0 B10R2.7 C1=CC=C2NN=CC2=C1 BB20-0656 [0,0,0,0,0,0|2,0,1]=3 1 B11R2.1 CC1=CNC2=CC=CC=C12 BB01-6044 [0,1,0,0,0,0|1,0,1]=3 2 B11R2.1 CC1=NNC2=CC=CC=C21 BB57-2499 [0,1,0,0,0,0|2,0,1]=4 3 B11R2.1 CN1N=NC2=CC=CC=C21 BB58-1288 [0,1,0,0,0,0|2,0,0]=3 4 B11R2.1 IC1=CNC2=NC=CC=C12 BB20-1522 [0,1,0,0,0,0|2,0,1]=4 5 B11R2.1 NC1=NNC2=C1C=CC=C2 BB58-1538 [0,1,0,0,0,0|2,0,1]=4 6 B11R2.1 NC1=NOC2=CC=CC=C21 BB01-4574 [0,1,0,0,0,0|2,1,0]=4 7 B11R2.1 NC1CCC2=C1C=CC=C2 BB01-6422 [0,1,0,0,0,0|2,0,1]=4 8 B11R2.1 O=C1NNC2=C1C=CC=C2 BB20-2294 [0,1,0,0,0,0|2,0,1]=4 9 B11R2.1 O=C1NSC2=CC=CC=C12 BB01-6797 [0,1,0,0,0,0|2,0,0]=3 10 B11R2.1 O=C1OCC2=C1C=CC=C2 BB01-6204 [0,1,0,0,0,0|3,0,0]=4 11 B11R2.1 ON1N=NC2=C1N=CC=C2 BB01-0957 [0,1,0,0,0,0|3,0,0]=4 12 B11R2.1 SC1=NN=C2C=CC=CN12 BB55-7717 [0,1,0,0,0,0|3,0,0]=4 13 B11R2.10 CC1=NC2=C(C=CC=C2)S1 BB01-7803 [0,1,0,0,0,0|0,0,0]=1 14 B11R2.10 CN1N=C2C=CC=CC2=N1 BB58-5196 [0,1,0,0,0,0|2,0,0]=3 15 B11R2.10 ClC1=NC2=C(C=CC=C2)O1 BB01-6283 [0,1,0,0,0,0|0,1,0]=2 16 B11R2.10 ClC1=NC2=C(C=CC=C2)S1 BB01-8318 [0,1,0,0,0,0|0,0,0]=1 17 B11R2.10 ClC1=NC2=CC=CC=C2N1 BB01-8305 [0,1,0,0,0,0|1,0,0]=2 18 B11R2.10 NC1=NC2=C(C=CC=C2)N1 BB20-0076 [0,1,0,0,0,0|1,0,0]=2 19 B11R2.10 NC1=NC2=C(C=CC=C2)S1 BB01-5914 [0,1,0,0,0,0|0,0,0]=1 20 B11R2.10 NC1CC2=CC=CC=C2C1 BB53-1264 [0,1,0,0,0,0|2,0,1]=4 21 B11R2.10 O=C1CC2=C(C=CC=C2)C1 BB01-8363 [0,1,0,0,0,0|2,0,0]=3 22 B11R2.10 SC1=NC2=C(C=CC=C2)O1 BB01-6019 [0,1,0,0,0,0|0,1,0]=2 23 B11R2.36 BrC1=CC2=C(C=C1)NC=C2 BB01-6196 [0,1,0,0,0,0|1,0,1]=3 24 B11R2.36 BrC1=CC2=C(C=C1)NCC2 BB57-5234 [0,1,0,0,0,0|1,0,2]=4 25 B11R2.36 CC1=CC=C2NC=CC2=C1 BB01-8311 [0,1,0,0,0,0|1,0,1]=3 26 B11R2.36 CC1=NC2=NC=NN2C=C1 BB58-0784 [0,1,0,0,0,0|3,0,0]=4 27 B11R2.36 ClC1=CC2=C(C=C1)NC=C2 BB01-1062 [0,1,0,0,0,0|1,0,1]=3 28 B11R2.36 ClC1=CC2=C(C=CN2)C=C1 BB01-0989 [0,1,0,0,0,0|1,0,1]=3 29 B11R2.36 ClC1=CC2=NSN=C2C=C1 BB55-4961 [0,1,0,0,0,0|2,0,0]=3 30 B11R2.36 ClC1=CC=C2C=CNC2=N1 BB58-4271 [0,1,0,0,0,0|2,0,1]=4 31 B11R2.36 NC1=CC2=C(C=C1)NCC2 BB01-5762 [0,1,0,0,0,0|1,0,2]=4 32 B11R2.36 NC1=CC2=C(C=C1)NN=C2 BB01-6275 [0,1,0,0,0,0|2,0,1]=4 33 B11R2.36 NC1=CC2=NSN=C2C=C1 BB01-6143 [0,1,0,0,0,0|2,0,0]=3 34 B11R2.106 CC1=C2NN=CC2=CC=C1 BB01-0299 [0,1,0,0,0,0|2,0,1]=4 35 B11R2.106 CC1=CC=CC2=C1C=CN2 BB01-0988 [0,1,0,0,0,0|1,0,1]=3 36 B11R2.106 ClC1=C2N=CNC2=NC=N1 BB01-6112 [0,1,0,0,0,0|3,0,0]=4 37 B11R2.106 ClC1=C2NC=CC2=CC=C1 BB55-7562 [0,1,0,0,0,0|1,0,1]=3 38 B11R2.106 ClC1=CC=CC2=C1C=CN2 BB01-0987 [0,1,0,0,0,0|1,0,1]=3 39 B11R2.106 ClC1=NC=NC2=C1C=CS2 BB58-5269 [0,1,0,0,0,0|3,0,0]=4 40 B11R2.106 NC1=C2C=CNC2=CC=C1 BB26-0516 [0,1,0,0,0,0|1,0,1]=3 41 B11R2.106 NC1=CC=CC2=NON=C12 BB01-6141 [0,1,0,0,0,0|2,0,0]=3 42 B11R2.106 NC1=CC=CC2=NSN=C12 BB01-6142 [0,1,0,0,0,0|2,0,0]=3 43 B11R2.106 NC1=NC=NC2=C1NC=N2 BB57-0196 [0,1,0,0,0,0|3,0,0]=4 44 B11R2.106 [O-][N+]1=C2NC=CC2=CC=C1 BB20-4942 [0,1,0,0,0,0|2,0,1]=4 45 B9R1.8 NNCC1=CC=CC=C1 BB58-2846 [0,0,1,0,0,0|2,0,1]=4 46 B9R1.8 O=CCC1=CC=CC=C1 BB01-5910 [0,0,1,0,0,0|1,1,0]=3 47 B9R1.8 S=C=NC1=CC=CC=C1 BB01-6169 [0,0,1,0,0,0|0,0,2]=3 48 B9R1.12 O=C\C=C\C1=CC=CO1 BB01-6397 [0,0,1,0,0,0|2,1,0]=4 49 B9R1.15 CC1=C(NN)C=CC=C1 BB01-6215 [0,0,1,0,0,0|2,0,1]=4 50 B9R1.15 CC1=CC=CC=C1CN BB58-0558 [0,0,1,0,0,0|3,0,0]=4 51 B9R1.15 CCC1=CC=CC=C1S BB01-6055 [0,0,1,0,0,0|1,0,1]=3 52 B9R1.15 COC1=CC=CC=C1S BB01-7834 [0,0,1,0,0,0|1,0,1]=3 53 B9R1.15 N#CC1=C(Cl)C=CC=C1 BB17-1794 [0,0,1,0,0,0|3,0,0]=4 54 B9R1.15 NCC1=C(N)C=CC=C1 BB57-0218 [0,0,1,0,0,0|2,0,1]=4 55 B9R1.15 NCC1=CC=CC=C1F BB01-4715 [0,0,1,0,0,0|3,0,0]=4 56 B9R1.15 NNC1=C(F)C=CC=C1 BB01-6116 [0,0,1,0,0,0|2,0,1]=4 57 B9R1.15 NNC1=CC=CC=C1Br BB55-7470 [0,0,1,0,0,0|2,0,1]=4 58 B9R1.15 NNC1=CC=CC=C1Cl BB57-0203 [0,0,1,0,0,0|2,0,1]=4 59 B9R1.15 O=CC1=C(F)C=CC=C1 BB01-6057 [0,0,1,0,0,0|3,0,0]=4 60 B11R2.20 C1=CC=C2OCCCC2=C1 BB57-6849 [0,0,0,0,0,1|1,1,1]=4 61 B11R2.20 C1=CC=C2SCCNC2=C1 BB01-2980 [0,0,0,0,0,1|0,0,2]=3 62 B8R1.2 C=CC1=CC=NC=C1 BB01-6325 [1,0,1,0,0,0|2,0,0]=4 63 B8R1.2 C=CC1=NC=CC=C1 BB01-6206 [1,0,1,0,0,0|2,0,0]=4 64 B8R1.2 NNC1=CC=CC=C1 BB01-6156 [1,0,1,0,0,0|1,0,1]=4 65 B8R1.11 CC1=C(C=O)SC=N1 BB01-0956 [1,0,1,0,0,0|1,0,1]=4 66 B8R1.11 O=CC1=C(Cl)N=CS1 BB58-0524 [1,0,1,0,0,0|2,0,0]=4 67 B10R1.1 CC1=CC=C(N=C=S)C=C1 BB17-0178 [0,1,1,0,0,0|0,0,2]=4 68 B10R1.1 CC1=CC=C(N=S=O)C=C1 BB58-0235 [0,1,1,0,0,0|1,1,0]=4 69 B10R1.1 CCSC1=CC=C(N)C=C1 BB57-4739 [0,1,1,0,0,0|1,0,1]=4 70 B10R1.1 O=C=NC1=CC=C(Br)C=C1 BB01-4438 [0,1,1,0,0,0|0,1,1]=4 71 B10R1.1 O=C=NC1=CC=C(F)C=C1 BB01-4426 [0,1,1,0,0,0|0,1,1]=4 72 B10R1.1 O=S=NC1=CC=C(Br)C=C1 BB58-0257 [0,1,1,0,0,0|1,1,0]=4 73 B10R1.1 O=S=NC1=CC=C(Cl)C=C1 BB58-0225 [0,1,1,0,0,0|1,1,0]=4 74 B10R1.1 S=C=NC1=CC=C(Br)C=C1 BB01-2838 [0,1,1,0,0,0|0,0,2]=4 75 B10R1.1 S=C=NC1=CC=C(Cl)C=C1 BB01-6633 [0,1,1,0,0,0|0,0,2]=4 76 B10R1.4 C=CCC1=C(O)C=CC=C1 BB01-3409 [0,1,1,0,0,0|2,0,0]=4 77 B10R1.4 CC1=CC=CC=C1N=C=O BB01-6514 [0,1,1,0,0,0|0,1,1]=4 78 B10R1.4 CC1=CC=CC=C1N=S=O BB58-0234 [0,1,1,0,0,0|1,1,0]=4 79 B10R1.4 FC1=CC=CC=C1N=C=S BB17-0183 [0,1,1,0,0,0|0,0,2]=4 80 B10R1.4 O=C=NC1=CC=CC=C1Br BB01-4421 [0,1,1,0,0,0|0,1,1]=4 81 B10R1.4 O=C=NC1=CC=CC=C1Cl BB01-7827 [0,1,1,0,0,0|0,1,1]=4 82 B10R1.4 O=C=NC1=CC=CC=C1F BB01-6096 [0,1,1,0,0,0|0,1,1]=4 83 B10R1.4 O=S=NC1=CC=CC=C1Cl BB58-0219 [0,1,1,0,0,0|1,1,0]=4 84 B10R1.4 O=S=NC1=CC=CC=C1F BB58-0245 [0,1,1,0,0,0|1,1,0]=4 85 B10R1.4 S=C=NC1=C(Br)C=CC=C1 BB01-8016 [0,1,1,0,0,0|0,0,2]=4 86 B10R1.10 CC1=CC(N=C=O)=CC=C1 BB01-4433 [0,1,1,0,0,0|0,1,1]=4 87 B10R1.10 CC1=CC(N=C=S)=CC=C1 BB17-0177 [0,1,1,0,0,0|0,0,2]=4 88 B10R1.10 CC1=CC(N=S=O)=CC=C1 BB58-0233 [0,1,1,0,0,0|1,1,0]=4 89 B10R1.10 FC1=CC=CC(N=C=S)=C1 BB01-6613 [0,1,1,0,0,0|0,0,2]=4 90 B10R1.10 O=C=NC1=CC=CC(Br)=C1 BB01-4430 [0,1,1,0,0,0|0,1,1]=4 91 B10R1.10 O=C=NC1=CC=CC(Cl)=C1 BB01-7826 [0,1,1,0,0,0|0,1,1]=4 92 B10R1.10 O=C=NC1=CC=CC(F)=C1 BB01-6546 [0,1,1,0,0,0|0,1,1]=4 93 B10R1.10 O=S=NC1=CC=CC(Br)=C1 BB58-0258 [0,1,1,0,0,0|1,1,0]=4 94 B10R1.10 O=S=NC1=CC=CC(Cl)=C1 BB58-0227 [0,1,1,0,0,0|1,1,0]=4 95 B10R1.10 O=S=NC1=CC=CC(F)=C1 BB58-0247 [0,1,1,0,0,0|1,1,0]=4 96 B10R1.10 S=C=NC1=CC=CC(Br)=C1 BB17-0191 [0,1,1,0,0,0|0,0,2]=4 97 B10R1.10 S=C=NC1=CC=CC(Cl)=C1 BB17-0175 [0,1,1,0,0,0|0,0,2]=4 98 B10R1.17 NCCSC1=CC=CC=C1 BB53-1253 [0,1,1,0,0,0|0,0,2]=4 99 B10R1.17 O=C=NCC1=CC=CC=C1 BB01-4445 [0,1,1,0,0,0|0,1,1]=4 100 B10R1.17 O=CNCC1=CC=CC=C1 BB20-1135 [0,1,1,0,0,0|0,1,1]=4 101 B10R1.17 OC\C=C\C1=CC=CC=C1 BB01-5912 [0,1,1,0,0,0|1,1,0]=4 102 B10R1.17 S=C=NCC1=CC=CC=C1 BB01-6211 [0,1,1,0,0,0|0,0,2]=4 103 B10R1.18 N=C(N)NC1=CC=CC=C1 BB01-2596 [0,1,1,0,0,0|1,0,0]=3 104 B10R1.18 NC(=S)CC1=CC=CC=C1 BB57-5511 [0,1,1,0,0,0|1,0,1]=4 105 B10R1.18 NC(=S)NC1=CC=CC=C1 BB01-7403 [0,1,1,0,0,0|0,0,2]=4 106 B10R1.66 O=C(Cl)\C=C\C1=CC=CS1 BB55-6084 [0,1,1,0,0,0|2,0,0]=4 107 B10R1.66 O=C(O)\C=C\C1=CC=CS1 BB01-2450 [0,1,1,0,0,0|2,0,0]=4 108 B10R1.66 O=C(O)\C=C\C1=CNC=N1 BB57-6594 [0,1,1,0,0,0|2,0,0]=4 109 B12R2.24 BrC1=CN=C2C=CC=CC2=C1 BB01-7804 [0,1,0,0,0,1|1,0,0]=3 110 B12R2.24 ClC1=CC2=CN=CC=C2C=C1 BB32-1617 [0,1,0,0,0,1|1,0,0]=3 111 B12R2.24 ClC1=NC2=CC=CC=C2C=C1 BB57-6789 [0,1,0,0,0,1|1,0,0]=3 112 B12R2.24 O=C1C=CC2=C(C=CC=C2)O1 BB01-7793 [0,1,0,0,0,1|1,1,0]=4 113 B12R2.24 O=C1CCC2=CC=CC=C2N1 BB20-4909 [0,1,0,0,0,1|1,0,1]=4 114 B12R2.24 O=C1CNC2=C(C=CC=C2)N1 BB01-4856 [0,1,0,0,0,1|1,0,1]=4 115 B12R2.24 O=C1COC2=CC=CC=C2N1 BB01-3566 [0,1,0,0,0,1|0,1,1]=4 116 B12R2.24 OC1=CC2=C(C=CC=N2)C=C1 BB57-3407 [0,1,0,0,0,1|1,0,0]=3 117 B12R2.24 OC1=CC=C2C=CC=CC2=N1 BB17-2144 [0,1,0,0,0,1|1,0,0]=3 118 B12R2.1081 BrC1=CC=CC2=C1C=CN=C2 BB01-7935 [0,1,0,0,0,1|1,0,0]=3 119 B12R2.1081 BrC1=CN=CC2=CC=CC=C12 BB01-4756 [0,1,0,0,0,1|1,0,0]=3 120 B12R2.1081 ClC1=NC=CC2=C1C=CC=C2 BB57-5158 [0,1,0,0,0,1|1,0,0]=3 121 B12R2.1081 O=C1CCSC2=C1C=CC=C2 BB01-5930 [0,1,0,0,0,1|1,0,1]=4 122 B12R2.1081 OC1=C2C=CC=CC2=NC=N1 BB01-6015 [0,1,0,0,0,1|1,0,0]=3 123 B12R2.1081 OC1=CC=CC2=C1C=CC=N2 BB57-3406 [0,1,0,0,0,1|1,0,0]=3 124 B12R2.1081 SC1=NC=NC2=CC=CC=C21 BB57-4839 [0,1,0,0,0,1|1,0,0]=3 125 B12R2.1081 SC1=NN=CC2=CC=CC=C21 BB57-5435 [0,1,0,0,0,1|2,0,0]=4 126 B12R2.1 N#CC1=CNC2=CC=CC=C12 BB01-0917 [0,2,0,0,0,0|1,0,1]=4 127 B12R2.18 CC1=C(C)C2=CC=CC=C2N1 BB01-8134 [0,2,0,0,0,0|1,0,1]=4 128 B12R2.18 CN1C(N)=NC2=C1C=CC=C2 BB01-3970 [0,2,0,0,0,0|1,0,0]=3 129 B12R2.18 CN1C(N)=NC2=C1C=CC=C2 BB05-0210 [0,2,0,0,0,0|1,0,0]=3 130 B12R2.18 CN1C2=CC=CC=C2N=C1S BB57-1880 [0,2,0,0,0,0|1,0,0]=3 131 B12R2.18 O=C1NC2=C(C=CC=C2)C1=O BB01-6155 [0,2,0,0,0,0|1,0,1]=4 132 B12R2.132 ClC1=CN2C(Br)=CN=C2C=C1 BB58-4249 [0,2,0,0,0,0|2,0,0]=4 133 B12R2.32 CCC1=NC2=C(C=CC=C2)S1 BB01-8168 [0,2,0,0,0,0|0,0,0]=2 134 B12R2.32 CSC1=NC2=NC=CC=C2O1 BB01-6708 [0,2,0,0,0,0|1,1,0]=4 135 B12R2.32 ClCC1=CN2C=CC=CC2=N1 BB58-3547 [0,2,0,0,0,0|2,0,0]=4 136 B12R2.32 ClCC1=NC2=C(C=CC=C2)O1 BB58-0369 [0,2,0,0,0,0|0,1,0]=3 137 B12R2.32 ClCC1=NC2=CC=CC=C2N1 BB01-4159 [0,2,0,0,0,0|1,0,0]=3 138 B12R2.32 N#CC1=CC2=CC=CC=C2O1 BB58-4707 [0,2,0,0,0,0|1,1,0]=4 139 B12R2.32 NNC1=NC2=C(C=CC=C2)O1 BB01-3787 [0,2,0,0,0,0|0,1,0]=3 140 B12R2.32 NNC1=NC2=CC=CC=C2S1 BB01-1080 [0,2,0,0,0,0|0,0,0]=2 141 B12R2.32 O=CC1=CC2=CC=CC=C2S1 BB58-0480 [0,2,0,0,0,0|1,0,0]=3 142 B12R2.32 O=CC1=NC2=CC=CC=C2S1 BB55-8341 [0,2,0,0,0,0|0,0,0]=2 143 B12R2.32 OCC1=NC2=C(C=CC=C2)S1 BB57-5255 [0,2,0,0,0,0|0,0,0]=2 144 B12R2.202 CC1=CC=CC2=CC(=O)N=C12 BB31-7827 [0,2,0,0,0,0|1,0,0]=3 145 B12R2.606 CC1=CC2=C(C=C1)N=C(N)S2 BB01-5975 [0,2,0,0,0,0|0,0,0]=2 146 B12R2.606 CC1=CC2=C(C=C1)NC(S)=N2 BB55-6685 [0,2,0,0,0,0|1,0,0]=3 147 B12R2.606 CC1=CC2=C(C=CC(Cl)=C2)N1 BB01-4589 [0,2,0,0,0,0|1,0,1]=4 148 B12R2.606 CC1=CC=C2NC(C)=CC2=C1 BB57-0361 [0,2,0,0,0,0|1,0,1]=4 149 B12R2.606 CC1=CC=C2NC(C)=NC2=C1 BB58-1921 [0,2,0,0,0,0|1,0,0]=3 150 B12R2.606 CC1=NC2=CC(O)=CC=C2S1 BB55-7898 [0,2,0,0,0,0|0,0,0]=2 151 B12R2.606 ClC1=CC=C2NC(Cl)=NC2=C1 BB01-3451 [0,2,0,0,0,0|1,0,0]=3 152 B12R2.606 NC1=CC2=C(C=C1)N=C(S)S2 BB01-1033 [0,2,0,0,0,0|0,0,0]=2 153 B12R2.606 NC1=NC2=C(C=C(Br)C=C2)S1 BB01-3772 [0,2,0,0,0,0|0,0,0]=2 154 B12R2.606 NC1=NC2=C(C=C(Cl)C=C2)S1 BB01-6023 [0,2,0,0,0,0|0,0,0]=2 155 B12R2.606 NC1=NC2=CC(Cl)=CC=C2O1 BB57-2374 [0,2,0,0,0,0|0,1,0]=3 156 B12R2.606 O=C1CC2=C(C=C(Cl)C=C2)N1 BB01-6274 [0,2,0,0,0,0|1,0,1]=4 157 B12R2.606 O=C1CC2=C(C=CC(Cl)=C2)N1 BB01-4814 [0,2,0,0,0,0|1,0,1]=4 158 B12R2.606 O=C1CC2=CC(O)=CC=C2O1 BB57-4868 [0,2,0,0,0,0|1,1,0]=4 159 B12R2.606 O=C1NC2=C(C=C(Br)C=C2)S1 BB55-6677 [0,2,0,0,0,0|0,0,1]=3 160 B12R2.606 O=C1NC2=C(C=CC(Cl)=C2)O1 BB55-6668 [0,2,0,0,0,0|0,1,1]=4 161 B12R2.606 O=C1NC2=CC(Br)=CC=C2O1 BB01-2820 [0,2,0,0,0,0|0,1,1]=4 162 B12R2.606 O=C1OC2=C(C=CC(O)=C2)S1 BB01-7816 [0,2,0,0,0,0|1,0,0]=3 163 B12R2.606 O=C1OC2=CC=C(O)C=C2S1 BB01-1137 [0,2,0,0,0,0|1,0,0]=3 164 B12R2.44 BrCC1=CC2=NSN=C2C=C1 BB57-4386 [0,2,0,0,0,0|2,0,0]=4 165 B12R2.44 C#CC1=CN2C=CN=C2C=C1 BB58-4255 [0,2,0,0,0,0|2,0,0]=4 166 B12R2.44 COC1=CC2=C(C=C1)NC=C2 BB01-4579 [0,2,0,0,0,0|1,0,1]=4 167 B12R2.44 COC1=CC2=C(C=CN2)C=C1 BB01-6798 [0,2,0,0,0,0|1,0,1]=4 168 B12R2.44 N#CC1=CC=C2NC=CC2=C1 BB57-4235 [0,2,0,0,0,0|1,0,1]=4 169 B12R2.44 O=CC1=CC2=NSN=C2C=C1 BB57-0399 [0,2,0,0,0,0|2,0,0]=4 170 B12R2.44 O=CC1=CC=C2C=CNC2=C1 BB01-0975 [0,2,0,0,0,0|1,0,1]=4 171 B12R2.44 O=CC1=CC=C2NC=CC2=C1 BB01-0974 [0,2,0,0,0,0|1,0,1]=4 172 B12R2.100 CC1=C(C)C=C2NN=NC2=C1 BB17-2644 [0,2,0,0,0,0|2,0,0]=4 173 B12R2.100 CC1=CC2=C(C=C1C)NC=N2 BB01-6010 [0,2,0,0,0,0|1,0,0]=3 174 B12R2.221 CC1=C2C=CNC2=C(Br)C=C1 BB31-3296 [0,2,0,0,0,0|1,0,1]=4 175 B12R2.315 O=CC1=C2C=CNC2=CC=C1 BB01-0973 [0,2,0,0,0,0|1,0,1]=4