CNc1cc(Nc2cccn(-c3cccnc3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5423859 Kd 0.001 nM
CNc1cc(Nc2cccn(-c3cnc(C)o3)c2=O)nc2c(C(=O)N[C@@H]3CC[C@H]3OC)cnn12 CHEMBL5440397 Kd 0.001 nM
CNc1cc(Nc2cccn(-c3ccc(F)cn3)c2=O)nc2c(C(=O)N[C@@H]3CC[C@H]3OC)cnn12 CHEMBL5414602 Kd 0.002 nM
CNc1cc(Nc2cccn(-c3nc(C)co3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5427850 Kd 0.002 nM
CNc1cc(Nc2cccn(-c3ocnc3C)c2=O)nc2c(C(=O)N[C@@H]3CC[C@H]3OC)cnn12 CHEMBL5419281 Kd 0.002 nM
CNc1cc(Nc2cccn([C@H]3C[C@H](OC)C3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5436767 Kd 0.002 nM
CNc1cc(Nc2cccn([C@H]3C[C@@H](OC)C3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5425400 Kd 0.002 nM
CNc1cc2nn3c(cnc13)C(=O)N[C@H](C)COCc1ccc(OC)c(c1)N2 CHEMBL5424894 Kd 0.002 nM
[2H]C([2H])([2H])n1nnc2c3cc(cc21)CO[C@@H]1CCC[C@H]1NC(=O)c1cnc2c(NC)cc(nn12)N3 CHEMBL5403297 Kd 0.002 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@@H]3CC[C@H]3OC)cnn12 CHEMBL5418744 Kd 0.003 nM
[2H]C([2H])([2H])O[C@@H]1CC[C@H]1NC(=O)c1cnn2c(NC)cc(Nc3cccn(-c4ncccc4F)c3=O)nc12 CHEMBL5396334 Kd 0.003 nM
CNc1cc(Nc2cccn(C3CCN(CCF)CC3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5403825 Kd 0.003 nM
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(C(=O)N[C@@H]3CC[C@H]3OC)cnn12 CHEMBL5314423 Kd 0.003 nM
CNc1cc(Nc2cccn(C(C)C)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5397381 Kd 0.004 nM
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5422616 Kd 0.004 nM
CNc1cc(Nc2cccn(C3CCOCC3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5414946 Kd 0.004 nM
CNc1cc(Nc2cccn([C@@H]3CCCOC3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5440491 Kd 0.004 nM
CNc1cc(Nc2cccn([C@H]3CC[C@@H](OC)CC3)c2=O)nc2c(C(=O)N[C@@H]3CC[C@H]3OC)cnn12 CHEMBL5438635 Kd 0.004 nM
CNc1cc(Nc2cccn(-c3ncco3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5428288 Kd 0.005 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(N3CC(O)C3)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL5439447 Kd 0.005 nM
CNc1cc(Nc2cccn(-c3cncc(F)c3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5398529 Kd 0.006 nM
CNc1cc(Nc2cccn([C@H]3CCCOC3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5411775 Kd 0.006 nM
CNc1cc(Nc2cccn(C3COC3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5431732 Kd 0.006 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3O)cnn12 CHEMBL5414851 Kd 0.007 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@H]3CCC3(F)F)cnn12 CHEMBL5402351 Kd 0.008 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL4435170 Kd 0.008 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2noc(CN3CCN(S(C)(=N)=O)CC3)n2)c1OC CHEMBL5416592 Kd 0.008 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-n2cc3c(n2)CN(S(C)(=N)=O)C3)c1OC CHEMBL5436959 Kd 0.009 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)CC2CC2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5427107 IC50 0.01 nM
CNc1cc(Nc2cccn(-c3cc(C)n(C)n3)c2=O)nn2c(C(=O)N[C@@H]3C[C@@H]3F)cnc12 CHEMBL4460368 Ki 0.015 nM
CC(=O)Nc1cc(Nc2cccc(S(C)(=O)=O)n2)c(-c2ccccn2)cn1 CHEMBL5427277 IC50 0.016 nM
CNc1cc(Nc2cccn(-c3ccc(C)nn3)c2=O)nn2c(C(=O)N[C@@H]3C[C@@H]3F)cnc12 CHEMBL4442827 Ki 0.018 nM
COCCOc1cc(Nc2cc(NC(C)=O)ncc2-c2ccccn2)nc(S(C)(=O)=O)c1 CHEMBL5422022 IC50 0.018 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@@H]3CC[C@@H]3O)cnn12 CHEMBL5433700 Kd 0.019 nM
CNC(=O)c1nnc(NC(=O)C2CC2)c2[nH]c(-c3ccc(N)cc3OC)cc12 CHEMBL5424497 Kd 0.019 nM
[2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(F)cn2)c1OC CHEMBL4789639 Ki 0.02 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@H]3C[C@@H]3OC)cnn12 CHEMBL5398548 Kd 0.023 nM
CNc1cc(Nc2cccn(-c3cccc(F)n3)c2=O)nn2c(C(=O)N[C@@H]3C[C@@H]3F)cnc12 CHEMBL4571920 Ki 0.024 nM
COc1cc(Nc2cc(NC(C)=O)ncc2-c2ccc(F)cn2)nc(S(C)(=O)=O)c1 CHEMBL5416227 IC50 0.026 nM
COc1cc(Nc2cc(NC(C)=O)ncc2-c2ccc3c(n2)OCC(C)(C)O3)nc(S(C)(=O)=O)c1 CHEMBL5418288 IC50 0.026 nM
COc1cc(Nc2cc(NC(C)=O)ncc2-c2ccc(C(C)(C)O)cn2)nc(S(C)(=O)=O)c1 CHEMBL5420349 IC50 0.027 nM
CNC(=O)c1nnc(NC(=O)N2CCC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL5419627 Kd 0.028 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)NCC3(CO)CC3)cnn12 CHEMBL5407138 Kd 0.033 nM
CNc1cc(Nc2cccn(-c3ccc(C)nc3)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5430689 Kd 0.034 nM
CNc1cc(Nc2cccn(-c3ccc(F)cn3)c2=O)nn2c(C(=O)N[C@@H]3C[C@@H]3F)cnc12 CHEMBL4439957 Ki 0.035 nM
CC(=O)Nc1cc(Nc2cccc(S(C)(=O)=O)c2)c(-c2ccccn2)cn1 CHEMBL5417355 IC50 0.038 nM
CNc1cc(Nc2cccnc2OC)nc2c(C(=O)NC3CC3)cnn12 CHEMBL5415951 Kd 0.039 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cc(C)ccn2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5437122 IC50 0.05 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cc(C)c(C)cn2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5440225 IC50 0.05 nM
N#Cc1cccc(F)c1-c1cc(Nc2ccc(N3CCOCC3)cn2)c2c(n1)CNC2=O CHEMBL5200655 Ki 0.051 nM
NC(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O CHEMBL4561663 Ki(app) 0.06 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(F)cn2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5412034 IC50 0.06 nM
CNc1cc(Nc2cccn(-c3ccc(F)cc3)c2=O)nc2c(C(=O)NC3CC3)cnn12 CHEMBL5404091 Kd 0.063 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@@H]3C[C@@H]3F)cnn12 CHEMBL5405569 Kd 0.068 nM
CNc1cc(Nc2cccn(-c3ccc(C(C)(C)O)cc3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4434711 Ki 0.07 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccccn2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4440718 Ki(app) 0.07 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cc(OC)ccn2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5418485 IC50 0.07 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@H]3C[C@H]3F)cnn12 CHEMBL5422880 Kd 0.073 nM
CNc1cc(Nc2cc(C)cc(C)c2)nc2c(C(=O)NC3CC3)cnn12 CHEMBL5420172 Kd 0.078 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5413544 IC50 0.08 nM
NC(=O)c1nnc(-c2c(F)cccc2F)cc1Nc1ccc(N2CCOCC2=O)cn1 CHEMBL5413489 IC50 0.08 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(N4CCC(F)(F)CC4)cn3)c21 CHEMBL5192374 Ki 0.081 nM
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nn2c(C(=O)N[C@@H]3C[C@@H]3F)cnc12 CHEMBL4532948 Ki 0.086 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@@H]3CC[C@@]3(C)OC)cnn12 CHEMBL5396767 Kd 0.086 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@@H]3C[C@H]3OC)cnn12 CHEMBL5424640 Kd 0.088 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cccc(C)n2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5439728 IC50 0.09 nM
CNc1cc(Nc2cccn(-c3ccc(C)nn3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4443010 Ki 0.091 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)NC3CC3)cnn12 CHEMBL5399515 Kd 0.099 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1nccc(-c2ccccn2)c1OC CHEMBL5411146 IC50 0.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cc(F)ccn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5416323 IC50 0.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cnc(C)cn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5396654 IC50 0.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(C(C)(C)N)cn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5411149 IC50 0.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(C(C)(C)O)cn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5437552 IC50 0.1 nM
CNc1cc(Nc2cccn(-c3cccnc3C)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5401172 Kd 0.105 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4435047 Ki 0.12 nM
CNc1cc(Nc2cc(C)cc(C)c2)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4293907 Ki 0.13 nM
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nn2c(C(=O)NC(C)C)cnc12 CHEMBL4438107 Ki 0.13 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@@H]3CC[C@H]3O)cnn12 CHEMBL5423799 Kd 0.13 nM
CNc1cc(Nc2cccn(-c3ccc(F)nc3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4474801 Ki 0.14 nM
CNc1cc(Nc2cccn(-c3ccc(F)cn3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4561123 Ki 0.15 nM
CCNC(=O)c1ccc(Nc2cc(-c3c(F)cccc3F)nc3c2C(=O)NC3)nc1 CHEMBL5198005 Ki 0.15 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(C(=O)N4CCCC4)cn3)c21 CHEMBL5197513 Ki 0.19 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(F)cn2)c1OC CHEMBL4784391 IC50 0.19 nM
Cn1cc(-c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc2)cn1 CHEMBL4078799 IC50 0.2 nM
CNc1cc(Nc2cccn(-c3ccc(C#N)cc3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4453441 Ki 0.2 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@H]3CC[C@@H]3OC)cnn12 CHEMBL5432382 Kd 0.2 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(C)=O)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5405178 IC50 0.2 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cccc(OC)n2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5403115 IC50 0.2 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5403477 IC50 0.2 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccccn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5403572 IC50 0.2 nM
NC(=O)c1nnc(-c2c(F)cccc2Cl)cc1Nc1ccc(N2CCOCC2)cc1 CHEMBL5440264 IC50 0.2 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.205 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(N4CCC(O)CC4)cn3)c21 CHEMBL5186817 Ki 0.21 nM
CNc1cc(Nc2cccn(-c3cccc(F)n3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4579439 Ki 0.22 nM
CCNC(=O)c1ccc(Nc2cc(-c3c(F)cccc3C#N)nc3c2C(=O)NC3)nc1 CHEMBL5178821 Ki 0.23 nM
CCNC(=O)C(C)(O)c1ccc(Nc2nc(-c3c(F)cccc3F)nc3c2C(=O)NC3)cc1 CHEMBL5184447 Ki 0.24 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(OC)cn2)c1OC CHEMBL4799019 IC50 0.25 nM
[2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cc(F)cc(-c2ncccn2)c1OC CHEMBL4793760 IC50 0.25 nM
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nn2c(C(=O)NC3CCC3)cnc12 CHEMBL4438296 Ki 0.26 nM
[2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cnc(C)cn2)c1OC CHEMBL4780233 IC50 0.27 nM
CNc1cc(Nc2cccn(-c3ccncc3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4585272 Ki 0.29 nM
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nn2c(C(=O)NCC(C)(C)CO)cnc12 CHEMBL4543066 Ki 0.29 nM
OCc1ccnc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)sc23)c1 CHEMBL3675689 Ki 0.3 nM
[C-]#[N+]c1cccc(F)c1-c1nc2c(C#N)cnc(Nc3cc(N)ncn3)c2s1 CHEMBL3675698 Ki 0.3 nM
Nc1cc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)ncn1 CHEMBL4084436 Ki 0.3 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cnc(C(C)(C)O)cn2)c1OC CHEMBL4799559 IC50 0.3 nM
CNC(=O)c1cnc(Nc2ccc(C#N)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL4469750 IC50 0.3 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)CCC)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5438688 IC50 0.3 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1nccc(-c2noc(C)n2)c1OC CHEMBL5408060 IC50 0.3 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@@H]3CCC3(F)F)cnn12 CHEMBL5427213 Kd 0.31 nM
CS(=O)(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O CHEMBL4530719 IC50 0.32 nM
CNc1cc(Nc2cccn(C3CC3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4547009 Ki 0.33 nM
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4466139 Ki 0.34 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(N4CCOCC4=O)cn3)c21 CHEMBL5181976 Ki 0.34 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(C(=O)N4CCOCC4)cc3)c21 CHEMBL5182688 Ki 0.35 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(N4CCOCC4)cn3)c21 CHEMBL5188608 Ki 0.36 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(C(=O)N4CC[C@H](O)C4)cc3)c21 CHEMBL5182922 Ki 0.37 nM
CNc1cc(Nc2cccn(-c3ncc(F)cn3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4437714 Ki 0.38 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@@H]3CC[C@@H](OC)C3)cnn12 CHEMBL5405274 Kd 0.38 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL2386635 Ki 0.4 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 IC50 0.4 nM
N#Cc1cnc(Nc2cc(N)ncn2)c2sc(-c3c(F)cccc3Cl)nc12 CHEMBL3675697 Ki 0.4 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL4089118 IC50 0.4 nM
Cc1cc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)ncn1 CHEMBL4062758 Ki 0.4 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)CC)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5409590 IC50 0.4 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL221959 IC50 0.4 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(C(C)(O)C(F)(F)F)cn2)c1OC CHEMBL4777175 IC50 0.44 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)NC3CC4(COC4)C3)cnn12 CHEMBL5419398 Kd 0.46 nM
CNc1cc(Nc2cccn(-c3cc(C)n(C)n3)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4454109 Ki 0.48 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncccn2)c1OC CHEMBL4799031 IC50 0.48 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ccc(C(C)(C)O)cn2)c1OC CHEMBL4796821 IC50 0.48 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@H]3CC[C@H]3O)cnn12 CHEMBL5437915 Kd 0.48 nM
[2H]C([2H])([2H])NC(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4444169 IC50 0.49 nM
O=C(Nc1nccc2nc(-c3c(Cl)cccc3Cl)sc12)C1CC1 CHEMBL3675685 Ki 0.5 nM
[C-]#[N+]c1cccc(Cl)c1-c1nc2ccnc(Nc3cc(CO)nc(C)n3)c2s1 CHEMBL3675700 Ki 0.5 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(-n3ccnn3)cc2)n1 CHEMBL4096821 IC50 0.5 nM
CNc1cc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)ncn1 CHEMBL4071399 Ki 0.5 nM
Clc1cccc(Cl)c1-c1nc2ccnc(Nc3cc(N4CCCC4)ncn3)c2[nH]1 CHEMBL4075453 Ki 0.5 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cnccn2)c1OC CHEMBL4782449 IC50 0.5 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 0.5 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)OC)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5399546 IC50 0.5 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cc(F)cc(-c2ncc(C(C)(C)O)cn2)c1OC CHEMBL4784838 IC50 0.51 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(C(=O)N4CCCC4)cc3)c21 CHEMBL5180050 Ki 0.51 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cc(F)cc(-c2ncc(C(=O)N(C)C)cn2)c1OC CHEMBL4792780 IC50 0.52 nM
[2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cnc(OC)cn2)c1OC CHEMBL4780315 IC50 0.54 nM
CC(C)[C@H](C)n1cc(-c2cc(N3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3763213 IC50 0.55 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(F)cn2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4583185 IC50 0.58 nM
Clc1cccc(Cl)c1-c1nc2ccnc(Nc3ccncn3)c2[nH]1 CHEMBL4074130 Ki 0.6 nM
CN(C)c1cc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)ncn1 CHEMBL4069942 Ki 0.6 nM
Clc1cccc(Cl)c1-c1nc2ccnc(Nc3cc(N4CCOCC4)ncn3)c2[nH]1 CHEMBL4093872 Ki 0.6 nM
N#Cc1cc(Cl)c(-c2nc3ccnc(Nc4cc(N)ncn4)c3[nH]2)c(Cl)c1 CHEMBL4092116 Ki 0.6 nM
CNc1cc(Nc2nccc3nc(-c4c(Cl)cc(C#N)cc4Cl)[nH]c23)ncn1 CHEMBL4062680 Ki 0.6 nM
NC(=O)c1nc(-c2c(F)cccc2Cl)oc1Nc1ccc(C(=O)N2CCOCC2)cc1 CHEMBL4476770 IC50 0.6 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(OCC)nn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5401385 IC50 0.6 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(N3CCOCC3)cn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5420187 IC50 0.6 nM
CO[C@@]1(c2cc(C)cc(-n3cc(C4CC4)c4cnc(NC(C)=O)cc43)n2)CCOC1 CHEMBL5409126 IC50 0.6 nM
Cc1cnc(Nc2ccc3c(c2)CNC3=O)nc1-c1cnn(CCC#N)c1 CHEMBL4845662 IC50 0.67 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 0.7 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)cc2)n1 CHEMBL4102140 IC50 0.7 nM
N#Cc1ccnc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)c1 CHEMBL4092191 Ki 0.7 nM
COc1cc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)ncn1 CHEMBL4099854 Ki 0.7 nM
Cc1cc(Nc2nccc3nc(-c4c(Cl)cc(C#N)cc4Cl)[nH]c23)ncn1 CHEMBL4076947 Ki 0.7 nM
COc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\OCC(O)CO)C(=O)N2 CHEMBL4065365 IC50 0.7 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ccc(C(C)(C)O)nn2)c1OC CHEMBL4797596 IC50 0.71 nM
CNc1cc(Nc2cccn(C)c2=O)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4517542 Ki 0.74 nM
[C-]#[N+]c1cc(C#N)cc([N+]#[C-])c1-c1nc2ccnc(Nc3cc(C)nc(C)n3)c2s1 CHEMBL3675699 Ki 0.8 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(F)cc3)C4)n[nH]c2c1 CHEMBL3644618 IC50 0.8 nM
O=C(Nc1nccc2cc(-c3c(Cl)cccc3Cl)sc12)C1CC1 CHEMBL4093172 Ki 0.8 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4444178 Ki(app) 0.8 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)CC)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL5430970 IC50 0.8 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(C(=O)Nc2ccc(N3CCCCC3=O)cc2)c1OC CHEMBL5273814 IC50 0.81 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(C(=O)N4CCOCC4)cn3)c21 CHEMBL5170973 Ki 0.83 nM
O=C1NCc2nc(-c3c(F)cccc3F)nc(Nc3ccc(C4CCNC4=O)cc3)c21 CHEMBL5182121 Ki 0.85 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3CCCC3)c(F)c2)c1OC CHEMBL5190418 IC50 0.85 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CCC2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5415132 IC50 0.9 nM
CC(C)[C@H](C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O CHEMBL3763991 IC50 0.92 nM
CNC(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4526283 IC50 0.92 nM
CNC(=O)c1cnc(Nc2ccccn2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4544320 IC50 0.95 nM
O=C1NCc2nc(-c3c(F)cccc3F)nc(Nc3ccc(CC(=O)N4CCN(CC(F)F)CC4)cc3)c21 CHEMBL5170148 Ki 0.97 nM
CC(C)[C@H](C)n1cc(-c2cc(C3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3764277 IC50 0.98 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N(CC)CC)cc2)c1OC CHEMBL5180664 IC50 0.98 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn([C@H](CC#N)C2CCCC2)c1 CHEMBL5395308 IC50 0.98 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 IC50 1.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 1.0 nM
Nc1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387225 Ki 1.0 nM
Cc1cc(Nc2nccc3nc(-c4c(Cl)cc(CO)cc4Cl)sc23)ncn1 CHEMBL3675690 Ki 1.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)CC#N)C4)n2)cn1 CHEMBL3944322 IC50 1.0 nM
OC1CCN(c2cc(Nc3nccc4nc(-c5c(Cl)cccc5Cl)[nH]c34)ncn2)CC1 CHEMBL4070262 Ki 1.0 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3CCCC3)cc2)c1OC CHEMBL5209315 IC50 1.0 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(F)cn2)cc1Nc1cccc(C(=O)Nc2ccc(N3CCCCC3=O)cc2)c1OC CHEMBL5282623 IC50 1.0 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(OC)nn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC CHEMBL5409445 IC50 1.0 nM
COC[C@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5412967 IC50 1.0 nM
CN(C)C(=O)c1ccc(Nc2cc(N3CC[C@@](C#N)(C4CC4)C3=O)ccn2)nc1 CHEMBL4636795 IC50 1.1 nM
CCNC(=O)c1ccc(Nc2cc(-c3c(F)cccc3Cl)nc3c2C(=O)NC3)nc1 CHEMBL5191597 Ki 1.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3CCCC3)cc2)c1OC CHEMBL5196735 IC50 1.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3C4CCC3CC4)cc2)c1OC CHEMBL5184093 IC50 1.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(F)cn2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3CCCC3)cc2)c1OC CHEMBL5193226 IC50 1.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(F)cc2)cc1Nc1nccc(-c2ncn(C)n2)c1OC CHEMBL5406364 IC50 1.1 nM
CC(C)[C@H](C)n1cc(-c2cc(N3CCS(=O)(=O)CC3)n(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3765517 IC50 1.2 nM
ClC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3954894 IC50 1.2 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL4061128 IC50 1.2 nM
Clc1cccc(Cl)c1-c1nc2ccnc(Nc3cc(N4CCN(C5COC5)CC4)ncn3)c2[nH]1 CHEMBL4097446 Ki 1.2 nM
OCCN1CCN(c2cc(Nc3nccc4nc(-c5c(Cl)cccc5Cl)[nH]c34)ncn2)CC1 CHEMBL4080904 Ki 1.2 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(C)cn2)c1OC CHEMBL4785957 IC50 1.2 nM
O=C(Nc1ccnc(NC(=O)[C@H]2C[C@H]2c2nn[nH]n2)c1)c1c(Cl)cccc1Cl CHEMBL2387219 Ki 1.3 nM
O=C(Nc1nccc2nn(-c3c(Cl)cccc3Cl)cc12)C1CC1 CHEMBL4100889 Ki 1.3 nM
CNC(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccccc1C(N)=O CHEMBL4537678 IC50 1.3 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ccncn2)c1OC CHEMBL4777648 IC50 1.3 nM
CCNC(=O)Cc1ccc(Nc2cc(-c3c(F)cccc3F)nc3c2C(=O)NC3)nc1 CHEMBL5207105 Ki 1.3 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3[C@H](C#N)C[C@@H]4C[C@@H]43)cc2)c1OC CHEMBL5203217 IC50 1.3 nM
N#Cc1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)[C@H]3C[C@H]3F)c2)c(Cl)c1 CHEMBL2387221 Ki 1.4 nM
COC(=O)Nc1nccc2nc(-c3c(Cl)cccc3Cl)sc12 CHEMBL3675686 Ki 1.4 nM
O=C(Nc1nccc2nc(-c3c(F)cccc3Cl)sc12)NC1CC1 CHEMBL3675688 Ki 1.4 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cccnn2)c1OC CHEMBL4788122 IC50 1.4 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2nccc(OC)n2)c1OC CHEMBL4776752 IC50 1.4 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cc(F)cc(C(=O)Nc2ccc(NC[C@H]3COCCO3)cc2)c1OC CHEMBL5203256 IC50 1.4 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(N3CCCCC3=O)cc2)c1OC CHEMBL5268371 IC50 1.4 nM
CC(C)C(C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O CHEMBL3763252 IC50 1.5 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780091 IC50 1.5 nM
N#Cc1cc(Cl)c(-c2nc3c(F)cnc(NC(=O)C4CC4)c3s2)c(Cl)c1 CHEMBL3675696 Ki 1.5 nM
CNC(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccc(F)c(F)c1OC CHEMBL4476830 IC50 1.5 nM
Cc1cc(Nc2ncc(C)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423027 IC50 1.5 nM
Cc1cc(Nc2ncc(Cl)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423566 IC50 1.5 nM
N#Cc1cc(F)c(C(=O)Nc2ccnc(NC(=O)[C@H]3C[C@H]3F)c2)c(Cl)c1 CHEMBL2387223 Ki 1.6 nM
O=C(Nc1ccnc(NC(=O)[C@H]2C[C@H]2F)c1)c1c(F)cccc1Cl CHEMBL2387222 Ki 1.6 nM
CCc1cc(Nc2nccc3nc(-c4c(Cl)cc(C(N)=O)cc4Cl)sc23)ncn1 CHEMBL3675694 Ki 1.6 nM
CNC(=O)c1cnc(Nc2ccccn2)cc1Nc1ccccc1C(N)=O CHEMBL4465409 IC50 1.6 nM
CNC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1ccccc1S(C)(=O)=O CHEMBL4438202 IC50 1.6 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ccccn2)c1OC CHEMBL4799830 IC50 1.6 nM
O=C1NCc2nc(-c3c(F)cccc3F)nc(Nc3ccc(C4CCCNC4=O)cc3)c21 CHEMBL5181361 Ki 1.6 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3C([2H])([2H])CCC3([2H])[2H])cc2)c1OC CHEMBL5207953 IC50 1.6 nM
CCS(=O)(=O)N1CCc2cc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)ccc21 CHEMBL4867814 IC50 1.61 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CCC#N)CC1 CHEMBL2386636 Ki 1.7 nM
C[C@@H]1NS(=O)(=O)c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc21 CHEMBL4066906 IC50 1.7 nM
O=C(Nc1nccc2nc(-c3c(Cl)cccc3Cl)[nH]c12)C1CC1 CHEMBL4064189 Ki 1.7 nM
N#Cc1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387124 Ki 1.8 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4104623 IC50 1.8 nM
CNC(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccccc1SC CHEMBL4469812 IC50 1.8 nM
CN1CCN(C(=O)Cc2ccc(Nc3nc(-c4c(F)cccc4F)nc4c3C(=O)NC4)cc2)CC1 CHEMBL5202260 Ki 1.8 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C3CCCNC3=O)cc2)c1OC CHEMBL5286565 IC50 1.8 nM
CC(=O)N1CCc2cc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)ccc21 CHEMBL4869302 IC50 1.81 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C)[nH]n3)nc21 CHEMBL3622150 IC50 1.9 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(NC[C@H]3COCCO3)cc2)c1OC CHEMBL5191508 IC50 1.9 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(N3CCCCS3(=O)=O)cc2)c1OC CHEMBL5267449 IC50 1.9 nM
COc1cc2c(=O)n(C3CCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4295151 IC50 1.93 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)CN2CCS(=O)(=O)CC2)nc1-c1cnn(C(C)C)c1 CHEMBL4862108 IC50 1.99 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cccc12 CHEMBL3359927 IC50 2.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL4089234 IC50 2.0 nM
CNc1cc(Nc2cc(C)cc(C)c2)nn2c(C(=O)NCC(C)(C)CO)cnc12 CHEMBL4289426 IC50 2.0 nM
Cc1cnc(Nc2ccc(N3CCC(N(C)CCO)CC3)c(F)c2)nc1-c1cnn(C(C)C)c1 CHEMBL4447631 IC50 2.0 nM
Cc1cnc(Nc2ccc3c(c2)CCN3S(=O)(=O)c2ccc(C(F)(F)F)cc2)nc1-c1cnn(CCC#N)c1 CHEMBL4873919 IC50 2.0 nM
N#CCCn1cc(-c2nc(Nc3ccc4c(c3)CCN4)ncc2F)cn1 CHEMBL4851075 IC50 2.0 nM
N#CCCn1cc(-c2nc(Nc3ccc4c(c3)CCN4C(=O)CN3CCS(=O)(=O)CC3)ncc2F)cn1 CHEMBL4865102 IC50 2.0 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cnn(CCC#N)c1 CHEMBL5402073 IC50 2.0 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1-c1cnn(CCC#N)c1 CHEMBL5435482 IC50 2.0 nM
COC[C@@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5404574 IC50 2.0 nM
COCCOC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5422886 IC50 2.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O[C@@H]3CCOC3)cn2)ncc1C(N)=O CHEMBL5407260 IC50 2.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O[C@H]3CCOC3)cn2)ncc1C(N)=O CHEMBL5396554 IC50 2.0 nM
CO[C@@]1(c2cc(C)cc(-n3nc(-c4cnn(C)c4)c4cnc(NC(N)=O)cc43)n2)CCOC1 CHEMBL5441067 Ki 2.0 nM
CO[C@@]1(c2cc(C)cc(-c3cc(C)n4cnc(NC(N)=O)cc34)n2)CCOC1 CHEMBL5397906 Ki 2.0 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)[C@H]2CCCN2C(=O)C2(C#N)CC2)nc1-c1cnn(C(C)C)c1 CHEMBL4873733 IC50 2.05 nM
COc1ccc(Cl)cc1-c1nc(C)sc1NC(=O)c1cnn2cccnc12 CHEMBL3667519 Ki 2.1 nM
CC(C)[C@@H](C)n1cc(-c2cc(C(C)(C)O)n(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3765822 IC50 2.1 nM
CO[C@@]1(c2cc(C)cc(-n3cc(C4CCN(C)CC4)c4cnc(NC(N)=O)cc43)n2)CCOC1 CHEMBL5439751 IC50 2.1 nM
COc1cc2c(=O)n(C3CCCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4291720 IC50 2.24 nM
COc1ccc(Cl)cc1-c1c(NC(=O)c2c(N)nn3cccnc23)cnn1CC(N)=O CHEMBL3667521 Ki 2.3 nM
Fc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3984960 IC50 2.3 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3CCSC3)cc2)c1OC CHEMBL5194842 IC50 2.3 nM
O=C(Nc1ccnc(NC(=O)[C@H]2C[C@H]2F)c1)c1c(Cl)cccc1Cl CHEMBL2387127 Ki 2.5 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(N3CCCCCC3=O)cc2)c1OC CHEMBL5281991 IC50 2.5 nM
BrC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3918308 IC50 2.6 nM
FC(F)(F)c1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3900746 IC50 2.6 nM
Cc1cnc(Nc2ccc3c(c2)CCN3S(=O)(=O)C2CC2)nc1-c1cnn(C(C)C)c1 CHEMBL4849458 IC50 2.69 nM
CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(C(=O)N[C@H]3CC[C@H](OC)C3)cnn12 CHEMBL5425044 Kd 2.7 nM
CN1CCN(C(=O)c2ccc3[nH]c4c(C(N)=O)cc(-c5ccc(Cl)cc5)cc4c3c2)CC1 CHEMBL3589169 IC50 2.8 nM
Clc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3954454 IC50 2.8 nM
N#CC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3900105 IC50 2.9 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL4100288 IC50 2.9 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)N3CCCC3)nc2)c1OC CHEMBL5198448 IC50 2.9 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCN(C)CC4)C3)n2)sn1 CHEMBL5396135 IC50 2.9 nM
CC(=O)Nc1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387110 Ki 3.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL4067915 IC50 3.0 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4590082 IC50 3.0 nM
O=C(CCCCCn1cc(Nc2ncc3ccn(Cc4cccc(F)c4)c3n2)cn1)NO CHEMBL5092781 IC50 3.0 nM
O=C(Nc1ccnc(NC(=O)C2CC2)c1)c1c(Cl)cc(O)cc1Cl CHEMBL2387112 Ki 3.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2)c1OC CHEMBL5204955 IC50 3.1 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(N3CCCCC3=O)c(Cl)c2)c1OC CHEMBL5270922 IC50 3.1 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 3.162 nM
COc1cc(-c2ccc(O)cc2)cc2cnc(Nc3cnn(C)c3)nc12 CHEMBL5084861 pIC50 3.162 nM
O=C(Nc1ccnc(NC(=O)[C@@H]2C[C@@H]2C(=O)O)c1)c1c(Cl)cccc1Cl CHEMBL2387218 Ki 3.2 nM
Cc1nc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)cc(N(C)C)n1 CHEMBL4065419 Ki 3.2 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(-n3ccccc3=O)cc2)c1OC CHEMBL5284638 IC50 3.2 nM
CNCc1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387119 Ki 3.3 nM
Fc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1C(F)(F)F CHEMBL3950680 IC50 3.3 nM
CC(C)c1nc(Nc2ccc(C(=O)O)cc2)c2c(=O)[nH]ccc2n1 CHEMBL5203504 Ki 3.3 nM
O=C(Nc1ccnc(NC(=O)C2CC2)c1)c1c(Cl)cc(-c2cn[nH]c2)cc1Cl CHEMBL2387126 Ki 3.4 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](NCC(F)(F)F)CC1 CHEMBL2386629 Ki 3.4 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn(CCC#N)c1 CHEMBL5438892 IC50 3.4 nM
Cc1cnc(Nc2cnn(C)c2)nc1N1CC2CCCC(C1)N2CCC#N CHEMBL5412619 IC50 3.4 nM
Cc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3891947 IC50 3.6 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)C2CC2)nc1-c1cnn(C(C)C)c1 CHEMBL4854704 IC50 3.76 nM
CNc1cc(Nc2cc(F)cc(F)c2OC)nn2c(C(=O)NC[C@](C)(O)CO)cnc12 CHEMBL4279883 EC50 3.8 nM
[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(C(=O)Nc2ccc(NC[C@H]3COCCO3)cc2)c1OC CHEMBL5179468 IC50 3.8 nM
CCCS(=O)(=O)N1CCc2cc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)ccc21 CHEMBL4845758 IC50 3.84 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C3CC3)cc2)n1 CHEMBL4077886 IC50 3.9 nM
CC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2)CC1 CHEMBL3905686 IC50 4.0 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1Cl CHEMBL4085737 IC50 4.0 nM
CNc1cc(Nc2cccc(-c3ccccc3)c2)nn2c(C(N)=O)cnc12 CHEMBL4291611 IC50 4.0 nM
N#CCCn1cc(-c2nc(Nc3ccc4c(c3)CCN4S(=O)(=O)C(F)(F)F)ncc2F)cn1 CHEMBL4873109 IC50 4.0 nM
CC(=O)Nc1cc2c(-c3cccc(S(=O)(=O)N(C)C)n3)cn(C)c2cn1 CHEMBL5394367 IC50 4.0 nM
Nc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3Cl)c2n1 CHEMBL3670393 Ki 4.1 nM
Cc1cc(Nc2nccc3nc(-c4c(Cl)cc(C5CC5)cc4Cl)sc23)ncn1 CHEMBL3675695 Ki 4.1 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1cnc2cnc3[nH]ccc3c21 CHEMBL2152297 Ki 4.2 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1nccc(-c2noc(CNC)n2)c1OC CHEMBL5433636 IC50 4.2 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4846921 IC50 4.3 nM
COc1cc2c(=O)n([C@@H]3CCCN(C(=O)CC#N)C3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4290597 IC50 4.35 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL2103743 Ki 4.39 nM
NCc1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387118 Ki 4.4 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2nccc(C)n2)c1OC CHEMBL4780057 IC50 4.5 nM
CCc1cc(O)ccc1-c1ccc2c(-c3ncc[nH]3)n[nH]c2c1 CHEMBL4086057 IC50 4.6 nM
N#CCC(=O)N1CCC[C@@H](n2cnc3cnc4[nH]ccc4c32)C1 CHEMBL2152300 Ki 4.7 nM
O=C(Nc1ccnc(NC(=O)C2CC2)c1)c1c(Cl)cccc1Cl CHEMBL2387224 Ki 4.8 nM
NC(=O)c1cnc2[nH]ccc2c1N[C@@H]1[C@@H]2CC3C[C@H]1C[C@@](O)(C3)C2 CHEMBL3137308 IC50 4.8 nM
COc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3919050 IC50 4.8 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2 CHEMBL4242999 IC50 4.8 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2 CHEMBL4238926 IC50 4.8 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(-c3ncn(C4CC4)n3)cc2)c1OC CHEMBL5279644 IC50 4.8 nM
NC(=O)c1cnc2[nH]ccc2c1NC1[C@@H]2CC3C[C@H]1CC(O)(C3)C2 CHEMBL5424861 IC50 4.8 nM
O=C(Nc1ccnc(Nc2ccncn2)c1)c1c(Cl)cccc1Cl CHEMBL2420827 Ki 4.9 nM
FC(F)(F)Oc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3986660 IC50 4.9 nM
N#C[C@]1(C2CC2)C(=O)N2C[C@H]1COCCCCOCc1cccc(n1)Nc1cc2ccn1 CHEMBL4643392 IC50 4.9 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(NC[C@H]4CCCO4)n3)cc2)CC1 CHEMBL3426891 IC50 5.0 nM
CNc1cc(Nc2ccccc2OC)nn2c(C(=O)NCC(C)(C)CO)cnc12 CHEMBL4295039 IC50 5.0 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(C2)C3O CHEMBL4446102 IC50 5.0 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)[C@H]2CCCN2)nc1-c1cnn(C(C)C)c1 CHEMBL4873455 IC50 5.0 nM
N#CCCn1cc(-c2nc(Nc3ccc4c(c3)CCN4C(=O)c3ccc(C(F)(F)F)cc3)ncc2F)cn1 CHEMBL4868858 IC50 5.0 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(NC[C@@H]3COCCO3)cc2)c1OC CHEMBL5200056 IC50 5.0 nM
CO[C@@]1(c2cccc(-c3cn(C)c4cnc(NC(N)=O)cc34)n2)CCOC1 CHEMBL5401070 IC50 5.0 nM
O=C(Nc1ccnc(NC(=O)[C@H]2C[C@H]2Cl)c1)c1c(Cl)cccc1Cl CHEMBL2387131 Ki 5.1 nM
Cc1nccc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)n1 CHEMBL4105148 Ki 5.1 nM
O=C1NCc2nc(-c3c(F)cccc3F)nc(Nc3ccc(CC(=O)N4CCOCC4)cc3)c21 CHEMBL5188061 Ki 5.1 nM
CNC(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccccc1OC CHEMBL4460194 IC50 5.2 nM
N#C[C@]1(C2CC2)C(=O)N2C[C@H]1COC/C=C\COCc1cccc(n1)Nc1cc2ccn1 CHEMBL4643899 IC50 5.2 nM
Cn1cc(Nc2nccc(N3CC4CCC(C3)N4C(=O)[C@@H]3CC3(F)F)n2)cn1 CHEMBL4747591 IC50 5.2 nM
O=C(Nc1ccnc(NC(=O)C2CC2)c1)c1c(Cl)cc(CO)cc1Cl CHEMBL2387114 Ki 5.4 nM
CC(C)[C@H](C)n1cc(-c2ccn(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3764030 IC50 5.5 nM
c1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3967397 IC50 5.5 nM
N#C[C@]1(C2CC2)C(=O)N2C[C@H]1COCC(=O)NCCCc1cccc(n1)Nc1cc2ccn1 CHEMBL4641006 IC50 5.5 nM
COc1ccc(Cl)cc1-c1c(NC(=O)c2cnn3cccnc23)cnn1CCO CHEMBL3667515 Ki 5.6 nM
Cc1cc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)ccn1 CHEMBL4073562 IC50 5.7 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(N3CCCCC3=O)cc2F)c1OC CHEMBL5270823 IC50 5.7 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)C2CC2(F)F)nc1-c1cnn(C(C)C)c1 CHEMBL4864674 IC50 5.72 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 5.8 nM
N#Cc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3908040 IC50 5.9 nM
CNC(=O)c1cnc(Nc2ncccc2F)cc1Nc1ccccc1C(N)=O CHEMBL4580693 IC50 5.9 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(NCC3CCOCC3)cc2)c1OC CHEMBL5177410 IC50 5.9 nM
C[C@]1(C#N)CCC[C@H]1Nc1c(C(N)=O)cnn2cccc12 CHEMBL3359926 IC50 6.0 nM
CNc1cc(Nc2cccc3c2OCCO3)nn2c(C(=O)NC3CC3)cnc12 CHEMBL4285841 IC50 6.0 nM
CNc1cc(Nc2cc(F)cc(F)c2OC)nn2c(C(=O)NCC(C)(C)CO)cnc12 CHEMBL4287761 IC50 6.0 nM
Cn1cc(-c2cn3nccc3c(-c3cnn([C@]4(CC#N)C[C@H](C#N)C4)c3)n2)cn1 CHEMBL4740298 IC50 6.0 nM
N#CCCn1cc(-c2nc(Nc3ccc4c(c3)CCN4C(=O)C3(C#N)CC3)ncc2F)cn1 CHEMBL4856634 IC50 6.0 nM
Cc1cnc(Nc2cnn(C(F)F)c2)nc1N1CCC2(CCNC2=O)CC1 CHEMBL5077096 IC50 6.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C)c(N4CCC5(CCNC5=O)CC4)n3)cc2)CC1 CHEMBL5077973 IC50 6.0 nM
COc1ccccc1Nc1cc(Nc2ccccn2)ncc1C(N)=O CHEMBL5409666 IC50 6.0 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@@H]1CCC[C@@H](O)C1 CHEMBL2159210 Ki 6.2 nM
O=C(Nc1ncnc2nc(-c3c(Cl)cccc3Cl)sc12)C1CC1 CHEMBL3675691 Ki 6.2 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cnc(C(=O)N(C)C)cn2)c1OC CHEMBL4777528 IC50 6.2 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)[C@@H]2C[C@@H]2F)nc1-c1cnn(C(C)C)c1 CHEMBL4864328 IC50 6.28 nM
CC(C)C(C)n1cc(-c2ccn(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3764637 IC50 6.3 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 6.31 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 6.31 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 6.31 nM
[2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncccn2)c1OC CHEMBL4789015 IC50 6.4 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(-n3cccn3)cc2)c1OC CHEMBL5278999 IC50 6.4 nM
COc1ncc(C#N)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL3667518 Ki 6.6 nM
Nc1n[nH]c2c(-c3ccccn3)cn(-c3ccccc3Cl)c(=O)c12 CHEMBL3764463 IC50 6.7 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)cc2)[C@H](C)C1 CHEMBL4744772 IC50 6.73 nM
O=c1[nH]ccc2c3[nH]c(-c4ccccc4Cl)nc3c3ccc(F)cc3c12 CHEMBL261386 IC50 7.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cccc23)CC[C@@]1(C)O CHEMBL3359915 IC50 7.0 nM
COC(=O)C1CCc2[nH]c(-c3c(N[C@H]4CC[C@@H](N)CC4)cc[nH]c3=O)nc2C1 CHEMBL3780467 IC50 7.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(C(=O)CC#N)CC4C3)n2)cn1 CHEMBL3977718 IC50 7.0 nM
CNc1cc(Nc2cc(C)cc(C)c2)nn2c(C(N)=O)cnc12 CHEMBL4279157 IC50 7.0 nM
Cn1cc(-c2cn3nccc3c(-c3cnn(C4(CC#N)CN(CC#N)C4)c3)n2)cn1 CHEMBL4741903 IC50 7.0 nM
N#CCCn1cc(-c2nc(Nc3ccc4c(c3)CNC4=O)ncc2F)cn1 CHEMBL4871133 IC50 7.0 nM
Cc1cnc(Nc2cnn(C(C)C)c2)nc1N1CCC2(CCNC2=O)CC1 CHEMBL5082590 IC50 7.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O)cn2)ncc1C(N)=O CHEMBL5407329 IC50 7.0 nM
CNc1cc(Nc2cccc3c2OCCC3)nc2c(C(=O)N[C@@H]3CCN(C)C3=O)cnn12 CHEMBL5405538 IC50 7.0 nM
O=C(Nc1ccnc(NC(=O)[C@@H]2C[C@@H]2F)c1)c1c(Cl)cccc1Cl CHEMBL2387128 Ki 7.1 nM
NC(=O)c1cnc(-c2c(F)cccc2F)nc1Nc1ccc(CC(=O)O)cc1 CHEMBL5170799 Ki 7.1 nM
Cc1ccc(C)c(-c2nn(C)cc2NC(=O)c2cnn3ccc(N)nc23)c1 CHEMBL2178803 Ki 7.3 nM
IC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3934116 IC50 7.3 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)N CHEMBL4096145 IC50 7.5 nM
CC(O)c1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387115 Ki 7.6 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(C(=O)N(C)C)cn2)c1OC CHEMBL4795231 IC50 7.6 nM
CC(=O)c1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387122 Ki 7.8 nM
COc1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387113 Ki 7.8 nM
CCNC(=O)Cc1ccc(Nc2nc(-c3c(F)cccc3F)nc3c2C(=O)NC3)cc1 CHEMBL5196877 Ki 7.8 nM
COc1ccc(S(=O)(=O)N2CCc3cc(Nc4ncc(C)c(-c5cnn(C(C)C)c5)n4)ccc32)cc1 CHEMBL4876729 IC50 7.82 nM
Cc1cccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)c1 CHEMBL4087655 IC50 7.9 nM
CC1(C)CCC[C@H]1Nc1c(C(N)=O)cnn2cccc12 CHEMBL3359908 IC50 8.0 nM
COc1ccnc2c(F)cc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc12 CHEMBL4088262 IC50 8.0 nM
CNc1cc(Nc2c(F)c(F)cc(F)c2F)nn2c(C(=O)NC[C@](C)(O)CO)cnc12 CHEMBL4291200 IC50 8.0 nM
C[C@](O)(CO)CNc1cc(Nc2cccc(-c3ccc(C(F)(F)F)cc3F)c2)nn2c(C(N)=O)cnc12 CHEMBL4290130 IC50 8.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 8.0 nM
CCS(=O)(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(=O)NC CHEMBL4453827 IC50 8.0 nM
N#CC[C@]1(n2cc(-c3nc(-c4cn[nH]c4)cn4nccc34)cn2)C[C@@H](C#N)C1 CHEMBL4781984 IC50 8.0 nM
Cn1cc(-c2cn3nccc3c(-c3cnn([C@]4(CC#N)C[C@H](CC#N)C4)c3)n2)cn1 CHEMBL4780288 IC50 8.0 nM
COc1cc(Nc2ncc(C)c(N3CCC4(CCNC4=O)CC3)n2)cc(OC)c1OC CHEMBL5078528 IC50 8.0 nM
N#CCC1CCN(c2nc(Nc3ccc(N4CCC(O)CC4)cc3)c3c(=O)[nH]ncc3n2)CC1 CHEMBL4594275 IC50 8.0 nM
CNc1cc(Nc2ccccc2OC)nc2c(C(=O)N[C@@H]3CCN(C)C3=O)cnn12 CHEMBL5433451 IC50 8.0 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(Cl)cc2)[C@@H](C)C1 CHEMBL4783938 IC50 8.17 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(N3CCCC3=O)cc2)c1OC CHEMBL5280466 IC50 8.3 nM
COc1cc2c(=O)n(C3CCCCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4281080 IC50 8.38 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(F)c2)[C@H](C)C1 CHEMBL5396523 IC50 8.42 nM
C[C@@H]1C[C@@H]1C(=O)Nc1cc(NC(=O)c2c(Cl)cccc2Cl)ccn1 CHEMBL2387132 Ki 8.5 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cc2)[C@H](C)C1 CHEMBL4761365 IC50 8.5 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(C(=O)N(CC)CC)cn2)c1OC CHEMBL4800399 IC50 8.5 nM
Cc1cc(Nc2nccc3nc(-c4ccccc4Cl)sc23)nc(C)n1 CHEMBL3675693 Ki 8.6 nM
Cc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cc1 CHEMBL4060536 IC50 8.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)cc4)cc23)CC[C@]1(C)N CHEMBL4091582 IC50 8.6 nM
COc1ccc(Nc2nc(-c3c(F)cccc3F)nc3c2C(=O)NC3)cc1 CHEMBL5207378 Ki 8.6 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 IC50 8.7 nM
CS(=O)(=O)c1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3943994 IC50 8.7 nM
O=C(Nc1nccc2nc(-c3c(Cl)cccc3Cl)oc12)C1CC1 CHEMBL4068427 Ki 8.8 nM
O=c1[nH]ccc(NC2CCOCC2)c1-c1nc2ccccc2[nH]1 CHEMBL3781427 IC50 9.0 nM
COc1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)ccc1C#N CHEMBL4072848 IC50 9.0 nM
N#CC[C@]1(n2cc(-c3nc(-c4cc[nH]n4)cn4nccc34)cn2)C[C@@H](C#N)C1 CHEMBL4791733 IC50 9.0 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(C(C)(C)O)cn2)c1OC CHEMBL4792231 IC50 9.0 nM
N#CCCn1cc(-c2nc(Nc3ccc4c(c3)CCN4S(=O)(=O)c3ccc(C(F)(F)F)cc3)ncc2F)cn1 CHEMBL4853438 IC50 9.0 nM
N#CCCn1cc(-c2nc(Nc3ccc4c(ccn4S(=O)(=O)C(F)(F)F)c3)ncc2F)cn1 CHEMBL4864387 IC50 9.0 nM
Cc1cnc(Nc2ccc(F)c(N)c2)nc1N1CCC2(CCNC2=O)CC1 CHEMBL5091093 IC50 9.0 nM
Cc1cnc(Nc2ccc(N3C4CCC3COC4)cc2)nc1N1CCC2(CCNC2=O)CC1 CHEMBL5091163 IC50 9.0 nM
CCS(=O)(=O)c1cccc(-c2cn(C)c3cnc(NC(C)=O)cc23)n1 CHEMBL5403272 IC50 9.0 nM
N#C[C@@H]1C[C@@H]1C(=O)Nc1cc(NC(=O)c2c(Cl)cccc2Cl)ccn1 CHEMBL2387134 Ki 9.1 nM
COc1ccc(Cl)cc1-c1nn(CC(=O)N2CCCC2C)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667522 Ki 9.1 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL3928932 IC50 9.1 nM
[N-]=[N+]=NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL4111044 IC50 9.2 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cc1 CHEMBL4078773 IC50 9.2 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(Cl)cn2)[C@@H](C)C1 CHEMBL5423944 IC50 9.32 nM
C#Cc1cc(Cl)c(C(=O)Nc2ccnc(NC(=O)C3CC3)c2)c(Cl)c1 CHEMBL2387125 Ki 9.5 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(C(=O)NCC)cc2)c1OC CHEMBL5189220 IC50 9.6 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)CCN2CCOCC2)nc1-c1cnn(C(C)C)c1 CHEMBL4858303 IC50 9.64 nM
CC(C)[C@@H](C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O CHEMBL3764383 IC50 9.7 nM
SC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3927252 IC50 9.7 nM
Cn1ccc(-c2cn(-c3ccccc3Cl)c(=O)c3c(N)n[nH]c23)n1 CHEMBL3765131 IC50 9.9 nM
Cc1cc(Nc2nccc3nc(-c4c(Cl)cccc4Cl)[nH]c23)nc(N(C)C)n1 CHEMBL4093092 Ki 9.9 nM