0 B22R2.308502 CC(=O)C(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000179758 [0,0,0,0,0,0|1,0,0]=1 1 B21R2.422 CC(=O)C(C)Sc1ccc(cc1)Oc2ccc(cc2)Cl 62a_100009814033_100000035638 [1,0,0,0,0,0|1,1,0]=3 2 B21R2.226259 C=C(C)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100000748629 [1,0,0,0,0,0|2,0,0]=3 3 B21R2.226259 C=C(C)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000748629 [1,0,0,0,0,0|2,0,0]=3 4 B21R2.226259 C=C(F)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100009893438 [1,0,0,0,0,0|2,0,0]=3 5 B21R2.226259 C=C(F)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000042424 [1,0,0,0,0,0|2,0,0]=3 6 B21R2.226259 CC(=O)CCc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000699841_100000723691 [1,0,0,0,0,0|2,1,0]=4 7 B21R2.226259 CC(=O)CCc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000723691_100000699841 [1,0,0,0,0,0|2,1,0]=4 8 B21R2.226259 CC(C)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100000210624 [1,0,0,0,0,0|2,0,1]=4 9 B21R2.226259 CC(C)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000210760 [1,0,0,0,0,0|2,0,1]=4 10 B21R2.226259 FC(F)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100011934356 [1,0,0,0,0,0|2,0,1]=4 11 B21R2.226259 FC(F)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100011934356 [1,0,0,0,0,0|2,0,1]=4 12 B21R2.2250034 C#CC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_200000035995 [1,0,0,0,0,0|1,0,1]=3 13 B21R2.2250034 CC(C#N)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000703298 [1,0,0,0,0,0|1,0,1]=3 14 B21R2.2250034 CCC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100011215416 [1,0,0,0,0,0|1,0,1]=3 15 B21R2.2250034 CCC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000758301 [1,0,0,0,0,0|1,0,1]=3 16 B23R2.396596 CC(Oc1ccc(cc1)Sc2ccc(c(c2Cl)Cl)Br)C(=O)N 62a_100000150412_200012356690 [0,1,0,0,0,0|1,2,0]=4 17 B23R2.396596 CC(Oc1ccc(cc1)Sc2ccc(c(c2Cl)Cl)Br)C(=O)N 62a_200012356690_100000150412 [0,1,0,0,0,0|1,2,0]=4 18 B23R2.3016798 CC(Oc1ccc(cc1)Sc2c(cc(cc2Br)Cl)Cl)C(=O)N 62a_100000150412_200009992027 [0,1,0,0,0,0|1,1,0]=3 19 B23R2.3016798 CC(Oc1ccc(cc1)Sc2c(cc(cc2Br)Cl)Cl)C(=O)N 62a_200009992027_100000150412 [0,1,0,0,0,0|1,1,0]=3 20 B23R2.3016798 CC(Oc1ccc(cc1)Sc2c(cc(cc2Cl)Br)Cl)C(=O)N 62a_100000150412_200011263224 [0,1,0,0,0,0|1,2,0]=4 21 B23R2.3016798 CC(Oc1ccc(cc1)Sc2c(cc(cc2Cl)Br)Cl)C(=O)N 62a_200011263224_100000150412 [0,1,0,0,0,0|1,2,0]=4 22 B23R2.3016798 CC(Oc1ccc(cc1)Sc2c(cc(cc2Cl)Cl)Cl)C(=O)N 62a_100000150412_200011216440 [0,1,0,0,0,0|1,1,0]=3 23 B23R2.3016798 CC(Oc1ccc(cc1)Sc2c(cc(cc2Cl)Cl)Cl)C(=O)N 62a_200011216440_100000150412 [0,1,0,0,0,0|1,1,0]=3 24 B23R2.4901181 CCC(=O)C(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000742827 [0,1,0,0,0,0|1,0,0]=2 25 B23R2.8289098 CC(Oc1ccc(cc1)Sc2cc(c(cc2Cl)Br)Cl)C(=O)N 62a_100000150412_200010244590 [0,1,0,0,0,0|1,2,0]=4 26 B23R2.8289098 CC(Oc1ccc(cc1)Sc2cc(c(cc2Cl)Br)Cl)C(=O)N 62a_200010244590_100000150412 [0,1,0,0,0,0|1,2,0]=4 27 B23R2.8289098 CC(Oc1ccc(cc1)Sc2cc(c(cc2Cl)Cl)Cl)C(=O)N 62a_100000150412_200011216203 [0,1,0,0,0,0|1,1,0]=3 28 B23R2.8289098 CC(Oc1ccc(cc1)Sc2cc(c(cc2Cl)Cl)Cl)C(=O)N 62a_200011216203_100000150412 [0,1,0,0,0,0|1,1,0]=3 29 B23R2.8306808 CC(=O)C(C)(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000075568 [0,1,0,0,0,0|1,0,0]=2 30 B23R2.8314338 CC(=O)C(C)Nc1ccc(c(c1)F)Oc2ccc(cc2Cl)Cl 2230a_100000669002_100009814033 [0,1,0,0,0,0|2,0,0]=3 31 B23R2.8314338 CC(=O)C(C)Nc1ccc(c(c1)F)Oc2ccc(cc2Cl)Cl 7a_100000669002_100000179758 [0,1,0,0,0,0|2,0,0]=3 32 B21R2.226258 CC(=O)N(C)c1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_200009816415_100000699841 [0,0,0,0,1,0|2,1,0]=4 33 B20R2.2807 C=CC(C)Sc1ccc(cc1)Oc2ccc(cc2)Cl 62a_100011215867_100000035638 [2,0,0,0,0,0|1,1,0]=4 34 B20R2.2807 CCC(C)Oc1ccc(cc1)Oc2ccc(cc2)Cl 34a_100000065651_100011215416 [2,0,0,0,0,0|1,0,1]=4 35 B20R2.2807 CCC(C)Oc1ccc(cc1)Oc2ccc(cc2)Cl 7a_100000065651_100000758301 [2,0,0,0,0,0|1,0,1]=4 36 B20R2.15796 C=C(C)COc1ccc(cc1)Oc2ccc(cc2)Cl 34a_100000065651_100000748629 [2,0,0,0,0,0|2,0,0]=4 37 B20R2.15796 C=C(C)COc1ccc(cc1)Oc2ccc(cc2)Cl 7a_100000065651_100000748629 [2,0,0,0,0,0|2,0,0]=4 38 B20R2.35507 C=CCOc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100015514636 [2,0,0,0,0,0|1,0,0]=3 39 B20R2.35507 C=CCOc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100015514636 [2,0,0,0,0,0|1,0,0]=3 40 B20R2.35507 C=CCOc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000172055_100000699841 [2,0,0,0,0,0|1,1,0]=4 41 B20R2.35507 C=CCOc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000699841_100000172055 [2,0,0,0,0,0|1,1,0]=4 42 B20R2.35507 CCCOc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100000210303 [2,0,0,0,0,0|1,0,1]=4 43 B20R2.35507 CCCOc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000210303 [2,0,0,0,0,0|1,0,1]=4 44 B20R2.35507 CSCOc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100011218213 [2,0,0,0,0,0|2,0,0]=4 45 B20R2.35507 FCCOc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100011217306 [2,0,0,0,0,0|1,0,1]=4 46 B20R2.35507 FCCOc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100011217306 [2,0,0,0,0,0|1,0,1]=4 47 B20R2.35507 O=CCCc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000699841_100011361538 [2,0,0,0,0,0|1,1,0]=4 48 B20R2.35507 O=CCCc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100011361538_100000699841 [2,0,0,0,0,0|1,1,0]=4 49 B20R2.156213 CC(=O)Oc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000699841_100000002173 [2,0,0,0,0,0|0,1,1]=4 50 B20R2.156213 CC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100000210206 [2,0,0,0,0,0|0,0,1]=3 51 B20R2.156213 CC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000210206 [2,0,0,0,0,0|0,0,1]=3 52 B20R2.156213 CC(C)Oc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000169947_100000699841 [2,0,0,0,0,0|0,1,1]=4 53 B20R2.156213 CC(C)Oc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000699841_100000169947 [2,0,0,0,0,0|0,1,1]=4 54 B22R2.4415 CCC(=O)C(C)Sc1ccc(cc1)Oc2ccc(cc2)Cl 62a_100000742827_100000035638 [1,1,0,0,0,0|1,1,0]=4 55 B22R2.23008 CC(=O)C(C)Nc1ccc(cc1)Oc2ccc(c(c2)Cl)Cl 2230a_100000297784_100009814033 [1,1,0,0,0,0|2,0,0]=4 56 B22R2.23008 CC(=O)C(C)Nc1ccc(cc1)Oc2ccc(c(c2)Cl)Cl 7a_100000297784_100000179758 [1,1,0,0,0,0|2,0,0]=4 57 B22R2.129980 CC(=O)C(C)(C)Sc1ccc(cc1)Oc2ccc(cc2)Cl 62a_100000075568_100000035638 [1,1,0,0,0,0|1,1,0]=4 58 B22R2.528570 CC(=O)C(C)Nc1ccc(c(c1)Cl)Oc2ccc(cc2)Cl 2230a_100000292064_100009814033 [1,1,0,0,0,0|2,0,0]=4 59 B22R2.528570 CC(=O)C(C)Nc1ccc(c(c1)Cl)Oc2ccc(cc2)Cl 7a_100000292064_100000179758 [1,1,0,0,0,0|2,0,0]=4 60 B22R2.146173 CC(=O)C(C)Oc1ccc(cc1)Cc2cc(ccc2Cl)Br 7a_100010114358_100000179758 [1,1,0,0,0,0|2,0,0]=4 61 B22R2.296376 CC(=O)C(C)Nc1ccc(c(c1)Cl)Oc2ccccc2Cl 2230a_100000292062_100009814033 [1,1,0,0,0,0|2,0,0]=4 62 B22R2.296376 CC(=O)C(C)Nc1ccc(c(c1)Cl)Oc2ccccc2Cl 7a_100000292062_100000179758 [1,1,0,0,0,0|2,0,0]=4 63 B22R2.544173 C=C(C#N)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100000694840 [1,1,0,0,0,0|2,0,0]=4 64 B22R2.544173 CCC(=O)COc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000747405 [1,1,0,0,0,0|1,0,0]=3 65 B22R2.544173 COC(=O)CCc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100000699841_100012357364 [1,1,0,0,0,0|1,1,0]=4 66 B22R2.544173 COC(=O)CCc1ccc(cc1)Sc2ccc(cc2Cl)Cl 62a_100012357364_100000699841 [1,1,0,0,0,0|1,1,0]=4 67 B22R2.710025 CC(CC#N)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100009813641 [1,1,0,0,0,0|1,0,1]=4 68 B22R2.710025 COCC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100000765312 [1,1,0,0,0,0|0,0,1]=3 69 B22R2.710025 COCC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000765312 [1,1,0,0,0,0|0,0,1]=3 70 B22R2.5656163 C#CC(C)(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100000038118 [1,1,0,0,0,0|1,0,1]=4 71 B22R2.5656163 CC(C)(C#N)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100011162410 [1,1,0,0,0,0|1,0,1]=4 72 B22R2.5656163 CC(C)(C#N)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100011162410 [1,1,0,0,0,0|1,0,1]=4 73 B24R2.3411968 CC(Oc1ccc(cc1)SCc2c(cc(cc2Cl)Cl)Cl)C(=O)N 62a_100000150412_100012339996 [0,1,0,0,0,1|1,1,0]=4 74 B24R2.3411968 CC(Oc1ccc(cc1)SCc2c(cc(cc2Cl)Cl)Cl)C(=O)N 62a_100012339996_100000150412 [0,1,0,0,0,1|1,1,0]=4 75 B24R2.11057364 CC(Oc1ccc(cc1)SCc2cc(c(cc2Cl)Cl)Cl)C(=O)N 62a_100000150412_100010220947 [0,1,0,0,0,1|1,1,0]=4 76 B24R2.11057364 CC(Oc1ccc(cc1)SCc2cc(c(cc2Cl)Cl)Cl)C(=O)N 62a_100010220947_100000150412 [0,1,0,0,0,1|1,1,0]=4 77 B24R2.17252550 COC(=O)CC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100009817358 [0,1,0,0,0,1|0,0,0]=2 78 B24R2.17252550 COC(=O)CC(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100009817358 [0,1,0,0,0,1|0,0,0]=2 79 B24R2.2817730 CCC(Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl)C(=O)OC 34a_200010192161_100000235869 [0,2,0,0,0,0|0,0,0]=2 80 B24R2.2817730 CCC(Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl)C(=O)OC 7a_200010192161_100000742303 [0,2,0,0,0,0|0,0,0]=2 81 B24R2.4125153 CCOC(=O)C(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100011216346 [0,2,0,0,0,0|0,0,0]=2 82 B24R2.4125153 CCOC(=O)C(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100011216346 [0,2,0,0,0,0|0,0,0]=2 83 B24R2.4125153 CCOC(=O)C(F)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100000760018 [0,2,0,0,0,0|1,0,0]=3 84 B24R2.4125153 CCOC(=O)C(F)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000040065 [0,2,0,0,0,0|1,0,0]=3 85 B24R2.6177338 CCC(=O)C(C)Nc1ccc(c(c1)F)Oc2ccc(cc2Cl)Cl 2230a_100000669002_100000742827 [0,2,0,0,0,0|2,0,0]=4 86 B24R2.6177338 CCC(=O)C(C)Nc1ccc(c(c1)F)Oc2ccc(cc2Cl)Cl 7a_100000669002_100000742827 [0,2,0,0,0,0|2,0,0]=4 87 B24R2.13646130 COC(OC)C(C)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_100011222894 [0,2,0,0,0,0|0,0,2]=4 88 B24R2.127533894 COC(=O)C(C)(F)Oc1ccc(cc1)Oc2ccc(cc2Cl)Cl 34a_200010192161_200009867631 [0,2,0,0,0,0|0,0,0]=2 89 B24R2.170194919 COC(=O)C(C)Oc1ccc(cc1F)Sc2ccc(cc2Br)Cl 62a_100000171756_100011219703 [0,2,0,0,0,0|0,2,0]=4 90 B24R2.170194919 COC(=O)C(C)Oc1ccc(cc1F)Sc2ccc(cc2Br)Cl 62a_100011219703_100000171756 [0,2,0,0,0,0|0,2,0]=4 91 B24R2.170194919 COC(=O)C(C)Oc1ccc(cc1F)Sc2ccc(cc2Cl)Br 62a_100000171756_100011216062 [0,2,0,0,0,0|0,2,0]=4 92 B24R2.170194919 COC(=O)C(C)Oc1ccc(cc1F)Sc2ccc(cc2Cl)Br 62a_100011216062_100000171756 [0,2,0,0,0,0|0,2,0]=4 93 B24R2.170194919 COC(=O)C(C)Oc1ccc(cc1F)Sc2ccc(cc2Cl)Cl 62a_100000171756_100000699841 [0,2,0,0,0,0|0,1,0]=3 94 B24R2.170194919 COC(=O)C(C)Oc1ccc(cc1F)Sc2ccc(cc2Cl)Cl 62a_100000699841_100000171756 [0,2,0,0,0,0|0,1,0]=3 95 B24R2.86752109 CC(=O)C(C)(C)Nc1ccc(c(c1)F)Oc2ccc(cc2Cl)Cl 7a_100000669002_100000075568 [0,2,0,0,0,0|2,0,0]=4 96 B22R3.718168 Clc1ccc(c(c1)Cl)Oc2ccc(cc2)OC3CCC3 34a_200010192161_100000749161 [1,0,0,1,0,0|1,0,1]=4 97 B22R3.11663590 CC1Cc2ccc(cc2C1=O)Sc3ccc(cc3Cl)Cl 62a_100000694082_100000699841 [1,0,0,1,0,0|1,1,0]=4 98 B22R3.11663590 CC1Cc2ccc(cc2C1=O)Sc3ccc(cc3Cl)Cl 62a_100000699841_100000694082 [1,0,0,1,0,0|1,1,0]=4 99 B22R3.78222868 CC1C(=O)Nc2c1ccc(c2)Sc3ccc(cc3Cl)Cl 62a_100000699841_100010201481 [0,0,0,1,1,0|1,1,0]=4 100 B24R3.123953630 CC1Oc2ccc(cc2NC1=O)SCc3ccc(cc3Cl)Cl 62a_100000188473_100000745501 [0,0,0,1,0,1|1,1,0]=4 101 B24R3.1506543787 Cc1c(ccc(c1Cl)Sc2ccc3c(c2)NC(=O)C(O3)C)Cl 62a_100010730154_100000745501 [0,1,0,1,0,0|1,1,0]=4 102 B24R3.58621049 CC1Oc2ccc(cc2NC1=O)Sc3c(cc(cc3Br)Cl)Cl 62a_200009992027_100000745501 [0,1,0,1,0,0|1,1,0]=4 103 B24R3.58621049 CC1Oc2ccc(cc2NC1=O)Sc3c(cc(cc3Cl)Cl)Cl 62a_200011216440_100000745501 [0,1,0,1,0,0|1,1,0]=4 104 B24R3.58621049 Cc1cc(cc(c1Sc2ccc3c(c2)NC(=O)C(O3)C)Cl)Cl 62a_200000035511_100000745501 [0,1,0,1,0,0|1,1,0]=4 105 B24R3.26722769 O=C1CCCC1Oc2ccc(cc2)Oc3ccc(cc3Cl)Cl 34a_200010192161_100000709159 [0,1,0,1,0,0|1,0,0]=3 106 B24R3.26722769 O=C1CCCC1Oc2ccc(cc2)Oc3ccc(cc3Cl)Cl 7a_200010192161_100000211823 [0,1,0,1,0,0|1,0,0]=3 107 B24R3.51394832 CC1Oc2ccc(cc2NC1=O)Sc3cc(c(cc3Cl)Cl)Cl 62a_200011216203_100000745501 [0,1,0,1,0,0|1,1,0]=4 108 B24R3.234599619 CC1(Oc2ccc(cc2NC1=O)Sc3ccc(cc3Cl)Cl)C 62a_100000699841_200010062244 [0,1,0,1,0,0|1,1,0]=4 109 B24R3.234599619 CC1(Oc2ccc(cc2NC1=O)Sc3ccc(cc3Cl)Cl)C 62a_200010062244_100000699841 [0,1,0,1,0,0|1,1,0]=4 110 B24R3.26740218 O=C1CCC1Nc2ccc(c(c2)F)Oc3ccc(cc3Cl)Cl 34a_100000669002_100009892977 [0,1,0,1,0,0|2,0,0]=4 111 B24R3.26740218 O=C1CCC1Nc2ccc(c(c2)F)Oc3ccc(cc3Cl)Cl 7a_100000669002_100009892977 [0,1,0,1,0,0|2,0,0]=4 112 B20R2.296 CC(=O)C(C)Sc1ccc(cc1)c2ccc(cc2)Cl 62a_100000043200_100009814033 [1,0,0,0,1,0|1,1,0]=4 113 B20R2.296 CC(=O)C(C)Sc1ccc(cc1)c2ccc(cc2)Cl 62a_100009814033_100000043200 [1,0,0,0,1,0|1,1,0]=4 114 B20R2.4834 CC(=O)CCc1ccc(cc1)c2ccc(cc2Cl)Cl 271570a_100012352019_100000723691 [1,0,0,0,1,0|2,0,0]=4 115 B22R2.528582 CC(=O)OC(C)Sc1ccc(cc1)Oc2ccc(cc2)Cl 62a_100009818208_100000035638 [1,0,0,0,0,1|1,1,0]=4 116 B22R2.147099 CC(=O)CCc1ccc(cc1)OCc2ccc(cc2Cl)Cl 34a_100000198047_100000188473 [1,0,0,0,0,1|2,0,0]=4 117 B22R2.147099 CC(=O)CCc1ccc(cc1)OCc2ccc(cc2Cl)Cl 7a_100000198047_100000188473 [1,0,0,0,0,1|2,0,0]=4 118 B22R2.308503 CC(=O)CCOc1ccc(cc1)Oc2ccc(cc2Cl)Cl 7a_200010192161_100000053229 [1,0,0,0,0,1|1,0,0]=3 119 B24R2.6580195 CC(=O)C(C)OCc1ccc(cc1)OCc2ccc(cc2Cl)Cl 7a_200000578215_100000179758 [0,0,0,0,0,2|1,0,0]=3