0 B8R1.18 CC1C(=O)SC(=S)N1 DA-39130 [0,0,0,0,0,0|2,0,2]=4 1 B8R1.18 Cc1c(cn(n1)C)I DA-39320 [0,0,0,0,0,0|3,0,0]=3 2 B8R1.18 Cc1c(nc(s1)Br)N DA-26777 [0,0,0,0,0,0|2,0,0]=2 3 B8R1.18 Cc1c(sc(=S)[nH]1)N DA-38013 [0,0,0,0,0,0|2,0,1]=3 4 B8R1.18 Cc1cc(nn1C)I DA-23532 [0,0,0,0,0,0|3,0,0]=3 5 B8R1.18 Cn1nc(c(n1)Br)Br DA-42888 [0,0,0,0,0,0|4,0,0]=4 6 B8R1.18 c1(c(sc(n1)Br)Br)Br DA-27347 [0,0,0,0,0,0|3,0,0]=3 7 B8R1.18 c1(c(sc(n1)Br)Br)Cl DA-27537 [0,0,0,0,0,0|3,0,0]=3 8 B8R1.18 c1(c(sc(n1)Br)Cl)Cl DA-26869 [0,0,0,0,0,0|3,0,0]=3 9 B8R1.18 c1(c(sc(n1)Cl)Br)Cl DA-37868 [0,0,0,0,0,0|3,0,0]=3 10 B8R1.18 c1(c(sc(n1)N)Cl)Br DA-23138 [0,0,0,0,0,0|3,0,0]=3 11 B7R1.2 CC1=NN=C(C1)N DA-37100 [1,0,0,0,0,0|3,0,0]=4 12 B7R1.2 Cc1c[nH]c(=O)s1 DA-37141 [1,0,0,0,0,0|1,0,1]=3 13 B7R1.2 Cc1cc(cs1)N DA-37078 [1,0,0,0,0,0|2,0,0]=3 14 B7R1.2 Cc1cc(sc1)I DA-26092 [1,0,0,0,0,0|2,0,0]=3 15 B7R1.2 Cc1cc(sn1)I DA-37273 [1,0,0,0,0,0|3,0,0]=4 16 B7R1.2 Cc1ccc(s1)O DA-37079 [1,0,0,0,0,0|2,0,0]=3 17 B7R1.2 Cc1cn(nn1)C DA-30217 [1,0,0,0,0,0|3,0,0]=4 18 B7R1.2 Cc1cnc([nH]1)N DA-37158 [1,0,0,0,0,0|2,0,0]=3 19 B7R1.2 Cc1nc(co1)Br DA-23144 [1,0,0,0,0,0|1,1,0]=3 20 B7R1.2 Cn1ncc(n1)Br DA-43568 [1,0,0,0,0,0|3,0,0]=4 21 B7R1.2 c1(nc(=O)[nH]s1)N DA-38086 [1,0,0,0,0,0|3,0,0]=4 22 B7R1.2 c1c([nH]c(=O)s1)N DA-21485 [1,0,0,0,0,0|2,0,1]=4 23 B7R1.2 c1c([nH]c(=S)s1)O DA-39362 [1,0,0,0,0,0|2,0,1]=4 24 B7R1.2 c1c(csc1Br)Cl DA-26854 [1,0,0,0,0,0|3,0,0]=4 25 B7R1.2 c1c(nc(s1)Br)I DA-26838 [1,0,0,0,0,0|2,0,0]=3 26 B7R1.2 c1c(nc(s1)Cl)N DA-28923 [1,0,0,0,0,0|2,0,0]=3 27 B7R1.2 c1c(sc(n1)Cl)Cl DA-27213 [1,0,0,0,0,0|2,0,0]=3 28 B7R1.4 Cc1c(=O)[nH]sn1 DA-39175 [1,0,0,0,0,0|3,0,0]=4 29 B7R1.4 Cc1c([nH]cn1)Cl DA-37509 [1,0,0,0,0,0|2,0,0]=3 30 B7R1.4 Cc1c(scn1)Cl DA-37506 [1,0,0,0,0,0|1,0,0]=2 31 B7R1.4 Cc1ccsc1I DA-26100 [1,0,0,0,0,0|2,0,0]=3 32 B7R1.4 Cc1cnoc1C DA-21946 [1,0,0,0,0,0|2,1,0]=4 33 B7R1.4 Cn1c(ncn1)I DA-37294 [1,0,0,0,0,0|3,0,0]=4 34 B7R1.4 c1csc(c1N)Br DA-28938 [1,0,0,0,0,0|3,0,0]=4 35 B7R1.4 c1nc(c(s1)Br)Br DA-22086 [1,0,0,0,0,0|2,0,0]=3 36 B7R1.4 c1nc(c(s1)Cl)Cl DA-21975 [1,0,0,0,0,0|2,0,0]=3 37 B9R1.22 C(c1c(nc(s1)Cl)Cl)O DA-27298 [0,1,0,0,0,0|2,0,0]=3 38 B9R1.22 CCc1c(cn(n1)C)N DA-23650 [0,1,0,0,0,0|3,0,0]=4 39 B9R1.22 Cc1[nH]c(c(n1)C=O)Cl DA-37561 [0,1,0,0,0,0|2,0,1]=4 40 B9R1.22 Cc1[nH]c(c(n1)CO)Cl DA-37559 [0,1,0,0,0,0|2,0,0]=3 41 B9R1.22 Cc1c(cc(s1)Br)C=O DA-37817 [0,1,0,0,0,0|2,0,1]=4 42 B9R1.22 Cc1c(cn(n1)C)C=C DA-40701 [0,1,0,0,0,0|2,0,1]=4 43 B9R1.22 Cc1c(nc(o1)C)CN DA-27183 [0,1,0,0,0,0|0,1,0]=2 44 B9R1.22 Cc1c(nc(s1)Br)CO DA-26776 [0,1,0,0,0,0|1,0,0]=2 45 B9R1.22 Cc1c(sc(=O)[nH]1)C=O DA-27390 [0,1,0,0,0,0|1,0,2]=4 46 B9R1.22 Cc1cc(sc1C=O)I DA-37275 [0,1,0,0,0,0|2,0,1]=4 47 B9R1.22 Cc1nc(c(s1)C#N)N DA-21362 [0,1,0,0,0,0|1,0,1]=3 48 B9R1.22 Cc1nn(c(=S)s1)C=O DA-37118 [0,1,0,0,0,0|2,0,1]=4 49 B9R1.22 c1c(c(sc1Cl)Cl)CBr DA-41829 [0,1,0,0,0,0|3,0,0]=4 50 B9R1.22 c1c(c(sc1Cl)Cl)CO DA-27239 [0,1,0,0,0,0|3,0,0]=4 51 B9R1.23 C(=O)c1nc(c(s1)Cl)Cl DA-21978 [0,1,0,0,0,0|2,0,1]=4 52 B9R1.23 CCn1cc(c(n1)C)N DA-29414 [0,1,0,0,0,0|3,0,0]=4 53 B9R1.23 Cc1c(sc(n1)CO)Br DA-37735 [0,1,0,0,0,0|1,0,0]=2 54 B9R1.23 Cc1c(sc(n1)NC)C DA-39995 [0,1,0,0,0,0|0,0,0]=1 55 B9R1.23 Cc1c(sc(n1)NN)C DA-26173 [0,1,0,0,0,0|1,0,0]=2 56 B9R1.23 Cn1c(cc(n1)CO)N DA-38068 [0,1,0,0,0,0|3,0,0]=4 57 B9R1.34 Cc1nc(cc(n1)N)N DA-25886 [0,0,0,0,0,1|3,0,0]=4 58 B9R1.69 Cc1c(c[nH]c(=O)n1)Br DA-37738 [0,0,0,0,0,1|3,0,0]=4 59 B9R1.69 Cc1c(cc(cn1)N)F DA-37353 [0,0,0,0,0,1|3,0,0]=4 60 B9R1.69 Cc1c(cnc(n1)Br)N DA-28944 [0,0,0,0,0,1|3,0,0]=4 61 B9R1.69 Cc1c(cnc(n1)Cl)Br DA-41858 [0,0,0,0,0,1|3,0,0]=4 62 B9R1.69 Cc1c(cnc(n1)Cl)O DA-26556 [0,0,0,0,0,1|3,0,0]=4 63 B9R1.69 Cc1c(cnc(n1)F)Cl DA-37566 [0,0,0,0,0,1|3,0,0]=4 64 B9R1.69 Cc1c(nc(cn1)N)C DA-41872 [0,0,0,0,0,1|2,0,0]=3 65 B9R1.69 Cc1c(nc(nn1)N)Cl DA-37466 [0,0,0,0,0,1|3,0,0]=4 66 B9R1.69 Cc1cc(c(cn1)C)Br DA-39962 [0,0,0,0,0,1|2,0,0]=3 67 B9R1.69 Cc1cc(c(cn1)O)Br DA-46642 [0,0,0,0,0,1|3,0,0]=4 68 B9R1.69 Cc1cc(c(nc1)I)O DA-26090 [0,0,0,0,0,1|3,0,0]=4 69 B9R1.69 Cc1cc(cnc1N)O DA-36577 [0,0,0,0,0,1|3,0,0]=4 70 B9R1.69 Cc1cc(ncc1C)I DA-26095 [0,0,0,0,0,1|2,0,0]=3 71 B9R1.69 Cc1cc(ncc1I)O DA-37268 [0,0,0,0,0,1|3,0,0]=4 72 B9R1.69 Cc1cc(ncc1O)Br DA-36427 [0,0,0,0,0,1|3,0,0]=4 73 B9R1.69 Cc1ccc(c(n1)Br)Cl DA-26903 [0,0,0,0,0,1|3,0,0]=4 74 B9R1.69 Cc1ccc(nc1Br)C DA-42573 [0,0,0,0,0,1|2,0,0]=3 75 B9R1.69 Cc1ccc(nc1Br)N DA-36414 [0,0,0,0,0,1|3,0,0]=4 76 B9R1.69 Cc1cnc(cc1Br)N DA-39846 [0,0,0,0,0,1|3,0,0]=4 77 B9R1.69 Cc1cnc(nc1Br)Br DA-27327 [0,0,0,0,0,1|3,0,0]=4 78 B9R1.69 Cc1ncc(c(n1)Cl)Cl DA-42977 [0,0,0,0,0,1|3,0,0]=4 79 B6R1.2 Cc1ccc[nH]1 DA-25958 [2,0,0,0,0,0|1,0,1]=4 80 B6R1.2 c1c(ncs1)I DA-39286 [2,0,0,0,0,0|1,0,0]=3 81 B6R1.2 c1c(ncs1)O DA-38955 [2,0,0,0,0,0|1,0,0]=3 82 B6R1.2 c1c(scn1)I DA-37263 [2,0,0,0,0,0|1,0,0]=3 83 B6R1.2 c1c(scn1)O DA-36993 [2,0,0,0,0,0|1,0,0]=3 84 B6R1.2 c1nnc(s1)N DA-30299 [2,0,0,0,0,0|2,0,0]=4 85 B8R1.1 C(c1nc(sn1)Cl)Br DA-24965 [1,1,0,0,0,0|2,0,0]=4 86 B8R1.1 CC1CN=C(S1)SC DA-21967 [1,1,0,0,0,0|0,0,2]=4 87 B8R1.1 CCc1csc(n1)Br DA-26848 [1,1,0,0,0,0|1,0,0]=3 88 B8R1.1 CNc1nc(cs1)O DA-27653 [1,1,0,0,0,0|1,0,0]=3 89 B8R1.1 COc1cc(cs1)Br DA-23146 [1,1,0,0,0,0|2,0,0]=4 90 B8R1.1 COc1nnc(s1)N DA-37228 [1,1,0,0,0,0|2,0,0]=4 91 B8R1.1 Cc1[nH]c(cn1)CBr DA-38453 [1,1,0,0,0,0|1,0,0]=3 92 B8R1.1 Cc1cc(cs1)CO DA-37106 [1,1,0,0,0,0|1,0,0]=3 93 B8R1.1 Cc1cc(n[nH]1)CN DA-37150 [1,1,0,0,0,0|2,0,0]=4 94 B8R1.1 Cc1cc(sc1)OC DA-28915 [1,1,0,0,0,0|1,0,0]=3 95 B8R1.1 Cc1ccc(o1)CCl DA-42213 [1,1,0,0,0,0|1,1,0]=4 96 B8R1.1 Cc1ccc(s1)C=C DA-26289 [1,1,0,0,0,0|1,0,1]=4 97 B8R1.1 Cc1ccc(s1)CCl DA-27775 [1,1,0,0,0,0|1,0,0]=3 98 B8R1.1 Cc1cnc([nH]1)SC DA-37140 [1,1,0,0,0,0|1,0,0]=3 99 B8R1.1 Cc1cnc(o1)CBr DA-27801 [1,1,0,0,0,0|0,1,0]=3 100 B8R1.1 Cc1cnc(s1)CBr DA-43197 [1,1,0,0,0,0|0,0,0]=2 101 B8R1.1 Cc1cnc(s1)CN DA-37119 [1,1,0,0,0,0|0,0,0]=2 102 B8R1.1 Cc1cnc(s1)OC DA-25992 [1,1,0,0,0,0|0,0,0]=2 103 B8R1.1 Cc1cnc(s1)SC DA-37139 [1,1,0,0,0,0|0,0,0]=2 104 B8R1.1 Cc1csc(n1)CBr DA-40623 [1,1,0,0,0,0|0,0,0]=2 105 B8R1.1 Cc1csc(n1)CCl DA-27783 [1,1,0,0,0,0|0,0,0]=2 106 B8R1.1 Cc1csc(n1)OC DA-26013 [1,1,0,0,0,0|0,0,0]=2 107 B8R1.1 Cc1csc(n1)SC DA-39146 [1,1,0,0,0,0|0,0,0]=2 108 B8R1.1 Cc1nc(co1)CCl DA-22275 [1,1,0,0,0,0|0,1,0]=3 109 B8R1.1 Cc1ncc(s1)C#C DA-38898 [1,1,0,0,0,0|0,0,1]=3 110 B8R1.1 Cn1cc(cn1)CBr DA-22311 [1,1,0,0,0,0|2,0,0]=4 111 B8R1.1 Cn1cc(cn1)CCl DA-22283 [1,1,0,0,0,0|2,0,0]=4 112 B8R1.1 Cn1cc(cn1)CCl DA-44000 [1,1,0,0,0,0|2,0,0]=4 113 B8R1.1 c1c(csc1CCl)Br DA-43535 [1,1,0,0,0,0|2,0,0]=4 114 B8R1.1 c1c(csc1CCl)Cl DA-39717 [1,1,0,0,0,0|2,0,0]=4 115 B8R1.1 c1c(csc1CO)Cl DA-39665 [1,1,0,0,0,0|2,0,0]=4 116 B8R1.1 c1c(nc(s1)C#N)Br DA-39909 [1,1,0,0,0,0|1,0,1]=4 117 B8R1.1 c1c(sc(n1)CO)Cl DA-37546 [1,1,0,0,0,0|1,0,0]=3 118 B8R1.50 Cc1csc(c1Br)C DA-25567 [1,1,0,0,0,0|1,0,0]=3 119 B8R1.11 CCc1c(scn1)C DA-39425 [1,1,0,0,0,0|0,0,0]=2 120 B8R1.11 Cc1c([nH]cn1)CBr DA-38449 [1,1,0,0,0,0|1,0,0]=3 121 B8R1.11 Cc1c(ccs1)C#N DA-25903 [1,1,0,0,0,0|1,0,1]=4 122 B8R1.11 Cc1c(con1)CCl DA-22273 [1,1,0,0,0,0|2,0,0]=4 123 B8R1.11 Cc1c(ncs1)CO DA-37097 [1,1,0,0,0,0|0,0,0]=2 124 B8R1.11 Cc1c(scn1)CBr DA-38448 [1,1,0,0,0,0|0,0,0]=2 125 B8R1.11 Cc1c(scn1)OC DA-37189 [1,1,0,0,0,0|0,0,0]=2 126 B8R1.11 Cc1c(snn1)CCl DA-38433 [1,1,0,0,0,0|1,0,0]=3 127 B8R1.11 Cc1ccsc1C=C DA-26290 [1,1,0,0,0,0|1,0,1]=4 128 B8R1.11 Cc1ccsc1CBr DA-27814 [1,1,0,0,0,0|1,0,0]=3 129 B8R1.11 Cn1c(ccn1)CCl DA-38442 [1,1,0,0,0,0|2,0,0]=4 130 B8R1.11 c1csc(c1Cl)CBr DA-41958 [1,1,0,0,0,0|2,0,0]=4 131 B8R1.11 c1csc(c1Cl)CCl DA-23859 [1,1,0,0,0,0|2,0,0]=4 132 B10R1.8 CCc1cc(nc(n1)C)N DA-36173 [0,1,0,0,0,1|2,0,0]=4 133 B10R1.8 Cc1cc(cc(n1)C)CCl DA-22280 [0,1,0,0,0,1|1,0,0]=3 134 B10R1.8 Cc1cc(cc(n1)Cl)CBr DA-22307 [0,1,0,0,0,1|2,0,0]=4 135 B10R1.8 Cc1cc(nc(=O)[nH]1)SC DA-43562 [0,1,0,0,0,1|2,0,0]=4 136 B10R1.8 Cc1cc(nc(n1)CO)N DA-21305 [0,1,0,0,0,1|2,0,0]=4 137 B10R1.8 Cc1nc(cc(n1)N)CO DA-36606 [0,1,0,0,0,1|2,0,0]=4 138 B10R1.22 Cc1c(c(=O)[nH]c(n1)C)I DA-37286 [0,1,0,0,0,1|2,0,0]=4 139 B10R1.22 Cc1c(c(nc(=O)[nH]1)C)Cl DA-43370 [0,1,0,0,0,1|2,0,0]=4 140 B10R1.22 Cc1c(c(nc(n1)Cl)C)Cl DA-43369 [0,1,0,0,0,1|2,0,0]=4 141 B10R1.22 Cc1c(c(nc(n1)Cl)C)F DA-47465 [0,1,0,0,0,1|2,0,0]=4 142 B10R1.22 Cc1c(c(nc(n1)N)C)Cl DA-37514 [0,1,0,0,0,1|2,0,0]=4 143 B10R1.22 Cc1cc(nc(c1N)C)Br DA-36497 [0,1,0,0,0,1|2,0,0]=4 144 B10R1.22 Cc1cc(nc(c1O)Br)C DA-48059 [0,1,0,0,0,1|2,0,0]=4 145 B10R1.25 Cc1c(cnc(n1)C)CBr DA-38455 [0,1,0,0,0,1|1,0,0]=3 146 B10R1.25 Cc1c(cnc(n1)C)OC DA-37208 [0,1,0,0,0,1|1,0,0]=3 147 B10R1.25 Cc1c(cnc(n1)Cl)OC DA-26457 [0,1,0,0,0,1|2,0,0]=4 148 B10R1.25 Cc1cc(c(cn1)CCl)N DA-38439 [0,1,0,0,0,1|2,0,0]=4 149 B10R1.25 Cc1cc(cnc1NC)Br DA-38915 [0,1,0,0,0,1|2,0,0]=4 150 B10R1.25 Cc1cc(cnc1SC)N DA-40381 [0,1,0,0,0,1|2,0,0]=4 151 B10R1.25 Cc1cc(cnc1SC)O DA-40382 [0,1,0,0,0,1|2,0,0]=4 152 B10R1.25 Cc1cc(ncc1CN)C DA-31980 [0,1,0,0,0,1|1,0,0]=3 153 B10R1.25 Cc1ccc(c(n1)C)C#N DA-27103 [0,1,0,0,0,1|1,0,1]=4 154 B10R1.30 CCc1c(cnc(n1)C)O DA-39444 [0,1,0,0,0,1|2,0,0]=4 155 B10R1.30 Cc1c(cc(nn1)Cl)OC DA-36280 [0,1,0,0,0,1|2,0,0]=4 156 B10R1.30 Cc1ccc(c(n1)OC)Cl DA-23848 [0,1,0,0,0,1|2,0,0]=4 157 B10R1.118 Cc1c(nc(c(n1)C)Cl)C DA-26667 [0,1,0,0,0,1|1,0,0]=3 158 B10R1.119 Cc1c(cnc(c1Br)C)N DA-37757 [0,1,0,0,0,1|2,0,0]=4 159 B10R1.176 CCc1ncc(c(n1)C)O DA-26240 [0,1,0,0,0,1|2,0,0]=4 160 B10R1.176 Cc1c(cc(cn1)CN)F DA-31874 [0,1,0,0,0,1|2,0,0]=4 161 B10R1.176 Cc1c(cc(cn1)CO)Br DA-31884 [0,1,0,0,0,1|2,0,0]=4 162 B10R1.176 Cc1c(cc(cn1)CO)Cl DA-37464 [0,1,0,0,0,1|2,0,0]=4 163 B10R1.176 Cc1c(cnc(n1)OC)O DA-26014 [0,1,0,0,0,1|2,0,0]=4 164 B10R1.176 Cc1c[nH]c(nc1=O)SC DA-43305 [0,1,0,0,0,1|2,0,0]=4 165 B10R1.176 Cc1cc(cnc1C)C=O DA-38235 [0,1,0,0,0,1|1,0,1]=4 166 B10R1.176 Cc1cc(cnc1C)CO DA-38237 [0,1,0,0,0,1|1,0,0]=3 167 B10R1.176 Cc1ccc(nc1C)C=O DA-38234 [0,1,0,0,0,1|1,0,1]=4 168 B10R1.34 Cc1c(c(sc1Br)OC)Br DA-27544 [0,2,0,0,0,0|2,0,0]=4 169 B10R1.35 CCn1cc(c(n1)C)CN DA-29412 [0,2,0,0,0,0|2,0,0]=4 170 B10R1.35 CSc1nc(c(s1)C#N)N DA-21477 [0,2,0,0,0,0|1,0,1]=4 171 B10R1.35 CSc1nc(c(s1)C=O)Cl DA-39715 [0,2,0,0,0,0|1,0,1]=4 172 B10R1.35 CSc1nc(c(s1)C=O)N DA-21476 [0,2,0,0,0,0|1,0,1]=4 173 B10R1.35 Cn1c(cc(n1)CO)OC DA-37219 [0,2,0,0,0,0|2,0,0]=4 174 B10R1.59 Cc1c(nc(o1)C)C(C)O DA-40315 [0,2,0,0,0,0|0,1,0]=3 175 B10R1.59 Cc1c(nc(s1)Br)C(=O)O DA-47457 [0,2,0,0,0,0|1,0,1]=4 176 B10R1.59 Cc1c(nc(s1)C)C(=O)O DA-47806 [0,2,0,0,0,0|0,0,1]=3 177 B10R1.59 Cc1c(nc(s1)N)C(=O)C DA-31506 [0,2,0,0,0,0|1,0,0]=3 178 B10R1.59 Cc1c(sc(=O)[nH]1)C(=O)C DA-38108 [0,2,0,0,0,0|1,0,1]=4 179 B10R1.59 Cc1c(sc(n1)Br)C(=O)C DA-31489 [0,2,0,0,0,0|1,0,0]=3 180 B10R1.59 Cc1nc(c(s1)N)C(=O)N DA-38035 [0,2,0,0,0,0|1,0,1]=4 181 B10R1.130 CCOc1c(nc(s1)C)Br DA-39850 [0,2,0,0,0,0|1,0,0]=3 182 B10R1.130 Cc1c(sc(n1)C)CCO DA-27262 [0,2,0,0,0,0|0,0,0]=2 183 B10R1.256 Cc1c(c(n(n1)C)C)C=C DA-45908 [0,2,0,0,0,0|2,0,0]=4 184 B10R1.256 Cc1c(c(n(n1)C)CO)Br DA-21325 [0,2,0,0,0,0|2,0,0]=4 185 B10R1.58 Cc1c(sc(n1)N(C)C)C DA-41271 [0,2,0,0,0,0|0,0,0]=2 186 B10R1.58 Cc1cc(nn1C)C(=O)C DA-31654 [0,2,0,0,0,0|2,0,0]=4 187 B10R1.58 Cc1cc(nn1C)C(Cl)Cl DA-24925 [0,2,0,0,0,0|2,0,0]=4 188 B10R1.131 CC1C(=O)N=C(S1)CC#N DA-21966 [0,2,0,0,0,0|1,0,1]=4 189 B10R1.131 Cc1c(oc(n1)CC#N)C DA-21949 [0,2,0,0,0,0|0,1,0]=3 190 B10R1.131 Cc1c(sc(n1)CCN)C DA-21947 [0,2,0,0,0,0|0,0,0]=2 191 B10R1.131 Cc1c(sc(n1)CCN)Cl DA-37508 [0,2,0,0,0,0|1,0,0]=3 192 B10R1.131 Cc1c(sc(n1)COC)C DA-27660 [0,2,0,0,0,0|0,0,0]=2