/C)c1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3952906 IC50 1.9 nM
CC(C)CNc1nc(/C=C2\CCC(=O)N2C)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3959560 IC50 1.9 nM
CC(C)CNc1cc(-c2ccc(F)cc2)cc2c1ncn2-c1ccc(C(=O)NC2CC2)cc1 CHEMBL3959905 IC50 1.9 nM
CCNC(=O)c1ccc(-c2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1C CHEMBL3941853 IC50 1.9 nM
COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047959 IC50 2.0 nM
COc1cc(N2CCN(S(=O)(=O)CCCN3CCOCC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047960 IC50 2.0 nM
COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1Nc1ncc2cccc(NC3CCCCC3)c2n1 CHEMBL3092039 IC50 2.0 nM
CC(C)[C@H](NC(=O)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1)c1ccccc1Cl CHEMBL3422083 IC50 2.0 nM
O=C(N[C@@H](c1ccccn1)C1CC1)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1 CHEMBL3422085 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC4CCOCC4)c3)ccc2cn1 CHEMBL3952050 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC(F)F)c3)ccc2cn1 CHEMBL3956584 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3ccc(C)nc3)ccc2cn1 CHEMBL3972834 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C)c3C)ccc2cn1 CHEMBL3971185 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C)c3)ccc2cn1 CHEMBL3964886 IC50 2.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(C)c3)ccc2cn1 CHEMBL3893520 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3897070 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC4(C)COC4)c3)ccc2cn1 CHEMBL3927384 IC50 2.0 nM
COCCn1cc(-c2ccc3cnc(Nc4ccc(-c5cnc(C)n5CCOC)cc4OC)cc3c2)cn1 CHEMBL3960490 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC(C)O)c3)ccc2cn1 CHEMBL3889988 IC50 2.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3921962 IC50 2.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3942820 IC50 2.0 nM
COc1c(Nc2cc3cc(-c4cnn(CC(C)(C)O)c4)ccc3cn2)ccc(-c2cnc(C)n2C)c1F CHEMBL3936321 IC50 2.0 nM
COc1cc(C(=O)N(C)C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3935724 IC50 2.0 nM
COc1cc(C(=O)NCCO)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3959731 IC50 2.0 nM
COc1cc(C(=O)N2CCS(=O)(=O)CC2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3938080 IC50 2.0 nM
COc1cc(C(=O)N2CCN(C)CC2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3897048 IC50 2.0 nM
COc1cc(-c2cnc(C)n2CC(C)(C)O)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3969515 IC50 2.0 nM
COc1cc(-c2nnc3n2CCN(C)C3)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3908069 IC50 2.0 nM
COC1CN(C(=O)c2ccc(Nc3cc4cc(-c5cnn(CC(C)(C)O)c5)ccc4cn3)c(OC(F)F)c2)C1 CHEMBL3940014 IC50 2.0 nM
CCOc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3977950 IC50 2.0 nM
COc1cc(C(=O)N2CCC(C#N)CC2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3892624 IC50 2.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cn(CC(C)(C)O)nn3)ccc2cn1 CHEMBL3959093 IC50 2.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2nc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3971255 IC50 2.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2nc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3960193 IC50 2.0 nM
COc1cccc(Oc2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)c1 CHEMBL3961732 IC50 2.0 nM
COc1cc(-c2cncn2C)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3962472 IC50 2.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3(C)COC3)c2n1 CHEMBL3911468 IC50 2.0 nM
COc1cc(-c2cnn(C)c2C)ccc1Nc1ncc2ccnc(N3CCC4(COC4)C3)c2n1 CHEMBL3906901 IC50 2.0 nM
COc1cc(-c2cnn(C)c2C)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3919425 IC50 2.0 nM
COc1cc(-c2nncn2C)ccc1Nc1ncc2c(C)cnc(NCC(C)(C)C)c2n1 CHEMBL3897889 IC50 2.0 nM
COc1cc(-c2nnnn2C)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3925302 IC50 2.0 nM
COc1cc(-c2nncn2C)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3890427 IC50 2.0 nM
COc1cc(-c2cnn(C)c2CO)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3910642 IC50 2.0 nM
COCCn1c(-c2ccc(Nc3ncc4ccnc(NCC5(C)CCOC5)c4n3)c(OC)c2)cnc1C CHEMBL3919267 IC50 2.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3946383 IC50 2.0 nM
COc1cc(-c2cn(C)nc2C)ccc1Nc1ncc2ccnc(NCC3(C)CCOC3)c2n1 CHEMBL3940708 IC50 2.0 nM
COC(C)(C)CNc1nccc2cnc(Nc3ccc(-c4cnn(C)c4)cc3OC(F)F)nc12 CHEMBL3943432 IC50 2.0 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)cc(N[C@H]4CCCC[C@H]4O)nc23)ccc1C(=O)NC1CC1 CHEMBL4467062 IC50 2.0 nM
N#Cc1ccccc1Nc1nc2ccc(-c3ccc(NC(=O)Cc4ccc(F)cc4)cc3)cn2n1 CHEMBL4635693 IC50 2.0 nM
CC(C)CNc1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL4649817 IC50 2.0 nM
COc1ccccc1-c1cc(NCCC(F)(F)F)c2ncc(-c3ccc(C(=O)NC4CC4)c(C)c3)n2c1 CHEMBL4637496 IC50 2.0 nM
CCc1cccc(CC)c1NC(=O)c1ccn(-c2nc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)cc3OC)nc3[nH]ccc23)c1 CHEMBL5081270 IC50 2.0 nM
CCc1cccc(CC)c1NC(=O)c1ccn(-c2nc(Nc3ccc(N4CCC(O)(C(=O)N5CCN(C)CC5)CC4)cc3OC)nc3[nH]ccc23)c1 CHEMBL5075313 IC50 2.0 nM
CCc1cccc(CC)c1NC(=O)c1cc(-c2nc(Nc3ccc(N4CCC(O)(CN5CCN(C)CC5)CC4)cc3OC)nc3[nH]ccc23)n(C)n1 CHEMBL5077668 IC50 2.0 nM
CCc1cccc(CC)c1NC(=O)c1ccn(-c2nc(Nc3ccc(N4CCC(C(=O)N5CCN(C)CC5)CC4)cc3OC)nc3[nH]ccc23)c1 CHEMBL5073101 IC50 2.0 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4F)cc32)cc1C CHEMBL3940120 IC50 2.1 nM
C=C(c1ccc(OC)c(F)c1)c1cc(NCCC(F)(F)F)c2ncn(-c3ccc(C(=O)NC4CC4)c(C)c3)c2c1 CHEMBL3987030 IC50 2.1 nM
O=C(N[C@@H](c1ccccn1)C1CCCC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5COC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422102 IC50 2.2 nM
Cc1cc(-c2cnn3c(NCCN4CCOCC4)nc(Oc4cccc(F)c4F)nc23)ccc1C(=O)NC1CC1 CHEMBL3819003 IC50 2.2 nM
Cc1cc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(Cl)cc4)cc32)ccc1C(=O)NC1CC1 CHEMBL3982309 IC50 2.2 nM
Cc1cc(-c2cnn3c(NCCN4CCOCC4)cc(Oc4cccc(F)c4)nc23)ccc1C(=O)NC1CC1 CHEMBL4541788 IC50 2.2 nM
Cc1cc(-c2cnn3c(NCC4CC4)cc(N[C@@H]4CCCC[C@H]4O)nc23)ccc1C(=O)NC1CC1 CHEMBL4444859 IC50 2.2 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(OC4CCCC4)nc23)ccc1C(=O)NC1CC1 CHEMBL3818533 IC50 2.3 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Nc4cccc(F)c4F)cc32)ccc1C(=O)NC1CC1 CHEMBL3954600 IC50 2.3 nM
CC(C)CNc1nc(C#Cc2ccc(C(N)=O)cc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3936426 IC50 2.4 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(Cl)cc4)cc32)ccc1C(=O)NC1CC1 CHEMBL3915035 IC50 2.4 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)c(F)c4)cc32)cc1C CHEMBL3951663 IC50 2.4 nM
Cc1cc(-c2cnn3c(NC[C@H]4C[C@H](O)C4)cc(NC4CCCC4)nc23)ccc1C(=O)NC1CC1 CHEMBL4443683 IC50 2.4 nM
Cc1cc(-c2cnn3c(NC[C@H]4C[C@](C)(O)C4)cc(Oc4cccnc4)nc23)ccc1C(=O)NC1CC1 CHEMBL4442392 IC50 2.4 nM
O=CN1[C@@H]2CC[C@H]1C[C@@H](Oc1ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccsc5)C5CCC5)cc34)cc1)C2 CHEMBL3422077 IC50 2.5 nM
CC(C)CNc1nc(C#CC(C)(C)O)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3892256 IC50 2.5 nM
CC(C)CNc1nc(C#Cc2ccc(S(N)(=O)=O)cc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3924045 IC50 2.5 nM
COc1cc(N2CCN(C3COC3)CC2)ccc1Nc1nc(O[C@H]2CCOC(C)(C)C2)c2cc[nH]c2n1 CHEMBL4569626 IC50 2.5 nM
Cc1nc(N2CCOCC2)ccc1Nc1nc(NC2CCOCC2)c2c(C#N)c[nH]c2n1 CHEMBL4450240 IC50 2.5 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)cc(Oc4ccccc4)nc23)ccc1C(=O)NC1CC1 CHEMBL4453553 IC50 2.5 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCN(C(C)=O)CC5)cc4OC)nc4[nH]ncc34)cc2C1=O CHEMBL5410634 IC50 2.596 nM
CN1CCC(Oc2ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccccc5)C5CC5)cc34)cc2)CC1 CHEMBL3422062 IC50 2.6 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(NC4CCCCC4)nc23)ccc1C(=O)NC1CC1 CHEMBL3817905 IC50 2.6 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(S(C)(=O)=O)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3962914 IC50 2.6 nM
Cc1cc(-c2cnn3c(NC[C@H]4C[C@@](C)(O)C4)cc(NC4CCCC4)nc23)ccc1C(=O)NC1CC1 CHEMBL4436045 IC50 2.6 nM
CN(C)CCCc1ccc(-c2n[nH]c3ccc(NC(=O)C(c4ccsc4)N4CCCC4)cc23)cc1S(C)(=O)=O CHEMBL3422053 IC50 2.7 nM
CN1CCC(Oc2ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccsc5)C5CCCC5)cc34)cc2)CC1 CHEMBL3422069 IC50 2.7 nM
CC(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1)c1ccccn1 CHEMBL3422098 IC50 2.7 nM
Cc1cc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(Cl)c(F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3929316 IC50 2.7 nM
COc1ccc(C(C)(O)c2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1F CHEMBL3962882 IC50 2.7 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)cc(N[C@H]4CCC[C@H]4O)nc23)ccc1C(=O)NC1CC1 CHEMBL4586082 IC50 2.7 nM
CN1[C@@H]2CC[C@H]1C[C@@H](Oc1ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccccc5)C5CC5)cc34)cc1)C2 CHEMBL3422075 IC50 2.8 nM
O=C(N[C@H](c1ccccc1)C1CC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422090 IC50 2.8 nM
c1nc2c(NC3CCCCC3)nc(Nc3ccc(N4CCOCC4)cc3)nc2[nH]1 CHEMBL188343 IC50 2.8 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3CC3)c2n1 CHEMBL3809925 Ki 2.8 nM
Cc1cc(-c2cnc3c(NCC4CCOCC4)cc(NC4CCCC4)nn23)ccc1C(=O)NC1CC1 CHEMBL3819182 IC50 2.8 nM
CC(C)CNc1nc(C2CC=CCC2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3916128 IC50 2.8 nM
COc1cccc(Nc2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)c1C CHEMBL3939024 IC50 2.8 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(C(F)F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3912036 IC50 2.8 nM
Cc1cc(-c2cnn3c(NC[C@H]4CC[C@H](O)CC4)cc(Oc4cccnc4)nc23)ccc1C(=O)NC1CC1 CHEMBL4540859 IC50 2.8 nM
CCC(=O)N[C@H]1CC[C@H](n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)CC1 CHEMBL4850608 Kd 2.8 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCC(O)(CN6CCN(C)CC6)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5081668 IC50 2.8 nM
NS(=O)(=O)c1cccc(-c2n[nH]c3ccc(NC(=O)C(c4ccsc4)N4CCCC4)cc23)c1 CHEMBL3330410 IC50 2.9 nM
COc1ccc(C(C)c2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1F CHEMBL3897511 IC50 2.9 nM
COc1ccc(Oc2cc(NCC3CCOCC3)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)c(SC)c1 CHEMBL3973829 IC50 2.9 nM
FC(F)(F)c1cc(N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047957 IC50 3.0 nM
COc1cc(N2CCN(C(=O)C3CCC(O)CC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047961 IC50 3.0 nM
COc1cc(N2CCN(C(=O)N3CCN(C)CC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047962 IC50 3.0 nM
COc1cc(N2CCN(C(=O)c3ccccn3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047964 IC50 3.0 nM
COc1cc(N2CCC(CC(=O)N3CCOCC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047972 IC50 3.0 nM
Cn1cc(-c2cc3cnc(Nc4ccc(-c5cncn5C)cc4Cl)cc3n2C(=O)OC(C)(C)C)cn1 CHEMBL3109945 IC50 3.0 nM
CN1CCC(Oc2ccc(-c3n[nH]c4ccc(NC(=O)C(c5ccsc5)N5CCCC5)cc34)cc2)CC1 CHEMBL3422058 IC50 3.0 nM
CC(C)CC(NC(=O)c1ccc2[nH]nc(-c3ccc(O[C@H]4C[C@H]5CC[C@@H](C4)N5C=O)cc3)c2c1)c1ccccn1 CHEMBL3422078 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C(C)C)c3)ccc2cn1 CHEMBL3923341 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cccnc3)ccc2cn1 CHEMBL3954800 IC50 3.0 nM
COc1cc(-c2cncn2C)ccc1Nc1cc2cc(-c3cnn(C)c3)ccc2cn1 CHEMBL3941591 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC4CCC4)c3)ccc2cn1 CHEMBL3903589 IC50 3.0 nM
COCCn1cc(-c2ccc3cnc(Nc4ccc(-c5cnc(C)n5CO)cc4OC)cc3c2)cn1 CHEMBL3967363 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C4COC4)c3)ccc2cn1 CHEMBL3986659 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C)c3CO)ccc2cn1 CHEMBL3915292 IC50 3.0 nM
COCCn1c(-c2ccc(Nc3cc4cc(-c5cnn(CC(C)(C)O)c5)ccc4cn3)c(OC)c2)cnc1C CHEMBL3966393 IC50 3.0 nM
COc1cc(-c2cnn(C)c2CO)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3915212 IC50 3.0 nM
Cc1ncc(-c2ccc(Nc3cc4cc(-c5cnn(CC(C)(C)O)c5)ccc4cn3)c(Cl)c2)n1C CHEMBL3967693 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC4(O)CCC4)c3)ccc2cn1 CHEMBL3900025 IC50 3.0 nM
COc1cc(-c2nnc3n2CCN(C(=O)OC(C)(C)C)C3)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3983963 IC50 3.0 nM
COc1nc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3962312 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)cnc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3934867 IC50 3.0 nM
COCCNC(=O)c1ccc(Nc2cc3cc(-c4cnn(CC(C)(C)O)c4)ccc3cn2)c(OC)c1 CHEMBL3913367 IC50 3.0 nM
COCCn1cc(-c2ccc3cnc(Nc4ccc(C(=O)N5CC(OC)C5)cc4OC)cc3c2)cn1 CHEMBL3936452 IC50 3.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)OC)c3)ccc2cn1 CHEMBL3966077 IC50 3.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(CC(O)C(F)(F)F)c3)ccc2cn1 CHEMBL3939833 IC50 3.0 nM
COc1cc(S(=O)(=O)N(C)C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3915669 IC50 3.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(CC(O)CO)c3)ccc2cn1 CHEMBL3955395 IC50 3.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(C4CCCC4O)c3)ccc2cn1 CHEMBL3952480 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C[C@@H](C)O)c3)ccc2cn1 CHEMBL4114209 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1cc2nc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3938200 IC50 3.0 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4O)cc32)cc1C CHEMBL3948697 IC50 3.0 nM
COc1cc(-c2cnn(CCN3CCN(C)CC3)c2)ccc1Nc1ncc2ccnc(NC3CCCCC3)c2n1 CHEMBL3930923 IC50 3.0 nM
COc1cc(-c2cnn(CCN(C)C)c2)ccc1Nc1ncc2ccnc(NC3CCCCC3)c2n1 CHEMBL3976598 IC50 3.0 nM
COc1cc(-c2cnn(CCO)c2)ccc1Nc1ncc2ccnc(NC3CCOCC3)c2n1 CHEMBL3890400 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCOCC3)c2n1 CHEMBL3939747 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC3CCOCC3)c2n1 CHEMBL3907465 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCC4(COC4)C3)c2n1 CHEMBL3893532 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CC4(COC4)C3)c2n1 CHEMBL3941982 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3(C)CCOC3)c2n1 CHEMBL3915042 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CC4(CCOCC4)C3)c2n1 CHEMBL3970871 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CC4(CCOC4)C3)c2n1 CHEMBL3901324 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCC4(CCOC4)C3)c2n1 CHEMBL3907282 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC(C)C3CCOC3)c2n1 CHEMBL3944189 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCC(CO)C3)c2n1 CHEMBL3908752 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1NC1=Nc2c(ccnc2N)CN1C[C@@]1(C)CCOC1 CHEMBL3952394 IC50 3.0 nM
COc1cc(-c2cnn(C)c2)ccc1NC1=Nc2c(ccnc2N)CN1C[C@]1(C)CCOC1 CHEMBL3941672 IC50 3.0 nM
COc1cc(-c2cnn(C)c2C)ccc1Nc1ncc2ccnc(NCC3(C)CCOC3)c2n1 CHEMBL3920481 IC50 3.0 nM
COc1cc(-c2nncn2C)ccc1Nc1ncc2c(C)cnc(NCC(C)(C)OC)c2n1 CHEMBL3929386 IC50 3.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)OC)c2n1 CHEMBL3912889 IC50 3.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(N3CC4(CCOC4)C3)c2n1 CHEMBL3907428 IC50 3.0 nM
COc1nc(-c2cnc(C)n2C)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3900773 IC50 3.0 nM
COc1nc(-c2cn(C)nc2C)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3925962 IC50 3.0 nM
COc1nc(-c2cnn(C)c2C)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3901423 IC50 3.0 nM
COc1nc(-c2cncn2C)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3956274 IC50 3.0 nM
COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3967187 IC50 3.0 nM
COc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)OC)c2n1 CHEMBL3917528 IC50 3.0 nM
COc1cc(-c2cn(C)nc2C)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3966905 IC50 3.0 nM
Cc1cc(-c2cnn3c(NCCN4CCOCC4)cc(Oc4ccccc4)nc23)ccc1C(=O)NC1CC1 CHEMBL4570284 IC50 3.0 nM
CC(C)CNc1nccn2c(-c3ccc4c(N)n[nH]c4c3)cnc12 CHEMBL4649445 IC50 3.0 nM
CC(C)CNc1cc(-c2ccccc2)nn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL4635532 IC50 3.0 nM
CCc1cccc(CC)c1NC(=O)c1cc(-c2nc(Nc3ccc(N4CCN(CC(=O)N(C)C)CC4)cc3OC)nc3[nH]ccc23)n(C)n1 CHEMBL5091689 IC50 3.0 nM
CCc1cccc(CC)c1NC(=O)c1cc(-c2nc(Nc3ccc(N4CCC(O)(C(=O)N5CCN(C)CC5)CC4)cc3OC)nc3[nH]ccc23)n(C)n1 CHEMBL5084062 IC50 3.0 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCC(C(=O)N6CC7(CN(C)C7)C6)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5085753 IC50 3.0 nM
CCOc1cc2c(-c3cccc(S(N)(=O)=O)c3)n[nH]c2cc1-c1cnn(C)c1 CHEMBL2380582 IC50 3.06 nM
CC(C)CNc1nc(C#CC(C)(C)C)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3914268 IC50 3.1 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(Cl)c(F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3968035 IC50 3.1 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(O)c4)cc32)cc1C CHEMBL3968179 IC50 3.1 nM
CC(C)(C)Nc1cc(NCC2CCOCC2)c2ncc(-c3ccc(C(=O)NC4CC4)cc3)n2n1 CHEMBL3410083 IC50 3.2 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(OC(F)F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3954178 IC50 3.2 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc(OC(C)C)c2cc[nH]c2n1 CHEMBL4467041 IC50 3.2 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)cc(NC4CCCC4)nc23)ccc1C(=O)NC1CC1 CHEMBL4456423 IC50 3.2 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2c(C#N)c[nH]c2n1 CHEMBL5092617 IC50 3.2 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCCC3)c2n1 CHEMBL3809219 Ki 3.3 nM
CCNC(=O)c1ccc(-n2cnc3c(NCC4CCOCC4)cc(Oc4cccc(F)c4F)cc32)cc1C CHEMBL3909667 IC50 3.3 nM
CCc1cccc(CC)c1NC(=O)c1ccn(-c2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc3[nH]ncc23)c1 CHEMBL5410080 IC50 3.371 nM
CC(C)CC#Cc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3945786 IC50 3.4 nM
CNC(=O)c1ccc(-n2cnc3c(NCC4CCOCC4)cc(Oc4cccc(F)c4F)cc32)cc1C CHEMBL3941117 IC50 3.4 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)c(F)c4)cc32)cc1C CHEMBL3957152 IC50 3.4 nM
CCc1cccc(CC)c1NC(=O)Nc1ccc2[nH]nc(-c3cccc(S(N)(=O)=O)c3)c2c1 CHEMBL3330260 IC50 3.5 nM
O=C(Cc1ccc(F)cc1)Nc1ccc(-c2ccc3nc(Nc4ccc(C(=O)N5CCOCC5)cc4)nn3c2)cc1 CHEMBL4638150 IC50 3.5 nM
CCc1ccccc1C(C(=O)Nc1ccc2[nH]nc(-c3cccc(S(N)(=O)=O)c3)c2c1)N(C)C CHEMBL3330409 IC50 3.6 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCC4CCOCC4)cc(Oc4ccccc4)nn23)cc1 CHEMBL3410075 IC50 3.6 nM
CNC(=O)c1ccc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(O)c(F)c4)cc32)cc1C CHEMBL3963479 IC50 3.6 nM
CCOc1cc2c(-c3ccc(C)c(S(N)(=O)=O)c3)n[nH]c2cc1-c1cnn(C)c1 CHEMBL2380583 IC50 3.67 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCC4CCOCC4)cc(Oc4ccccc4F)nn23)cc1 CHEMBL3410077 IC50 3.7 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC(C)C)c2n1 CHEMBL3809287 Ki 3.7 nM
CC(C)CNc1nc(C#CCN(C)Cc2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3904212 IC50 3.7 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(SCCCCO)nc(-c4ccccc4)cn23)cc1 CHEMBL3889635 IC50 3.7 nM
Cc1cc(-c2cnn3c(NC[C@H]4C[C@@](C)(O)C4)cc(Oc4ccccn4)cc23)ccc1C(=O)NC1CC1 CHEMBL5093783 IC50 3.8 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nc(-n2ccc(C(=O)Nc3c(C)cccc3C)c2)c2cn[nH]c2n1 CHEMBL5417870 IC50 3.808 nM
O=C(N[C@@H](c1ncccn1)C1CCCC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422096 IC50 3.9 nM
CCCCC[C@@H](O)C#Cc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL4113454 IC50 3.9 nM
CC(C)CNc1nc(C2=CCCC2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3908179 IC50 3.9 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(OC)c(F)c4)cc32)cc1C CHEMBL3977818 IC50 3.9 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(C(=O)NC5CC5)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3939416 IC50 3.9 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Nc4ccccc4O)cc32)ccc1C(=O)NC1CC1 CHEMBL3936434 IC50 3.9 nM
N#Cc1ccccc1Nc1nc2ccc(-c3ccc(NC(=O)CCC4CC4)cc3)cn2n1 CHEMBL4633081 IC50 3.9 nM
CCC(=O)N[C@H]1CC[C@@H](n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)CC1 CHEMBL4863607 Kd 3.9 nM
COc1cc(N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047955 IC50 4.0 nM
COc1cc(N2CCC(C(=O)N3CCC(N(C)C)C3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047969 IC50 4.0 nM
COc1cc(N2CCC(C(=O)N3CCOCC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047970 IC50 4.0 nM
CCN(CC)CC1CCN(c2ccc(Nc3nc(NC4CCCCC4)c4nc[nH]c4n3)c(OC)c2)CC1 CHEMBL2048079 IC50 4.0 nM
COc1cc(N2CCC(C(=O)N3CC(O)C3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2048082 IC50 4.0 nM
CN(C)C1CCN(C(=O)c2ccc(Nc3cc4c(cn3)cc(-c3cnn(C)c3)n4C(=O)OC(C)(C)C)c(Cl)c2)CC1 CHEMBL3109938 IC50 4.0 nM
NS(=O)(=O)c1cccc(-c2n[nH]c3ccc(C(=O)NC(c4ccsc4)C4CC4)cc23)c1 CHEMBL3330282 IC50 4.0 nM
CN1CCC(Oc2ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccccn5)C5CCCC5)cc34)cc2)CC1 CHEMBL3422071 IC50 4.0 nM
CC(C)C[C@H](NC(=O)c1ccc2[nH]nc(-c3ccc(N4[C@H]5COC[C@H]4CC(O)C5)cc3)c2c1)c1ccccn1 CHEMBL3422101 IC50 4.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnco3)ccc2cn1 CHEMBL3950999 IC50 4.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cncs3)ccc2cn1 CHEMBL3947731 IC50 4.0 nM
Cc1ncc(-c2ccc(Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)c(Cl)c2)n1C CHEMBL3979350 IC50 4.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnnn3C)ccc2cn1 CHEMBL3928685 IC50 4.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC(F)(F)F)c3)ccc2cn1 CHEMBL3968867 IC50 4.0 nM
COCc1c(-c2ccc(Nc3cc4cc(-c5cnn(CC(C)(C)O)c5)ccc4cn3)c(OC)c2)cnn1C CHEMBL3934743 IC50 4.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3931863 IC50 4.0 nM
COc1cc(-c2cnn(C)c2C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3920860 IC50 4.0 nM
CC(C)(O)Cn1cc(-c2ccc3cnc(Nc4ccc(S(C)(=O)=O)cc4Cl)cc3c2)cn1 CHEMBL3936850 IC50 4.0 nM
CCC(O)Cn1cc(-c2ccc3cnc(Nc4ccc(C(=O)N5CC(OC)C5)cc4OC)cc3c2)cn1 CHEMBL3953896 IC50 4.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(CC(O)C(C)C)c3)ccc2cn1 CHEMBL3948589 IC50 4.0 nM
CNC(=O)c1ccc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(OC)c(F)c4)cc32)cc1C CHEMBL3958092 IC50 4.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1ncc2ccnc(-c3cnn(C)c3)c2n1 CHEMBL3902936 IC50 4.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC(C)(C)CO)c2n1 CHEMBL3955250 IC50 4.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC(C)C3CC3)c2n1 CHEMBL3956968 IC50 4.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC(CO)CO)c2n1 CHEMBL3914990 IC50 4.0 nM
COCC(CO)Nc1nccc2cnc(Nc3ccc(-c4cnn(C)c4)cc3OC)nc12 CHEMBL3942968 IC50 4.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCCC(CO)C3)c2n1 CHEMBL3965853 IC50 4.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCOC(CO)C3)c2n1 CHEMBL3951218 IC50 4.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCC(C#N)CC3)c2n1 CHEMBL3986071 IC50 4.0 nM
COc1cc(-c2cnn(C)c2C)ccc1Nc1ncc2ccnc(NCC3(C)COC3)c2n1 CHEMBL3943831 IC50 4.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3972481 IC50 4.0 nM
COc1cc(-c2nncn2C)ccc1Nc1ncc2c(C)cnc(NCC3(C)COC3)c2n1 CHEMBL3958301 IC50 4.0 nM
COc1cc(N2CCC(N3CCOCC3)CC2)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3973410 IC50 4.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3934920 IC50 4.0 nM
COCCn1c(-c2ccc(Nc3ncc4ccnc(NCC(C)(C)OC)c4n3)c(OC)c2)cnc1C CHEMBL3950465 IC50 4.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3947135 IC50 4.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1ncc2cc(C)nc(N3CCC3(C)C)c2n1 CHEMBL4242054 Ki 4.0 nM
C/C=C(\C)c1cn2c(-c3ccc(C(=O)NC4CC4)c(C)c3)cnc2c(NCCC(F)(F)F)n1 CHEMBL3908648 IC50 4.0 nM
CCc1cccc(CC)c1NC(=O)c1cc(-c2nc(Nc3ccc(N4CCC(C(=O)N5CCN(C)CC5)CC4)cc3OC)nc3[nH]ccc23)n(C)n1 CHEMBL5085278 IC50 4.0 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCC(N6CCN(C)CC6)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5086022 IC50 4.0 nM
CCc1cccc(CC)c1NC(=O)c1ccn(-c2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3OC)nc3[nH]ncc23)c1 CHEMBL5410578 IC50 4.026 nM
CN(C)CC(=O)N1CCC(Oc2ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccccc5)C5CC5)cc34)cc2)CC1 CHEMBL3422074 IC50 4.1 nM
O=C(N[C@@H](c1ccccn1)C1CCCC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422094 IC50 4.1 nM
CC(C)CNc1nc(C#CC2(O)CCCC2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3981317 IC50 4.1 nM
C/C=C(\C)c1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3979726 IC50 4.1 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4O)cc32)cc1C CHEMBL3945388 IC50 4.1 nM
N#Cc1ccc(-c2cc(NCC3CCOCC3)c3ncc(-c4ccc(C(=O)NC5CC5)cc4)n3n2)cc1 CHEMBL3410072 IC50 4.2 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCC4CCOCC4)cc(NC4CCCC4)nn23)cc1 CHEMBL3410081 IC50 4.2 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N[C@H](C)C(C)(C)C)c2n1 CHEMBL3809210 Ki 4.2 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)nc(C#CCN4CCS(=O)(=O)CC4)cn23)ccc1C(=O)NC1CC1 CHEMBL3985176 IC50 4.2 nM
CC(C)CNc1nc(C2=CCCCC2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3963266 IC50 4.2 nM
CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1 CHEMBL3904602 Kd 4.2 nM
CCC(=O)N[C@H]1CC[C@@H](n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)c(OC)c4)nc32)CC1 CHEMBL4853778 Kd 4.2 nM
CC(C)(C)CCS(=O)(=O)c1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3936082 IC50 4.3 nM
O=C(N[C@H](c1ccccc1F)C1CC1)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1 CHEMBL3422081 IC50 4.4 nM
O=C(N[C@@H](c1ccccn1)C1CCCC1)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1 CHEMBL3422087 IC50 4.6 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)cc4F)cc32)cc1C CHEMBL3891167 IC50 4.6 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)cc4F)cc32)cc1C CHEMBL3974414 IC50 4.6 nM
N#Cc1ccccc1Nc1nc2ccc(-c3ccc(NC(=O)CC(F)(F)F)cc3)cn2n1 CHEMBL4634241 IC50 4.6 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4)cc32)cc1C CHEMBL3892083 IC50 4.7 nM
O=C(N[C@@H](c1ccccc1F)C1CC1)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1 CHEMBL3422082 IC50 4.8 nM
CC(C)CNc1nc(C#CCO)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3969327 IC50 4.8 nM
CC(C)CNc1nc(C#CCC(C)O)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3905273 IC50 4.8 nM
CCCC(O)C#Cc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3891742 IC50 4.8 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(-c4ccnn4C)cc32)ccc1C(=O)NC1CC1 CHEMBL3891502 IC50 4.8 nM
COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1nc(OC2CCCC2)c2c(-c3ccc(OC)c(OC)c3)n[nH]c2n1 CHEMBL5397510 IC50 4.842 nM
O=C(NC1CC1)c1ccc(-c2cnn3c(NCC4CCOCC4)nc(Oc4ccccc4)nc23)cc1 CHEMBL3818766 IC50 4.9 nM
COc1cc(N2CCN(C(=O)N3CCC(O)C3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047966 IC50 5.0 nM
COc1cc(N2CCC(CN3CCOCC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047971 IC50 5.0 nM
COc1cc(N2CCC(CC(=O)N3CCN(C)CC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2048078 IC50 5.0 nM
COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1Nc1ncc2cccc(-c3ccccc3)c2n1 CHEMBL3092037 IC50 5.0 nM
Cn1cc(-c2cc3cnc(Nc4ccc(C(=O)N5CCS(=O)(=O)CC5)cc4Cl)cc3n2C(=O)OC(C)(C)C)cn1 CHEMBL3109939 IC50 5.0 nM
CSc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3950916 IC50 5.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnc(C)n3C)ccc2cn1 CHEMBL3967658 IC50 5.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC4COC4)c3)ccc2cn1 CHEMBL3964942 IC50 5.0 nM
CC(C)(O)Cn1cc(-c2ccc3cnc(Nc4ccc(-c5cncnc5)cc4Cl)cc3c2)cn1 CHEMBL3908898 IC50 5.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3947387 IC50 5.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(C(C)C(C)(C)O)c3)ccc2cn1 CHEMBL3941483 IC50 5.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(C4COCC4O)c3)ccc2cn1 CHEMBL3963197 IC50 5.0 nM
COc1cc(-c2cnc(C#N)n2C)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3905563 IC50 5.0 nM
CNC(=O)c1ccc2cnc(Nc3ccc(-c4cnc(C)n4C)cc3OC)cc2c1 CHEMBL3969576 IC50 5.0 nM
COc1cc(C(=O)N2CC(F)(F)C2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1 CHEMBL3945345 IC50 5.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C[C@H](C)O)c3)ccc2cn1 CHEMBL3898637 IC50 5.0 nM
COc1cc(-c2cn(C)nc2C)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3961036 IC50 5.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3COC3)c2n1 CHEMBL3897546 IC50 5.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3CCOC3)c2n1 CHEMBL3891081 IC50 5.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3979358 IC50 5.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3(O)CC3)c2n1 CHEMBL3957023 IC50 5.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N[S+]([O-])C(C)(C)C)c2n1 CHEMBL3957712 IC50 5.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(C3=CCOCC3)c2n1 CHEMBL3934857 IC50 5.0 nM
COc1cc(-c2nncn2C)ccc1Nc1ncc2c(C)cnc(NCC3(C)CCOC3)c2n1 CHEMBL3921877 IC50 5.0 nM
CCOc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCC4(COC4)C3)c2n1 CHEMBL3944328 IC50 5.0 nM
COc1cc(-c2cn(C)nc2C)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)OC)c2n1 CHEMBL3976429 IC50 5.0 nM
CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(-c4ccc5nc(C)oc5c4)c[nH]c3n2)c(OC)c1 CHEMBL4062218 IC50 5.0 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCCC(F)(F)F)nccn23)cc1 CHEMBL4647298 IC50 5.0 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)nc(CCc4ccccc4)cn23)ccc1C(=O)NC1CC1 CHEMBL4643612 IC50 5.0 nM
CC(C)CNc1cc(-c2ccccc2)cc2c1ncn2-c1ccc(C(=O)NC2CC2)cc1 CHEMBL3940165 IC50 5.0 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(S(=O)(=O)CCCCO)nc(-c4ccccc4)cn23)cc1 CHEMBL3962168 IC50 5.1 nM
CS(=O)(=NC(=O)C(F)(F)F)c1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3892540 IC50 5.2 nM
OCC#Cc1cn2c(-c3ccc(-c4cnc(C5CC5)[nH]4)cc3)cnc2c(NCC2CCC2)n1 CHEMBL3923312 IC50 5.3 nM
Cc1ccc(F)cc1Oc1cc(NCCC(F)(F)F)c2ncn(-c3ccc(C(=O)NC4CC4)c(C)c3)c2c1 CHEMBL3965094 IC50 5.3 nM
Cc1cc(-c2cnn3c(NC[C@H]4C[C@](C)(O)C4)cc(NC4CCCC4)nc23)ccc1C(=O)NC1CC1 CHEMBL4438979 IC50 5.3 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCC(C(=O)N(C)CCN(C)C)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5079606 IC50 5.3 nM
CC(C)Nc1cc(NCC2CCOCC2)c2ncc(-c3ccc(C(=O)NC4CC4)cc3)n2n1 CHEMBL3410082 IC50 5.5 nM
CNC(=O)NCCC#Cc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3899429 IC50 5.5 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)cc4)cc32)cc1C CHEMBL3960778 IC50 5.5 nM
Cc1nc(N2CCOCC2)ccc1Nc1nc(NC(C)(C)CO)c2c(C#N)c[nH]c2n1 CHEMBL4436510 IC50 5.5 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCC4CCOCC4)cc(Oc4ccc(F)cc4)nn23)cc1 CHEMBL3410076 IC50 5.6 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCC4CCOCC4)cc(NC4CCCCC4)nn23)cc1 CHEMBL3410080 IC50 5.6 nM
CCC(O)C#Cc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3928700 IC50 5.6 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(O)cc4)cc32)cc1C CHEMBL3963909 IC50 5.6 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(O)c4)cc32)cc1C CHEMBL3960929 IC50 5.6 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCC(C(=O)N6CCN(C)CC6)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5085182 IC50 5.6 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(NC4CCCC4)nc23)ccc1C(=O)NC1CC1 CHEMBL3819637 IC50 5.8 nM
C=C(C)c1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3955978 IC50 5.8 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(OC)c(F)c4)cc32)cc1C CHEMBL3952855 IC50 5.8 nM
CS(=O)(=O)c1cccc(-c2n[nH]c3ccc(NC(=O)C(c4ccsc4)N4CCCC4)cc23)c1 CHEMBL3422054 IC50 5.9 nM
CN(C)C(=O)c1ccc(Nc2cc3c(cn2)cc(-c2cnn(C)c2)n3C(=O)OC(C)(C)C)c(Cl)c1 CHEMBL3109933 IC50 6.0 nM
CC(C)[C@H](NC(=O)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1)c1ccccc1Cl CHEMBL3422089 IC50 6.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C4CCOCC4)c3)ccc2cn1 CHEMBL3914429 IC50 6.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(CC4COC(C)(C)O4)c3)ccc2cn1 CHEMBL3960118 IC50 6.0 nM
Cc1ncc(-c2ccc(Nc3cc4cc(-c5cnn(CC(C)(C)O)c5)ccc4cn3)cc2)n1C CHEMBL3916165 IC50 6.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2cc(-c3cnn(C(C)C(C)(C)O)c3)ccc2cn1 CHEMBL3962522 IC50 6.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1cc2nc(-c3cnn(C)c3)ccc2cn1 CHEMBL3976277 IC50 6.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2c(-c3cnn(C)c3)cccc2cn1 CHEMBL3913764 IC50 6.0 nM
Cc1ncc(-c2ccc(Nc3cc4c(-c5cnn(C)c5)cccc4cn3)c(Cl)c2)n1C CHEMBL3983562 IC50 6.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CC(F)(F)C3)c2n1 CHEMBL3892546 IC50 6.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC(C)(C)O)c2n1 CHEMBL3937781 IC50 6.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCC(O)C3)c2n1 CHEMBL3924360 IC50 6.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCN(S(C)(=O)=O)CC3)c2n1 CHEMBL3963190 IC50 6.0 nM
COc1cc(-c2nncn2C)ccc1Nc1ncc2c(C)cnc(N3CC4(CCOC4)C3)c2n1 CHEMBL3949656 IC50 6.0 nM
Clc1cc(-c2cncnc2)ccc1Nc1ncc2ccnc(N3CCC4(COC4)C3)c2n1 CHEMBL3943079 IC50 6.0 nM
CS(=O)(=O)c1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3983003 IC50 6.0 nM
CCc1cccc(CC)c1NC(=O)c1cc(-c2nc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)cc3OC)nc3[nH]ccc23)n(C)n1 CHEMBL5086435 IC50 6.0 nM
CC(C)CNc1nc(C#Cc2ccccn2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3979142 IC50 6.1 nM
CC(C)CNc1nc(C2CCCC2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3899442 IC50 6.1 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(C)cc(=O)n([C@H]3CC[C@@H](NCC4CC4)CC3)c2n1 CHEMBL4870731 Kd 6.1 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCOCC5)cc4OC)nc4[nH]ncc34)cc2C1=O CHEMBL5428851 IC50 6.14 nM
C/C=C/c1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3905045 IC50 6.2 nM
CC(C)CNc1nc(C2CC2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3977752 IC50 6.2 nM
O=C(NC1CC1)c1ccc(-c2cnc3c([S@+]([O-])CC(F)(F)F)nc(-c4ccccc4)cn23)cc1 CHEMBL3892762 IC50 6.2 nM
CCNC(=O)c1ccc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(O)c(F)c4)cc32)cc1C CHEMBL3987047 IC50 6.3 nM
N#Cc1ccccc1Nc1nc2ccc(-c3ccc(NC(=O)CC4CC4)cc3)cn2n1 CHEMBL4644831 IC50 6.3 nM
Cc1cc(N2CCOCC2)ccc1Nc1nc(NC2CCCCC2)c2c(C#N)c[nH]c2n1 CHEMBL5080463 IC50 6.3 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(S(C)(=O)=O)cc4)cc32)ccc1C(=O)NC1CC1 CHEMBL3925881 IC50 6.4 nM
COc1ccc(C(=O)c2cc(NCCC(F)(F)F)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1F CHEMBL3922969 IC50 6.4 nM
CC(C)CS(=O)(=O)c1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3969364 IC50 6.4 nM
CC(C)(C)Nc1nc(Nc2ccc(C(N)=O)cc2)cc(N)c1C#N CHEMBL2089255 IC50 6.4 nM
COc1cc(N2CCCC2=O)ccc1Nc1nc(NC2CCCCC2)c2c(C#N)c[nH]c2n1 CHEMBL5092060 IC50 6.4 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 6.5 nM
CC(C)CCS(=O)(=O)c1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3911744 IC50 6.5 nM
N#Cc1ccc(-c2cn3c(-c4ccc(C(=O)NC5CC5)cc4)cnc3c(NCC3CCOCC3)n2)cc1 CHEMBL3410071 IC50 6.6 nM
CCNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(F)c4)cc32)cc1C CHEMBL3938572 IC50 6.6 nM
CC(C)CNc1nc(C#CCN)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3919790 IC50 6.7 nM
CC(C)CNc1nc(C#Cc2cccc(O)c2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3965784 IC50 6.7 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(OCc5ccccc5)cc4)cc32)ccc1C(=O)NC1CC1 CHEMBL3911094 IC50 6.7 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(OC)cc4F)cc32)cc1C CHEMBL3955140 IC50 6.7 nM
COc1ccc(Oc2cc(NCC3CCOCC3)c3ncn(-c4ccc(C(=O)NC5CC5)c(C)c4)c3c2)cc1SC CHEMBL3918542 IC50 6.7 nM
CCNC(=O)c1ccc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(O)cc4F)cc32)cc1C CHEMBL3950164 IC50 6.7 nM
O=S1(=O)CCN(CC#Cc2cn3c(-c4ccc(-c5cnc(C6CC6)[nH]5)cc4)cnc3c(NCCC(F)(F)F)n2)CC1 CHEMBL3890816 IC50 6.8 nM
COc1c(F)cccc1Oc1cc(NCCC(F)(F)F)c2ncn(-c3ccc(C(=O)NC4CC4)c(C)c3)c2c1 CHEMBL3891496 IC50 6.8 nM
COc1cc(N2CCC(CC(=O)N3CCC(N(C)C)C3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2048080 IC50 7.0 nM
COc1cc(N2CCC(CC(=O)N3CCCC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2048081 IC50 7.0 nM
Cn1cc(-c2cc3cnc(Nc4ccc(C(=O)N5CCC5)cc4Cl)cc3n2C(=O)OC(C)(C)C)cn1 CHEMBL3109936 IC50 7.0 nM
COc1cc(OC2CCN(C)CC2)ccc1Nc1ncc2c(n1)n(C1CCCC1)c(=O)n2C CHEMBL2140523 IC50 7.0 nM
O=C(NC1CC1)c1ccc(-c2cnn3c(NCC4CCOCC4)nc(NC4CCCC4)nc23)cc1F CHEMBL3819164 IC50 7.0 nM
CCn1cc(-c2ccc3cnc(Nc4ccc(-c5cnc(C)n5C)cc4OC)cc3c2)cn1 CHEMBL3946697 IC50 7.0 nM
COCC1CN(C(=O)c2ccc(Nc3cc4cc(-c5cnn(CC(C)(C)O)c5)ccc4cn3)c(OC)c2)C1 CHEMBL3982743 IC50 7.0 nM
CCOc1cc(-c2nncn2C)ccc1Nc1cc2cc(-c3cnn(CC4(O)CCC4)c3)ccc2cn1 CHEMBL3893854 IC50 7.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1cc2nc(C(=O)N(C)C)ccc2cn1 CHEMBL3899024 IC50 7.0 nM
CNC(=O)c1ccc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(OC)cc4F)cc32)cc1C CHEMBL3950088 IC50 7.0 nM
COc1cc(-c2cncn2C)ccc1Nc1cc2c(-c3cnn(C)c3)cccc2cn1 CHEMBL3937996 IC50 7.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC3CCCC3)c2n1 CHEMBL3920802 IC50 7.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3(O)CCC3)c2n1 CHEMBL3962571 IC50 7.0 nM
COc1cc(-c2cnc(C)n2C)ccc1Nc1cc2c(-c3cnn(C)c3)nccc2cn1 CHEMBL3897816 IC50 7.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC(C)CO)c2n1 CHEMBL3936402 IC50 7.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCOC(C)C3)c2n1 CHEMBL3934763 IC50 7.0 nM
CCn1cc(-c2ccc(Nc3ncc4ccnc(NCC(C)(C)OC)c4n3)c(OC)c2)cn1 CHEMBL3901354 IC50 7.0 nM
COc1cc(C2CCOCC2)ccc1Nc1ncc2ccnc(NCC3(C)CCOC3)c2n1 CHEMBL3934282 IC50 7.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(-c3ccncc3)c2n1 CHEMBL3966906 IC50 7.0 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)cc(N[C@@H](C4CC4)C(C)(C)O)nc23)ccc1C(=O)NC1CC1 CHEMBL4542474 IC50 7.0 nM
Cc1cc(-c2ccc3nc(Nc4ccccc4C#N)nn3c2)cc(C)c1O CHEMBL4646296 IC50 7.0 nM
Cc1cc(-c2cnc3c(NCCC(F)(F)F)nc(C#N)cn23)ccc1C(=O)NC1CC1 CHEMBL4649409 IC50 7.0 nM
OCC#Cc1cn2c(-c3ccc(-c4cnc(C5CC5)[nH]4)cc3)cnc2c(NCCC(F)(F)F)n1 CHEMBL3891380 IC50 7.1 nM
COCc1cccc(-c2cn3c(-c4ccc(C(=O)NC5CC5)cc4)cnc3c(NCC(C)C)n2)c1 CHEMBL3901706 IC50 7.1 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(S(=O)(=O)Cc4ccco4)nc(-c4ccccc4)cn23)cc1 CHEMBL3924366 IC50 7.1 nM
CC(C)CNc1nc(C#CCNC(N)=O)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3894347 IC50 7.2 nM
Cc1cc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4ccc(F)c(C(F)(F)F)c4)cc32)ccc1C(=O)NC1CC1 CHEMBL3959748 IC50 7.2 nM
COc1cc(C(=O)N(C)C)ccc1Nc1nc(OC2COC2)c2cc[nH]c2n1 CHEMBL4547530 IC50 7.2 nM
CN1[C@@H]2CC[C@H]1C[C@H](Oc1ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccccc5)C5CC5)cc34)cc1)C2 CHEMBL3422076 IC50 7.3 nM
CNC(=O)c1ccc(-n2cnc3c(NCC4CCOCC4)cc(Oc4ccc(O)cc4F)cc32)cc1C CHEMBL3932135 IC50 7.3 nM
CN1CCN(c2ccc(-c3n[nH]c4ccc(NC(=O)C(c5ccsc5)N5CCCC5)cc34)cc2)CC1 CHEMBL3422056 IC50 7.4 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCC4CCOCC4)cc(OC4CCCCC4)nn23)cc1 CHEMBL3410074 IC50 7.5 nM
CCCCCS(=O)(=O)c1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3945141 IC50 7.5 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCC(O)(C(=O)N6CCN(C)CC6)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5077627 IC50 7.5 nM
CN1CCN(c2ccc(-c3n[nH]c4ccc(C(=O)NCC5(N6CCOCC6)CCCCC5)cc34)cc2)CC1 CHEMBL3422060 IC50 7.6 nM
CC(C)CNc1nc(C#CCCO)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3952552 IC50 7.6 nM
N#Cc1ccccc1Nc1nc2ccc(-c3ccc(C(=O)NCc4ccccc4)cc3)cn2n1 CHEMBL4646772 IC50 7.6 nM
CN1CCC(c2ccc(Nc3ncc4c(n3)-n3ccc(C(N)=O)c3CC4)cc2)CC1 CHEMBL5438574 IC50 7.6 nM
O=C(NCC1(N2CCOCC2)CCCCC1)c1ccc2[nH]nc(-c3ccc(N4CCOCC4)cc3)c2c1 CHEMBL3422067 IC50 7.7 nM
CCS(=O)(=O)c1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3940190 IC50 7.7 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(S(=O)(=O)C[C@H]4CCCO4)nc(-c4ccccc4)cn23)cc1 CHEMBL3927121 IC50 7.8 nM
CCC(=O)N[C@H]1CC[C@@H](n2c(=O)cc(C3CC3)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)CC1 CHEMBL4853433 Kd 7.9 nM
Cn1cc(-c2cc3[nH]nc(-c4cccc(S(N)(=O)=O)c4)c3cc2OC2CCCCC2)cn1 CHEMBL2380585 IC50 7.93 nM
COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1Nc1ncc2cccc(-c3cccnc3)c2n1 CHEMBL3092038 IC50 8.0 nM
Cn1cc(-c2cc3cnc(Nc4ccc(C(=O)N5CCS(=O)(=O)CC5)cc4Cl)cc3[nH]2)cn1 CHEMBL3109972 IC50 8.0 nM
CN1CCC(Oc2ccc(-c3n[nH]c4ccc(NC(=O)C(c5ccsc5)C5CCCC5)cc34)cc2)CC1 CHEMBL3422068 IC50 8.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(-c3cnn(C)c3)c2n1 CHEMBL3809656 IC50 8.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(CC4(O)CCC4)c3)ccc2cn1 CHEMBL3954076 IC50 8.0 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1 CHEMBL3935276 IC50 8.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCC4(CCC4)C3)c2n1 CHEMBL3980623 IC50 8.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC3CCOC3)c2n1 CHEMBL3940472 IC50 8.0 nM
CCOc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(-c3cnn(C)c3)c2n1 CHEMBL3808471 IC50 8.0 nM
Cc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3CC3)c2n1 CHEMBL3905145 IC50 8.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC3CCO3)c2n1 CHEMBL3943003 IC50 8.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CC(C#N)C3)c2n1 CHEMBL3895956 IC50 8.0 nM
COCCNc1nccc2cnc(Nc3ccc(-c4cnn(C)c4)cc3OC)nc12 CHEMBL3920865 IC50 8.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NCC(C)O)c2n1 CHEMBL3898257 IC50 8.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCC(OC)CC3)c2n1 CHEMBL3961196 IC50 8.0 nM
COc1cc(C(=O)N2CCN(C)CC2)ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1 CHEMBL3967347 IC50 8.0 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(SC[C@H]4CCCO4)nc(-c4ccccc4)cn23)cc1 CHEMBL3899078 IC50 8.0 nM
CC(C)CNc1ccnn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL4632548 IC50 8.0 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(S(=O)(=O)CC(F)(F)F)nc(-c4ccccc4)cn23)cc1 CHEMBL3923281 IC50 8.1 nM
O=C(N[C@H](c1ccccn1)C1CCCC1)c1ccc2[nH]nc(-c3ccc(N4C5CCCC4COC5)cc3)c2c1 CHEMBL3422088 IC50 8.3 nM
CC(C)(C)OC(=O)NCCCNc1nc(-c2ccncc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3979921 IC50 8.3 nM
CC(=O)Nc1cccc(Oc2nc(NCC3CCOCC3)n3ncc(-c4ccc(C(=O)NC5CC5)c(C)c4)c3n2)c1 CHEMBL3817949 IC50 8.4 nM
CC(C)CNc1nc(C#CCO)cn2c(-c3ccc(-c4cnc(C5CC5)[nH]4)cc3)cnc12 CHEMBL3943677 IC50 8.4 nM
O=C(NC1CC1)c1ccc(-c2cnc3c(NCC4CCOCC4)nc(-c4ccccc4)cn23)cc1 CHEMBL3410070 IC50 8.5 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1nc(-n2ccc(C(=O)Nc3c(C)cccc3C)c2)c2cn[nH]c2n1 CHEMBL5429411 IC50 8.516 nM
CSc1cn2c(-c3ccc(C(=O)NC4CC4)c(C)c3)cnc2c(NCCC(F)(F)F)n1 CHEMBL3896987 IC50 8.6 nM
CNC(=O)c1ccc(-n2cnc3c(NCCC(F)(F)F)cc(Oc4cccc(OC)c4)cc32)cc1C CHEMBL3948893 IC50 8.8 nM
NS(=O)(=O)c1cccc(-c2n[nH]c3ccc(NC(=O)C(c4ccccc4)N4CCCC4)cc23)c1 CHEMBL3330407 IC50 8.9 nM
C[S@@+]([O-])c1nc(-c2ccccc2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3954341 IC50 8.9 nM
CNC(=O)C(=O)N1CCN(c2ccc(Nc3nc(NC4CCCCC4)c4nc[nH]c4n3)c(OC)c2)CC1 CHEMBL2047963 IC50 9.0 nM
COc1cc(N2CCN(Cc3ccccn3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047965 IC50 9.0 nM
COc1cc(N2CCN(CC3CCOC3)CC2)ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1 CHEMBL2047967 IC50 9.0 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc2cccc(NC3CCCCC3)c2n1 CHEMBL3092036 IC50 9.0 nM
Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(NC4CCOCC4)nc23)ccc1C(=O)NC1CC1 CHEMBL3818733 IC50 9.0 nM
COCC(Cn1cc(-c2ccc3cnc(Nc4ccc(C(=O)N5CC(OC)C5)cc4OC)cc3c2)cn1)OC CHEMBL3950107 IC50 9.0 nM
COc1cc(C(=O)N2CC(OC)C2)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)n3)ccc2cn1 CHEMBL3984326 IC50 9.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(N3CCN(C)CC3)c2n1 CHEMBL3958074 IC50 9.0 nM
COc1cc(-c2cnn(C)c2)ccc1Nc1ncc2ccnc(NC3CCN(C)CC3)c2n1 CHEMBL3929447 IC50 9.0 nM
COc1cc(-c2cnn(C)c2CO)ccc1Nc1ncc2cc(C)nc(NCC(C)(C)OC)c2n1 CHEMBL3955235 IC50 9.0 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCN(CC(=O)N(C)C)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5087340 IC50 9.0 nM
CCC(=O)Nc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-n1ccc(C(=O)Nc3c(CC)cccc3CC)c1CC2 CHEMBL5077230 IC50 9.06 nM
CCC(=O)N1CCC(n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)CC1 CHEMBL4859127 Kd 9.3 nM
O=CN1CCC(Oc2ccc(-c3n[nH]c4ccc(C(=O)NC(c5ccccn5)C5CC5)cc34)cc2)CC1 CHEMBL3422073 IC50 9.4 nM
CC(O)C#Cc1cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc2c(NCC(C)C)n1 CHEMBL3980908 IC50 9.6 nM
CCOc1cc2c(-c3cccc(S(N)(=O)=O)c3)n[nH]c2cc1-c1cn[nH]c1 CHEMBL2380581 IC50 9.76 nM
CC(C)CNc1nc(C#CC2CCCCC2)cn2c(-c3ccc(C(=O)NC4CC4)cc3)cnc12 CHEMBL3957777 IC50 9.9 nM