COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 0.83 nM
CC(C)[C@H](NC(=O)c1cc(C2C=C3N=C(c4ccc(OCCN5CCCCC5)cc4)C=CN3N2)cs1)C(F)(F)F CHEMBL5280560 IC50 1.6 nM
O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL3605057 IC50 2.9 nM
CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1 CHEMBL4516990 IC50 2.9 nM
O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CC1 CHEMBL5266681 IC50 2.9 nM
O=C1CCCc2cc(Nc3ncc(C(F)(F)F)c(NC4CC4)n3)ccc21 CHEMBL4796600 IC50 3.0 nM
FC(F)(F)c1cnc(Nc2ccc3ncccc3c2)nc1NC1CC1 CHEMBL4746440 IC50 5.0 nM
FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1NC1CC1 CHEMBL4741912 IC50 5.0 nM
c1ccc2c(Nc3cc(C4CCC4)[nH]n3)nc(Nc3ccc4[nH]cnc4c3)nc2c1 CHEMBL3605055 IC50 5.3 nM
FC(F)(F)c1cnc(Nc2ccc3nn[nH]c3c2)nc1NC1CC1 CHEMBL4782961 IC50 6.0 nM
FC(F)(F)c1cnc(Nc2ccc3c(c2)OCCCO3)nc1NC1CC1 CHEMBL4758769 IC50 7.0 nM
O=C(N[C@@H](C1CC1)C(F)(F)F)c1cc(C2C=C3N=C(c4ccc(F)cc4)C=CN3N2)cs1 CHEMBL5269042 IC50 8.3 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 8.95 nM
C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL4435393 IC50 9.0 nM
NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc5ccccc45)c3c2)C1 CHEMBL4167070 IC50 11.0 nM
COc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1OC CHEMBL4779423 IC50 13.0 nM
O=C(Nc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1)C1CC1 CHEMBL4778997 IC50 13.0 nM
FC(F)(F)c1cnc(Nc2ccc3nccnc3c2)nc1NC1CC1 CHEMBL4748400 IC50 13.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 14.0 nM
COc1cncc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)c1 CHEMBL4795918 IC50 14.0 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]ncc3c2)nc1NC1CC1 CHEMBL4794151 IC50 14.0 nM
FC(F)(F)c1cnc(Nc2ccc3c(c2)OCCO3)nc1NC1CC1 CHEMBL4799009 IC50 14.0 nM
FC(F)(F)c1cnc(Nc2cnc3ccccc3c2)nc1NC1CC1 CHEMBL4792540 IC50 16.0 nM
FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CCC1 CHEMBL4793366 IC50 17.0 nM
CC(C)CN(CC(=O)N1CCN(CC(OCc2ccc3ccccc3c2)c2ccc(Cl)cc2Cl)CC1)CC(C)C CHEMBL4125718 EC50 18.94 nM
FC(F)(F)c1cnc(Nc2ccc3ncoc3c2)nc1NC1CC1 CHEMBL4800057 IC50 19.0 nM
Nc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1 CHEMBL4789210 IC50 20.0 nM
FC(F)(F)c1cnc(Nc2ccc3c(c2)OCO3)nc1NC1CC1 CHEMBL4748802 IC50 21.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 23.0 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]ccc3c2)nc1NC1CC1 CHEMBL4754535 IC50 23.0 nM
N[C@@H]1CCC[C@@H](C(=O)Nc2ccc3[nH]nc(Nc4cccc5ccccc45)c3c2)C1 CHEMBL4159827 IC50 24.0 nM
O=C(Nc1cc(F)ccc1F)[C@H](NC(=S)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 CHEMBL4204256 EC50 24.14 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 Kd apparent 28.0 nM
O=C(CC(F)(F)F)N1CCN(Cc2ccnc(Nc3nc4ccc(-c5cnn(CC6CC6)c5)cc4[nH]3)c2)CC1 CHEMBL4468020 IC50 28.0 nM
FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CC1 CHEMBL4776497 IC50 29.0 nM
O=C(C1CC1)N(C(=O)C1CC1)c1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1 CHEMBL4786152 IC50 30.0 nM
CCN1CCOc2cc(Nc3ncc(C(F)(F)F)c(NC4CC4)n3)cnc21 CHEMBL4750700 IC50 31.0 nM
Nc1nc2cc(Nc3nc(Nc4cc(C5CCC5)[nH]n4)c4ccccc4n3)ccc2[nH]1 CHEMBL5279228 IC50 31.0 nM
c1ccc2c(Nc3cc(C4CCC4)[nH]n3)nc(Nc3ccc4[nH]ncc4c3)nc2c1 CHEMBL5276694 IC50 31.0 nM
CNc1nc(Nc2cnc3[nH]ccc3c2)ncc1C(F)(F)F CHEMBL4747695 IC50 34.0 nM
NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc5ncccc45)c3c2)C1 CHEMBL4176003 IC50 40.0 nM
FC(F)(F)c1cnc(Nc2ccnnc2)nc1NC1CC1 CHEMBL4787833 IC50 40.0 nM
O=C(Nc1ccc(F)cc1F)[C@H](NCCc1ccc(F)cc1)c1ccccc1 CHEMBL4210617 EC50 40.8 nM
FC1(F)Oc2ccc(Nc3ncc(C(F)(F)F)c(NC4CC4)n3)cc2O1 CHEMBL4777354 IC50 42.0 nM
CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=N)C4CCC4)n3)ccc2C1 CHEMBL4127042 IC50 45.0 nM
N[C@H]1CCC[C@@H](C(=O)Nc2ccc3[nH]nc(Nc4cccc5ccccc45)c3c2)C1 CHEMBL4170480 IC50 45.0 nM
CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CC4)n3)ccc2C1 CHEMBL5288376 IC50 45.0 nM
Oc1ccccc1Nc1ncc(C(F)(F)F)c(NC2CC2)n1 CHEMBL4755602 IC50 50.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 53.0 nM
CN1CCN(CC(OC(=O)c2ccc3c(c2)OCO3)c2ccccc2)CC1 CHEMBL4208925 EC50 54.84 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 55.0 nM
O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)C1CC1 CHEMBL3603853 IC50 67.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 82.0 nM
O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)c1cccs1 CHEMBL577784 IC50 87.0 nM
CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br CHEMBL4128069 IC50 108.0 nM
COc1ccccc1Nc1n[nH]c2ccc(NC(=O)C3CCCC(N)C3)cc12 CHEMBL4167729 IC50 110.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 115.0 nM
NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I CHEMBL3605056 IC50 120.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 135.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1 CHEMBL4538174 Kd 140.0 nM
Nc1ccc(Nc2nc(Nc3cc(C4CC4)[nH]n3)c3ccccc3n2)cc1 CHEMBL5274568 IC50 160.0 nM
COC(=O)c1cccc(Nc2n[nH]c3ccc(NC(=O)C4CCCC(N)C4)cc23)c1 CHEMBL4168817 IC50 183.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 188.0 nM
Cc1csc(-c2nnc(Nc3ccc(Oc4ncccc4-c4ccnc(N)n4)cc3)c3ccccc23)c1 CHEMBL2140408 Kd apparent 190.0 nM
Nc1nc(Nc2ccc3c(c2)OCO3)ncc1C(F)(F)F CHEMBL4794090 IC50 230.0 nM
NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4ccnc5ccccc45)c3c2)C1 CHEMBL4160882 IC50 239.0 nM
NC1CCCC(C(=O)Nc2ccc3[nH]nc(NC(=O)c4ccccc4)c3c2)C1 CHEMBL4161514 IC50 242.0 nM
CC(C)Oc1cncnc1-c1ccc2nc(Nc3cc([C@@H](C)N4CCN(C(=O)CC(F)(F)F)CC4)ccn3)[nH]c2c1 CHEMBL4543618 IC50 263.0 nM
Clc1ccc(CO[C@@H](Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 CHEMBL1232474 EC50 263.1 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 270.0 nM
NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc(C(F)(F)F)c4)c3c2)C1 CHEMBL4164280 IC50 288.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 300.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 311.0 nM
O=C(Nc1ccc2[nH]nc(Nc3cccc4ccccc34)c2c1)C1CCNCC1 CHEMBL4163621 IC50 315.0 nM
Nc1n[nH]c2ccc(NC(=O)[C@H]3CCC[C@@H](N)C3)cc12 CHEMBL4172115 IC50 330.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 340.0 nM
Nc1n[nH]c2ccc(NC(=O)C3CCCC(N)C3)cc12 CHEMBL4177033 IC50 368.0 nM
COCc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4566796 IC50 368.0 nM
NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4ccc(Br)cc4)c3c2)C1 CHEMBL4175598 IC50 416.0 nM
C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(OCC5CC5)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL4454902 IC50 416.0 nM
COc1ccc(CNc2n[nH]c3ccc(NC(=O)C4CCCC(N)C4)cc23)cc1 CHEMBL4160498 IC50 477.0 nM
Nc1n[nH]c2ccc(NC(=O)C3CCNCC3)cc12 CHEMBL4173259 IC50 560.0 nM
NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc5cccnc45)c3c2)C1 CHEMBL4165390 IC50 589.0 nM
Nc1n[nH]c2ccc(NC(=O)C3CCCNC3)cc12 CHEMBL4168766 IC50 670.0 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 Kd apparent 810.0 nM
CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C CHEMBL1230607 Kd apparent 838.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 839.0 nM
Nc1n[nH]c2ccc(NC(=O)C3CCCCN3)cc12 CHEMBL4176627 IC50 840.0 nM
NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4ccccc4F)c3c2)C1 CHEMBL4172165 IC50 840.0 nM
Cc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4538751 IC50 980.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 1000.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM