O=C(c1cnc(NC2(c3cnccn3)CCC2)nc1)N1CCC2(CCOCC2)C1 CHEMBL5084938 IC50 0.04 nM
O=C(c1cnc(NC2(c3cnccn3)CCC2)nc1)N1CC2(CCOCC2)C1 CHEMBL5089503 IC50 0.04 nM
CC(C)(Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cnccn1 CHEMBL5085625 IC50 0.06 nM
CC(C)(Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cncnc1 CHEMBL5082540 IC50 0.08 nM
CC(C)(Nc1ncc(C(=O)N2CC3(CCOCC3)C2)cn1)c1cnccn1 CHEMBL5072128 IC50 0.11 nM
O=C(c1cnc(NC2(c3cncnc3)CCC2)nc1)N1CCC2(CCOCC2)C1 CHEMBL5087511 IC50 0.12 nM
C[C@H](Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cnccn1 CHEMBL5088348 IC50 0.24 nM
O=C(c1cnc(NC2(c3cncnc3)CC2)nc1)N1CCC2(CCOCC2)C1 CHEMBL5087956 IC50 0.28 nM
O=C(c1cnc(NC2(c3cnccn3)COC2)nc1)N1CCC2(CCOCC2)C1 CHEMBL5081075 IC50 0.35 nM
O=C(c1cnc(NC2(c3cncnc3)COC2)nc1)N1CCC2(CCOCC2)C1 CHEMBL5092354 IC50 0.43 nM
C[C@H](Nc1ncc(C(=O)N2CC3(CCOCC3)C2)cn1)c1cnccn1 CHEMBL5083289 IC50 0.6 nM
C[C@H](Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cncnc1 CHEMBL5082701 IC50 0.68 nM
O=C(c1cnc(NCc2cccnc2)nc1)N1CCC2(CCOCC2)C1 CHEMBL5074743 IC50 1.3 nM
C[C@@H](Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cnccn1 CHEMBL5090508 IC50 3.12 nM
O=C(c1cnc(NCc2cnccn2)nc1)N1CC2(CCOCC2)C1 CHEMBL5092194 IC50 3.4 nM
N#Cc1cccc(C(=O)c2cnc(NC3(c4cncnc4)CC3)nc2)c1 CHEMBL5092926 IC50 4.1 nM
N#Cc1cccc(C(=O)c2cnc(NCc3cccnc3)nc2)c1 CHEMBL5071943 IC50 4.4 nM
O=C(c1cnc(NCc2cnccn2)nc1)N1CCC2(CCOCC2)C1 CHEMBL4802040 IC50 6.85 nM
N#CC1CCCN(C(=O)c2cnc(NC3(c4cncnc4)CC3)nc2)C1 CHEMBL5091378 Kd 7.2 nM
O=C(c1cnc(NCc2cncnc2)nc1)N1CCC2(CCOCC2)C1 CHEMBL5094296 IC50 7.7 nM
CS(=O)(=O)[C@@H]1CCCN(C(=O)c2cnc(NC3(c4cncnc4)CC3)nc2)C1 CHEMBL5086259 IC50 10.6 nM
O=C(c1cnc(NC2(c3cncnc3)CC2)nc1)N1CCCCC1 CHEMBL5093642 IC50 12.3 nM
N#Cc1cccc(C(=O)c2cnc(NC3(c4ccccc4)CC3)nc2)c1 CHEMBL5088351 IC50 22.0 nM
C[C@@H](Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cncnc1 CHEMBL5077966 IC50 27.9 nM
N#Cc1cccc(C(=O)c2cnc(NCc3cncnc3)nc2)c1 CHEMBL5078862 IC50 33.0 nM
CS(=O)(=O)C1CCCN(C(=O)c2cnc(NC3(c4cncnc4)CC3)nc2)C1 CHEMBL5087573 Kd 37.0 nM
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1ccc(OC(F)(F)F)cc1 CHEMBL5172300 IC50 38.0 nM
Cc1cccc(C(=O)c2cnc(NCc3cccnc3)nc2)c1 CHEMBL5070210 IC50 52.0 nM
N#C[C@@H]1CCCN(C(=O)c2cnc(NC3(c4cncnc4)CC3)nc2)C1 CHEMBL5094835 IC50 52.0 nM
O=C(c1ccccc1)c1cnc(NCc2cccnc2)nc1 CHEMBL5077449 IC50 53.0 nM
N#Cc1cccc(C(=O)c2cnc(NCc3ccccc3)nc2)c1 CHEMBL5085510 IC50 80.0 nM
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1ccc(F)cc1 CHEMBL5178654 IC50 100.0 nM
O=C(c1cnc(NCc2cccnc2)nc1)c1cccs1 CHEMBL5069997 IC50 160.0 nM
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1cccc(F)c1 CHEMBL5181854 IC50 160.0 nM
CN(C(=O)C1CC(F)(F)C1)[C@H]1CCN(C(=O)c2ccc(NC(C)(C)C)nc2)C1 CHEMBL4789364 IC50 200.0 nM
CC(=O)N(C)[C@H]1CCN(C(=O)c2ccc(NC(C)(C)CCO)nc2)C1 CHEMBL4756953 IC50 200.0 nM
CCC(C)(C)Nc1ccc(C(=O)N2CC[C@H](N(C)C(C)=O)C2)cn1 CHEMBL4760519 IC50 200.0 nM
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1ccccc1F CHEMBL5173400 IC50 230.0 nM
CN(C(=O)[C@@H]1CCCO1)[C@H]1CCN(C(=O)c2ccc(NC(C)(C)C)nc2)C1 CHEMBL4753498 IC50 300.0 nM
CC(C)(C)Nc1ccc(C(=O)N2CC[C@H](N3CCOC3=O)C2)cn1 CHEMBL4799998 IC50 300.0 nM
CC(C)(C)Nc1ccc(C(=O)N2CC(C)(c3ccccn3)C2)cn1 CHEMBL4752209 IC50 300.0 nM
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1cccc(OC(F)(F)F)c1 CHEMBL5170185 IC50 410.0 nM
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1ccc(Cl)c(Cl)c1 CHEMBL5201071 IC50 600.0 nM
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1ccc(Cl)cc1 CHEMBL5182223 IC50 770.0 nM
COc1ccc(CC(=O)CCNC(=O)[C@H](O)C(C)(C)CO)cc1 CHEMBL5188262 IC50 770.0 nM
CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1ccccc1 CHEMBL5170521 IC50 780.0 nM